LOCUS       NM_000730               1746 bp    mRNA    linear   PRI 05-AUG-2024
DEFINITION  Homo sapiens cholecystokinin A receptor (CCKAR), mRNA.
ACCESSION   NM_000730
VERSION     NM_000730.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1746)
  AUTHORS   Harikumar,K.G., Zhao,P., Cary,B.P., Xu,X., Desai,A.J., Dong,M.,
            Mobbs,J.I., Toufaily,C., Furness,S.G.B., Christopoulos,A.,
            Belousoff,M.J., Wootten,D., Sexton,P.M. and Miller,L.J.
  TITLE     Cholesterol-dependent dynamic changes in the conformation of the
            type 1 cholecystokinin receptor affect ligand binding and G protein
            coupling
  JOURNAL   PLoS Biol 22 (7), e3002673 (2024)
   PUBMED   39083706
  REMARK    GeneRIF: Cholesterol-dependent dynamic changes in the conformation
            of the type 1 cholecystokinin receptor affect ligand binding and G
            protein coupling.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1746)
  AUTHORS   Liu,Q., Yang,D., Zhuang,Y., Croll,T.I., Cai,X., Dai,A., He,X.,
            Duan,J., Yin,W., Ye,C., Zhou,F., Wu,B., Zhao,Q., Xu,H.E., Wang,M.W.
            and Jiang,Y.
  TITLE     Ligand recognition and G-protein coupling selectivity of
            cholecystokinin A receptor
  JOURNAL   Nat Chem Biol 17 (12), 1238-1244 (2021)
   PUBMED   34556862
REFERENCE   3  (bases 1 to 1746)
  AUTHORS   Mobbs,J.I., Belousoff,M.J., Harikumar,K.G., Piper,S.J., Xu,X.,
            Furness,S.G.B., Venugopal,H., Christopoulos,A., Danev,R.,
            Wootten,D., Thal,D.M., Miller,L.J. and Sexton,P.M.
  TITLE     Structures of the human cholecystokinin 1 (CCK1) receptor bound to
            Gs and Gq mimetic proteins provide insight into mechanisms of G
            protein selectivity
  JOURNAL   PLoS Biol 19 (6), e3001295 (2021)
   PUBMED   34086670
  REMARK    GeneRIF: Structures of the human cholecystokinin 1 (CCK1) receptor
            bound to Gs and Gq mimetic proteins provide insight into mechanisms
            of G protein selectivity.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1746)
  AUTHORS   Li,Y. and Cui,Z.J.
  TITLE     Photodynamic Activation of Cholecystokinin 1 Receptor with
            Different Genetically Encoded Protein Photosensitizers and from
            Varied Subcellular Sites
  JOURNAL   Biomolecules 10 (10), 1423 (2020)
   PUBMED   33050050
  REMARK    GeneRIF: Photodynamic Activation of Cholecystokinin 1 Receptor with
            Different Genetically Encoded Protein Photosensitizers and from
            Varied Subcellular Sites.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1746)
  AUTHORS   Kazmi,H.R., Chandra,A., Nigam,J., Baghel,K., Srivastava,M.,
            Maurya,S.S. and Parmar,D.
  TITLE     Polymorphism and Expression Profile of Cholecystokinin Type A
            Receptor in Relation to Gallstone Disease Susceptibility
  JOURNAL   Biochem Genet 54 (5), 665-675 (2016)
   PUBMED   27287528
  REMARK    GeneRIF: Study shows downregulation of CCKAR gene expression in
            A1/A1 genotype of gallstone disease patients as compared with
            control with significant variation in its expression pattern in
            relation to polymorphism.
REFERENCE   6  (bases 1 to 1746)
  AUTHORS   Kennedy,K., Gigoux,V., Escrieut,C., Maigret,B., Martinez,J.,
            Moroder,L., Frehel,D., Gully,D., Vaysse,N. and Fourmy,D.
  TITLE     Identification of two amino acids of the human cholecystokinin-A
            receptor that interact with the N-terminal moiety of
            cholecystokinin
  JOURNAL   J Biol Chem 272 (5), 2920-2926 (1997)
   PUBMED   9006937
REFERENCE   7  (bases 1 to 1746)
  AUTHORS   Miller,L.J., Holicky,E.L., Ulrich,C.D. and Wieben,E.D.
