LOCUS       NM_176875               2019 bp    mRNA    linear   PRI 05-AUG-2024
DEFINITION  Homo sapiens cholecystokinin B receptor (CCKBR), transcript variant
            1, mRNA.
ACCESSION   NM_176875 NM_000731
VERSION     NM_176875.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2019)
  AUTHORS   Harikumar,K.G., Zhao,P., Cary,B.P., Xu,X., Desai,A.J., Dong,M.,
            Mobbs,J.I., Toufaily,C., Furness,S.G.B., Christopoulos,A.,
            Belousoff,M.J., Wootten,D., Sexton,P.M. and Miller,L.J.
  TITLE     Cholesterol-dependent dynamic changes in the conformation of the
            type 1 cholecystokinin receptor affect ligand binding and G protein
            coupling
  JOURNAL   PLoS Biol 22 (7), e3002673 (2024)
   PUBMED   39083706
  REMARK    GeneRIF: Cholesterol-dependent dynamic changes in the conformation
            of the type 1 cholecystokinin receptor affect ligand binding and G
            protein coupling.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2019)
  AUTHORS   Lvovs,A., Matrov,D., Kurrikoff,T., Veidebaum,T. and Harro,J.
  TITLE     Cholecystokinin B receptor gene polymorphism (rs2941026) is
            associated with anxious personality and suicidal thoughts in a
            longitudinal study
  JOURNAL   Acta Neuropsychiatr 34 (4), 201-211 (2022)
   PUBMED   34924075
  REMARK    GeneRIF: Cholecystokinin B receptor gene polymorphism (rs2941026)
            is associated with anxious personality and suicidal thoughts in a
            longitudinal study.
REFERENCE   3  (bases 1 to 2019)
  AUTHORS   Sato,Y., Ban,S., Katayama,Y. and Mitsui,T.
  TITLE     Unique membranous gastrin receptor expression of parietal cells and
            its distribution pattern in the gastric oxyntic mucosa and fundic
            gland polyps
  JOURNAL   Hum Pathol 125, 23-34 (2022)
   PUBMED   35430166
  REMARK    GeneRIF: Unique membranous gastrin receptor expression of parietal
            cells and its distribution pattern in the gastric oxyntic mucosa
            and fundic gland polyps.
REFERENCE   4  (bases 1 to 2019)
  AUTHORS   Meng,L.L., Wang,J.L., Xu,S.P., Zu,L.D., Yan,Z.W., Zhang,J.B.,
            Han,Y.Q. and Fu,G.H.
  TITLE     Low serum gastrin associated with ER+ breast cancer development via
            inactivation of CCKBR/ERK/P65 signaling
  JOURNAL   BMC Cancer 18 (1), 824 (2018)
   PUBMED   30115027
  REMARK    GeneRIF: We concluded that low serum gastrin is related to
            increased risk of ER(+) BC development. The results also
            established that CCKBR/ERK/P65 signaling function is generally
            tumor suppressive in ER(+) BC, indicating therapies should focus on
            restoring, not inhibiting, CCKBR/ERK/P65 pathway activity.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2019)
  AUTHORS   Smith,J.P. and Solomon,T.E.
  TITLE     Cholecystokinin and pancreatic cancer: the chicken or the egg?
  JOURNAL   Am J Physiol Gastrointest Liver Physiol 306 (2), G91-G101 (2014)
   PUBMED   24177032
  REMARK    Review article
REFERENCE   6  (bases 1 to 2019)
  AUTHORS   Miyake,A.
  TITLE     A truncated isoform of human CCK-B/gastrin receptor generated by
            alternative usage of a novel exon
  JOURNAL   Biochem Biophys Res Commun 208 (1), 230-237 (1995)
   PUBMED   7887934
REFERENCE   7  (bases 1 to 2019)
  AUTHORS   Ito,M., Iwata,N., Taniguchi,T., Murayama,T., Chihara,K. and
            Matsui,T.
  TITLE     Functional characterization of two cholecystokinin-B/gastrin
            receptor isoforms: a preferential splice donor site in the human
            receptor gene
  JOURNAL   Cell Growth Differ 5 (10), 1127-1135 (1994)
   PUBMED   7848914
REFERENCE   8  (bases 1 to 2019)
  AUTHORS   Herget,T., Sethi,T., Wu,S.V., Walsh,J.H. and Rozengurt,E.
  TITLE     Cholecystokinin stimulates Ca2+ mobilization and clonal growth in
            small cell lung cancer through CCKA and CCKB/gastrin receptors
  JOURNAL   Ann N Y Acad Sci 713, 283-297 (1994)
   PUBMED   8185170
  REMARK    Review article
REFERENCE   9  (bases 1 to 2019)
  AUTHORS   Lee,Y.M., Beinborn,M., McBride,E.W., Lu,M., Kolakowski,L.F. Jr. and
            Kopin,A.S.
