LOCUS       NM_002981                594 bp    mRNA    linear   PRI 23-MAR-2024
DEFINITION  Homo sapiens C-C motif chemokine ligand 1 (CCL1), mRNA.
ACCESSION   NM_002981
VERSION     NM_002981.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 594)
  AUTHORS   Iwata,M., Haraguchi,R., Kitazawa,R., Ito,C., Ogawa,K., Takada,Y.
            and Kitazawa,S.
  TITLE     Reduced chemokine C-C motif ligand 1 expression may negatively
            regulate colorectal cancer progression at liver metastatic sites
  JOURNAL   J Cell Mol Med 28 (7), e18193 (2024)
   PUBMED   38506205
  REMARK    GeneRIF: Reduced chemokine C-C motif ligand 1 expression may
            negatively regulate colorectal cancer progression at liver
            metastatic sites.
REFERENCE   2  (bases 1 to 594)
  AUTHORS   Wang,X.Y., Bian,M.R., Lin,G.Q., Yu,L., Zhang,Y.M. and Wu,D.P.
  TITLE     Tandem bispecific CD123/CLL-1 CAR-T cells exhibit specific
            cytolytic effector functions against human acute myeloid leukaemia
  JOURNAL   Eur J Haematol 112 (1), 83-93 (2024)
   PUBMED   37712633
  REMARK    GeneRIF: Tandem bispecific CD123/CLL-1 CAR-T cells exhibit specific
            cytolytic effector functions against human acute myeloid leukaemia.
REFERENCE   3  (bases 1 to 594)
  AUTHORS   Bandow,K., Smith,A., Watkins,T., Shenk,S., Gerami-Naini,B. and
            Garlick,J.A.
  TITLE     CC chemokine ligand 20 (CCL20) positively regulates collagen type I
            production in 3D skin equivalent tissues
  JOURNAL   Exp Dermatol 32 (4), 379-391 (2023)
   PUBMED   36398464
REFERENCE   4  (bases 1 to 594)
  AUTHORS   Xiao,Y., Huang,Y., Jiang,J., Chen,Y. and Wei,C.
  TITLE     Identification of the prognostic value of Th1/Th2 ratio and a novel
            prognostic signature in basal-like breast cancer
  JOURNAL   Hereditas 160 (1), 2 (2023)
   PUBMED   36694223
  REMARK    GeneRIF: Identification of the prognostic value of Th1/Th2 ratio
            and a novel prognostic signature in basal-like breast cancer.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 594)
  AUTHORS   Yang,D., Chen,Q., Hoover,D.M., Staley,P., Tucker,K.D., Lubkowski,J.
            and Oppenheim,J.J.
  TITLE     Many chemokines including CCL20/MIP-3alpha display antimicrobial
            activity
  JOURNAL   J Leukoc Biol 74 (3), 448-455 (2003)
   PUBMED   12949249
  REMARK    GeneRIF: CCL1 is an antimicrobial protein with bacteriocidal
            activity against E. coli and S. aureus.
REFERENCE   6  (bases 1 to 594)
  AUTHORS   Maho,A., Carter,A., Bensimon,A., Vassart,G. and Parmentier,M.
  TITLE     Physical mapping of the CC-chemokine gene cluster on the human
            17q11. 2 region
  JOURNAL   Genomics 59 (2), 213-223 (1999)
   PUBMED   10409433
REFERENCE   7  (bases 1 to 594)
  AUTHORS   Paolini,J.F., Willard,D., Consler,T., Luther,M. and Krangel,M.S.
  TITLE     The chemokines IL-8, monocyte chemoattractant protein-1, and I-309
            are monomers at physiologically relevant concentrations
  JOURNAL   J Immunol 153 (6), 2704-2717 (1994)
   PUBMED   8077676
  REMARK    Erratum:[J Immunol 1996 Apr 15;;156(8):following 3088]
REFERENCE   8  (bases 1 to 594)
  AUTHORS   Miller,M.D. and Krangel,M.S.
  TITLE     The human cytokine I-309 is a monocyte chemoattractant
  JOURNAL   Proc Natl Acad Sci U S A 89 (7), 2950-2954 (1992)
   PUBMED   1557400
REFERENCE   9  (bases 1 to 594)
  AUTHORS   Miller,M.D., Wilson,S.D., Dorf,M.E., Seuanez,H.N., O'Brien,S.J. and
            Krangel,M.S.
  TITLE     Sequence and chromosomal location of the I-309 gene. Relationship
            to genes encoding a family of inflammatory cytokines
  JOURNAL   J Immunol 145 (8), 2737-2744 (1990)
   PUBMED   2212659
REFERENCE   10 (bases 1 to 594)
  AUTHORS   Miller,M.D., Hata,S., De Waal Malefyt,R. and Krangel,M.S.
