LOCUS       NM_000729               1504 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens cholecystokinin (CCK), transcript variant 1, mRNA.
ACCESSION   NM_000729 XM_005265527
VERSION     NM_000729.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1504)
  AUTHORS   Arnold,R.A., Fowler,D.K. and Peters,J.H.
  TITLE     TRPV1 enhances cholecystokinin signaling in primary vagal afferent
            neurons and mediates the central effects on spontaneous glutamate
            release in the NTS
  JOURNAL   Am J Physiol Cell Physiol 326 (1), C112-C124 (2024)
   PUBMED   38047304
  REMARK    GeneRIF: TRPV1 enhances cholecystokinin signaling in primary vagal
            afferent neurons and mediates the central effects on spontaneous
            glutamate release in the NTS.
REFERENCE   2  (bases 1 to 1504)
  AUTHORS   Barde,S., Aguila,J., Zhong,W., Solarz,A., Mei,I., Prud'homme,J.,
            Palkovits,M., Turecki,G., Mulder,J., Uhlen,M., Nagy,C.,
            Mechawar,N., Hedlund,E. and Hokfelt,T.
  TITLE     Substance P, NPY, CCK and their receptors in five brain regions in
            major depressive disorder with transcriptomic analysis of locus
            coeruleus neurons
  JOURNAL   Eur Neuropsychopharmacol 78, 54-63 (2024)
   PUBMED   37931511
  REMARK    GeneRIF: Substance P, NPY, CCK and their receptors in five brain
            regions in major depressive disorder with transcriptomic analysis
            of locus coeruleus neurons.
REFERENCE   3  (bases 1 to 1504)
  AUTHORS   Iwanaga,T.
  TITLE     Anatomical basis of gastrin- and CCK-secreting cells and their
            functions. A review
  JOURNAL   Biomed Res 44 (3), 81-95 (2023)
   PUBMED   37258205
  REMARK    GeneRIF: Anatomical basis of gastrin- and CCK-secreting cells and
            their functions. A review.
            Review article
REFERENCE   4  (bases 1 to 1504)
  AUTHORS   Chou,L., Chang,Y., Lan,K., Liu,M., Lu,Y., Li,X., Li,P. and Xu,Y.
  TITLE     CCK regulates osteogenic differentiation through TNFalpha/NF-kappaB
            in peri-implantitis
  JOURNAL   J Int Med Res 50 (12), 3000605221141312 (2022)
   PUBMED   36495169
  REMARK    GeneRIF: CCK regulates osteogenic differentiation through
            TNFalpha/NF-kappaB in peri-implantitis.
REFERENCE   5  (bases 1 to 1504)
  AUTHORS   Burton Murray,H., Becker,K.R., Harshman,S., Breithaupt,L.,
            Kuhnle,M., Dreier,M.J., Hauser,K., Freizinger,M., Eddy,K.T.,
            Misra,M., Kuo,B., Micali,N., Thomas,J.J. and Lawson,E.A.
  TITLE     Elevated Fasting Satiety-Promoting Cholecystokinin (CCK) in
            Avoidant/Restrictive Food Intake Disorder Compared to Healthy
            Controls
  JOURNAL   J Clin Psychiatry 83 (5) (2022)
   PUBMED   35830620
  REMARK    GeneRIF: Elevated Fasting Satiety-Promoting Cholecystokinin (CCK)
            in Avoidant/Restrictive Food Intake Disorder Compared to Healthy
            Controls.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1504)
  AUTHORS   Eberlein,G.A., Eysselein,V.E., Davis,M.T., Lee,T.D., Shively,J.E.,
            Grandt,D., Niebel,W., Williams,R., Moessner,J., Zeeh,J. et al.
  TITLE     Patterns of prohormone processing. Order revealed by a new
            procholecystokinin-derived peptide
  JOURNAL   J Biol Chem 267 (3), 1517-1521 (1992)
   PUBMED   1370477
REFERENCE   7  (bases 1 to 1504)
  AUTHORS   Lund,T., Geurts van Kessel,A.H., Haun,S. and Dixon,J.E.
  TITLE     The genes for human gastrin and cholecystokinin are located on
            different chromosomes
  JOURNAL   Hum Genet 73 (1), 77-80 (1986)
   PUBMED   3011648
REFERENCE   8  (bases 1 to 1504)
  AUTHORS   Takahashi,Y., Fukushige,S., Murotsu,T. and Matsubara,K.
  TITLE     Structure of human cholecystokinin gene and its chromosomal
            location
  JOURNAL   Gene 50 (1-3), 353-360 (1986)
   PUBMED   3582983
REFERENCE   9  (bases 1 to 1504)
  AUTHORS   Takahashi,Y., Kato,K., Hayashizaki,Y., Wakabayashi,T., Ohtsuka,E.,
            Matsuki,S., Ikehara,M. and Matsubara,K.
  TITLE     Molecular cloning of the human cholecystokinin gene by use of a
            synthetic probe containing deoxyinosine
  JOURNAL   Proc Natl Acad Sci U S A 82 (7), 1931-1935 (1985)
   PUBMED   3856870
REFERENCE   10 (bases 1 to 1504)
  AUTHORS   Studler,J.M., Javoy-Agid,F., Cesselin,F., Legrand,J.C. and Agid,Y.
  TITLE     CCK-8-Immunoreactivity distribution in human brain: selective
            decrease in the substantia nigra from parkinsonian patients
  JOURNAL   Brain Res 243 (1), 176-179 (1982)
   PUBMED   6288173
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BM544754.1, HY140623.1,
            BC111026.1, CB154424.1, AC018358.20 and BI756101.1.