  TITLE     The human brain cholecystokinin-B/gastrin receptor. Cloning and
            characterization
  JOURNAL   J Biol Chem 268 (11), 8164-8169 (1993)
   PUBMED   7681836
REFERENCE   10 (bases 1 to 2019)
  AUTHORS   Pisegna,J.R., de Weerth,A., Huppi,K. and Wank,S.A.
  TITLE     Molecular cloning of the human brain and gastric cholecystokinin
            receptor: structure, functional expression and chromosomal
            localization
  JOURNAL   Biochem Biophys Res Commun 189 (1), 296-303 (1992)
   PUBMED   1280419
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC022762.8 and AC068733.12.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_176875.3.
            
            Summary: This gene encodes a G-protein coupled receptor for gastrin
            and cholecystokinin (CCK), regulatory peptides of the brain and
            gastrointestinal tract. This protein is a type B gastrin receptor,
            which has a high affinity for both sulfated and nonsulfated CCK
            analogs and is found principally in the central nervous system and
            the gastrointestinal tract. Alternative splicing results in
            multiple transcript variants. A misspliced transcript variant
            including an intron has been observed in cells from colorectal and
            pancreatic tumors. [provided by RefSeq, Dec 2015].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.274990.1,
                                           SRR3476690.982740.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2142586, SAMEA2145743
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000334619.7/ ENSP00000335544.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-242               AC022762.8         176073-176314
            243-494             AC022762.8         185904-186155
            495-744             AC022762.8         186323-186572
            745-902             AC068733.12        9047-9204
            903-2019            AC068733.12        9412-10528
FEATURES             Location/Qualifiers
     source          1..2019
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11p15.4"
     gene            1..2019
                     /gene="CCKBR"
                     /gene_synonym="CCK-2R; CCK-B; CCK2R; GASR"
                     /note="cholecystokinin B receptor"
                     /db_xref="GeneID:887"
                     /db_xref="HGNC:HGNC:1571"
                     /db_xref="MIM:118445"
     exon            1..242
                     /gene="CCKBR"
                     /gene_synonym="CCK-2R; CCK-B; CCK2R; GASR"
                     /inference="alignment:Splign:2.1.0"
     CDS             92..1435
                     /gene="CCKBR"
                     /gene_synonym="CCK-2R; CCK-B; CCK2R; GASR"
                     /note="isoform 1 is encoded by transcript variant 1;
                     gastrin receptor; CCK2 receptor; CCK-B receptor;
                     cholecystokinin-2 receptor; cholecystokinin type 2
                     receptor"
                     /codon_start=1
                     /product="gastrin/cholecystokinin type B receptor isoform
                     1"
                     /protein_id="NP_795344.1"
                     /db_xref="CCDS:CCDS7761.1"
                     /db_xref="GeneID:887"
                     /db_xref="HGNC:HGNC:1571"
                     /db_xref="MIM:118445"
                     /translation="MELLKLNRSVQGTGPGPGASLCRPGAPLLNSSSVGNLSCEPPRI
                     RGAGTRELELAIRITLYAVIFLMSVGGNMLIIVVLGLSRRLRTVTNAFLLSLAVSDLL
                     LAVACMPFTLLPNLMGTFIFGTVICKAVSYLMGVSVSVSTLSLVAIALERYSAICRPL
                     QARVWQTRSHAARVIVATWLLSGLLMVPYPVYTVVQPVGPRVLQCVHRWPSARVRQTW
                     SVLLLLLLFFIPGVVMAVAYGLISRELYLGLRFDGDSDSDSQSRVRNQGGLPGAVHQN
                     GRCRPETGAVGEDSDGCYVQLPRSRPALELTALTAPGPGSGSRPTQAKLLAKKRVVRM
