LOCUS       NM_001080414            7519 bp    mRNA    linear   PRI 04-OCT-2024
DEFINITION  Homo sapiens coiled-coil domain containing 88C (CCDC88C),
            transcript variant 1, mRNA.
ACCESSION   NM_001080414 XM_029353
VERSION     NM_001080414.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7519)
  AUTHORS   Chen,Y.J., Wang,W.J., Zou,D.F., Luo,J.X., Jin,P.Y., Jin,L.,
            Liu,X.R., Liao,W.P., Li,B. and Chen,Y.J.
  CONSRTM   China Epilepsy Gene 1.0 Project
  TITLE     CCDC88C variants are associated with focal epilepsy and
            genotype-phenotype correlation
  JOURNAL   Clin Genet 105 (4), 397-405 (2024)
   PUBMED   38173219
  REMARK    GeneRIF: CCDC88C variants are associated with focal epilepsy and
            genotype-phenotype correlation.
REFERENCE   2  (bases 1 to 7519)
  AUTHORS   Caputo,D., Cetica,V., Paoli,S., Rosati,A. and Lazzeri,S.
  TITLE     Confirmation of the Pathogenetic Role of the CCDC88C Gene in
            Early-Onset Pure Spastic Paraplegia
  JOURNAL   Mov Disord 38 (8), 1561-1562 (2023)
   PUBMED   37317935
  REMARK    GeneRIF: Confirmation of the Pathogenetic Role of the CCDC88C Gene
            in Early-Onset Pure Spastic Paraplegia.
REFERENCE   3  (bases 1 to 7519)
  AUTHORS   Boros,F.A., Szpisjak,L., Bozo,R., Kelemen,E., Zadori,D.,
            Salamon,A., Danis,J., Kalmar,T., Maroti,Z., Molnar,M.J.,
            Klivenyi,P., Szell,M. and Adam,E.
  TITLE     Spinocerebellar Ataxia in a Hungarian Female Patient with a Novel
            Variant of Unknown Significance in the CCDC88C Gene
  JOURNAL   Int J Mol Sci 24 (3), 2617 (2023)
   PUBMED   36768938
  REMARK    GeneRIF: Spinocerebellar Ataxia in a Hungarian Female Patient with
            a Novel Variant of Unknown Significance in the CCDC88C Gene.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 7519)
  AUTHORS   Chai,S., Liu,D., Liu,Y. and Sang,M.
  TITLE     A Novel c.3636-4 A&gt;G Mutation in the CCDC88C Plays a Causative
            Role in Familial Spinocerebellar Ataxia
  JOURNAL   Hum Hered 88 (1), 91-97 (2023)
   PUBMED   37899026
  REMARK    GeneRIF: A Novel c.3636-4 A>G Mutation in the CCDC88C Plays a
            Causative Role in Familial Spinocerebellar Ataxia.
REFERENCE   5  (bases 1 to 7519)
  AUTHORS   Marguet,F., Vezain,M., Marcorelles,P., Audebert-Bellanger,S.,
            Cassinari,K., Drouot,N., Chambon,P., Gonzalez,B.J., Horowitz,A.,
            Laquerriere,A. and Saugier-Veber,P.
  TITLE     Neuropathological hallmarks of fetal hydrocephalus linked to
            CCDC88C pathogenic variants
  JOURNAL   Acta Neuropathol Commun 9 (1), 104 (2021)
   PUBMED   34092257
  REMARK    GeneRIF: Neuropathological hallmarks of fetal hydrocephalus linked
            to CCDC88C pathogenic variants.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 7519)
  AUTHORS   Drielsma,A., Jalas,C., Simonis,N., Desir,J., Simanovsky,N.,
            Pirson,I., Elpeleg,O., Abramowicz,M. and Edvardson,S.
