LOCUS       NM_015603               2027 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens coiled-coil domain containing 9 (CCDC9), mRNA.
ACCESSION   NM_015603
VERSION     NM_015603.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2027)
  AUTHORS   Lim,S.H., Snider,J., Birimberg-Schwartz,L., Ip,W., Serralha,J.C.,
            Botelho,H.M., Lopes-Pacheco,M., Pinto,M.C., Moutaoufik,M.T.,
            Zilocchi,M., Laselva,O., Esmaeili,M., Kotlyar,M., Lyakisheva,A.,
            Tang,P., Lopez Vazquez,L., Akula,I., Aboualizadeh,F., Wong,V.,
            Grozavu,I., Opacak-Bernardi,T., Yao,Z., Mendoza,M., Babu,M.,
            Jurisica,I., Gonska,T., Bear,C.E., Amaral,M.D. and Stagljar,I.
  TITLE     CFTR interactome mapping using the mammalian membrane two-hybrid
            high-throughput screening system
  JOURNAL   Mol Syst Biol 18 (2), e10629 (2022)
   PUBMED   35156780
REFERENCE   2  (bases 1 to 2027)
  AUTHORS   Drew,K., Wallingford,J.B. and Marcotte,E.M.
  TITLE     hu.MAP 2.0: integration of over 15,000 proteomic experiments builds
            a global compendium of human multiprotein assemblies
  JOURNAL   Mol Syst Biol 17 (5), e10016 (2021)
   PUBMED   33973408
REFERENCE   3  (bases 1 to 2027)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   4  (bases 1 to 2027)
  AUTHORS   Sha,Y., Xu,Y., Wei,X., Liu,W., Mei,L., Lin,S., Ji,Z., Wang,X.,
            Su,Z., Qiu,P., Chen,J. and Wang,X.
  TITLE     CCDC9 is identified as a novel candidate gene of severe
            asthenozoospermia
  JOURNAL   Syst Biol Reprod Med 65 (6), 465-473 (2019)
   PUBMED   31502483
  REMARK    GeneRIF: homozygous variant (NC_000019.9: g.47763960C>T,
            NM_015603.3, NP_056418.1: p. Ser109Leu) associated with severe
            asthenozoospermia
REFERENCE   5  (bases 1 to 2027)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   6  (bases 1 to 2027)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   7  (bases 1 to 2027)
  AUTHORS   Lee,O.H., Kim,H., He,Q., Baek,H.J., Yang,D., Chen,L.Y., Liang,J.,
            Chae,H.K., Safari,A., Liu,D. and Songyang,Z.
  TITLE     Genome-wide YFP fluorescence complementation screen identifies new
            regulators for telomere signaling in human cells
  JOURNAL   Mol Cell Proteomics 10 (2), M110.001628 (2011)
   PUBMED   21044950
REFERENCE   8  (bases 1 to 2027)
  AUTHORS   Oh,J.H., Yang,J.O., Hahn,Y., Kim,M.R., Byun,S.S., Jeon,Y.J.,
            Kim,J.M., Song,K.S., Noh,S.M., Kim,S., Yoo,H.S., Kim,Y.S. and
            Kim,N.S.
  TITLE     Transcriptome analysis of human gastric cancer
  JOURNAL   Mamm Genome 16 (12), 942-954 (2005)
   PUBMED   16341674
REFERENCE   9  (bases 1 to 2027)
  AUTHORS   Beausoleil,S.A., Jedrychowski,M., Schwartz,D., Elias,J.E.,
            Villen,J., Li,J., Cohn,M.A., Cantley,L.C. and Gygi,S.P.
  TITLE     Large-scale characterization of HeLa cell nuclear phosphoproteins
  JOURNAL   Proc Natl Acad Sci U S A 101 (33), 12130-12135 (2004)
   PUBMED   15302935
REFERENCE   10 (bases 1 to 2027)
  AUTHORS   Simpson,J.C., Wellenreuther,R., Poustka,A., Pepperkok,R. and
            Wiemann,S.
