LOCUS       NM_002986               1005 bp    mRNA    linear   PRI 10-MAR-2024
DEFINITION  Homo sapiens C-C motif chemokine ligand 11 (CCL11), mRNA.
ACCESSION   NM_002986
VERSION     NM_002986.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1005)
  AUTHORS   Zou,C., Zhang,W., Li,M., He,D., Han,Y., Liu,M. and Lu,M.
  TITLE     Association between CCL5, CCL11, and CCL17 polymorphisms and atopic
            dermatitis risk: A systematic review and meta-analysis
  JOURNAL   Medicine (Baltimore) 103 (8), e36897 (2024)
   PUBMED   38394497
  REMARK    GeneRIF: Association between CCL5, CCL11, and CCL17 polymorphisms
            and atopic dermatitis risk: A systematic review and meta-analysis.
REFERENCE   2  (bases 1 to 1005)
  AUTHORS   Chen,X., Meng,C., Wang,X., Wu,Z., Sun,X., Sun,C., Zheng,L., Li,W.,
            Jia,W. and Tang,T.
  TITLE     Exploring CCL11 in breast cancer: unraveling its anticancer
            potential and immune modulatory effects involving the Akt-S6
            signaling
  JOURNAL   J Cancer Res Clin Oncol 150 (2), 69 (2024)
   PUBMED   38305920
  REMARK    GeneRIF: Exploring CCL11 in breast cancer: unraveling its
            anticancer potential and immune modulatory effects involving the
            Akt-S6 signaling.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1005)
  AUTHORS   Bhattacharyya,S., Oon,C., Diaz,L., Sandborg,H., Stempinski,E.S.,
            Saoi,M., Morgan,T.K., Lopez,C.S., Cross,J.R. and Sherman,M.H.
  TITLE     Autotaxin-lysolipid signaling suppresses a CCL11-eosinophil axis to
            promote pancreatic cancer progression
  JOURNAL   Nat Cancer 5 (2), 283-298 (2024)
   PUBMED   38195933
  REMARK    GeneRIF: Autotaxin-lysolipid signaling suppresses a
            CCL11-eosinophil axis to promote pancreatic cancer progression.
REFERENCE   4  (bases 1 to 1005)
  AUTHORS   Lavandoski,P., Pierdona,V., Maurmann,R.M., Grun,L.K., Guma,F.T.C.R.
            and Barbe-Tuana,F.M.
  TITLE     Eotaxin-1/CCL11 promotes cellular senescence in human-derived
            fibroblasts through pro-oxidant and pro-inflammatory pathways
  JOURNAL   Front Immunol 14, 1243537 (2023)
   PUBMED   37860000
  REMARK    GeneRIF: Eotaxin-1/CCL11 promotes cellular senescence in
            human-derived fibroblasts through pro-oxidant and pro-inflammatory
            pathways.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1005)
  AUTHORS   Chen,J., Zhou,Y., Sun,Y., Yuan,S., Kalla,R., Sun,J., Zhao,J.,
            Wang,L., Chen,X., Zhou,X., Dai,S., Zhang,Y., Ho,G.T., Xia,D.,
            Cao,Q., Liu,Z., Larsson,S.C., Wang,X., Ding,K., Halfvarson,J.,
            Li,X., Theodoratou,E. and Satsangi,J.
  TITLE     Bidirectional Mendelian Randomisation Analysis Provides Evidence
            for the Causal Involvement of Dysregulation of CXCL9, CCL11 and
            CASP8 in the Pathogenesis of Ulcerative Colitis
  JOURNAL   J Crohns Colitis 17 (5), 777-785 (2023)
   PUBMED   36576886
  REMARK    GeneRIF: Bidirectional Mendelian Randomisation Analysis Provides
            Evidence for the Causal Involvement of Dysregulation of CXCL9,
            CCL11 and CASP8 in the Pathogenesis of Ulcerative Colitis.
REFERENCE   6  (bases 1 to 1005)
  AUTHORS   Yang,D., Chen,Q., Hoover,D.M., Staley,P., Tucker,K.D., Lubkowski,J.
            and Oppenheim,J.J.