  TITLE     Two novel CCDC88C mutations confirm the role of DAPLE in autosomal
            recessive congenital hydrocephalus
  JOURNAL   J Med Genet 49 (11), 708-712 (2012)
   PUBMED   23042809
  REMARK    GeneRIF: Our data validate CCDC88C as causing autosomal recessive,
            primary non-syndromic congenital hydrocephalus, suggesting this
            gene may be an important cause of congenital hydrocephalus.
REFERENCE   7  (bases 1 to 7519)
  AUTHORS   Ekici,A.B., Hilfinger,D., Jatzwauk,M., Thiel,C.T., Wenzel,D.,
            Lorenz,I., Boltshauser,E., Goecke,T.W., Staatz,G.,
            Morris-Rosendahl,D.J., Sticht,H., Hehr,U., Reis,A. and Rauch,A.
  TITLE     Disturbed Wnt Signalling due to a Mutation in CCDC88C Causes an
            Autosomal Recessive Non-Syndromic Hydrocephalus with Medial
            Diverticulum
  JOURNAL   Mol Syndromol 1 (3), 99-112 (2010)
   PUBMED   21031079
REFERENCE   8  (bases 1 to 7519)
  AUTHORS   Enomoto,A., Ping,J. and Takahashi,M.
  TITLE     Girdin, a novel actin-binding protein, and its family of proteins
            possess versatile functions in the Akt and Wnt signaling pathways
  JOURNAL   Ann N Y Acad Sci 1086, 169-184 (2006)
   PUBMED   17185515
  REMARK    Review article
REFERENCE   9  (bases 1 to 7519)
  AUTHORS   Oshita,A., Kishida,S., Kobayashi,H., Michiue,T., Asahara,T.,
            Asashima,M. and Kikuchi,A.
  TITLE     Identification and characterization of a novel Dvl-binding protein
            that suppresses Wnt signalling pathway
  JOURNAL   Genes Cells 8 (12), 1005-1017 (2003)
   PUBMED   14750955
REFERENCE   10 (bases 1 to 7519)
  AUTHORS   Perlman,S.
  TITLE     Hereditary Ataxia Overview
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301317
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DR006516.1, AK302839.1,
            AL133153.3, BX283171.1, AB040942.2, AL135818.3 and AL137353.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_001080414.3.
            
            Summary: This gene encodes a ubiquitously expressed coiled-coil
            domain-containing protein that interacts with the dishevelled
            protein and is a negative regulator of the Wnt signalling pathway.
            The protein encoded by this gene has a PDZ-domain binding motif in
            its C-terminus with which it interacts with the dishevelled
            protein. Dishevelled is a scaffold protein involved in the
            regulation of the Wnt signaling pathway. The Wnt signaling pathway
            plays an important role in embryonic development, tissue
            maintenance, and cancer progression. Mutations in this gene cause
            autosomal recessive, primary non-syndromic congenital
            hydrocephalus; a condition characterized by excessive accumulation
            of cerebrospinal fluid in the ventricles of the brain. [provided by
            RefSeq, Jan 2013].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA1965299, SAMEA1966682
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000389857.11/ ENSP00000374507.6
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-198               DR006516.1         31-228
            199-879             AK302839.1         3-683
            880-939             AL133153.3         34904-34963         c