  TITLE     Systematic subcellular localization of novel proteins identified by
            large-scale cDNA sequencing
  JOURNAL   EMBO Rep 1 (3), 287-292 (2000)
   PUBMED   11256614
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BM737911.1, CR977312.1, BC009743.2, AK302153.1 and AL050284.1.
            
            On Nov 22, 2018 this sequence version replaced NM_015603.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AL050284.1, BC002787.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000221922.11/ ENSP00000221922.5
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-144               BM737911.1         52-195
            145-528             CR977312.1         112-495
            529-1807            BC009743.2         476-1754
            1808-1822           AK302153.1         1780-1794
            1823-2027           AL050284.1         1807-2011
FEATURES             Location/Qualifiers
     source          1..2027
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.32"
     gene            1..2027
                     /gene="CCDC9"
                     /note="coiled-coil domain containing 9"
                     /db_xref="GeneID:26093"
                     /db_xref="HGNC:HGNC:24560"
     exon            1..85
                     /gene="CCDC9"
                     /inference="alignment:Splign:2.1.0"
     exon            86..159
                     /gene="CCDC9"
                     /inference="alignment:Splign:2.1.0"
     CDS             157..1752
                     /gene="CCDC9"
                     /codon_start=1
                     /product="coiled-coil domain-containing protein 9"
                     /protein_id="NP_056418.1"
                     /db_xref="CCDS:CCDS12698.1"
                     /db_xref="GeneID:26093"
                     /db_xref="HGNC:HGNC:24560"
                     /translation="MAATLDLKSKEEKDAELDKRIEALRRKNEALIRRYQEIEEDRKK
                     AELEGVAVTAPRKGRSVEKENVAVESEKNLGPSRRSPGTPRPPGASKGGRTPPQQGGR
                     AGMGRASRSWEGSPGEQPRGGGAGGRGRRGRGRGSPHLSGAGDTSISDRKSKEWEERR
                     RQNIEKMNEEMEKIAEYERNQREGVLEPNPVRNFLDDPRRRSGPLEESERDRREESRR
                     HGRNWGGPDFERVRCGLEHERQGRRAGLGSAGDMTLSMTGRERSEYLRWKQEREKIDQ
                     ERLQRHRKPTGQWRREWDAEKTDGMFKDGPVPAHEPSHRYDDQAWARPPKPPTFGEFL
                     SQHKAEASSRRRRKSSRPQAKAAPRAYSDHDDRWETKEGAASPAPETPQPTSPETSPK
                     ETPMQPPEIPAPAHRPPEDEGEENEGEEDEEWEDISEDEEEEEIEVEEGDEEEPAQDH
                     QAPEAAPTGIPCSEQAHGVPFSPEEPLLEPQAPGTPSSPFSPPSGHQPVSDWGEEVEL
                     NSPRTTHLAGALSPGEAWPFESV"
     exon            160..264
                     /gene="CCDC9"
                     /inference="alignment:Splign:2.1.0"
     exon            265..366
                     /gene="CCDC9"
                     /inference="alignment:Splign:2.1.0"
     exon            367..618
                     /gene="CCDC9"
                     /inference="alignment:Splign:2.1.0"
     exon            619..702
                     /gene="CCDC9"
                     /inference="alignment:Splign:2.1.0"
     exon            703..876
                     /gene="CCDC9"
                     /inference="alignment:Splign:2.1.0"
     exon            877..1058
                     /gene="CCDC9"
                     /inference="alignment:Splign:2.1.0"
