LOCUS       NM_018318               2519 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens coiled-coil domain containing 91 (CCDC91), transcript
            variant 1, mRNA.
ACCESSION   NM_018318 XM_005253413
VERSION     NM_018318.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2519)
  AUTHORS   Zhu,Y., Bai,Y., Yan,W., Li,M., Wu,F., Xu,M., Wu,N., Ge,H. and
            Liu,Y.
  TITLE     A mutation in CCDC91, Homo sapiens coiled-coil domain containing 91
            protein, cause autosomal-dominant acrokeratoelastoidosis
  JOURNAL   Eur J Hum Genet 32 (6), 647-655 (2024)
   PUBMED   38627542
  REMARK    GeneRIF: A mutation in CCDC91, Homo sapiens coiled-coil domain
            containing 91 protein, cause autosomal-dominant
            acrokeratoelastoidosis.
REFERENCE   2  (bases 1 to 2519)
  AUTHORS   Nakajima,M., Koido,M., Guo,L., Terao,C. and Ikegawa,S.
  TITLE     A novel CCDC91 isoform associated with ossification of the
            posterior longitudinal ligament of the spine works as a non-coding
            RNA to regulate osteogenic genes
  JOURNAL   Am J Hum Genet 110 (4), 638-647 (2023)
   PUBMED   36990086
  REMARK    GeneRIF: A novel CCDC91 isoform associated with ossification of the
            posterior longitudinal ligament of the spine works as a non-coding
            RNA to regulate osteogenic genes.
REFERENCE   3  (bases 1 to 2519)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 2519)
  AUTHORS   Nakajima,M., Takahashi,A., Tsuji,T., Karasugi,T., Baba,H.,
            Uchida,K., Kawabata,S., Okawa,A., Shindo,S., Takeuchi,K.,
            Taniguchi,Y., Maeda,S., Kashii,M., Seichi,A., Nakajima,H.,
            Kawaguchi,Y., Fujibayashi,S., Takahata,M., Tanaka,T., Watanabe,K.,
            Kida,K., Kanchiku,T., Ito,Z., Mori,K., Kaito,T., Kobayashi,S.,
            Yamada,K., Takahashi,M., Chiba,K., Matsumoto,M., Furukawa,K.,
            Kubo,M., Toyama,Y. and Ikegawa,S.
  CONSRTM   Genetic Study Group of Investigation Committee on Ossification of
            the Spinal Ligaments
  TITLE     A genome-wide association study identifies susceptibility loci for
            ossification of the posterior longitudinal ligament of the spine
  JOURNAL   Nat Genet 46 (9), 1012-1016 (2014)
   PUBMED   25064007
REFERENCE   5  (bases 1 to 2519)
  AUTHORS   Berndt,S.I., Gustafsson,S., Magi,R., Ganna,A., Wheeler,E.,
            Feitosa,M.F., Justice,A.E., Monda,K.L., Croteau-Chonka,D.C.,
            Day,F.R., Esko,T., Fall,T., Ferreira,T., Gentilini,D.,
            Jackson,A.U., Luan,J., Randall,J.C., Vedantam,S., Willer,C.J.,
            Winkler,T.W., Wood,A.R., Workalemahu,T., Hu,Y.J., Lee,S.H.,
            Liang,L., Lin,D.Y., Min,J.L., Neale,B.M., Thorleifsson,G., Yang,J.,
            Albrecht,E., Amin,N., Bragg-Gresham,J.L., Cadby,G., den Heijer,M.,
            Eklund,N., Fischer,K., Goel,A., Hottenga,J.J., Huffman,J.E.,
            Jarick,I., Johansson,A., Johnson,T., Kanoni,S., Kleber,M.E.,
            Konig,I.R., Kristiansson,K., Kutalik,Z., Lamina,C., Lecoeur,C.,
