LOCUS       NM_025140               2790 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens coiled-coil domain containing 92 (CCDC92), transcript
            variant 1, mRNA.
ACCESSION   NM_025140
VERSION     NM_025140.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2790)
  AUTHORS   Ren,L., Du,W., Song,D., Lu,H., Hamblin,M.H., Wang,C., Du,C.,
            Fan,G.C., Becker,R.C. and Fan,Y.
  TITLE     Genetic ablation of diabetes-associated gene Ccdc92 reduces obesity
            and insulin resistance in mice
  JOURNAL   iScience 26 (1), 105769 (2022)
   PUBMED   36594018
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2790)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 2790)
  AUTHORS   Kuroda,M., Halfmann,P.J., Hill-Batorski,L., Ozawa,M., Lopes,T.J.S.,
            Neumann,G., Schoggins,J.W., Rice,C.M. and Kawaoka,Y.
  TITLE     Identification of interferon-stimulated genes that attenuate Ebola
            virus infection
  JOURNAL   Nat Commun 11 (1), 2953 (2020)
   PUBMED   32528005
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2790)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 2790)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2790)
  AUTHORS   Chaki,M., Airik,R., Ghosh,A.K., Giles,R.H., Chen,R., Slaats,G.G.,
            Wang,H., Hurd,T.W., Zhou,W., Cluckey,A., Gee,H.Y., Ramaswami,G.,
            Hong,C.J., Hamilton,B.A., Cervenka,I., Ganji,R.S., Bryja,V.,
            Arts,H.H., van Reeuwijk,J., Oud,M.M., Letteboer,S.J., Roepman,R.,
            Husson,H., Ibraghimov-Beskrovnaya,O., Yasunaga,T., Walz,G.,
            Eley,L., Sayer,J.A., Schermer,B., Liebau,M.C., Benzing,T., Le
            Corre,S., Drummond,I., Janssen,S., Allen,S.J., Natarajan,S.,
            O'Toole,J.F., Attanasio,M., Saunier,S., Antignac,C.,
            Koenekoop,R.K., Ren,H., Lopez,I., Nayir,A., Stoetzel,C.,
            Dollfus,H., Massoudi,R., Gleeson,J.G., Andreoli,S.P., Doherty,D.G.,
            Lindstrad,A., Golzio,C., Katsanis,N., Pape,L., Abboud,E.B.,
            Al-Rajhi,A.A., Lewis,R.A., Omran,H., Lee,E.Y., Wang,S.,
            Sekiguchi,J.M., Saunders,R., Johnson,C.A., Garner,E., Vanselow,K.,
            Andersen,J.S., Shlomai,J., Nurnberg,G., Nurnberg,P., Levy,S.,
            Smogorzewska,A., Otto,E.A. and Hildebrandt,F.
  TITLE     Exome capture reveals ZNF423 and CEP164 mutations, linking renal
            ciliopathies to DNA damage response signaling
  JOURNAL   Cell 150 (3), 533-548 (2012)
   PUBMED   22863007
REFERENCE   7  (bases 1 to 2790)
  AUTHORS   Simonis,N., Rual,J.F., Lemmens,I., Boxus,M., Hirozane-Kishikawa,T.,
            Gatot,J.S., Dricot,A., Hao,T., Vertommen,D., Legros,S., Daakour,S.,
            Klitgord,N., Martin,M., Willaert,J.F., Dequiedt,F., Navratil,V.,
            Cusick,M.E., Burny,A., Van Lint,C., Hill,D.E., Tavernier,J.,
            Kettmann,R., Vidal,M. and Twizere,J.C.
