LOCUS       NM_019044               6833 bp    mRNA    linear   PRI 19-FEB-2025
DEFINITION  Homo sapiens CCC complex scaffolding subunit CCDC93 (CCDC93), mRNA.
ACCESSION   NM_019044 NM_031447
VERSION     NM_019044.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6833)
  AUTHORS   Kumar,N., Yang,M.L., Sun,P., Hunker,K.L., Li,J., Jia,J., Fan,F.,
            Wang,J., Ning,X., Gao,W., Xu,M., Zhang,J., Chang,L., Chen,Y.E.,
            Huo,Y., Zhang,Y. and Ganesh,S.K.
  TITLE     Genetic variation in CCDC93 is associated with elevated central
            systolic blood pressure, impaired arterial relaxation, and
            mitochondrial dysfunction
  JOURNAL   PLoS Genet 20 (9), e1011151 (2024)
   PUBMED   39250516
  REMARK    GeneRIF: Genetic variation in CCDC93 is associated with elevated
            central systolic blood pressure, impaired arterial relaxation, and
            mitochondrial dysfunction.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6833)
  AUTHORS   Healy,M.D., McNally,K.E., Butkovic,R., Chilton,M., Kato,K.,
            Sacharz,J., McConville,C., Moody,E.R.R., Shaw,S.,
            Planelles-Herrero,V.J., Yadav,S.K.N., Ross,J., Borucu,U.,
            Palmer,C.S., Chen,K.E., Croll,T.I., Hall,R.J., Caruana,N.J.,
            Ghai,R., Nguyen,T.H.D., Heesom,K.J., Saitoh,S., Berger,I.,
            Schaffitzel,C., Williams,T.A., Stroud,D.A., Derivery,E.,
            Collins,B.M. and Cullen,P.J.
  TITLE     Structure of the endosomal Commander complex linked to
            Ritscher-Schinzel syndrome
  JOURNAL   Cell 186 (10), 2219-2237 (2023)
   PUBMED   37172566
REFERENCE   3  (bases 1 to 6833)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   4  (bases 1 to 6833)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (bases 1 to 6833)
  AUTHORS   Rimbert,A., Dalila,N., Wolters,J.C., Huijkman,N., Smit,M.,
            Kloosterhuis,N., Riemsma,M., van der Veen,Y., Singla,A., van
            Dijk,F., Frikke-Schmidt,R., Burstein,E., Tybjaerg-Hansen,A., van de
            Sluis,B. and Kuivenhoven,J.A.
  CONSRTM   Biobank-Based Integrative Omics Studies Consortium
  TITLE     A common variant in CCDC93 protects against myocardial infarction
            and cardiovascular mortality by regulating endosomal trafficking of
            low-density lipoprotein receptor
  JOURNAL   Eur Heart J 41 (9), 1040-1053 (2020)
   PUBMED   31630160
  REMARK    GeneRIF: A common variant in CCDC93 protects against myocardial
            infarction and cardiovascular mortality by regulating endosomal
            trafficking of low-density lipoprotein receptor.
REFERENCE   6  (bases 1 to 6833)
  AUTHORS   McNally,K.E., Faulkner,R., Steinberg,F., Gallon,M., Ghai,R.,
            Pim,D., Langton,P., Pearson,N., Danson,C.M., Nagele,H.,
            Morris,L.L., Singla,A., Overlee,B.L., Heesom,K.J., Sessions,R.,
            Banks,L., Collins,B.M., Berger,I., Billadeau,D.D., Burstein,E. and
            Cullen,P.J.
  TITLE     Retriever is a multiprotein complex for retromer-independent
            endosomal cargo recycling
  JOURNAL   Nat Cell Biol 19 (10), 1214-1225 (2017)
   PUBMED   28892079
REFERENCE   7  (bases 1 to 6833)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   8  (bases 1 to 6833)
  AUTHORS   Hein,M.Y., Hubner,N.C., Poser,I., Cox,J., Nagaraj,N., Toyoda,Y.,
            Gak,I.A., Weisswange,I., Mansfeld,J., Buchholz,F., Hyman,A.A. and
            Mann,M.