  TITLE     Abnormal processing of the human cholecystokinin receptor gene in
            association with gallstones and obesity
  JOURNAL   Gastroenterology 109 (4), 1375-1380 (1995)
   PUBMED   7557108
REFERENCE   8  (bases 1 to 1746)
  AUTHORS   Huppi,K., Siwarski,D., Pisegna,J.R. and Wank,S.
  TITLE     Chromosomal localization of the gastric and brain receptors for
            cholecystokinin (CCKAR and CCKBR) in human and mouse
  JOURNAL   Genomics 25 (3), 727-729 (1995)
   PUBMED   7759110
REFERENCE   9  (bases 1 to 1746)
  AUTHORS   de Weerth,A., Pisegna,J.R., Huppi,K. and Wank,S.A.
  TITLE     Molecular cloning, functional expression and chromosomal
            localization of the human cholecystokinin type A receptor
  JOURNAL   Biochem Biophys Res Commun 194 (2), 811-818 (1993)
   PUBMED   8343165
REFERENCE   10 (bases 1 to 1746)
  AUTHORS   Ulrich,C.D., Ferber,I., Holicky,E., Hadac,E., Buell,G. and
            Miller,L.J.
  TITLE     Molecular cloning and functional expression of the human
            gallbladder cholecystokinin A receptor
  JOURNAL   Biochem Biophys Res Commun 193 (1), 204-211 (1993)
   PUBMED   8503909
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC093637.5 and L19315.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 17, 2019 this sequence version replaced NM_000730.2.
            
            Summary: This gene encodes a G-protein coupled receptor that binds
            non-sulfated members of the cholecystokinin (CCK) family of peptide
            hormones. This receptor is a major physiologic mediator of
            pancreatic enzyme secretion and smooth muscle contraction of the
            gallbladder and stomach. In the central and peripheral nervous
            system this receptor regulates satiety and the release of
            beta-endorphin and dopamine. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: L19315.1, AK313978.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2157511 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000295589.4/ ENSP00000295589.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 5' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-64                AC093637.5         100574-100637       c
            65-1596             L19315.1           1-1532
            1597-1643           L19315.1           1538-1584
            1644-1663           AC093637.5         91632-91651         c
            1664-1739           L19315.1           1603-1678
            1740-1746           L19315.1           1680-1686
FEATURES             Location/Qualifiers
     source          1..1746
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4p15.2"
     gene            1..1746
                     /gene="CCKAR"
                     /gene_synonym="CCK-1R; CCK-A; CCK1-R; CCK1R; CCKRA"
                     /note="cholecystokinin A receptor"
                     /db_xref="GeneID:886"
                     /db_xref="HGNC:HGNC:1570"
                     /db_xref="MIM:118444"
     exon            1..329
                     /gene="CCKAR"
                     /gene_synonym="CCK-1R; CCK-A; CCK1-R; CCK1R; CCKRA"
                     /inference="alignment:Splign:2.1.0"
     CDS             218..1504
                     /gene="CCKAR"
                     /gene_synonym="CCK-1R; CCK-A; CCK1-R; CCK1R; CCKRA"
                     /note="cholecystokinin-1 receptor; cholecystokinin type-A
                     receptor; CCK-AR; CCK-A receptor; cholecystokinin type 1
                     receptor"
                     /codon_start=1
                     /product="cholecystokinin receptor type A"
                     /protein_id="NP_000721.1"
                     /db_xref="CCDS:CCDS3438.1"
