LOCUS       NM_005893               1947 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens calicin (CCIN), mRNA.
ACCESSION   NM_005893
VERSION     NM_005893.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1947)
  AUTHORS   Jin,H.J., Fan,Y., Yang,X., Dong,Y., Zhang,X.Z., Geng,X.Y., Yan,Z.,
            Wu,L., Ma,M., Li,B., Lyu,Q., Pan,Y., Liu,M., Kuang,Y. and Chen,S.R.
  TITLE     Disruption in CYLC1 leads to acrosome detachment, sperm head
            deformity, and male in/subfertility in humans and mice
  JOURNAL   Elife 13, 95054 (2024)
   PUBMED   38573307
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1947)
  AUTHORS   Fan,Y., Huang,C., Chen,J., Chen,Y., Wang,Y., Yan,Z., Yu,W., Wu,H.,
            Yang,Y., Nie,L., Huang,S., Wang,F., Wang,H., Hua,Y., Lyu,Q.,
            Kuang,Y. and Lei,M.
  TITLE     Mutations in CCIN cause teratozoospermia and male infertility
  JOURNAL   Sci Bull (Beijing) 67 (20), 2112-2123 (2022)
   PUBMED   36546111
REFERENCE   3  (bases 1 to 1947)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   4  (bases 1 to 1947)
  AUTHORS   de Mateo,S., Castillo,J., Estanyol,J.M., Ballesca,J.L. and Oliva,R.
  TITLE     Proteomic characterization of the human sperm nucleus
  JOURNAL   Proteomics 11 (13), 2714-2726 (2011)
   PUBMED   21630459
REFERENCE   5  (bases 1 to 1947)
  AUTHORS   Lecuyer,C., Dacheux,J.L., Hermand,E., Mazeman,E., Rousseaux,J. and
            Rousseaux-Prevost,R.
  TITLE     Actin-binding properties and colocalization with actin during
            spermiogenesis of mammalian sperm calicin
  JOURNAL   Biol Reprod 63 (6), 1801-1810 (2000)
   PUBMED   11090452
REFERENCE   6  (bases 1 to 1947)
  AUTHORS   von Bulow,M., Heid,H., Hess,H. and Franke,W.W.
  TITLE     Molecular nature of calicin, a major basic protein of the mammalian
            sperm head cytoskeleton
  JOURNAL   Exp Cell Res 219 (2), 407-413 (1995)
   PUBMED   7641791
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL158830.17, AK313763.1 and
            BC019251.2.
            
            On May 17, 2019 this sequence version replaced NM_005893.2.
            
            Summary: The protein encoded by this gene is a basic protein of the
            sperm head cytoskeleton. This protein contains kelch repeats and a
            BTB/POZ domain and is necessary for normal morphology during sperm
            differentiation. This gene is intronless. [provided by RefSeq, Jul
            2008].
            