  TITLE     A human interactome in three quantitative dimensions organized by
            stoichiometries and abundances
  JOURNAL   Cell 163 (3), 712-723 (2015)
   PUBMED   26496610
REFERENCE   9  (bases 1 to 6833)
  AUTHORS   Phillips-Krawczak,C.A., Singla,A., Starokadomskyy,P., Deng,Z.,
            Osborne,D.G., Li,H., Dick,C.J., Gomez,T.S., Koenecke,M.,
            Zhang,J.S., Dai,H., Sifuentes-Dominguez,L.F., Geng,L.N.,
            Kaufmann,S.H., Hein,M.Y., Wallis,M., McGaughran,J., Gecz,J.,
            Sluis,Bv., Billadeau,D.D. and Burstein,E.
  TITLE     COMMD1 is linked to the WASH complex and regulates endosomal
            trafficking of the copper transporter ATP7A
  JOURNAL   Mol Biol Cell 26 (1), 91-103 (2015)
   PUBMED   25355947
REFERENCE   10 (bases 1 to 6833)
  AUTHORS   Hinch,A.G., Tandon,A., Patterson,N., Song,Y., Rohland,N.,
            Palmer,C.D., Chen,G.K., Wang,K., Buxbaum,S.G., Akylbekova,E.L.,
            Aldrich,M.C., Ambrosone,C.B., Amos,C., Bandera,E.V., Berndt,S.I.,
            Bernstein,L., Blot,W.J., Bock,C.H., Boerwinkle,E., Cai,Q.,
            Caporaso,N., Casey,G., Cupples,L.A., Deming,S.L., Diver,W.R.,
            Divers,J., Fornage,M., Gillanders,E.M., Glessner,J., Harris,C.C.,
            Hu,J.J., Ingles,S.A., Isaacs,W., John,E.M., Kao,W.H., Keating,B.,
            Kittles,R.A., Kolonel,L.N., Larkin,E., Le Marchand,L.,
            McNeill,L.H., Millikan,R.C., Murphy,A., Musani,S.,
            Neslund-Dudas,C., Nyante,S., Papanicolaou,G.J., Press,M.F.,
            Psaty,B.M., Reiner,A.P., Rich,S.S., Rodriguez-Gil,J.L.,
            Rotter,J.I., Rybicki,B.A., Schwartz,A.G., Signorello,L.B.,
            Spitz,M., Strom,S.S., Thun,M.J., Tucker,M.A., Wang,Z.,
            Wiencke,J.K., Witte,J.S., Wrensch,M., Wu,X., Yamamura,Y.,
            Zanetti,K.A., Zheng,W., Ziegler,R.G., Zhu,X., Redline,S.,
            Hirschhorn,J.N., Henderson,B.E., Taylor,H.A. Jr., Price,A.L.,
            Hakonarson,H., Chanock,S.J., Haiman,C.A., Wilson,J.G., Reich,D. and
            Myers,S.R.
  TITLE     The landscape of recombination in African Americans
  JOURNAL   Nature 476 (7359), 170-175 (2011)
   PUBMED   21775986
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC012052.1, BC028609.1, AC009404.5, AY726577.1 and BU621185.1.
            
            On Nov 25, 2018 this sequence version replaced NM_019044.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR18074968.527639.1, AB209993.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000376300.7/ ENSP00000365477.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1803              BC012052.1         8-1810
            1804-2718           BC028609.1         1870-2784
            2719-3943           AC009404.5         100744-101968       c
            3944-6743           AY726577.1         1-2800
            6744-6833           BU621185.1         21-110              c
FEATURES             Location/Qualifiers
     source          1..6833
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q14.1"
     gene            1..6833
                     /gene="CCDC93"
                     /note="CCC complex scaffolding subunit CCDC93"
                     /db_xref="GeneID:54520"
                     /db_xref="HGNC:HGNC:25611"
                     /db_xref="MIM:620553"
     exon            1..117
                     /gene="CCDC93"
                     /inference="alignment:Splign:2.1.0"