            Li,G., Mangino,M., McArdle,W.L., Medina-Gomez,C.,
            Muller-Nurasyid,M., Ngwa,J.S., Nolte,I.M., Paternoster,L.,
            Pechlivanis,S., Perola,M., Peters,M.J., Preuss,M., Rose,L.M.,
            Shi,J., Shungin,D., Smith,A.V., Strawbridge,R.J., Surakka,I.,
            Teumer,A., Trip,M.D., Tyrer,J., Van Vliet-Ostaptchouk,J.V.,
            Vandenput,L., Waite,L.L., Zhao,J.H., Absher,D., Asselbergs,F.W.,
            Atalay,M., Attwood,A.P., Balmforth,A.J., Basart,H., Beilby,J.,
            Bonnycastle,L.L., Brambilla,P., Bruinenberg,M., Campbell,H.,
            Chasman,D.I., Chines,P.S., Collins,F.S., Connell,J.M.,
            Cookson,W.O., de Faire,U., de Vegt,F., Dei,M., Dimitriou,M.,
            Edkins,S., Estrada,K., Evans,D.M., Farrall,M., Ferrario,M.M.,
            Ferrieres,J., Franke,L., Frau,F., Gejman,P.V., Grallert,H.,
            Gronberg,H., Gudnason,V., Hall,A.S., Hall,P., Hartikainen,A.L.,
            Hayward,C., Heard-Costa,N.L., Heath,A.C., Hebebrand,J., Homuth,G.,
            Hu,F.B., Hunt,S.E., Hypponen,E., Iribarren,C., Jacobs,K.B.,
            Jansson,J.O., Jula,A., Kahonen,M., Kathiresan,S., Kee,F.,
            Khaw,K.T., Kivimaki,M., Koenig,W., Kraja,A.T., Kumari,M.,
            Kuulasmaa,K., Kuusisto,J., Laitinen,J.H., Lakka,T.A.,
            Langenberg,C., Launer,L.J., Lind,L., Lindstrom,J., Liu,J.,
            Liuzzi,A., Lokki,M.L., Lorentzon,M., Madden,P.A., Magnusson,P.K.,
            Manunta,P., Marek,D., Marz,W., Mateo Leach,I., McKnight,B.,
            Medland,S.E., Mihailov,E., Milani,L., Montgomery,G.W., Mooser,V.,
            Muhleisen,T.W., Munroe,P.B., Musk,A.W., Narisu,N., Navis,G.,
            Nicholson,G., Nohr,E.A., Ong,K.K., Oostra,B.A., Palmer,C.N.,
            Palotie,A., Peden,J.F., Pedersen,N., Peters,A., Polasek,O.,
            Pouta,A., Pramstaller,P.P., Prokopenko,I., Putter,C.,
            Radhakrishnan,A., Raitakari,O., Rendon,A., Rivadeneira,F.,
            Rudan,I., Saaristo,T.E., Sambrook,J.G., Sanders,A.R., Sanna,S.,
            Saramies,J., Schipf,S., Schreiber,S., Schunkert,H., Shin,S.Y.,
            Signorini,S., Sinisalo,J., Skrobek,B., Soranzo,N., Stancakova,A.,
            Stark,K., Stephens,J.C., Stirrups,K., Stolk,R.P., Stumvoll,M.,
            Swift,A.J., Theodoraki,E.V., Thorand,B., Tregouet,D.A., Tremoli,E.,
            Van der Klauw,M.M., van Meurs,J.B., Vermeulen,S.H., Viikari,J.,
            Virtamo,J., Vitart,V., Waeber,G., Wang,Z., Widen,E., Wild,S.H.,
            Willemsen,G., Winkelmann,B.R., Witteman,J.C., Wolffenbuttel,B.H.,
            Wong,A., Wright,A.F., Zillikens,M.C., Amouyel,P., Boehm,B.O.,
            Boerwinkle,E., Boomsma,D.I., Caulfield,M.J., Chanock,S.J.,
            Cupples,L.A., Cusi,D., Dedoussis,G.V., Erdmann,J., Eriksson,J.G.,
            Franks,P.W., Froguel,P., Gieger,C., Gyllensten,U., Hamsten,A.,
            Harris,T.B., Hengstenberg,C., Hicks,A.A., Hingorani,A., Hinney,A.,
            Hofman,A., Hovingh,K.G., Hveem,K., Illig,T., Jarvelin,M.R.,
