LOCUS       NM_021825               3990 bp    mRNA    linear   PRI 22-SEP-2024
DEFINITION  Homo sapiens coiled-coil domain containing 90B (CCDC90B),
            transcript variant 1, mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_021825
VERSION     NM_021825.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3990)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 3990)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 3990)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   4  (bases 1 to 3990)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 3990)
  AUTHORS   Adlakha,J., Karamichali,I., Sangwallek,J., Deiss,S., Bar,K.,
            Coles,M., Hartmann,M.D., Lupas,A.N. and Hernandez Alvarez,B.
  TITLE     Characterization of MCU-Binding Proteins MCUR1 and CCDC90B -
            Representatives of a Protein Family Conserved in Prokaryotes and
            Eukaryotic Organelles
  JOURNAL   Structure 27 (3), 464-475 (2019)
   PUBMED   30612859
  REMARK    GeneRIF: Using MCUR1, the functionally characterized paralog of
            study the role of individual domains, results find that the
            conserved head domain in CCDC90B interacts directly with
            mitochondrial calcium uniporter and is destabilized upon Ca(2+)
            binding.
REFERENCE   6  (bases 1 to 3990)
  AUTHORS   Tomar,D., Dong,Z., Shanmughapriya,S., Koch,D.A., Thomas,T.,
            Hoffman,N.E., Timbalia,S.A., Goldman,S.J., Breves,S.L.,
            Corbally,D.P., Nemani,N., Fairweather,J.P., Cutri,A.R., Zhang,X.,
            Song,J., Jana,F., Huang,J., Barrero,C., Rabinowitz,J.E.,
            Luongo,T.S., Schumacher,S.M., Rockman,M.E., Dietrich,A., Merali,S.,
            Caplan,J., Stathopulos,P., Ahima,R.S., Cheung,J.Y., Houser,S.R.,
            Koch,W.J., Patel,V., Gohil,V.M., Elrod,J.W., Rajan,S. and Madesh,M.
  TITLE     MCUR1 Is a Scaffold Factor for the MCU Complex Function and
            Promotes Mitochondrial Bioenergetics
  JOURNAL   Cell Rep 15 (8), 1673-1685 (2016)
   PUBMED   27184846
REFERENCE   7  (bases 1 to 3990)
  AUTHORS   Hendrickson,S.L., Lautenberger,J.A., Chinn,L.W., Malasky,M.,
            Sezgin,E., Kingsley,L.A., Goedert,J.J., Kirk,G.D., Gomperts,E.D.,
            Buchbinder,S.P., Troyer,J.L. and O'Brien,S.J.
  TITLE     Genetic variants in nuclear-encoded mitochondrial genes influence
            AIDS progression
  JOURNAL   PLoS One 5 (9), e12862 (2010)
   PUBMED   20877624
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
            Publication Status: Online-Only
REFERENCE   8  (bases 1 to 3990)
  AUTHORS   Simpson,J.C., Wellenreuther,R., Poustka,A., Pepperkok,R. and
            Wiemann,S.
  TITLE     Systematic subcellular localization of novel proteins identified by
            large-scale cDNA sequencing
  JOURNAL   EMBO Rep 1 (3), 287-292 (2000)
   PUBMED   11256614
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AP000873.5.