  TITLE     Many chemokines including CCL20/MIP-3alpha display antimicrobial
            activity
  JOURNAL   J Leukoc Biol 74 (3), 448-455 (2003)
   PUBMED   12949249
  REMARK    GeneRIF: CCL11 is an antimicrobial protein with bacteriocidal
            activity against E. coli and S. aureus.
REFERENCE   7  (bases 1 to 1005)
  AUTHORS   Daugherty,B.L., Siciliano,S.J., DeMartino,J.A., Malkowitz,L.,
            Sirotina,A. and Springer,M.S.
  TITLE     Cloning, expression, and characterization of the human eosinophil
            eotaxin receptor
  JOURNAL   J Exp Med 183 (5), 2349-2354 (1996)
   PUBMED   8642344
REFERENCE   8  (bases 1 to 1005)
  AUTHORS   Garcia-Zepeda,E.A., Rothenberg,M.E., Ownbey,R.T., Celestin,J.,
            Leder,P. and Luster,A.D.
  TITLE     Human eotaxin is a specific chemoattractant for eosinophil cells
            and provides a new mechanism to explain tissue eosinophilia
  JOURNAL   Nat Med 2 (4), 449-456 (1996)
   PUBMED   8597956
REFERENCE   9  (bases 1 to 1005)
  AUTHORS   Kitaura,M., Nakajima,T., Imai,T., Harada,S., Combadiere,C.,
            Tiffany,H.L., Murphy,P.M. and Yoshie,O.
  TITLE     Molecular cloning of human eotaxin, an eosinophil-selective CC
            chemokine, and identification of a specific eosinophil eotaxin
            receptor, CC chemokine receptor 3
  JOURNAL   J Biol Chem 271 (13), 7725-7730 (1996)
   PUBMED   8631813
REFERENCE   10 (bases 1 to 1005)
  AUTHORS   Ponath,P.D., Qin,S., Ringler,D.J., Clark-Lewis,I., Wang,J.,
            Kassam,N., Smith,H., Shi,X., Gonzalo,J.A., Newman,W.,
            Gutierrez-Ramos,J.C. and Mackay,C.R.
  TITLE     Cloning of the human eosinophil chemoattractant, eotaxin.
            Expression, receptor binding, and functional properties suggest a
            mechanism for the selective recruitment of eosinophils
  JOURNAL   J Clin Invest 97 (3), 604-612 (1996)
   PUBMED   8609214
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BF197516.1, U46573.1,
            AI446061.1, Z75668.1 and AC005549.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 17, 2019 this sequence version replaced NM_002986.2.
            
            Summary: This antimicrobial gene is one of several chemokine genes
            clustered on the q-arm of chromosome 17. Chemokines form a
            superfamily of secreted proteins involved in immunoregulatory and
            inflammatory processes. The superfamily is divided into four
            subfamilies based on the arrangement of the N-terminal cysteine
            residues of the mature peptide. This chemokine, a member of the CC
            subfamily, displays chemotactic activity for eosinophils, but not
            mononuclear cells or neutrophils. This eosinophil-specific
            chemokine is thought to be involved in eosinophilic inflammatory
            diseases such as atopic dermatitis, allergic rhinitis, asthma and
            parasitic infections. [provided by RefSeq, Sep 2014].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DRR138521.410073.1,
                                           DRR138520.53706.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match                 :: ENST00000305869.4/
                                                  ENSP00000302234.3
            Protein has antimicrobial activity :: PMID: 12949249
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-14                BF197516.1         369-382             c
            15-488              U46573.1           1-474
            489-499             AI446061.1         280-290             c
            500-758             U46573.1           489-747
            759-795             Z75668.1           749-785
            796-851             U46573.1           784-839
            852-1005            AC005549.1         28433-28586         c
FEATURES             Location/Qualifiers