     CDS             76..1971
                     /gene="CCDC93"
                     /note="coiled-coil domain containing 93"
                     /codon_start=1
                     /product="coiled-coil domain-containing protein 93"
                     /protein_id="NP_061917.3"
                     /db_xref="CCDS:CCDS2121.2"
                     /db_xref="GeneID:54520"
                     /db_xref="HGNC:HGNC:25611"
                     /db_xref="MIM:620553"
                     /translation="MGLPRGPEGQGLPEVETREDEEQNVKLTEILELLVAAGYFRARI
                     KGLSPFDKVVGGMTWCITTCNFDVDVDLLFQENSTIGQKIALSEKIVSVLPRMKCPHQ
                     LEPHQIQGMDFIHIFPVVQWLVKRAIETKEEMGDYIRSYSVSQFQKTYSLPEDDDFIK
                     RKEKAIKTVVDLSEVYKPRRKYKRHQGAEELLDEESRIHATLLEYGRRYGFSRQSKME
                     KAEDKKTALPAGLSATEKADAHEEDELRAAEEQRIQSLMTKMTAMANEESRLTASSVG
                     QIVGLCSAEIKQIVSEYAEKQSELSAEESPEKLGTSQLHRRKVISLNKQIAQKTKHLE
                     ELRASHTSLQARYNEAKKTLTELKTYSEKLDKEQAALEKIESKADPSILQNLRALVAM
                     NENLKSQEQEFKAHCREEMTRLQQEIENLKAERAPRGDEKTLSSGEPPGTLTSAMTHD
                     EDLDRRYNMEKEKLYKIRLLQARRNREIAILHRKIDEVPSRAELIQYQKRFIELYRQI
                     SAVHKETKQFFTLYNTLDDKKVYLEKEISLLNSIHENFSQAMASPAARDQFLRQMEQI
                     VEGIKQSRMKMEKKKQENKMRRDQLNDQYLELLEKQRLYFKTVKEFKEEGRKNEMLLS
                     KVKAKAS"
     exon            118..231
                     /gene="CCDC93"
                     /inference="alignment:Splign:2.1.0"
     exon            232..326
                     /gene="CCDC93"
                     /inference="alignment:Splign:2.1.0"
     exon            327..438
                     /gene="CCDC93"
                     /inference="alignment:Splign:2.1.0"
     exon            439..537
                     /gene="CCDC93"
                     /inference="alignment:Splign:2.1.0"
     exon            538..594
                     /gene="CCDC93"
                     /inference="alignment:Splign:2.1.0"
     exon            595..695
                     /gene="CCDC93"
                     /inference="alignment:Splign:2.1.0"
     exon            696..732
                     /gene="CCDC93"
                     /inference="alignment:Splign:2.1.0"
     exon            733..825
                     /gene="CCDC93"
                     /inference="alignment:Splign:2.1.0"
     exon            826..876
                     /gene="CCDC93"
                     /inference="alignment:Splign:2.1.0"
     exon            877..963
                     /gene="CCDC93"
                     /inference="alignment:Splign:2.1.0"
     exon            964..1080
                     /gene="CCDC93"
                     /inference="alignment:Splign:2.1.0"
     exon            1081..1143
                     /gene="CCDC93"
                     /inference="alignment:Splign:2.1.0"
     exon            1144..1217
                     /gene="CCDC93"
                     /inference="alignment:Splign:2.1.0"
     exon            1218..1299
                     /gene="CCDC93"
                     /inference="alignment:Splign:2.1.0"
     exon            1300..1371
                     /gene="CCDC93"
                     /inference="alignment:Splign:2.1.0"
     exon            1372..1425
                     /gene="CCDC93"
                     /inference="alignment:Splign:2.1.0"
     exon            1426..1488