            Jockel,K.H., Keinanen-Kiukaanniemi,S.M., Kiemeney,L.A., Kuh,D.,
            Laakso,M., Lehtimaki,T., Levinson,D.F., Martin,N.G., Metspalu,A.,
            Morris,A.D., Nieminen,M.S., Njolstad,I., Ohlsson,C.,
            Oldehinkel,A.J., Ouwehand,W.H., Palmer,L.J., Penninx,B., Power,C.,
            Province,M.A., Psaty,B.M., Qi,L., Rauramaa,R., Ridker,P.M.,
            Ripatti,S., Salomaa,V., Samani,N.J., Snieder,H., Sorensen,T.I.,
            Spector,T.D., Stefansson,K., Tonjes,A., Tuomilehto,J.,
            Uitterlinden,A.G., Uusitupa,M., van der Harst,P., Vollenweider,P.,
            Wallaschofski,H., Wareham,N.J., Watkins,H., Wichmann,H.E.,
            Wilson,J.F., Abecasis,G.R., Assimes,T.L., Barroso,I., Boehnke,M.,
            Borecki,I.B., Deloukas,P., Fox,C.S., Frayling,T., Groop,L.C.,
            Haritunian,T., Heid,I.M., Hunter,D., Kaplan,R.C., Karpe,F.,
            Moffatt,M.F., Mohlke,K.L., O'Connell,J.R., Pawitan,Y., Schadt,E.E.,
            Schlessinger,D., Steinthorsdottir,V., Strachan,D.P.,
            Thorsteinsdottir,U., van Duijn,C.M., Visscher,P.M., Di Blasio,A.M.,
            Hirschhorn,J.N., Lindgren,C.M., Morris,A.P., Meyre,D., Scherag,A.,
            McCarthy,M.I., Speliotes,E.K., North,K.E., Loos,R.J. and
            Ingelsson,E.
  TITLE     Genome-wide meta-analysis identifies 11 new loci for anthropometric
            traits and provides insights into genetic architecture
  JOURNAL   Nat Genet 45 (5), 501-512 (2013)
   PUBMED   23563607
REFERENCE   6  (bases 1 to 2519)
  AUTHORS   Lango Allen,H., Estrada,K., Lettre,G., Berndt,S.I., Weedon,M.N.,
            Rivadeneira,F., Willer,C.J., Jackson,A.U., Vedantam,S.,
            Raychaudhuri,S., Ferreira,T., Wood,A.R., Weyant,R.J., Segre,A.V.,
            Speliotes,E.K., Wheeler,E., Soranzo,N., Park,J.H., Yang,J.,
            Gudbjartsson,D., Heard-Costa,N.L., Randall,J.C., Qi,L., Vernon
            Smith,A., Magi,R., Pastinen,T., Liang,L., Heid,I.M., Luan,J.,
            Thorleifsson,G., Winkler,T.W., Goddard,M.E., Sin Lo,K., Palmer,C.,
            Workalemahu,T., Aulchenko,Y.S., Johansson,A., Zillikens,M.C.,
            Feitosa,M.F., Esko,T., Johnson,T., Ketkar,S., Kraft,P., Mangino,M.,
            Prokopenko,I., Absher,D., Albrecht,E., Ernst,F., Glazer,N.L.,
            Hayward,C., Hottenga,J.J., Jacobs,K.B., Knowles,J.W., Kutalik,Z.,
            Monda,K.L., Polasek,O., Preuss,M., Rayner,N.W., Robertson,N.R.,
            Steinthorsdottir,V., Tyrer,J.P., Voight,B.F., Wiklund,F., Xu,J.,
            Zhao,J.H., Nyholt,D.R., Pellikka,N., Perola,M., Perry,J.R.,
            Surakka,I., Tammesoo,M.L., Altmaier,E.L., Amin,N., Aspelund,T.,
            Bhangale,T., Boucher,G., Chasman,D.I., Chen,C., Coin,L.,
            Cooper,M.N., Dixon,A.L., Gibson,Q., Grundberg,E., Hao,K., Juhani
            Junttila,M., Kaplan,L.M., Kettunen,J., Konig,I.R., Kwan,T.,
            Lawrence,R.W., Levinson,D.F., Lorentzon,M., McKnight,B.,
            Morris,A.P., Muller,M., Suh Ngwa,J., Purcell,S., Rafelt,S.,