            
            On Apr 29, 2021 this sequence version replaced NM_021825.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK315787.1, AF271782.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            MANE Ensembl match                 :: ENST00000529689.6/
                                                  ENSP00000434724.1
            RefSeq Select criteria             :: based on manual assertion,
                                                  conservation, expression,
                                                  longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-495               AP000873.5         155966-156460       c
            496-615             AP000873.5         150234-150353       c
            616-719             AP000873.5         148819-148922       c
            720-821             AP000873.5         144732-144833       c
            822-863             AP000873.5         144044-144085       c
            864-935             AP000873.5         143886-143957       c
            936-989             AP000873.5         143740-143793       c
            990-1104            AP000873.5         135957-136071       c
            1105-3990           AP000873.5         129173-132058       c
FEATURES             Location/Qualifiers
     source          1..3990
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q14.1"
     gene            1..3990
                     /gene="CCDC90B"
                     /gene_synonym="MDS011; MDS025"
                     /note="coiled-coil domain containing 90B"
                     /db_xref="GeneID:60492"
                     /db_xref="HGNC:HGNC:28108"
                     /db_xref="MIM:620753"
     exon            1..495
                     /gene="CCDC90B"
                     /gene_synonym="MDS011; MDS025"
                     /inference="alignment:Splign:2.1.0"
     CDS             396..1160
                     /gene="CCDC90B"
                     /gene_synonym="MDS011; MDS025"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; coiled-coil domain-containing protein 90B,
                     mitochondrial"
                     /codon_start=1
                     /product="coiled-coil domain-containing protein 90B,
                     mitochondrial isoform 1 precursor"
                     /protein_id="NP_068597.2"
                     /db_xref="CCDS:CCDS8266.1"
                     /db_xref="GeneID:60492"
                     /db_xref="HGNC:HGNC:28108"
                     /db_xref="MIM:620753"
                     /translation="MNSRQAWRLFLSQGRGDRWVSRPRGHFSPALRREFFTTTTKEGY
                     DRRPVDITPLEQRKLTFDTHALVQDLETHGFDKTQAETIVSALTALSNVSLDTIYKEM
                     VTQAQQEITVQQLMAHLDAIRKDMVILEKSEFANLRAENEKMKIELDQVKQQLMHETS
                     RIRADNKLDINLERSRVTDMFTDQEKQLMETTTEFTKKDTQTKSIISETSNKIDAEIA
                     SLKTLMESNKLETIRYLAASVFTCLAIALGFYRFWK"
     exon            496..615
                     /gene="CCDC90B"
                     /gene_synonym="MDS011; MDS025"
                     /inference="alignment:Splign:2.1.0"
     exon            616..719
                     /gene="CCDC90B"
                     /gene_synonym="MDS011; MDS025"
                     /inference="alignment:Splign:2.1.0"
     exon            720..821
                     /gene="CCDC90B"
                     /gene_synonym="MDS011; MDS025"
                     /inference="alignment:Splign:2.1.0"
     exon            822..863
                     /gene="CCDC90B"
                     /gene_synonym="MDS011; MDS025"
                     /inference="alignment:Splign:2.1.0"
     exon            864..935
                     /gene="CCDC90B"
                     /gene_synonym="MDS011; MDS025"