            
            On May 17, 2019 this sequence version replaced NM_000729.5.
            
            Summary: This gene encodes a member of the gastrin/cholecystokinin
            family of proteins. The encoded preproprotein is proteolytically
            processed to generate multiple protein products, including the
            peptide hormones cholecystokinin-8, -12, -33, and others. The
            encoded peptides have been shown to regulate gastric acid secretion
            and food intake. A sulfated form of cholecystokinin-8 may modulate
            neuronal activity in the brain. Alternative splicing results in
            multiple transcript variants. [provided by RefSeq, Nov 2015].
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Both variants 1 and 2 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC111026.1, SRR1803617.255006.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145743, SAMEA2157437
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000396169.7/ ENSP00000379472.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-8                 BM544754.1         34-41
            9-15                HY140623.1         5-11
            16-482              BC111026.1         1-467
            483-598             CB154424.1         410-525
            599-776             BC111026.1         584-761
            777-777             AC018358.20        5076-5076
            778-1503            BC111026.1         763-1488
            1504-1504           BI756101.1         675-675
FEATURES             Location/Qualifiers
     source          1..1504
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p22.1"
     gene            1..1504
                     /gene="CCK"
                     /note="cholecystokinin"
                     /db_xref="GeneID:885"
                     /db_xref="HGNC:HGNC:1569"
                     /db_xref="MIM:118440"
     exon            1..502
                     /gene="CCK"
                     /inference="alignment:Splign:2.1.0"
     exon            503..671
                     /gene="CCK"
                     /inference="alignment:Splign:2.1.0"
     exon            672..882
                     /gene="CCK"
                     /inference="alignment:Splign:2.1.0"
     exon            883..1098
                     /gene="CCK"
                     /inference="alignment:Splign:2.1.0"
     CDS             885..1232
                     /gene="CCK"
                     /note="prepro-cholecystokinin; cholecystokinin
                     triacontatriapeptide"
                     /codon_start=1
                     /product="cholecystokinin preproprotein"
                     /protein_id="NP_000720.1"
                     /db_xref="CCDS:CCDS2696.1"
                     /db_xref="GeneID:885"
                     /db_xref="HGNC:HGNC:1569"
                     /db_xref="MIM:118440"
                     /translation="MNSGVCLCVLMAVLAAGALTQPVPPADPAGSGLQRAEEAPRRQL
                     RVSQRTDGESRAHLGALLARYIQQARKAPSGRMSIVKNLQNLDPSHRISDRDYMGWMD
                     FGRRSAEEYEYPS"
     exon            1099..1504
                     /gene="CCK"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1485..1490
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CCK"
                     /note="hexamer: ATTAAA"
     polyA_site      1504
                     /gene="CCK"
                     /note="major polyA site"
ORIGIN      
        1 attccagagg gaattccaga gcggaatacg gattccgatt ttaaaataag cgcttctaaa
       61 tctttctcct tgcatctaag acgggtgggg gaaagaaagg gagaggagtt gaggtcccaa
      121 ggttcaaggc ctggtgatct ccaggtccca ggctgggcgg cctcggtgca cggagagggc
      181 gaggggcgtg ttgtggagcc ttggcaaggc gctgctcttc ctcgcgcctc ggtttgcggt
      241 ctgtgaaatg gggttggcag tgcctttgca gggacgcggc gaactcaagc accagcaagc
      301 ggactcgaac tcaaagggtt tcagggtgta gacgaccaga gcgcactgag gggctccagg
      361 tcggcccgct ccggagccgg gagagtaacc gcgtgcaggg aaaggcgcac ggcagcctcg
      421 gtgcctccct tccctccacc ggacgggtga ctgactaggg gtgaggtcct cacctccagg
      481 ctgcgcagct gagttctgga agctgcgtca agagaggccc aggacaccaa gagccagctg
      541 tggccagagc cctttcactg acccagaaca ctggccctcg gaaacctgga gaactgcgag
      601 ggcttttaat gcggctgaga agaaagtgaa gaccccgact cctcctctct ccttcgaaag
      661 agccgacaca ggagccactt caaccggttg tcgccccagt ggccgccctc tgagcacgtg
      721 ttactgccag tctgcgtcag cgttgggtaa atacatgact ggccgacgcc gccgggtggg
      781 gctatttaag agacagccgc ccgctggtcc tccctgaact tggctcagct gccgggctgc
      841 tccggttgga aacgccaagc cagctgcgtc ctaatccaaa agccatgaac agcggcgtgt
      901 gcctgtgcgt gctgatggcg gtactggcgg ctggcgccct gacgcagccg gtgcctcccg
      961 cagatcccgc gggctccggg ctgcagcggg cagaggaggc gccccgtagg cagctgaggg
     1021 tatcgcagag aacggatggc gagtcccgag cgcacctggg cgccctgctg gcaagataca
     1081 tccagcaggc ccggaaagct ccttctggac gaatgtccat cgttaagaac ctgcagaacc
     1141 tggaccccag ccacaggata agtgaccggg actacatggg ctggatggat tttggccgtc
     1201 gcagtgccga ggagtatgag tacccctcct agaggaccca gccgccatca gcccaacggg
     1261 aagcaacctc ccaacccaga ggaggcagaa taagaaaaca atcacactca taactcattg
     1321 tctgtggagt ttgacattgt atgtatctat ttattaagtt ctcaatgtga aaaatgtgtc
     1381 tgtaagattg tccagtgcaa ccacacacct caccagaatt gtgcaaatgg aagacaaaat
     1441 gttttcttca tctgtgactc ctggtctgaa aatgttgtta tgctattaaa gtgatttcat
     1501 tctg
//