            Salem,R.M., Salvi,E., Sanna,S., Shi,J., Sovio,U., Thompson,J.R.,
            Turchin,M.C., Vandenput,L., Verlaan,D.J., Vitart,V., White,C.C.,
            Ziegler,A., Almgren,P., Balmforth,A.J., Campbell,H., Citterio,L.,
            De Grandi,A., Dominiczak,A., Duan,J., Elliott,P., Elosua,R.,
            Eriksson,J.G., Freimer,N.B., Geus,E.J., Glorioso,N., Haiqing,S.,
            Hartikainen,A.L., Havulinna,A.S., Hicks,A.A., Hui,J., Igl,W.,
            Illig,T., Jula,A., Kajantie,E., Kilpelainen,T.O., Koiranen,M.,
            Kolcic,I., Koskinen,S., Kovacs,P., Laitinen,J., Liu,J., Lokki,M.L.,
            Marusic,A., Maschio,A., Meitinger,T., Mulas,A., Pare,G.,
            Parker,A.N., Peden,J.F., Petersmann,A., Pichler,I.,
            Pietilainen,K.H., Pouta,A., Ridderstrale,M., Rotter,J.I.,
            Sambrook,J.G., Sanders,A.R., Schmidt,C.O., Sinisalo,J., Smit,J.H.,
            Stringham,H.M., Bragi Walters,G., Widen,E., Wild,S.H.,
            Willemsen,G., Zagato,L., Zgaga,L., Zitting,P., Alavere,H.,
            Farrall,M., McArdle,W.L., Nelis,M., Peters,M.J., Ripatti,S., van
            Meurs,J.B., Aben,K.K., Ardlie,K.G., Beckmann,J.S., Beilby,J.P.,
            Bergman,R.N., Bergmann,S., Collins,F.S., Cusi,D., den Heijer,M.,
            Eiriksdottir,G., Gejman,P.V., Hall,A.S., Hamsten,A., Huikuri,H.V.,
            Iribarren,C., Kahonen,M., Kaprio,J., Kathiresan,S., Kiemeney,L.,
            Kocher,T., Launer,L.J., Lehtimaki,T., Melander,O., Mosley,T.H. Jr.,
            Musk,A.W., Nieminen,M.S., O'Donnell,C.J., Ohlsson,C., Oostra,B.,
            Palmer,L.J., Raitakari,O., Ridker,P.M., Rioux,J.D., Rissanen,A.,
            Rivolta,C., Schunkert,H., Shuldiner,A.R., Siscovick,D.S.,
            Stumvoll,M., Tonjes,A., Tuomilehto,J., van Ommen,G.J., Viikari,J.,
            Heath,A.C., Martin,N.G., Montgomery,G.W., Province,M.A., Kayser,M.,
            Arnold,A.M., Atwood,L.D., Boerwinkle,E., Chanock,S.J., Deloukas,P.,
            Gieger,C., Gronberg,H., Hall,P., Hattersley,A.T., Hengstenberg,C.,
            Hoffman,W., Lathrop,G.M., Salomaa,V., Schreiber,S., Uda,M.,
            Waterworth,D., Wright,A.F., Assimes,T.L., Barroso,I., Hofman,A.,
            Mohlke,K.L., Boomsma,D.I., Caulfield,M.J., Cupples,L.A.,
            Erdmann,J., Fox,C.S., Gudnason,V., Gyllensten,U., Harris,T.B.,
            Hayes,R.B., Jarvelin,M.R., Mooser,V., Munroe,P.B., Ouwehand,W.H.,
            Penninx,B.W., Pramstaller,P.P., Quertermous,T., Rudan,I.,
            Samani,N.J., Spector,T.D., Volzke,H., Watkins,H., Wilson,J.F.,
            Groop,L.C., Haritunians,T., Hu,F.B., Kaplan,R.C., Metspalu,A.,
            North,K.E., Schlessinger,D., Wareham,N.J., Hunter,D.J.,
            O'Connell,J.R., Strachan,D.P., Wichmann,H.E., Borecki,I.B., van
            Duijn,C.M., Schadt,E.E., Thorsteinsdottir,U., Peltonen,L.,
            Uitterlinden,A.G., Visscher,P.M., Chatterjee,N., Loos,R.J.,
            Boehnke,M., McCarthy,M.I., Ingelsson,E., Lindgren,C.M.,
            Abecasis,G.R., Stefansson,K., Frayling,T.M. and Hirschhorn,J.N.