                     /gene="CCDC93"
                     /inference="alignment:Splign:2.1.0"
     exon            1489..1597
                     /gene="CCDC93"
                     /inference="alignment:Splign:2.1.0"
     exon            1598..1680
                     /gene="CCDC93"
                     /inference="alignment:Splign:2.1.0"
     exon            1681..1718
                     /gene="CCDC93"
                     /inference="alignment:Splign:2.1.0"
     exon            1719..1803
                     /gene="CCDC93"
                     /inference="alignment:Splign:2.1.0"
     exon            1804..1917
                     /gene="CCDC93"
                     /inference="alignment:Splign:2.1.0"
     exon            1918..6833
                     /gene="CCDC93"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2292..2297
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CCDC93"
                     /note="hexamer: AATAAA"
     polyA_site      2319
                     /gene="CCDC93"
                     /note="major polyA site"
     regulatory      6718..6723
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CCDC93"
                     /note="hexamer: ATTAAA"
     polyA_site      6743
                     /gene="CCDC93"
                     /note="major polyA site"
     regulatory      6813..6818
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CCDC93"
                     /note="hexamer: GATAAA"
     polyA_site      6833
                     /gene="CCDC93"
                     /note="major polyA site"
ORIGIN      
        1 agctccgcgg cagggacagc ttcctccgga cgcttggcgg gcttcgctct cgccttacga
       61 cagcccggtc ggatcatggg gttgcccagg gggccggagg gccagggtct cccggaggtg
      121 gaaacaagag aagatgaaga acaaaatgtc aagttgactg aaattctgga gctcttggtt
      181 gcagctgggt atttcagggc aagaattaaa ggcttatcac cctttgacaa ggtagtagga
      241 ggaatgactt ggtgtatcac cacttgcaac tttgatgtag atgttgattt gctctttcaa
      301 gaaaactcta cgataggtca aaaaatagct ctgtcagaaa aaattgtctc ggtcctgcca
      361 aggatgaaat gcccacacca gctggagccc caccagatcc aggggatgga ttttattcac
      421 atatttcctg ttgttcagtg gctggtgaaa cgagctatag aaacaaaaga agagatgggt
      481 gactatatcc gctcctactc tgtatcccag ttccagaaga cttacagtct ccctgaggat
      541 gatgacttca taaagagaaa agaaaaggcc atcaagacag ttgtggacct ctcagaagtg
      601 tacaagcccc gtcggaaata caaacgccac cagggagcag aggagctact tgatgaagaa
      661 tctcgaatcc atgctacact tttggaatat ggcaggagat atggatttag ccgccagagc
      721 aaaatggaga aggctgagga caagaaaacg gcacttccag cagggctgtc agctacagaa
      781 aaagctgatg cccacgagga agatgagctt cgagcagctg aagagcagcg tattcagtcg
      841 ctgatgacca agatgaccgc tatggcaaat gaggagagcc gtctcaccgc aagctccgtg
      901 ggccagattg tgggactctg ctctgctgag atcaagcaga ttgtgtccga gtatgcagag
      961 aagcagtctg agctatcagc tgaagaaagt ccagaaaaat taggaacctc ccagctacat
     1021 cgccggaaag tcatttcctt gaacaaacag attgcgcaaa agaccaaaca tcttgaagag
     1081 ctgcgagcaa gtcacaccag cctacaagcc agatataatg aagccaagaa aacgctgaca
     1141 gagctgaaga cttacagtga gaaactggac aaagagcaag cagccctcga gaagatagaa
     1201 tccaaagctg atccaagtat cctacagaac ctgagagcac ttgtagccat gaatgaaaat
     1261 ctgaaaagtc aagaacagga atttaaagca cattgtcgag aggagatgac acgactacag
     1321 caagaaattg aaaacctgaa agctgagaga gcaccacgtg gagatgaaaa gaccctctcc
     1381 agtggagagc cgcctggtac cttgacctct gcaatgactc atgacgaaga cctagacaga