  TITLE     Host-pathogen interactome mapping for HTLV-1 and -2 retroviruses
  JOURNAL   Retrovirology 9, 26 (2012)
   PUBMED   22458338
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 2790)
  AUTHORS   Teslovich,T.M., Musunuru,K., Smith,A.V., Edmondson,A.C.,
            Stylianou,I.M., Koseki,M., Pirruccello,J.P., Ripatti,S.,
            Chasman,D.I., Willer,C.J., Johansen,C.T., Fouchier,S.W., Isaacs,A.,
            Peloso,G.M., Barbalic,M., Ricketts,S.L., Bis,J.C., Aulchenko,Y.S.,
            Thorleifsson,G., Feitosa,M.F., Chambers,J., Orho-Melander,M.,
            Melander,O., Johnson,T., Li,X., Guo,X., Li,M., Shin Cho,Y., Jin
            Go,M., Jin Kim,Y., Lee,J.Y., Park,T., Kim,K., Sim,X., Twee-Hee
            Ong,R., Croteau-Chonka,D.C., Lange,L.A., Smith,J.D., Song,K., Hua
            Zhao,J., Yuan,X., Luan,J., Lamina,C., Ziegler,A., Zhang,W.,
            Zee,R.Y., Wright,A.F., Witteman,J.C., Wilson,J.F., Willemsen,G.,
            Wichmann,H.E., Whitfield,J.B., Waterworth,D.M., Wareham,N.J.,
            Waeber,G., Vollenweider,P., Voight,B.F., Vitart,V.,
            Uitterlinden,A.G., Uda,M., Tuomilehto,J., Thompson,J.R., Tanaka,T.,
            Surakka,I., Stringham,H.M., Spector,T.D., Soranzo,N., Smit,J.H.,
            Sinisalo,J., Silander,K., Sijbrands,E.J., Scuteri,A., Scott,J.,
            Schlessinger,D., Sanna,S., Salomaa,V., Saharinen,J., Sabatti,C.,
            Ruokonen,A., Rudan,I., Rose,L.M., Roberts,R., Rieder,M.,
            Psaty,B.M., Pramstaller,P.P., Pichler,I., Perola,M., Penninx,B.W.,
            Pedersen,N.L., Pattaro,C., Parker,A.N., Pare,G., Oostra,B.A.,
            O'Donnell,C.J., Nieminen,M.S., Nickerson,D.A., Montgomery,G.W.,
            Meitinger,T., McPherson,R., McCarthy,M.I., McArdle,W., Masson,D.,
            Martin,N.G., Marroni,F., Mangino,M., Magnusson,P.K., Lucas,G.,
            Luben,R., Loos,R.J., Lokki,M.L., Lettre,G., Langenberg,C.,
            Launer,L.J., Lakatta,E.G., Laaksonen,R., Kyvik,K.O., Kronenberg,F.,
            Konig,I.R., Khaw,K.T., Kaprio,J., Kaplan,L.M., Johansson,A.,
            Jarvelin,M.R., Janssens,A.C., Ingelsson,E., Igl,W., Kees
            Hovingh,G., Hottenga,J.J., Hofman,A., Hicks,A.A., Hengstenberg,C.,
            Heid,I.M., Hayward,C., Havulinna,A.S., Hastie,N.D., Harris,T.B.,
            Haritunians,T., Hall,A.S., Gyllensten,U., Guiducci,C., Groop,L.C.,
            Gonzalez,E., Gieger,C., Freimer,N.B., Ferrucci,L., Erdmann,J.,
            Elliott,P., Ejebe,K.G., Doring,A., Dominiczak,A.F., Demissie,S.,
            Deloukas,P., de Geus,E.J., de Faire,U., Crawford,G., Collins,F.S.,
            Chen,Y.D., Caulfield,M.J., Campbell,H., Burtt,N.P.,
            Bonnycastle,L.L., Boomsma,D.I., Boekholdt,S.M., Bergman,R.N.,
            Barroso,I., Bandinelli,S., Ballantyne,C.M., Assimes,T.L.,
            Quertermous,T., Altshuler,D., Seielstad,M., Wong,T.Y., Tai,E.S.,
            Feranil,A.B., Kuzawa,C.W., Adair,L.S., Taylor,H.A. Jr.,
            Borecki,I.B., Gabriel,S.B., Wilson,J.G., Holm,H.,
            Thorsteinsdottir,U., Gudnason,V., Krauss,R.M., Mohlke,K.L.,
            Ordovas,J.M., Munroe,P.B., Kooner,J.S., Tall,A.R., Hegele,R.A.,
            Kastelein,J.J., Schadt,E.E., Rotter,J.I., Boerwinkle,E.,
            Strachan,D.P., Mooser,V., Stefansson,K., Reilly,M.P., Samani,N.J.,
            Schunkert,H., Cupples,L.A., Sandhu,M.S., Ridker,P.M., Rader,D.J.,
            van Duijn,C.M., Peltonen,L., Abecasis,G.R., Boehnke,M. and
            Kathiresan,S.
  TITLE     Biological, clinical and population relevance of 95 loci for blood
            lipids
  JOURNAL   Nature 466 (7307), 707-713 (2010)
   PUBMED   20686565
REFERENCE   9  (bases 1 to 2790)
  AUTHORS   Chasman,D.I., Pare,G., Mora,S., Hopewell,J.C., Peloso,G.,
            Clarke,R., Cupples,L.A., Hamsten,A., Kathiresan,S., Malarstig,A.,
            Ordovas,J.M., Ripatti,S., Parker,A.N., Miletich,J.P. and
            Ridker,P.M.