            940-1021            AL133153.3         34115-34196         c
            1022-1180           AL133153.3         33631-33789         c
            1181-1327           AL133153.3         21536-21682         c
            1328-1341           AL133153.3         20536-20549         c
            1342-1823           BX283171.1         2-483
            1824-2251           AL133153.3         9321-9748           c
            2252-3138           AB040942.2         135-1021
            3139-3139           AL133153.3         2850-2850           c
            3140-4851           AB040942.2         1023-2734
            4852-4852           AL135818.3         63344-63344         c
            4853-6104           AB040942.2         2736-3987
            6105-6105           AL135818.3         56797-56797         c
            6106-6489           AB040942.2         3989-4372
            6490-6490           AL135818.3         56412-56412         c
            6491-6608           AB040942.2         4374-4491
            6609-6609           AL135818.3         56293-56293         c
            6610-6686           AB040942.2         4493-4569
            6687-7519           AL137353.1         1-833
FEATURES             Location/Qualifiers
     source          1..7519
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q32.11-q32.12"
     gene            1..7519
                     /gene="CCDC88C"
                     /gene_synonym="DAPLE; HKRP2; HYC1; KIAA1509; SCA40"
                     /note="coiled-coil domain containing 88C"
                     /db_xref="GeneID:440193"
                     /db_xref="HGNC:HGNC:19967"
                     /db_xref="MIM:611204"
     exon            1..190
                     /gene="CCDC88C"
                     /gene_synonym="DAPLE; HKRP2; HYC1; KIAA1509; SCA40"
                     /inference="alignment:Splign:2.1.0"
     CDS             131..6217
                     /gene="CCDC88C"
                     /gene_synonym="DAPLE; HKRP2; HYC1; KIAA1509; SCA40"
                     /note="Dvl-associating protein with a high frequency of
                     leucine residues; hook-related protein 2; spinocerebellar
                     ataxia 40"
                     /codon_start=1
                     /product="protein Daple"
                     /protein_id="NP_001073883.2"
                     /db_xref="CCDS:CCDS45151.1"
                     /db_xref="GeneID:440193"
                     /db_xref="HGNC:HGNC:19967"
                     /db_xref="MIM:611204"
                     /translation="MDVTVSELLELFLQSPLVTWVKTFGPFGSGSQDNLTMYMDLVDG
                     IFLNQIMLQIDPRPTNQRINKHVNNDVNLRIQNLTILVRNIKTYYQEVLQQLIVMNLP
                     NVLMIGRDPLSGKSMEEIKKVLLLVLGCAVQCERKEEFIERIKQLDIETQAGIVAHIQ
                     EVTHNQENVFDLQWLELPDVAPEELEALSRSMVLHLRRLIDQRDECTELIVDLTQERD
                     YLQAQHPPSPIKSSSADSTPSPTSSLSSEDKQHLAVELADTKARLRRVRQELEDKTEQ
                     LVDTRHEVDQLVLELQKVKQENIQLAADARSARAYRDELDSLREKANRVERLELELTR
                     CKEKLHDVDFYKARMEELREDNIILIETKAMLEEQLTAARARGDKVHELEKENLQLKS
                     KLHDLELDRDTDKKRIEELLEENMVLEIAQKQSMNESAHLGWELEQLSKNADLSDASR
                     KSFVFELNECASSRILKLEKENQSLQSTIQGLRDASLVLEESGLKCGELEKENHQLSK
                     KIEKLQTQLEREKQSNQDLETLSEELIREKEQLQSDMETLKADKARQIKDLEQEKDHL