                     /inference="alignment:Splign:2.1.0"
     exon            936..989
                     /gene="CCDC90B"
                     /gene_synonym="MDS011; MDS025"
                     /inference="alignment:Splign:2.1.0"
     exon            990..1104
                     /gene="CCDC90B"
                     /gene_synonym="MDS011; MDS025"
                     /inference="alignment:Splign:2.1.0"
     exon            1105..3990
                     /gene="CCDC90B"
                     /gene_synonym="MDS011; MDS025"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1283..1288
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CCDC90B"
                     /gene_synonym="MDS011; MDS025"
                     /note="hexamer: ACTAAA"
     polyA_site      1312
                     /gene="CCDC90B"
                     /gene_synonym="MDS011; MDS025"
     regulatory      1594..1599
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CCDC90B"
                     /gene_synonym="MDS011; MDS025"
                     /note="hexamer: AATGAA"
     polyA_site      1615
                     /gene="CCDC90B"
                     /gene_synonym="MDS011; MDS025"
                     /note="major polyA site"
     regulatory      2699..2704
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CCDC90B"
                     /gene_synonym="MDS011; MDS025"
                     /note="hexamer: ATTAAA"
     polyA_site      2722
                     /gene="CCDC90B"
                     /gene_synonym="MDS011; MDS025"
     regulatory      3780..3785
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CCDC90B"
                     /gene_synonym="MDS011; MDS025"
                     /note="hexamer: AATATA"
     polyA_site      3799
                     /gene="CCDC90B"
                     /gene_synonym="MDS011; MDS025"
     regulatory      3956..3961
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CCDC90B"
                     /gene_synonym="MDS011; MDS025"
                     /note="hexamer: AATAAA"
     regulatory      3969..3974
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CCDC90B"
                     /gene_synonym="MDS011; MDS025"
                     /note="hexamer: CATAAA"
     polyA_site      3979
                     /gene="CCDC90B"
                     /gene_synonym="MDS011; MDS025"
     polyA_site      3990
                     /gene="CCDC90B"
                     /gene_synonym="MDS011; MDS025"
ORIGIN      
        1 aaatgcgact ccatctcccc cgacccaagc gcgtaatggc cgctggctat cttgggggag
       61 ccagctgttg gactatgccc cactgccagg aaacaggcgc cggaaggttc tctgacaaga
      121 tctcgctttc ctagggcggt gaaggcgttc aaaggtcggg aaggggcgct gggagaagcg
      181 gggcagcgct gagccatgct cgcgaactgt gggtctgtct gtgaagagac ccagtttcgt
      241 gggaccacgg tggcgcctgc gctgggaggt gagcttgtga cagagcgaaa actacaattc
      301 ccagcattcc tgtggtgcca gaactacctt gcccgaaagc ctgtgcgaga tttaccccgt
      361 cttccgcctc cctcccaccg gaaaactctg aggacatgaa tagtcgccag gcttggcggc
      421 tctttctctc ccaaggcaga ggagatcgtt gggtttcaag gccccgcggg catttctcgc
      481 cggccctgcg gagagagttc ttcactacca caaccaagga gggatatgat aggcggccag
      541 tggatataac tcctttagaa caaaggaaat taacttttga tacccatgca ttggttcagg
      601 acttggaaac tcatggattt gacaaaacac aagcagaaac aattgtatca gcgttaactg
      661 ctttatcaaa tgtcagcctg gatactatct ataaagagat ggtcactcaa gctcaacagg
      721 aaataacagt acaacagcta atggctcatt tggatgctat caggaaagac atggtcatcc
      781 tagagaaaag tgaatttgca aatctgagag cagagaatga gaaaatgaaa attgaattag
      841 accaagttaa gcaacaacta atgcatgaaa ccagtcgaat cagagcagat aataaactgg
      901 atatcaactt agaaaggagc agagtaacag atatgtttac agatcaagaa aagcaactta
      961 tggaaacaac tacagaattt acaaaaaagg atactcaaac caaaagtatt atttcagaga