     exon            1059..1105
                     /gene="CCDC9"
                     /inference="alignment:Splign:2.1.0"
     exon            1106..1241
                     /gene="CCDC9"
                     /inference="alignment:Splign:2.1.0"
     exon            1242..1347
                     /gene="CCDC9"
                     /inference="alignment:Splign:2.1.0"
     exon            1348..2027
                     /gene="CCDC9"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2005..2010
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CCDC9"
                     /note="hexamer: AATAAA"
     polyA_site      2027
                     /gene="CCDC9"
                     /note="major polyA site"
ORIGIN      
        1 aggaagtgac gcgcctggcc cgggagctgc ggtcgcagag gccgacggag ccggagtcgc
       61 ggacgccgcg gggtctccgg gacaggaacc ctcagtgctg cgtctagatt ctgcagggga
      121 ggtttgctgg gaccttggct ccacgcagcc agcgaaatgg cagccacact cgatttgaaa
      181 tcaaaggagg agaaggatgc tgagttggac aagaggatcg aggctcttcg gcggaagaat
      241 gaggccctca tccggcgcta ccaggagatt gaggaagacc gtaagaaagc tgaacttgag
      301 ggagtcgcag tcacagctcc ccgaaagggc cgctcagtgg agaaggagaa cgtggcagtg
      361 gagtcggaga agaacctggg tccttcccgg aggtctcctg ggacccctcg gcccccaggg
      421 gccagcaagg ggggccggac tcctccacag cagggaggcc gggccggcat gggccgagca
      481 tcgcgcagct gggagggcag ccccggggag cagcctcgag gaggaggagc tgggggccgt
      541 ggccggaggg gccggggccg aggttcacct cacctctctg gagctggaga cacctcaatc
      601 tctgaccgta aatccaagga gtgggaggag cggcgcaggc agaacattga gaagatgaat
      661 gaggagatgg agaagatcgc cgagtatgag cgcaaccagc gggaaggggt tcttgaaccc
      721 aacccagtgc ggaacttcct ggacgacccc cggcgacgca gcgggcccct ggaggagtct
      781 gagcgggacc gccgggagga gagccgccgg cacggccgca actggggggg ccccgacttc
      841 gagcgggtgc gctgtggcct tgagcacgag cggcagggcc gccgagctgg cctgggcagt
      901 gctggagaca tgacgttgtc catgacgggc cgggagcggt cggagtacct gcgctggaag
      961 caggagaggg agaagatcga ccaggagcgg ctgcagaggc accgcaagcc cactggccag
     1021 tggaggcgcg agtgggatgc cgagaagacc gatgggatgt tcaaggatgg cccagtccct
     1081 gcccatgaac catcccaccg ctatgatgac caggcctggg cccggccccc gaagccccct
     1141 acttttgggg agttcctgtc ccagcacaaa gctgaggcca gcagccgcag aaggagaaag
     1201 agcagtcggc cccaggccaa ggcagcgccc agggcctaca gtgaccatga tgaccgctgg
     1261 gagacaaaag aaggggcagc atccccagcc cctgagactc cacagcctac ttcccccgag
     1321 acttccccca aggagacacc catgcagcca cccgagatcc cagctcctgc ccaccggcct
     1381 cctgaagacg agggggaaga gaatgagggg gaagaggatg aagaatggga ggacataagt
     1441 gaggatgagg aagaggagga gatcgaggtg gaagaaggtg atgaggagga accagcccaa
     1501 gaccaccaag ccccagaggc tgcccccacc gggatcccct gcagtgagca ggcccacgga
     1561 gtccccttca gtccggagga gcccctgctg gagccccagg cccctggcac gccttccagc
     1621 cctttctcac cacccagcgg ccaccagcct gtgtccgatt ggggtgaaga ggtggagctg
     1681 aattctcccc ggaccactca cctggctggc gccctctccc cgggtgaggc ctggcctttt
     1741 gagagtgtat gaagctggct gcctgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt
     1801 gtgtgtgcgc gcgcgcgcgc gcgcgcgcgc gcgctagagg ggtgtggctg gtgggggacc
     1861 cttggggctg ggccctggga cccagtgtgc cccacagccc tgtcagctga gggggtagcg
     1921 cagcccatgc tcttctgtac tgtcatgccc gtctctggaa tgtccactcc cagagcctgc
     1981 cccagccctt cgagccccct ccccaataaa gaattcacat cctccaa
//