  TITLE     Forty-three loci associated with plasma lipoprotein size,
            concentration, and cholesterol content in genome-wide analysis
  JOURNAL   PLoS Genet 5 (11), e1000730 (2009)
   PUBMED   19936222
  REMARK    GeneRIF: Observational study and genome-wide association study of
            gene-disease association. (HuGE Navigator)
REFERENCE   10 (bases 1 to 2790)
  AUTHORS   Girard,A., Sachidanandam,R., Hannon,G.J. and Carmell,M.A.
  TITLE     A germline-specific class of small RNAs binds mammalian Piwi
            proteins
  JOURNAL   Nature 442 (7099), 199-202 (2006)
   PUBMED   16751776
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            HY035895.1, BC017186.2 and AC079315.30.
            
            On Jun 2, 2019 this sequence version replaced NM_025140.2.
            
            Transcript Variant: This variant (1) represents the predominant
            transcript and encodes isoform 1. Variants 1-5 encode the same
            protein (isoform 1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC017186.2, AK026124.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2153932 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000238156.8/ ENSP00000238156.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-223               HY035895.1         156-378
            224-2007            BC017186.2         1-1784
            2008-2790           AC079315.30        111122-111904       c
FEATURES             Location/Qualifiers
     source          1..2790
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q24.31"
     gene            1..2790
                     /gene="CCDC92"
                     /note="coiled-coil domain containing 92"
                     /db_xref="GeneID:80212"
                     /db_xref="HGNC:HGNC:29563"
     exon            1..303
                     /gene="CCDC92"
                     /inference="alignment:Splign:2.1.0"
     exon            304..396
                     /gene="CCDC92"
                     /inference="alignment:Splign:2.1.0"
     CDS             363..1358
                     /gene="CCDC92"
                     /note="isoform 1 is encoded by transcript variant 1;
                     coiled-coil domain-containing protein 92; limkain beta 2"
                     /codon_start=1
                     /product="coiled-coil domain-containing protein 92 isoform
                     1"
                     /protein_id="NP_079416.1"
                     /db_xref="CCDS:CCDS9256.1"
                     /db_xref="GeneID:80212"
                     /db_xref="HGNC:HGNC:29563"
                     /translation="MTSPHFSSYDEGPLDVSMAATNLENQLHSAQKNLLFLQREHAST
                     LKGLHSEIRRLQQHCTDLTYELTVKSSEQTGDGTSKSSELKKRCEELEAQLKVKENEN
                     AELLKELEQKNAMITVLENTIKEREKKYLEELKAKSHKLTLLSSELEQRASTIAYLTS
                     QLHAAKKKLMSSSGTSDASPSGSPVLASYKPAPPKDKLPETPRRRMKKSLSAPLHPEF
                     EEVYRFGAESRKLLLREPVDAMPDPTPFLLARESAEVHLIKERPLVIPPIASDRSGEQ
                     HSPAREKPHKAHVGVAHRIHHATPPQAQPEVKTLAVDQVNGGKVVRKHSGTDRTV"
     exon            397..543
                     /gene="CCDC92"
                     /inference="alignment:Splign:2.1.0"
     exon            544..585
                     /gene="CCDC92"
                     /inference="alignment:Splign:2.1.0"
     exon            586..2790
                     /gene="CCDC92"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1983..1988
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CCDC92"
                     /note="hexamer: AACAAA"
     polyA_site      2007
                     /gene="CCDC92"
                     /note="major polyA site"
     regulatory      2678..2683
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CCDC92"
                     /note="hexamer: AAGAAA"
     polyA_site      2701