     source          1..1005
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q12"
     gene            1..1005
                     /gene="CCL11"
                     /gene_synonym="SCYA11"
                     /note="C-C motif chemokine ligand 11"
                     /db_xref="GeneID:6356"
                     /db_xref="HGNC:HGNC:10610"
                     /db_xref="MIM:601156"
     exon            1..143
                     /gene="CCL11"
                     /gene_synonym="SCYA11"
                     /inference="alignment:Splign:2.1.0"
     CDS             68..361
                     /gene="CCL11"
                     /gene_synonym="SCYA11"
                     /note="small inducible cytokine subfamily A (Cys-Cys),
                     member 11 (eotaxin); eotaxin-1; chemokine (C-C motif)
                     ligand 11; eosinophil chemotactic protein"
                     /codon_start=1
                     /product="eotaxin precursor"
                     /protein_id="NP_002977.1"
                     /db_xref="CCDS:CCDS11279.1"
                     /db_xref="GeneID:6356"
                     /db_xref="HGNC:HGNC:10610"
                     /db_xref="MIM:601156"
                     /translation="MKVSAALLWLLLIAAAFSPQGLAGPASVPTTCCFNLANRKIPLQ
                     RLESYRRITSGKCPQKAVIFKTKLAKDICADPKKKWVQDSMKYLDQKSPTPKP"
     exon            144..255
                     /gene="CCL11"
                     /gene_synonym="SCYA11"
                     /inference="alignment:Splign:2.1.0"
     exon            256..1005
                     /gene="CCL11"
                     /gene_synonym="SCYA11"
                     /inference="alignment:Splign:2.1.0"
     regulatory      361..366
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CCL11"
                     /gene_synonym="SCYA11"
                     /note="hexamer: AATAAT"
     polyA_site      385
                     /gene="CCL11"
                     /gene_synonym="SCYA11"
                     /note="major polyA site"
     regulatory      754..759
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CCL11"
                     /gene_synonym="SCYA11"
                     /note="hexamer: AGTAAA"
     regulatory      776..781
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CCL11"
                     /gene_synonym="SCYA11"
                     /note="hexamer: CATAAA"
     polyA_site      781
                     /gene="CCL11"
                     /gene_synonym="SCYA11"
     polyA_site      806
                     /gene="CCL11"
                     /gene_synonym="SCYA11"
ORIGIN      
        1 agagaggctg agaccaaccc agaaaccacc acctctcacg ccaaagctca caccttcagc
       61 ctccaacatg aaggtctccg cagcacttct gtggctgctg ctcatagcag ctgccttcag
      121 cccccagggg ctcgctgggc cagcttctgt cccaaccacc tgctgcttta acctggccaa
      181 taggaagata ccccttcagc gactagagag ctacaggaga atcaccagtg gcaaatgtcc
      241 ccagaaagct gtgatcttca agaccaaact ggccaaggat atctgtgccg accccaagaa
      301 gaagtgggtg caggattcca tgaagtatct ggaccaaaaa tctccaactc caaagccata
      361 aataatcacc atttttgaaa ccaaaccaga gcctgagtgt tgcctaattt gttttccctt
      421 cttacaatgc attctgaggt aacctcatta tcagtccaaa gggcatgggt tttattatat
      481 atatatattt ttttttttaa aaaaaaaacg tattgcattt aatttattga ggctttaaaa
      541 cttatcctcc atgaatatca gttattttta aactgtaaag ctttgtgcag attctttacc
      601 ccctgggagc cccaattcga tcccctgtca cgtgtgggca atgttccccc tctcctctct
      661 tcctccctgg aatcttgtaa aggtcctggc aaagatgatc agtatgaaaa tgtcattgtt
      721 cttgtgaacc caaagtgtga ctcattaaat ggaagtaaat gttgttttag gaatacataa
      781 agtatgtgca tattttatta tagtcactag ttgtaatttt tttgtgggaa atccacactg
      841 agctgagggg gacaaagatg gctgtggcca agaggggctt ggttaagggg gtgggaacta
      901 tgtccctggg aaatgagttt ttggcttagc tggtcttcat tgaaatgcag ggtgaaactg
      961 acaaacccat tccagccctc tattcccatt ttcaacagta tttcc
//