            ##Evidence-Data-START##
            Transcript is intronless :: HM005688.1, BC019251.2 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000335119.4/ ENSP00000334996.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4                 AL158830.17        70891-70894
            5-1882              AK313763.1         6-1883
            1883-1947           BC019251.2         1847-1911
FEATURES             Location/Qualifiers
     source          1..1947
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9p13.3"
     gene            1..1947
                     /gene="CCIN"
                     /gene_synonym="BTBD20; KBTBD14; SPGF91"
                     /note="calicin"
                     /db_xref="GeneID:881"
                     /db_xref="HGNC:HGNC:1568"
                     /db_xref="MIM:603960"
     exon            1..1947
                     /gene="CCIN"
                     /gene_synonym="BTBD20; KBTBD14; SPGF91"
                     /inference="alignment:Splign:2.1.0"
     CDS             116..1882
                     /gene="CCIN"
                     /gene_synonym="BTBD20; KBTBD14; SPGF91"
                     /note="testis tissue sperm-binding protein Li 65n"
                     /codon_start=1
                     /product="calicin"
                     /protein_id="NP_005884.2"
                     /db_xref="CCDS:CCDS6599.1"
                     /db_xref="GeneID:881"
                     /db_xref="HGNC:HGNC:1568"
                     /db_xref="MIM:603960"
                     /translation="MKLEFTEKNYNSFVLQNLNRQRKRKEYWDMALSVDNHVFFAHRN
                     VLAAVSPLVRSLISSNDMKTADELFITIDTSYLSPVTVDQLLDYFYSGKVVISEQNVE
                     ELLRGAQYFNTPRLRVHCNDFLIKSICRANCLRYLFLAELFELKEVSDVAYSGIRDNF
                     HYWASPEGSMHFMRCPPVIFGRLLRDENLHVLNEDQALSALINWVYFRKEDREKYFKK
                     FFNYINLNAVSNKTLVFASNKLVGMENTSSHTTLIESVLMDRKQERPCSLLVYQRKGA
                     LLDSVVILGGQKAHGQFNDGVFAYIIQENLWMKLSDMPYRAAALSATSAGRYIYISGG
                     TTEQISGLKTAWRYDMDDNSWTKLPDLPIGLVFHTMVTCGGTVYSVGGSIAPRRYVSN
                     IYRYDERKEVWCLAGKMSIPMDGTAVITKGDRHLYIVTGRCLVKGYISRVGVVDCFDT
                     STGDVVQCITFPIEFNHRPLLSFQQDNILCVHSHRQSVEINLQKVKASKTTTSVPVLP
                     NSCPLDVSHAICSIGDSKVFVCGGVTTASDVQTKDYTINPNAFLLDQKTGKWKTLAPP
                     PEALDCPACCLAKLPCKILQRI"
     regulatory      1903..1908
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CCIN"
                     /gene_synonym="BTBD20; KBTBD14; SPGF91"
                     /note="hexamer: AGTAAA"
     polyA_site      1947
                     /gene="CCIN"
                     /gene_synonym="BTBD20; KBTBD14; SPGF91"
                     /note="major polyA site"
ORIGIN      
        1 ctctcttctc cctggtcaac cgctctgcaa acaaccatca atctgatccc acaggcctga
       61 gaaagtctgc tctccagtac ctgctgctga tctgtttcag ccgacaagag gcaccatgaa
      121 attggaattc acggagaaaa actacaatag cttcgtgctg cagaacctga acagacagag
      181 gaaacgcaaa gagtactggg acatggccct gagtgtggac aaccacgtct tctttgcaca
      241 tcgcaatgtg ctggctgctg tctccccact ggtgaggagc ctcatctcca gcaatgacat
      301 gaagaccgct gatgagcttt tcatcaccat tgacaccagt tacctgagcc cggtcacagt
      361 ggaccagctt ctggactact tctatagcgg caaggtggtg atctccgagc aaaatgtgga
      421 ggagctgctt cgtggggctc agtatttcaa cacaccacgc cttcgagttc actgtaacga
      481 cttccttatt aagtccatct gccgtgccaa ctgcttgcgc tacctcttct tggctgagct
      541 gtttgagctc aaagaggtat cagacgtagc ttactctggc attcgggaca acttccacta
      601 ctgggccagt cctgagggct ccatgcactt catgcgctgt ccacctgtta tctttggccg
      661 cctgctccgt gatgaaaacc ttcacgtgct caatgaagac caggcgctca gcgcactcat
      721 caattgggtg tacttccgga aggaggatcg ggagaagtat ttcaagaagt tcttcaatta
      781 catcaatctc aatgctgtct ccaataagac gctggtgttt gccagcaaca agctggtggg
      841 catggagaac acctcatccc atacaaccct gattgagagt gtcctgatgg accgcaagca
      901 ggagcggcca tgcagcctgc tggtctacca gcggaaaggg gccctgcttg attccgtggt
      961 catcctcggt ggccagaagg cccacggcca gttcaatgat ggagtgtttg cttatatcat
     1021 ccaggagaac ctgtggatga agctctcaga catgccctat cgggcagcag cacttagtgc
     1081 cacctctgct ggtcgctaca tctacatctc tggtggcacc actgagcaga tttcagggct
     1141 gaagacagcc tggcggtatg acatggatga caactcctgg accaagttgc ctgacctgcc
     1201 catcgggctt gtcttccaca ccatggtgac ctgtgggggg acagtgtact cagtgggcgg
     1261 gagcattgcc ccaaggcggt atgtctccaa catctatcgc tatgatgagc ggaaggaagt
     1321 ctggtgcctg gcaggaaaga tgagcatccc catggatggc accgccgtga tcactaaagg
     1381 agacaggcat ctgtacattg tcactggacg gtgcttggtg aaaggttata tctcccgggt
     1441 cggggtagtg gactgctttg acaccagcac tggggacgtg gtccagtgta tcaccttccc
     1501 cattgagttc aaccatcggc ccctgctctc tttccaacag gacaacatcc tctgcgtgca
     1561 cagccaccgg cagagtgtgg aaatcaatct gcagaaggtg aaggcaagca agacgaccac
     1621 ctcagtgcct gtcttgccca acagctgccc cttggatgtg tcccatgcta tatgctccat
     1681 tggagacagc aaggtgtttg tatgtggggg tgtcaccact gccagcgatg tccagacaaa
     1741 ggactacacc atcaatccaa atgccttctt gctggaccaa aagacaggca agtggaagac
     1801 cctggctcct ccaccagagg cactggactg tcctgcctgc tgtctagcca agctaccttg
     1861 caagattctt caaaggattt aaacatttta agtgggagaa taagtaaatg cattattatt
     1921 cacgatttaa tgagagaaag agaggaa
//