                     /gene="CCDC92"
     regulatory      2759..2764
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CCDC92"
                     /note="hexamer: AACAAA"
     polyA_site      2790
                     /gene="CCDC92"
ORIGIN      
        1 agacacaggc ccgccgccgc gccggcgcct agcccgccgg gtcagcgcgg ccaggcctcg
       61 ccgccggccc cgctcccagg gtgcaccgcg gctagcgctg gggtgggagc gggcgagatg
      121 cgccgggcgg gcggtgccca ctgacctccc tcggcggccc ggcccgggca gcgcccgagc
      181 ccaggcagcc ccgcccgccg cgccccgccc agcccatggg ccacgggccc ccaccgccgc
      241 ccgccgggag gaccgagcct aagagggcag ccgcctgaag gaacgcgacg gcggcgcccg
      301 cagtattttt cagtgctgta caagcgtctt gaattactct ggtagctttt ccagaaagac
      361 ccatgacttc accacatttc tcgagttacg atgaaggtcc tctggatgtc agcatggcag
      421 ccacaaacct ggagaaccag ctgcacagcg cacagaagaa cctcctgttc cttcagcggg
      481 agcatgccag cacgctcaag gggctgcact ccgagatcag gcggctgcag cagcactgca
      541 cagatttaac atatgagctg acagtcaaaa gttcggaaca gacaggagac gggacttcta
      601 aaagcagtga attaaagaaa agatgtgaag agctggaagc ccaactgaaa gtgaaagaga
      661 acgaaaatgc tgagttgttg aaagaactgg agcagaaaaa cgcgatgatc acagtgctgg
      721 agaacaccat caaggagcga gagaagaagt acctggagga gctgaaggcc aagagtcaca
      781 agctgaccct gctgtctagc gagctggagc agcgggccag caccatcgcc tacctgacct
      841 cccagctgca cgccgccaag aagaagctca tgagctccag cgggacctca gatgccagcc
      901 cgtcagggag ccccgtgctg gccagctaca agccagcgcc ccccaaagac aagctacccg
      961 aaacgcctcg ccgccgcatg aaaaagagcc tctcagcccc cttgcacccg gaatttgaag
     1021 aggtctacag attcggggca gagagcagga aactcctttt gcgggaacca gtggatgcta
     1081 tgcccgaccc caccccattt ctgctggcta gggagtccgc cgaggtccac ctcatcaaag
     1141 agaggcccct cgtcatcccc cccatcgcct ccgaccgaag cggcgagcag cacagcccgg
     1201 cccgcgaaaa gccgcacaag gcccacgtcg gggtggcaca tcggatccac cacgccaccc
     1261 cgccgcaggc ccagcccgag gtgaagaccc tggcggtcga ccaggtgaac ggaggcaagg
     1321 tggtgaggaa gcactcaggg acggacagaa ctgtgtgaag cccgccgtgc cccaccccgc
     1381 gctgtccatg cactgtgagc accactggga aatctcagcc acaccttttc tgtttaatcc
     1441 catgcatgcc aaacactttt cacacctacc gacccattct ccttctgctt ctcttgccct
     1501 cttcttcaca ccaaaatatg atcgtgtccc tgccgcagaa tatgtatttc ctaattgctg
     1561 tggccaaacg cctgtgtgcc gaatcgcttg cttctgatcc cgctccgtgt aacctaagtg
     1621 cgctgcaggc aaagcccagg ccacggctgc gtcactactg atgttcacga tgccacacag
     1681 tcacacacct aattcattct caagtcggag caacacatac caaccttgac cttatcctca
     1741 agctccaggg cagcctggcc gagcagcccc tgctccctcc tggagaccct tgtcacctcc
     1801 cgagctcctc ctggagaccc ctgtcacctc ctgaccaacc tttcccaggg cggcaccgat
     1861 caccgagcag ccgtgcgtgt atctcaagga actaaataag atgacgctac tcctcatagc
     1921 accacaacct gaatgtgtgt tcatattttt ttgttagttt tatccaaaat gtttaagatc
     1981 ccaacaaact ttattttcta aacctgcctt ccttctgttt tgtgtctttt attaaacaaa
     2041 cacctgaagg agggctagga gactgcagga gggagagcaa tcacaggtcc cagaagcgac
     2101 tccggcctcc tcccggccca gagctagtcc ttagaatgtg ctgcgctcct gagcttctgt
     2161 gggaagctgc ttttgcctct gatggcccct gcccactgtg ctgcccgtgc tagcccctct
     2221 cctccctcat ggagtgaagc cacccctcac ctccaggtgg ccagccaggg ctccaggcca
     2281 gcctcatggt gcacagaggg aaggggtgcc cagtgaccac tggtcctgga ggttctgtgt
     2341 ccttacctga ccccacacag acccaggcag gctgggggta gaagctcatg caggaactaa
     2401 acactaagct caacaacttc acagtcgccg tagcaggtca gagccaaaga agctagggcc
     2461 agagagttct ggaaggggga gaagtggctc caggtgactg gtcacttctg ctctgtgccc
     2521 gacatcatca gcccttcttg ccaaaaagga gcatctgctg aaacagacct ggatcatcga
     2581 aaacacacct ttggaaatta cattaggatt ctcacttgtg ccaatgctat gtatgccagg
     2641 cacttttgcc taatcaagtg ttttctctga gaaggaaaag aaaactccac acatcttaaa
     2701 atactctcca atatttactt tttgattata taaattcctt ttaaaaagta gtattaaaaa
     2761 caaaaccatt caggttaatt tgtatggaaa
//