                     NRAMWSLRERSQVSSEARMKDVEKENKALHQTVTEANGKLSQLEFEKRQLHRDLEQAK
                     EKGERAEKLERELQRLQEENGRLARKVTSLETATEKVEALEHESQGLQLENRTLRKSL
                     DTLQNVSLQLEGLERDNKQLDAENLELRRLVETMRFTSTKLAQMERENQQLEREKEEL
                     RKNVDLLKALGKKSERLELSYQSVSAENLRLQQSLESSSHKTQTLESELGELEAERQA
                     LRRDLEALRLANAQLEGAEKDRKALEQEVAQLEKDKKLLEKEAKRLWQQVELKDAVLD
                     DSTAKLSAVEKESRALDKELARCRDAAGKLKELEKDNRDLTKQVTVHARTLTTLREDL
                     VLEKLKSQQLSSELDKLSQELEKVGLNRELLLQEDDSGSDTKYKILEGRNESALKTTL
                     AMKEEKIVLLEAQMEEKASLNRQLESELQMLKKECETLRQNQGEGQHLQNSFKHPAGK
                     TAASHQGKEAWGPGHKEATMELLRVKDRAIELERNNAALQAEKQLLKEQLQHLETQNV
                     TFSSQILTLQKQSAFLQEHNTTLQTQTAKLQVENSTLSSQSAALTAQYTLLQNHHTAK
                     ETENESLQRQQEQLTAAYEALLQDHEHLGTLHERQSAEYEALIRQHSCLKTLHRNLEL
                     EHKELGERHGDMLKRKAELEEREKVLTTEREALQQEQRTNALAMGENQRLRGELDRVN
                     FLHHQLKGEYEELHAHTKELKTSLNNAQLELNRWQARFDELKEQHQTMDISLTKLDNH
                     CELLSRLKGNLEEENHHLLSQIQLLSQQNQMLLEQNMENKEQYHEEQKQYIDKLNALR
                     RHKEKLEEKIMDQYKFYDPPPKKKNHWIGAKALVKLIKPKKEGSRERLKSTVDSPPWQ
                     LESSDPASPAASQPLRSQAENPDTPALGSNCAEERDAHNGSVGKGPGDLKPKRGSPHR
                     GSLDRTDASTDLAMRSWPSELGSRTCSTSATTTAPSNSTPIARHPGRTKGYNSDDNLC
                     EPSLEFEVPNHRQYVSRPSSLESSRNTSSNSSPLNLKGSSEQLHGRSESFSSEDLIPS
                     RDLATLPREASTPGRNALGRHEYPLPRNGPLPQEGAQKRGTAPPYVGVRPCSASPSSE
                     MVTLEEFLEESNRSSPTHDTPSCRDDLLSDYFRKASDPPAIGGQPGPPAKKEGAKMPT
                     NFVAPTVKMAAPTSEGRPLKPGQYVKPNFRLTEAEAPPSVAPRQAQPPQSLSLGRPRQ
                     APVPPASHAPASRSASLSRAFSLASADLLRASGPEACKQESPQKLGAPEALGGRETGS
                     HTLQSPAPPSSHSLARERTPLVGKAGSSCQGPGPRSRPLDTRRFSLAPPKEERLAPLH
                     QSATAPAIATAGAGAAAAGSGSNSQLLHFSPAAAPAARTKPKAPPRSGEVATITPVRA
                     GLSLSEGDGVPGQGCSEGLPAKSPGRSPDLAPHLGRALEDCSRGSVSKSSPASPEPGG
                     DPQTVWYEYGCV"
     exon            191..291
                     /gene="CCDC88C"
                     /gene_synonym="DAPLE; HKRP2; HYC1; KIAA1509; SCA40"
                     /inference="alignment:Splign:2.1.0"
     exon            292..400
                     /gene="CCDC88C"
                     /gene_synonym="DAPLE; HKRP2; HYC1; KIAA1509; SCA40"
                     /inference="alignment:Splign:2.1.0"
     exon            401..470
                     /gene="CCDC88C"
                     /gene_synonym="DAPLE; HKRP2; HYC1; KIAA1509; SCA40"
                     /inference="alignment:Splign:2.1.0"
     exon            471..529
                     /gene="CCDC88C"
                     /gene_synonym="DAPLE; HKRP2; HYC1; KIAA1509; SCA40"
                     /inference="alignment:Splign:2.1.0"
     exon            530..613
                     /gene="CCDC88C"
                     /gene_synonym="DAPLE; HKRP2; HYC1; KIAA1509; SCA40"
                     /inference="alignment:Splign:2.1.0"
     exon            614..754
                     /gene="CCDC88C"
                     /gene_synonym="DAPLE; HKRP2; HYC1; KIAA1509; SCA40"
                     /inference="alignment:Splign:2.1.0"
     exon            755..939
                     /gene="CCDC88C"