     1021 ccagtaataa aattgacgct gaaattgctt ccttaaaaac actgatggaa tctaacaaac
     1081 ttgagacaat tcgttatctt gcagcttcgg tgtttacttg cctggcaata gcattgggat
     1141 tttatagatt ctggaagtag tattaatgct catcctgctg tggctgttgg cttcttagaa
     1201 caccaaaccg ggagagattt actttgaaca ttgtcagttg cagcaaaaat ttactacaca
     1261 agattattcg aagtgtatac ggactaaaag aggaagtgtt ttagaatgag aagagatact
     1321 gtgtctttat tgtgtgtgtg tgagtgcagg tgtgtgtctt tattatattg aaaagctgtc
     1381 actcagacct ggtttgagat agaagagcat tttgtccttt tgatagttaa tagaaattga
     1441 accagagttt tcttatgttt gcttgaacag ttgtgtaaat catacaggat tttgtgggta
     1501 ttggttgaat atttgtaaac cattccctag cctacatatt tattactgaa ttaactttcc
     1561 tgataaccat tgcataatta catttttcta taaaatgaaa gattattaca acaaagttgt
     1621 gtgggttttc aaagtgactt accatatagt tggagattga tttctttttg gtaatgaact
     1681 aaaacaataa attttaaaat gataggccag gcgcggtggc tcacacctgt aatctcagca
     1741 ctttgggagg ctgaggcggg tggatcactt gaggtcagga gttctagacc agcctggcca
     1801 acatggtgaa accccgtctc tgctaaaaat acaaaaatta gccaggcatg gtggcacatg
     1861 cctgtaattc cagctactcg ggaggctgag gcaggagaat cttgcagtga gccgagatag
     1921 caccactgca ctccagcctg ggtgacagag caagactcca ttacctaaat aaataaatgt
     1981 gtgctttagt gcaaattaca acacttaata tgaaatctgt agagttgcta aatattgagc
     2041 tctgattatt acatgtattt tttaaatatt tgatactcaa aaaccagttt atccctgctt
     2101 cttaatgtag tttaagttaa cccatcttaa atttattaca taaaacaaag cttttcttaa
     2161 tgacttcaat tcagcaaaca ttgatatcta gtacctactc tcaagaaact cataggaaaa
     2221 tttaaattcg tattttgttt tgttattaga tatatttttt cttacaaagt aatatctatt
     2281 agtaaatcat atgtaatttc aaagaaattt taaaatatcc ttttcatctt agttcttcag
     2341 tcttacccag atcaagaaga caagaccaga aagtaaacat tttgagttca taatgccttg
     2401 gtaatagcta taaaagtttg acaatcatta ttcaaaatag ccttgtcatt tgtttagcta
     2461 taaacaggga atctgcagta tagagcagtc aagagattgg tccatatggt ccagtgagtg
     2521 agagtcaggc tttccaacta tattttcctc aaaaatctaa ctgctggttt gttttcaaaa
     2581 gaaaaacctt gacattatcc tgttacattc tgattcattt ttatctctat tgcctaagag
     2641 agttcttagt atattataga ttaattttca ctgagtcaat taataagtta ccatatatat
     2701 taaagtccac tgtaacaaag tatactgcat ttgttcagtt aaccaatatg actgcctgct
     2761 atatgccaaa cagcatgcta gtccctgtgt gcacagagat gaacatggtt tcattctcat
     2821 tgaattgaca atcttaagga gagagacata aacaagtaaa ttattggttt gttaagattt
     2881 aaaatattct aaaatattaa gagggaatgc gtctttcctc catgtgaagg aagctccagt
     2941 agcataacac tgtcgtcact cttcatcccc ttatccactc tgccctaggt aaagtgactt
     3001 gcccaattgt aaatctggaa ggagaaacaa ggtgcaatta gcccacttcc tccccactcc
     3061 tgtttgggac cagcccatct gaagagacat tcattctgtt ctgcttctat gggatcaggc
     3121 tctgcctctg caggatgagg cctggcccag tagagcaatg cttgagacag ggtaaatctg
     3181 tccagttcta gagttcagtg ataagaagct tactggcctt aagatgaaac ccatattctc
     3241 ttgctgagca cagtggcaca catctatagt cctagctgct tgggaggctg cggcagcagg
     3301 attgcttgag ccaaggagtt catcaaggct aaagtgtacc atgatcatac ctataaatag
     3361 tcactgcact ccagcctggc aacacatgag accctgtctc ctaaaaaaaa acttctccaa
     3421 tagttttatc agcaaataaa ggtgtttttt aggcctctat attagtttat tcattcttca
     3481 tcttagttat attcacaacc cagaatggaa aggaggtatg ccatttattg gaccttctca
     3541 agccccaaca aataaatata cttattccca ggttatacag ccactaaata ttaaatagat
     3601 ctgcgttctt tctcattgta ggggtttagc aaacaaagtg ctttgtatcc aataacagaa
     3661 gaatagaaat atgcatacca taccctgtcc ccattacttt tagatcctat atcctttcca
     3721 tgaaacttca ttttgatggt ggttctgggg ttcaggtaaa tttttgtttc agtgatggaa
     3781 atatatgaaa taaggatgag aggattgtgt ttctatatgc cttaaaacta tacctctatt
     3841 ccagcacttg cacttcacta tgaaacagca attatacgta tctttttcct acactaaact
     3901 acaagttctc agaaggcctc tagacacatg tgaggtactt gttaaacgcc tgtggaataa
     3961 atgatactca taaatctcag ttgaccttaa
//