     1441 cggtataata tggagaaaga gaaactttac aagatacgtt tactacaggc tcgaagaaat
     1501 cgagaaatag caattttgca ccgcaagatt gatgaagtcc ctagccgtgc cgagctaata
     1561 cagtatcaga agagatttat tgaactctac cgccagattt cagcagtgca caaagaaacc
     1621 aagcagttct tcactttata taataccctg gatgataaaa aggtttattt ggaaaaagag
     1681 attagtctgc tgaactcaat tcatgagaac ttctcacagg ccatggcctc ccctgctgcc
     1741 cgggaccagt ttttacgtca gatggaacag attgtggaag gaattaagca aagtagaatg
     1801 aagatggaaa agaaaaagca agagaacaaa atgagaagag accagttgaa cgaccagtac
     1861 ttggagctgt tagaaaagca gaggctatac tttaagactg tgaaagagtt caaggaggag
     1921 ggccgcaaga acgagatgct gctgtccaag gtgaaagcga aggcctcctg aacatcccca
     1981 gccgtggctg tatgtcattg attttacttt taagcaccgt atatcaccta caagatcatg
     2041 aaatggttct gaaagcgaca gtagagagat gcagttgtga tgatttcaac aacctggatg
     2101 ttttctttct cctctttgct tccattcatc tctgttggct gctgttgatg gagtcagaca
     2161 gtaaacacgt ggcttggata acacccatca tcctatgaag aatataggga gtacttgttc
     2221 tctgttgatt caacttttat gtctccagta acattgcgct tatgaaggta cctgtatttg
     2281 tatggactct gaataaagaa gaattcattt gtttagcaag tattagttca gcaaccactg
     2341 agaaataagc actgaggaag attcagagac gtgtaaaaca cagttcctac tgcacaagta
     2401 cccagcaggt ggcccaggga ggcagataca gcacacttga ccgcagaact gggctatcca
     2461 agatgttttt cagtaaacag aaggcattta gctgaaatga tcagcccatg tagtgttggt
     2521 cacttgggcc tttcacctgc catggtacct tttgttccca gctcctccag gtgccagcca
     2581 gcaggcttgg tggtgacagc aactggaacg aaagttcagt gttgttttaa tttttatacg
     2641 ttactcaagt tgatttctca gaaaattgaa aacagacctt gtgctgagga cacgtcaata
     2701 aaaattatac cttcccctgc cccaatgttc atgtgagtca cagcatgcag aggggctgtg
     2761 catccccctc attgaaggca catttgatga ggctacgctg cagatgggtc atggtctgag
     2821 ccaggagaga gatagacact gttccctgca ctcaaggcaa gtagggtgtc aggaggaaga
     2881 gcagtagggt ttgcagagat ccagggaaac ttcctggagg aggcagcatt tgagccctat
     2941 ctaaagggag aatcggatgt tgataggaag actgttttaa atgaaaatac actatgatta
     3001 aaaacccaag agagtgcaga ggagtacaag gcatgcatgt tgggaaagga gggaataagc
     3061 tagtctctgc aggaggcttc agagacccgt ctgggaagta gggctgagac taggctttgg
     3121 agggccttga agggcagctg agggttgatt ttaatccttg gaaatgacca gtgcagatca
     3181 aacatggagc tcctgctgcc ctggtcctca ggagtctggt aactcagtca tgttctgtag
     3241 gtttgtgctc cattttgcat aaatcttgca aacataccag gtggcaggtt tgcacagtaa
     3301 cacaaaagct taaacatgtc aagcaagtgg ggcattcagc agccacagaa atgtgttcat
     3361 ttttagtccc taatggatgt gattaagcag ggctgatgtg tacagattta aaaacacaca
     3421 cacgtgctgg attaaaaaca gccactggtt tcagtgccag ggccagcaag gcctacctga
     3481 gccaggcgga agcagcagct tgcaaataga aactgccacc tgcgagcgct tcttgggtca
     3541 tgtgcagctc cacctcagct ggtccctgag ccgtggtcat gtgggggttt tgaagggcta
     3601 agttgaagca agtaattgca aaagaacagg tggcactctg agggcagggg aaggagacag
     3661 aagtttgact gcgtttgaaa ttatttcagt cagggaaaca tctgcgttgt cttgttaagc
     3721 agcttgtagg cccacccctg gctaactgaa ctttgtgagc agttggggca gttatttgaa
     3781 tatttgtcca aaggtggtag ggaggcagat gacattctgg ggttactgga gtccacctct
     3841 gtgctgatgg ggaaagtatg gcatgatgaa tccaaagcaa ccagtaattc tttttgaaag
     3901 tgcaggcatt tattttgagc tgtatttcat aggagtttca tttggtttgg ttttggtata
     3961 gagaggtgtc catagatctc tattcccttt ttttttttat cgacaaggcc tactacggat
     4021 aaatcagttt ttgttgcctg aatacacttt gaattagact acagaagcca gtttgagctc
     4081 aaatttcaca cttgctgcag acaactctca gtgtggacag tgcctttctg agtaattagg