  TITLE     Hundreds of variants clustered in genomic loci and biological
            pathways affect human height
  JOURNAL   Nature 467 (7317), 832-838 (2010)
   PUBMED   20881960
REFERENCE   7  (bases 1 to 2519)
  AUTHORS   Chen,X., Li,X., Wang,P., Liu,Y., Zhang,Z., Zhao,G., Xu,H., Zhu,J.,
            Qin,X., Chen,S., Hu,L. and Kong,X.
  TITLE     Novel association strategy with copy number variation for
            identifying new risk Loci of human diseases
  JOURNAL   PLoS One 5 (8), e12185 (2010)
   PUBMED   20808825
  REMARK    GeneRIF: Observational study and genome-wide association study of
            gene-disease association. (HuGE Navigator)
            Publication Status: Online-Only
REFERENCE   8  (bases 1 to 2519)
  AUTHORS   Mardones,G.A., Burgos,P.V., Brooks,D.A., Parkinson-Lawrence,E.,
            Mattera,R. and Bonifacino,J.S.
  TITLE     The trans-Golgi network accessory protein p56 promotes long-range
            movement of GGA/clathrin-containing transport carriers and
            lysosomal enzyme sorting
  JOURNAL   Mol Biol Cell 18 (9), 3486-3501 (2007)
   PUBMED   17596511
  REMARK    GeneRIF: p56 tightly cooperates with the GGAs in the sorting of
            cathepsin D to lysosomes, probably by enabling the movement of
            GGA-containing transport carriers.
REFERENCE   9  (bases 1 to 2519)
  AUTHORS   Collins,B.M., Praefcke,G.J., Robinson,M.S. and Owen,D.J.
  TITLE     Structural basis for binding of accessory proteins by the appendage
            domain of GGAs
  JOURNAL   Nat Struct Biol 10 (8), 607-613 (2003)
   PUBMED   12858163
REFERENCE   10 (bases 1 to 2519)
  AUTHORS   Lui,W.W., Collins,B.M., Hirst,J., Motley,A., Millar,C., Schu,P.,
            Owen,D.J. and Robinson,M.S.
  TITLE     Binding partners for the COOH-terminal appendage domains of the
            GGAs and gamma-adaptin
  JOURNAL   Mol Biol Cell 14 (6), 2385-2398 (2003)
   PUBMED   12808037
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA303929.1, DA390133.1, AY289196.1, BC018679.1, AK001950.1,
            AL570537.3 and BU739164.1.
            
            On Jun 2, 2019 this sequence version replaced NM_018318.4.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1). Variants 1, 3-6, and 12 all encode the same isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660807.184489.1,
                                           SRR1660807.27129.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000536442.6/ ENSP00000445660.2
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-9                 DA303929.1         30-38
            10-577              DA390133.1         4-571
            578-1139            AY289196.1         394-955
            1140-1279           BC018679.1         1374-1513
            1280-1534           AY289196.1         1096-1350
            1535-2079           AK001950.1         837-1381
            2080-2460           AL570537.3         1-381               c
            2461-2519           BU739164.1         18-76               c
FEATURES             Location/Qualifiers
     source          1..2519
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12p11.22"
     gene            1..2519
                     /gene="CCDC91"
                     /gene_synonym="HSD8; p56"
                     /note="coiled-coil domain containing 91"
                     /db_xref="GeneID:55297"
                     /db_xref="HGNC:HGNC:24855"
                     /db_xref="MIM:617366"
     exon            1..186