                     /db_xref="GeneID:886"
                     /db_xref="HGNC:HGNC:1570"
                     /db_xref="MIM:118444"
                     /translation="MDVVDSLLVNGSNITPPCELGLENETLFCLDQPRPSKEWQPAVQ
                     ILLYSLIFLLSVLGNTLVITVLIRNKRMRTVTNIFLLSLAVSDLMLCLFCMPFNLIPN
                     LLKDFIFGSAVCKTTTYFMGTSVSVSTFNLVAISLERYGAICKPLQSRVWQTKSHALK
                     VIAATWCLSFTIMTPYPIYSNLVPFTKNNNQTANMCRFLLPNDVMQQSWHTFLLLILF
                     LIPGIVMMVAYGLISLELYQGIKFEASQKKSAKERKPSTTSSGKYEDSDGCYLQKTRP
                     PRKLELRQLSTGSSSRANRIRSNSSAANLMAKKRVIRMLIVIVVLFFLCWMPIFSANA
                     WRAYDTASAERRLSGTPISFILLLSYTSSCVNPIIYCFMNKRFRLGFMATFPCCPNPG
                     PPGARGEVGEEEEGGTTGASLSRFSYSHMSASVPPQ"
     exon            330..581
                     /gene="CCKAR"
                     /gene_synonym="CCK-1R; CCK-A; CCK1-R; CCK1R; CCKRA"
                     /inference="alignment:Splign:2.1.0"
     exon            582..843
                     /gene="CCKAR"
                     /gene_synonym="CCK-1R; CCK-A; CCK1-R; CCK1R; CCKRA"
                     /inference="alignment:Splign:2.1.0"
     exon            844..971
                     /gene="CCKAR"
                     /gene_synonym="CCK-1R; CCK-A; CCK1-R; CCK1R; CCKRA"
                     /inference="alignment:Splign:2.1.0"
     exon            972..1746
                     /gene="CCKAR"
                     /gene_synonym="CCK-1R; CCK-A; CCK1-R; CCK1R; CCKRA"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 actgcctttt ccacaacagg agtacaaatg ctggagtgag tgaggtgaac tcaagtcgcc
       61 tttaggaatg gctgaaaaag cccacacctg gaaatcactc cctccctgct cctccacggc
      121 aggttgcatc tgcgagacgc ttcggtcatt agaggaatga gccgggagtg agcaattcac
      181 cagctctcca gcacttggtg gaaagcagca ggcaaggatg gatgtggttg acagccttct
      241 tgtgaatgga agcaacatca ctcctccctg tgaactcggg ctcgaaaatg agacgctttt
      301 ctgcttggat cagccccgtc cttccaaaga gtggcagcca gcggtgcaga ttctcttgta
      361 ctccttgata ttcctgctca gcgtgctggg aaacacgctg gtcatcaccg tgctgattcg
      421 gaacaagcgg atgcggacgg tcaccaacat cttcctcctc tccctggctg tcagcgacct
      481 catgctctgt ctcttctgca tgccgttcaa cctcatcccc aatctgctca aggatttcat
      541 cttcgggagc gccgtttgca agaccaccac ctacttcatg ggcacctctg tgagtgtatc
      601 tacctttaat ctggtagcca tatctctaga gagatatggt gcgatttgca aacccttaca
      661 gtcccgggtc tggcagacaa aatcccatgc tttgaaggtg attgctgcta cctggtgcct
      721 ttcctttacc atcatgactc cgtaccccat ttatagcaac ttggtgcctt ttaccaaaaa
      781 taacaaccag accgcgaata tgtgccgctt tctactgcca aatgatgtta tgcagcagtc
      841 ctggcacaca ttcctgttac tcatcctctt tcttattcct ggaattgtga tgatggtggc
      901 atatggatta atctctttgg aactctacca gggaataaaa tttgaggcta gccagaagaa
      961 gtctgctaaa gaaaggaaac ctagcaccac cagcagcggc aaatatgagg acagcgatgg
     1021 gtgttacctg caaaagacca ggcccccgag gaagctggag ctccggcagc tgtccaccgg
     1081 cagcagcagc agggccaacc gcatccggag taacagctcc gcagccaacc tgatggccaa
     1141 gaaaagggtg atccgcatgc tcatcgtcat cgtggtcctc ttcttcctgt gctggatgcc
     1201 catcttcagc gccaacgcct ggcgggccta cgacaccgcc tccgcagagc gccgcctctc
     1261 aggaaccccc atttccttca tcctcctcct gtcctacacc tcctcctgcg tcaaccccat
     1321 catctactgc ttcatgaaca aacgcttccg cctcggcttc atggccacct tcccctgctg
     1381 ccccaatcct ggtcccccag gggcgagggg agaggtgggg gaggaggagg aaggcgggac
     1441 cacaggagcc tctctgtcca ggttctcgta cagccatatg agtgcctcgg tgccacccca
     1501 gtgagatgtc ccctgaccct ccaccgcaga aggaaggcag ggaggaggca gagaagaaag
     1561 aacggaagaa gagatcagga agagaaggag cagagctgat ggagaaggaa ggctccatct
     1621 ccagtgggaa ctcttcaagg tctgcttttc atccttcatc tggattccag agcactgctc
     1681 cagtggggcc atgattggtt tctaggcagt tcaaagcagg atatgttaag taacactcac
     1741 catcag
//