                     /gene_synonym="DAPLE; HKRP2; HYC1; KIAA1509; SCA40"
                     /inference="alignment:Splign:2.1.0"
     exon            940..1021
                     /gene="CCDC88C"
                     /gene_synonym="DAPLE; HKRP2; HYC1; KIAA1509; SCA40"
                     /inference="alignment:Splign:2.1.0"
     exon            1022..1180
                     /gene="CCDC88C"
                     /gene_synonym="DAPLE; HKRP2; HYC1; KIAA1509; SCA40"
                     /inference="alignment:Splign:2.1.0"
     exon            1181..1327
                     /gene="CCDC88C"
                     /gene_synonym="DAPLE; HKRP2; HYC1; KIAA1509; SCA40"
                     /inference="alignment:Splign:2.1.0"
     exon            1328..1472
                     /gene="CCDC88C"
                     /gene_synonym="DAPLE; HKRP2; HYC1; KIAA1509; SCA40"
                     /inference="alignment:Splign:2.1.0"
     exon            1473..1657
                     /gene="CCDC88C"
                     /gene_synonym="DAPLE; HKRP2; HYC1; KIAA1509; SCA40"
                     /inference="alignment:Splign:2.1.0"
     exon            1658..1795
                     /gene="CCDC88C"
                     /gene_synonym="DAPLE; HKRP2; HYC1; KIAA1509; SCA40"
                     /inference="alignment:Splign:2.1.0"
     exon            1796..2866
                     /gene="CCDC88C"
                     /gene_synonym="DAPLE; HKRP2; HYC1; KIAA1509; SCA40"
                     /inference="alignment:Splign:2.1.0"
     exon            2867..2994
                     /gene="CCDC88C"
                     /gene_synonym="DAPLE; HKRP2; HYC1; KIAA1509; SCA40"
                     /inference="alignment:Splign:2.1.0"
     exon            2995..3136
                     /gene="CCDC88C"
                     /gene_synonym="DAPLE; HKRP2; HYC1; KIAA1509; SCA40"
                     /inference="alignment:Splign:2.1.0"
     exon            3137..3325
                     /gene="CCDC88C"
                     /gene_synonym="DAPLE; HKRP2; HYC1; KIAA1509; SCA40"
                     /inference="alignment:Splign:2.1.0"
     exon            3326..3487
                     /gene="CCDC88C"
                     /gene_synonym="DAPLE; HKRP2; HYC1; KIAA1509; SCA40"
                     /inference="alignment:Splign:2.1.0"
     exon            3488..3765
                     /gene="CCDC88C"
                     /gene_synonym="DAPLE; HKRP2; HYC1; KIAA1509; SCA40"
                     /inference="alignment:Splign:2.1.0"
     exon            3766..3909
                     /gene="CCDC88C"
                     /gene_synonym="DAPLE; HKRP2; HYC1; KIAA1509; SCA40"
                     /inference="alignment:Splign:2.1.0"
     exon            3910..4096
                     /gene="CCDC88C"
                     /gene_synonym="DAPLE; HKRP2; HYC1; KIAA1509; SCA40"
                     /inference="alignment:Splign:2.1.0"
     exon            4097..4242
                     /gene="CCDC88C"
                     /gene_synonym="DAPLE; HKRP2; HYC1; KIAA1509; SCA40"
                     /inference="alignment:Splign:2.1.0"
     exon            4243..4332
                     /gene="CCDC88C"
                     /gene_synonym="DAPLE; HKRP2; HYC1; KIAA1509; SCA40"
                     /inference="alignment:Splign:2.1.0"