                     /gene="CCDC91"
                     /gene_synonym="HSD8; p56"
                     /inference="alignment:Splign:2.1.0"
     exon            187..230
                     /gene="CCDC91"
                     /gene_synonym="HSD8; p56"
                     /inference="alignment:Splign:2.1.0"
     CDS             201..1526
                     /gene="CCDC91"
                     /gene_synonym="HSD8; p56"
                     /note="isoform 1 is encoded by transcript variant 1;
                     coiled-coil domain-containing protein 91; GGA-binding
                     partner; p56 accessory protein"
                     /codon_start=1
                     /product="coiled-coil domain-containing protein 91 isoform
                     1"
                     /protein_id="NP_060788.3"
                     /db_xref="CCDS:CCDS8716.1"
                     /db_xref="GeneID:55297"
                     /db_xref="HGNC:HGNC:24855"
                     /db_xref="MIM:617366"
                     /translation="MDDDDFGGFEAAETFDGGSGETQTTSPAIPWAAFPAVSGVHLSP
                     SSPEIVLDRDHSSSIGCLSSDAIISSPENTHAANSIVSQTIPKAQIQQSTHTHLDISL
                     FPLGLTDEKSNGTIALVDDSEDPGANVSNIQLQQKISSLEIKLKVSEEEKQRIKQDVE
                     SLMEKHNVLEKGFLKEKEQEAISFQDRYKELQEKHKQELEDMRKAGHEALSIIVDEYK
                     ALLQSSVKQQVEAIEKQYISAIEKQAHKCEELLNAQHQRLLEMLDTEKELLKEKIKEA
                     LIQQSQEQKEILEKCLEEERQRNKEALVSAAKLEKEAVKDAVLKVVEEERKNLEKAHA
                     EERELWKTEHAKDQEKVSQEIQKAIQEQRKISQETVKAAIIEEQKRSEKAVEEAVKRT
                     RDELIEYIKEQKRLDQVIRQRSLSSLELFLSCAQKQLSALIATEPVDIE"
     exon            231..309
                     /gene="CCDC91"
                     /gene_synonym="HSD8; p56"
                     /inference="alignment:Splign:2.1.0"
     exon            310..467
                     /gene="CCDC91"
                     /gene_synonym="HSD8; p56"
                     /inference="alignment:Splign:2.1.0"
     exon            468..671
                     /gene="CCDC91"
                     /gene_synonym="HSD8; p56"
                     /inference="alignment:Splign:2.1.0"
     exon            672..776
                     /gene="CCDC91"
                     /gene_synonym="HSD8; p56"
                     /inference="alignment:Splign:2.1.0"
     exon            777..854
                     /gene="CCDC91"
                     /gene_synonym="HSD8; p56"
                     /inference="alignment:Splign:2.1.0"
     exon            855..962
                     /gene="CCDC91"
                     /gene_synonym="HSD8; p56"
                     /inference="alignment:Splign:2.1.0"
     exon            963..1055
                     /gene="CCDC91"
                     /gene_synonym="HSD8; p56"
                     /inference="alignment:Splign:2.1.0"
     exon            1056..1124
                     /gene="CCDC91"
                     /gene_synonym="HSD8; p56"
                     /inference="alignment:Splign:2.1.0"
     exon            1125..1301
                     /gene="CCDC91"
                     /gene_synonym="HSD8; p56"
                     /inference="alignment:Splign:2.1.0"
     exon            1302..1415
                     /gene="CCDC91"
                     /gene_synonym="HSD8; p56"
                     /inference="alignment:Splign:2.1.0"
     exon            1416..2519
                     /gene="CCDC91"
                     /gene_synonym="HSD8; p56"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2497..2502
