LOCUS       NM_152638               2962 bp    mRNA    linear   PRI 10-JUL-2024
DEFINITION  Homo sapiens coiled-coil glutamate rich protein 1 (CCER1),
            transcript variant 1, mRNA.
ACCESSION   NM_152638
VERSION     NM_152638.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2962)
  AUTHORS   Qin,D., Gu,Y., Zhang,Y., Wang,S., Jiang,T., Wang,Y., Wang,C.,
            Chen,C., Zhang,T., Xu,W., Wang,H., Zhang,K., Hu,L., Li,L., Xie,W.,
            Wu,X. and Hu,Z.
  TITLE     Phase-separated CCER1 coordinates the histone-to-protamine
            transition and male fertility
  JOURNAL   Nat Commun 14 (1), 8209 (2023)
   PUBMED   38081819
  REMARK    GeneRIF: Phase-separated CCER1 coordinates the histone-to-protamine
            transition and male fertility.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2962)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   3  (bases 1 to 2962)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 2962)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2962)
  AUTHORS   Shen,L., Kondo,Y., Guo,Y., Zhang,J., Zhang,L., Ahmed,S., Shu,J.,
            Chen,X., Waterland,R.A. and Issa,J.P.
  TITLE     Genome-wide profiling of DNA methylation reveals a class of
            normally methylated CpG island promoters
  JOURNAL   PLoS Genet 3 (10), 2023-2036 (2007)
   PUBMED   17967063
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC078873.22 and BC027600.2.
            
            On May 17, 2019 this sequence version replaced NM_152638.3.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the functional protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript is intronless :: BC027600.2 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000358859.3/ ENSP00000351727.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-168               AC078873.22        11767-11934         c
            169-2962            BC027600.2         169-2962
FEATURES             Location/Qualifiers
     source          1..2962
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q21.33"
     gene            1..2962
                     /gene="CCER1"
                     /gene_synonym="C12orf12"
                     /note="coiled-coil glutamate rich protein 1"
                     /db_xref="GeneID:196477"
                     /db_xref="HGNC:HGNC:28373"
                     /db_xref="MIM:620881"
     exon            1..2962
                     /gene="CCER1"
                     /gene_synonym="C12orf12"
                     /inference="alignment:Splign:2.1.0"
     CDS             435..1655
                     /gene="CCER1"
                     /gene_synonym="C12orf12"
                     /codon_start=1
                     /product="coiled-coil domain-containing glutamate-rich
                     protein 1"
                     /protein_id="NP_689851.1"
                     /db_xref="CCDS:CCDS9036.1"
                     /db_xref="GeneID:196477"
                     /db_xref="HGNC:HGNC:28373"
                     /db_xref="MIM:620881"
                     /translation="MTQTLDTREDPLNLGGGGGGGCGCGWAHSASLSSWSSCHRRRPG
                     APAYNRPHRYSPKTEYGPPRKQPKQQHGPGFWFQPPVCSNWGCWGGPWRPPPPGFWKF
                     PCPVQVFRVYGLHPLCFCCCSCWSGSWNPGWVKPPGRKKRWGRRGRGLRHHPRHSYPR
                     SPPADVSTLPRPVKLYEWREPGMRAPPNTTQFIMNQIYEDMRQQEKVERQQEALRAQK
                     ATVSGEASPARSSGNDAPPGGSKETWGLQETLYGFVQNPSLAFSPNPEENQSLAPLLV
                     EEEEEKKNDDEEEYDQEVCDAKEASEEEEEVEDEEEEVEDEEEEEVEEAEYVEEGEEE
                     LEEEELEEEEEVLEENEQRGEEFHLPLEMPLSIFVEAEEKRENFISCTFLNPEQIIPK
                     VPQESLFMAQDFNC"
     regulatory      2944..2949
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CCER1"
                     /gene_synonym="C12orf12"
                     /note="hexamer: AATAAA"
     polyA_site      2962
                     /gene="CCER1"