  TITLE     A novel polypeptide secreted by activated human T lymphocytes
  JOURNAL   J Immunol 143 (9), 2907-2916 (1989)
   PUBMED   2809212
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC011193.3, M57502.1 and
            DA620119.1.
            
            On Jul 12, 2013 this sequence version replaced NM_002981.1.
            
            Summary: This antimicrobial gene is one of several chemokine genes
            clustered on the q-arm of chromosome 17. Chemokines form a
            superfamily of secreted proteins involved in immunoregulatory and
            inflammatory processes. The superfamily is divided into four
            subfamilies based on the arrangement of the N-terminal cysteine
            residues of the mature peptide. This chemokine, a member of the CC
            subfamily, is secreted by activated T cells and displays
            chemotactic activity for monocytes but not for neutrophils. It
            binds to the chemokine (C-C motif) receptor 8. [provided by RefSeq,
            Sep 2014].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DA620119.1, BX093610.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match                 :: ENST00000225842.4/
                                                  ENSP00000225842.3
            Protein has antimicrobial activity :: PMID: 12949249
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-22                AC011193.3         127122-127143
            23-542              M57502.1           1-520
            543-594             DA620119.1         541-592
FEATURES             Location/Qualifiers
     source          1..594
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q12"
     gene            1..594
                     /gene="CCL1"
                     /gene_synonym="I-309; P500; SCYA1; SISe; TCA3"
                     /note="C-C motif chemokine ligand 1"
                     /db_xref="GeneID:6346"
                     /db_xref="HGNC:HGNC:10609"
                     /db_xref="MIM:182281"
     exon            1..148
                     /gene="CCL1"
                     /gene_synonym="I-309; P500; SCYA1; SISe; TCA3"
                     /inference="alignment:Splign:2.1.0"
     CDS             73..363
                     /gene="CCL1"
                     /gene_synonym="I-309; P500; SCYA1; SISe; TCA3"
                     /note="small inducible cytokine A1 (I-309, homologous to
                     mouse Tca-3); T lymphocyte-secreted protein I-309;
                     inflammatory cytokine I-309; C-C motif chemokine 1;
                     chemokine (C-C motif) ligand 1"
                     /codon_start=1
                     /product="C-C motif chemokine 1 precursor"
                     /protein_id="NP_002972.1"
                     /db_xref="CCDS:CCDS11282.1"
                     /db_xref="GeneID:6346"
                     /db_xref="HGNC:HGNC:10609"
                     /db_xref="MIM:182281"
                     /translation="MQIITTALVCLLLAGMWPEDVDSKSMQVPFSRCCFSFAEQEIPL
                     RAILCYRNTSSICSNEGLIFKLKRGKEACALDTVGWVQRHRKMLRHCPSKRK"
     exon            149..260
                     /gene="CCL1"
                     /gene_synonym="I-309; P500; SCYA1; SISe; TCA3"
                     /inference="alignment:Splign:2.1.0"
     exon            261..594
                     /gene="CCL1"
                     /gene_synonym="I-309; P500; SCYA1; SISe; TCA3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      519..524
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CCL1"
                     /gene_synonym="I-309; P500; SCYA1; SISe; TCA3"
                     /note="hexamer: ATTATA"
     polyA_site      541
                     /gene="CCL1"
                     /gene_synonym="I-309; P500; SCYA1; SISe; TCA3"
                     /note="major polyA site"
ORIGIN      
        1 acagtggtga gctcttagct tcaccaggct catcaaagct gctccaggaa ggcccaagcc
       61 agaccagaag acatgcagat catcaccaca gccctggtgt gcttgctgct agctgggatg
      121 tggccggaag atgtggacag caagagcatg caggtaccct tctccagatg ttgcttctca
      181 tttgcggagc aagagattcc cctgagggca atcctgtgtt acagaaatac cagctccatc
      241 tgctccaatg agggcttaat attcaagctg aagagaggca aagaggcctg cgccttggac
      301 acagttggat gggttcagag gcacagaaaa atgctgaggc actgcccgtc aaaaagaaaa
      361 tgagcagatt tctttccatt gtgggctctg gaaaccacat ggcttcacct gtccccgaaa
      421 ctaccagccc tacaccattc cttctgccct gcttttgcta ggtcacagag gatctgcttg
      481 gtcttgataa gctatgttgt tgcactttaa acatttaaat tatacaatca tcaaccccca
      541 accctctggg tctcttggat ttcagagtga aaacttgatt ggcattgaga ggtg
//