     4141 atgttacatg actttttggt gaagccgtat agggtaagga gatgccccaa ggcccctgat
     4201 catttcagaa gccacctgga gcaccagaag gggtcatctt cccagggcta tggctctgtg
     4261 tgcttagaca gacatagtat ggaattgtgc tctaagccca caggcttctc cggagttaaa
     4321 aggaagcaag aacatcctta agttactttt tcaaaatatg cgcttcagga ggaaccaggt
     4381 ttccccagga gagagaggct ccctgctcaa tcagcacagg gagttgctag cgggcaggct
     4441 gcccagtgct gtggaatctc cgccagcctc tgggttgggg gctccctccc acttcttgct
     4501 tcttatggag tacatgggac tgctctgctt taagccgcga tcagagctgt tgtgagcagg
     4561 acaagattgc gtgatcacga ggtgcgtggg gagatgctag gacatttgtt gatgtctttg
     4621 acctgtgctc cgtctctgtt ggatgactgg gttagctaac accactagag ggaggtacag
     4681 aatgttaaac agtcgtcaga gtcacactga gggttgtttt aacagagggc aaattcccag
     4741 tttgtcaagc atatctctgt tagagtccga agttcatggt tttaatggtt ctagctcgta
     4801 gcccttaata ttttcaggat agctgggtcc tgccagtgtc cgctgagtcc atcagcacaa
     4861 ccagaaggtc cagggtccag gcatgggaag cattctctga caataccgag ccctcgggac
     4921 ctcctgaaac cttgagcaga ggctggagaa gaccttcaga cagtcctttt actacctcac
     4981 aaagtgccat gcccgggacc tcagacctca gggttgtgac gttgttgatg ttgtcaggcc
     5041 ccagtacgtc tctagtgacc gaagcagacc tgcctgaaag ggcactccgg acagtgagcc
     5101 ctggctctaa cctgtgccct catatttctg ctgcctcata tggtcttgtt tgcccactct
     5161 gtaggtgact gatcacccta aaagggaggt aggtatctag cagtagcaca gttactttga
     5221 gcctgaccac ttgttctgaa gtgcagatgt tgaaacatgc attgaggaag aacactttaa
     5281 ggaagcactt tatgatttac tcatggctgg tgttggcctc aaagtaaaag aacatcttaa
     5341 tgcagaacag tacaataaag agccccatag gatggatgcc atcatctgtc cccatggttg
     5401 ggattgccaa ggaaagtgcc ttgttctgtg catcttcaga atcccccagg ccctctcttg
     5461 atccttttca tgaagtccag agcattcctt ctattacagg ctgaagatgc attgtaaaag
     5521 gtaatgctat aatagtattc cctcttctca ataaatgtgc aaaactggag aatctggtgc
     5581 tgatctgcag catacttgac aacacaggga ataccgtgga tgttccacgc cagccttaca
     5641 tccgtcccca ttgcctgccc atgtccagtg gccctgcgca acaaaagtaa gggcttgtct
     5701 taccacactc tccccagcat ctagctcaag gtagatgact gactgggaaa ttccggttgg
     5761 ataaaatggc ttttccacat tgcaactttg catctctatt aggaaaattt agattgaacc
     5821 tttcctctac ttgatgctta gtttgagaac agttttcaca actttagagg gtctctctca
     5881 gagtatgtta tactgtaacc ttgaagtttg agatgaaaca aggtgtcaga ggttttgaat
     5941 ctttcaaagg aattgccttt tacagatttt tttttttatt ccctaagaag ggaaaaagag
     6001 agggaagaac tacactaatg ttagagataa ggtatgtttt ggctcaaaat gtgtcatgaa
     6061 cctaaaggta acttgatggg cagaaatgtc tcagccatgt gaaccaagaa gtgggaccac
     6121 agtgcaaggc tgtgggtggc agcactagat acggtggtgg caggagtgtg acatgtaggc
     6181 actccatggg ggacagctgg acggtgtcta tcaaaagtgc aaatgcataa gctctttgaa
     6241 ctagcaatgc tactcctaag aattgtacct gtgtacaagg tacttgtgta caagagtttt
     6301 tgttgaaaca ttgtaatagc aaaaagttgg agagtgccac caatacaggg gaatggttaa
     6361 atacattatg gccagcttaa acaatggaat agtttgtaga aatttaaaac aatggatcct
     6421 gtgtgtgtgt actaccatag aatgggcccc aagatgcatg attaagtgag gaaaaaagcc
     6481 catggtatcc taatgtttgg aatggagaaa gtgtgtagat gtatgtgtgt gcatatgttt
     6541 tcacacagac gtatacacgt gtatatcata tgtccacctg catatgccta ggatgtctct
     6601 gggaggatat ctagcagccc ggcagcctga attgcctctg ggaagagggg tgggaatgac
     6661 ttttcaatgt acaccttttg taccttttga attttgtacc atgtacatgt attatctatt
     6721 aaaaaatagt tcttaatttt taatttggta tacttttctt aatagaacca aaatggaaga
     6781 aaattctgat tctctaaatc tgctttctta aagataaagc ctttgattca aaa
//