                     /gene_synonym="C12orf12"
                     /note="major polyA site"
ORIGIN      
        1 acagtcctgc caggacggcg acagtgaagc acctgggttg agagggagca gcaggtaact
       61 gcgcaacccc tgcctccccc ggccccagcc cgtgcctcag cagagccggg tgtggtgggg
      121 acccgggagt gggtctcact gcgtgtcgcc tgccaacacc ttcctccccc accatcctta
      181 cccagcccca gtcccaccca gcacacctgg gcgagacaac ccaggtgcga aggacaagcg
      241 attactaccg aagagcgtgc aaaccaggaa gagagcagcc tcctggagag gaaaacgtga
      301 tcccaggggt agacacgtgg cgctgcgtgg agagacaggt tgacgagacg aggctcttct
      361 gaccgtccta cctggcaaaa cttgacgaca gcttcaggtc gctaccatct ggacctctcg
      421 gagctccctg aaccatgact cagaccctcg acacaaggga agaccctctg aacctgggcg
      481 gcggtggcgg cggcggctgt ggctgtggct gggcacactc ggcctccttg agctcctggt
      541 cgtcctgcca tcgaaggcgc ccgggtgctc cagcgtacaa tagaccgcac cgatatagcc
      601 ccaagaccga gtatgggccc ccaaggaagc agccgaagca acagcacggc ccgggctttt
      661 ggttccaacc acccgtgtgc tctaactggg ggtgctgggg agggccctgg cgcccacccc
      721 ctccaggatt ctggaaattc ccctgcccgg tgcaagtgtt tcgggtgtat ggcctgcacc
      781 ctctctgctt ttgctgctgc tcctgctgga gcgggtcctg gaaccctggc tgggtgaagc
      841 ccccaggcag gaagaagcgc tggggccgca gaggccgcgg cctgcgccac caccctcgcc
      901 actcctaccc gcggagcccg ccagcggatg tgagcacgct gccgcggccg gtcaagctgt
      961 atgagtggag agagcctggc atgcgagcgc cgcccaacac cacccaattc atcatgaacc
     1021 agatctacga ggacatgagg cagcaggaga aggtggagcg tcagcaggag gcgctgcggg
     1081 cgcagaaggc cacggtgagc ggcgaggcct ccccagccag atcctccgga aacgacgcgc
     1141 cccctggcgg cagcaaggaa acctggggac tgcaggaaac tctgtatggc tttgtgcaga
     1201 atccctctct agcattcagt cccaacccag aggaaaacca gtctcttgcc ccgctgctgg
     1261 tggaagaaga ggaggagaag aaaaatgatg atgaggagga gtatgaccag gaggtgtgtg
     1321 atgcaaagga ggcgagcgag gaggaagaag aggtcgaaga tgaggaggaa gaggtcgaag
     1381 atgaggagga agaagaggtc gaagaggctg aatatgtgga ggagggagag gaggagctgg
     1441 aagaggagga gctggaagag gaagaggagg tcctggagga gaacgagcag agaggggaag
     1501 aatttcactt gcctctggaa atgcctttat caatcttcgt agaggctgaa gaaaagagag
     1561 agaactttat aagctgcact tttttaaacc cagagcagat aattcccaaa gtgccacagg
     1621 aatccctgtt catggcacag gactttaact gttagacatc agaaaaggga ttgagaaaag
     1681 ggatggaact gatttgaggc taaactggat tagcaattta ttaaaaactg attaaaaagt
     1741 gagttccatt aataaacaga tctatgtaaa caccttcttt ggccattata aaatgtttaa
     1801 aatttgatgc gtatgtgtat gactatgggt gggtggtggg gaagctttca aatataattt
     1861 tactggaact gattaaaggc caagtatttt attactacca tttgaatatt ttcatttggt
     1921 gttttcccct ctagaaaaca gagttgctgt tgttttttta aatctggcaa tgctgaaaaa
     1981 gcgtttgttt ttgaaacaaa tttatacaac ttggccactt aatgagcttg gaatcaagag
     2041 atagtttatt acatgcgtaa gaagcacatt ctaacgctac taaatgttca ccagtgctct
     2101 taacataact gaagccattt tcaatccctg tattttttca acaatatttt tcctcataga
     2161 tttttccacc atcagagttc atttttgagg gttatatttt gttaacctca tttgcaggct
     2221 cttgtgtcat cgcttattga tattccttgt tccacagtgc tatggatctt cctcagaaga
     2281 acatgaagtt gcttctgtgg aactggttat ctgccatggc ctcaacaatc cataatccag
     2341 tcatggagag gattccccat ggtcagaagt caacttgcac atctagttaa agtccaaggt
     2401 aactgcaaac agtggaacat ggcttaggtt ttgaagcctc gttattggat atagtcttta
     2461 tcctaagttc tgaggagcca taaaaatagt tttccagaat ggattttttt ttttagataa
     2521 aaagattatc taccttttgg gggtggaata tcttattttg tttttgaatt tgtctttgtt
     2581 ataaagaaga gtaaaacaaa gatgtgtaag tgtgagtctg tgtgagctag tttctgatgt
     2641 ctaaacagca attacctatg gagaatacat cattcaaagt aatagctttt gttcaaacat
     2701 ttttaggaag taataataca tttcttcctg gacagttgat aaaagttcca tccatagcat
     2761 atttccagaa tatccctaga tgatgaattt aaacatgcct tctcagaaat taaatctttt
     2821 gactttgaac cacaagttag catttatttg ttgaagagaa gaatgtgtgg tgatgtctta
     2881 cctgaatgtt ggttgttact gatatattac aattttcaag gtgataagct tgagctatta
     2941 aataataaaa agtattaaag ta
//