                     LLVIVVLFFLCWLPVYSANTWRAFDGPGAHRALSGAPISFIHLLSYASACVNPLVYCF
                     MHRRFRQACLETCARCCPRPPRARPRALPDEDPPTPSIASLSRLSYTTISTLGPG"
     exon            243..494
                     /gene="CCKBR"
                     /gene_synonym="CCK-2R; CCK-B; CCK2R; GASR"
                     /inference="alignment:Splign:2.1.0"
     exon            495..744
                     /gene="CCKBR"
                     /gene_synonym="CCK-2R; CCK-B; CCK2R; GASR"
                     /inference="alignment:Splign:2.1.0"
     exon            745..902
                     /gene="CCKBR"
                     /gene_synonym="CCK-2R; CCK-B; CCK2R; GASR"
                     /inference="alignment:Splign:2.1.0"
     exon            903..2019
                     /gene="CCKBR"
                     /gene_synonym="CCK-2R; CCK-B; CCK2R; GASR"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1994..1999
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CCKBR"
                     /gene_synonym="CCK-2R; CCK-B; CCK2R; GASR"
                     /note="hexamer: AATAAA"
     polyA_site      2019
                     /gene="CCKBR"
                     /gene_synonym="CCK-2R; CCK-B; CCK2R; GASR"
                     /note="major polyA site"
ORIGIN      
        1 agcctgagcc ggaatcgcag cgtgagcagg tggagccgcg ttgggagccc gccgggtcga
       61 gctgagtaag gcggcgggct cggcgggggc catggagctg ctaaagctga accggagcgt
      121 gcagggaacc ggacccgggc cgggggcttc cctgtgccgc ccgggggcgc ctctcctcaa
      181 cagcagcagt gtgggcaacc tcagctgcga gccccctcgc attcgcggag ccgggacacg
      241 agaattggag ctggccatta gaatcactct ttacgcagtg atcttcctga tgagcgttgg
      301 aggaaatatg ctcatcatcg tggtcctggg actgagccgc cgcctgagga ctgtcaccaa
      361 tgccttcctc ctctcactgg cagtcagcga cctcctgctg gctgtggctt gcatgccctt
      421 caccctcctg cccaatctca tgggcacatt catctttggc accgtcatct gcaaggcggt
      481 ttcctacctc atgggggtgt ctgtgagtgt gtccacgcta agcctcgtgg ccatcgcact
      541 ggagcggtac agcgccatct gccgaccact gcaggcacga gtgtggcaga cgcgctccca
      601 cgcggctcgc gtgattgtag ccacgtggct gctgtccgga ctactcatgg tgccctaccc
      661 cgtgtacact gtcgtgcaac cagtggggcc tcgtgtgctg cagtgcgtgc atcgctggcc
      721 cagtgcgcgg gtccgccaga cctggtccgt actgctgctt ctgctcttgt tcttcatccc
      781 gggtgtggtt atggccgtgg cctacgggct tatctctcgc gagctctact tagggcttcg
      841 ctttgacggc gacagtgaca gcgacagcca aagcagggtc cgaaaccaag gcgggctgcc
      901 aggggctgtt caccagaacg ggcgttgccg gcctgagact ggcgcggttg gcgaagacag
      961 cgatggctgc tacgtgcaac ttccacgttc ccggcctgcc ctggagctga cggcgctgac
     1021 ggctcctggg ccgggatccg gctcccggcc cacccaggcc aagctgctgg ctaagaagcg
     1081 cgtggtgcga atgttgctgg tgatcgttgt gctttttttt ctgtgttggt tgccagttta
     1141 tagtgccaac acgtggcgcg cctttgatgg cccgggtgca caccgagcac tctcgggtgc
     1201 tcctatctcc ttcattcact tgctgagcta cgcctcggcc tgtgtcaacc ccctggtcta
     1261 ctgcttcatg caccgtcgct ttcgccaggc ctgcctggaa acttgcgctc gctgctgccc
     1321 ccggcctcca cgagctcgcc ccagggctct tcccgatgag gaccctccca ctccctccat
     1381 tgcttcgctg tccaggctta gctacaccac catcagcaca ctgggccctg gctgaggagt
     1441 agaggggccg tgggggttga ggcagggcaa atgacatgca ctgacccttc cagacatacg
     1501 aaacacaaac cacaactgac acaggaaacc aacacccaaa gcatggacta accccaacgc
     1561 acaggaaaag gtagcttacc tgacacaaga ggaataagaa tggagcagta catgggaaag
     1621 gaggcatgcc tctgatatgg gactgagcct ggcccataga aacatgacac tgaccttgga
     1681 gagacacagc gtccctagca gtgaactatt tctacacagt gggaactctg acaagggctg
     1741 acctgcctct cacacacata gattaatggc actgattgtt ttagagacta tggagcctgg
     1801 cacaggactg attctgggat gctcctagtt tgacctcaca gtgacccttc ccaatcagca
     1861 ctgaaaatac catcaggcct aatctcatac ctctgaccaa caggctgttc tgcactgaaa
     1921 aggttcttca tccctttcca gttaaggacc gtggccctgc cctctccttc cttacccaaa
     1981 ctgttcaaga aataataaat tgtttggctt cctcctgaa
//