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CCDC91"
                     /gene_synonym="HSD8; p56"
                     /note="hexamer: AATAAA"
     polyA_site      2519
                     /gene="CCDC91"
                     /gene_synonym="HSD8; p56"
                     /note="major polyA site"
ORIGIN      
        1 agaggtgttc gaagccgggt ggtgcgtggg ctaccccaac ctgtgtggct gggccgcggt
       61 ctcccctcaa gggcctgggg ccgtgcctcg ggtgtacgcg taggggtctg tgtgctgggg
      121 gtggctcacc gggcagcgtg ggtgagcggc gcagcggcgg cagcggagag cgagagaggg
      181 gagcaggtgc cacttgaaga atggatgatg atgattttgg tggttttgag gctgcggaga
      241 cttttgatgg tggaagtggt gaaacccaaa caacatctcc tgctattcct tgggctgcct
      301 ttcctgcagt atctggagtc catctttcac catcttctcc tgagattgta ctggaccgtg
      361 accactcttc ttccattggc tgcctctctt ctgatgccat tatttcatca ccagagaata
      421 cacatgcagc aaatagcatt gtgagtcaaa ctattccaaa agcacagatt cagcaatcaa
      481 cacacactca tctggatatc tcactttttc cattgggttt aactgatgaa aaaagtaatg
      541 gaacaattgc ccttgtggat gattctgagg atcctggagc caatgtatct aacatacagc
      601 ttcagcaaaa aatttcaagt ctggagatta aactcaaagt atctgaagaa gaaaaacaga
      661 gaattaaaca ggatgtggaa tcattgatgg aaaagcataa tgtcttagaa aaaggctttc
      721 taaaagaaaa agagcaagag gccatttctt ttcaagatag atacaaagaa cttcaggaaa
      781 aacataaaca agaattggaa gacatgagga aagctggtca cgaagccctc agcattattg
      841 tggatgaata taaggcacta ctgcagtctt cagttaagca acaagtagaa gctattgaaa
      901 aacagtacat ttctgcaatt gagaaacagg cacacaagtg tgaggagttg ctaaatgctc
      961 agcatcagag gctccttgaa atgctagata cagagaagga actgttaaaa gaaaaaataa
     1021 aggaagcttt gattcagcaa tctcaagaac agaaggaaat attggaaaag tgtttggagg
     1081 aagaaaggca aagaaataaa gaggcattag tatccgctgc aaagcttgaa aaagaagcag
     1141 tgaaggatgc agttttaaaa gtcgtagaag aagaaagaaa aaatttagaa aaagcgcatg
     1201 ctgaagaaag ggaattatgg aagacagaac atgcaaaaga tcaagaaaaa gtatctcagg
     1261 aaattcaaaa agctatacaa gaacaaagaa aaataagtca ggaaactgtt aaggcagcaa
     1321 taatagaaga gcagaaacga agtgaaaagg ctgtggaaga ggcagtgaaa agaacaagag
     1381 atgaattgat agagtatata aaagaacaga aaaggctcga tcaagtcatc cgccaaagaa
     1441 gcctgtccag tttggaactg ttcctctcct gtgcacagaa acagttaagt gctttaatag
     1501 ctacggaacc agttgacatt gaataaaaag aacatgacaa acccacactg gcattggata
     1561 aatcatatta caccttcaaa atacacactc tgaattataa agatgtgttt gttttctttc
     1621 caaatcatgt agaattgatt tccagttcaa ggataaacca aaacaatatt tagaactatc
     1681 aagtgatcta atttattttc ttttggtttc ttctttacat ttactgttat tttattatta
     1741 ttagtagtag cagcaacaga gtatgatatg acccaaaagc cattgtaaag tgccacatta
     1801 ccaaaattaa ttaagtaaac tttatagcct gtgggagtct attatatatt attttgcaaa
     1861 agtagtaaat atattattgt ttcatgatga ctcttgatga gatgctagaa tgtaaccata
     1921 catttatctt attttgagga tagaaatagc atggatttca acatcactta tttatctgta
     1981 taattggaaa taaaacaccg atatgataga gaatcattcc ggcattacct aacctcttct
     2041 gcagttggat ctatgtattt tcattggtct actgaaaaca aacaatacaa ttaaaagcac
     2101 taaagattat tatattaatt caactttgat ctgatatatc acttaaacta aaggggtgtg
     2161 tgtggtgtat gcttgtttcc tatttctgct ctttaaagat actttgaatc aataaaacca
     2221 ttagtctaca aatcaaattg tgaacttaat ctctagaaag agaatataac tcagccattt
     2281 ataggaattt aggttcaagt acaggatata tgaaatcttt tcccagtatt tcagaatgta
     2341 cttaattcac aggcaggatg cttcaatgca aaatcatgaa tatttttaat tcaaaactaa
     2401 aatgtcatta atatgtatgt atgcaaatgt tttatcttat tttctgaaat gcatctactt
     2461 tcatgggctt tgtacgtttc tgagatttct cagtgtaata aaaagagctc ccaaactta
//