     exon            4333..4571
                     /gene="CCDC88C"
                     /gene_synonym="DAPLE; HKRP2; HYC1; KIAA1509; SCA40"
                     /inference="alignment:Splign:2.1.0"
     exon            4572..4760
                     /gene="CCDC88C"
                     /gene_synonym="DAPLE; HKRP2; HYC1; KIAA1509; SCA40"
                     /inference="alignment:Splign:2.1.0"
     exon            4761..4829
                     /gene="CCDC88C"
                     /gene_synonym="DAPLE; HKRP2; HYC1; KIAA1509; SCA40"
                     /inference="alignment:Splign:2.1.0"
     exon            4830..4898
                     /gene="CCDC88C"
                     /gene_synonym="DAPLE; HKRP2; HYC1; KIAA1509; SCA40"
                     /inference="alignment:Splign:2.1.0"
     exon            4899..5188
                     /gene="CCDC88C"
                     /gene_synonym="DAPLE; HKRP2; HYC1; KIAA1509; SCA40"
                     /inference="alignment:Splign:2.1.0"
     exon            5189..7519
                     /gene="CCDC88C"
                     /gene_synonym="DAPLE; HKRP2; HYC1; KIAA1509; SCA40"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7498..7503
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CCDC88C"
                     /gene_synonym="DAPLE; HKRP2; HYC1; KIAA1509; SCA40"
                     /note="hexamer: AATAAA"
     polyA_site      7519
                     /gene="CCDC88C"
                     /gene_synonym="DAPLE; HKRP2; HYC1; KIAA1509; SCA40"
                     /note="major polyA site"
ORIGIN      
        1 gcctttgtct cccgggcgcg agccgccgca gccccgcgcc cgctgctcgc tgcggagccg
       61 ttttgtgccg cggcgcgggg gaacggggac gcggggcggg gggcgcggag ccggcgggcg
      121 cagcctcagc atggacgtga cagtctcgga gctcctggag ctcttcctgc agagcccgct
      181 ggtgacctgg gtgaaaactt ttggcccgtt tggaagcggc agccaggaca acctgactat
      241 gtacatggat ttagtggacg gcatcttttt gaaccaaatt atgctgcaaa tagatcccag
      301 gcccacaaat caacgcatca ataagcacgt caacaatgat gtgaaccttc gcattcagaa
      361 tttgaccatc ttggtgagaa acattaagac ctactaccag gaagttctcc agcagctgat
      421 tgtaatgaat ttgcccaatg ttttgatgat tggcagagac ccactgtctg ggaagagcat
      481 ggaggaaatc aagaaggtgc tgctgctggt gctgggctgt gctgtccagt gtgagaggaa
      541 agaggagttc attgaaagaa tcaaacagct ggacattgag acccaggctg gcatcgtggc
      601 ccatatccag gaggtgactc acaaccaaga gaacgtgttt gacctgcagt ggctggagct
      661 gcccgacgtg gctccggagg agctggaggc cctgtcgagg agcatggtgc tccacctgcg
      721 gaggctcatc gaccagcggg acgagtgcac cgagctgatc gtggacctca ctcaggaacg
      781 ggactacctg caggcacagc atccacccag ccccatcaag tcctccagcg ccgactccac
      841 tcccagcccc accagcagcc tctctagcga agacaagcag cacctggccg tagagctggc
      901 cgacaccaag gccaggctgc ggcgcgtcag gcaggagctg gaggataaga cagagcagct
      961 tgtggacacc agacatgagg tggaccagct ggtgctggaa ctgcagaaag ttaagcagga
     1021 gaacatccag ctagcggcag acgcccggtc tgctcgtgcc tatcgagacg agctggattc
     1081 cctgcgggag aaggcgaacc gcgtggagag gctggagctg gagctgaccc gctgcaagga
     1141 gaagctgcac gacgtggact tctacaaggc ccgcatggag gagctgagag aagataatat
     1201 cattttaatt gaaaccaagg ccatgctgga ggaacagctg actgctgctc gggcccgggg
     1261 cgataaagtc catgagctgg aaaaggagaa cctgcagctg aaatccaagc ttcacgacct
     1321 ggaattggac cgggacacag ataagaaacg aattgaggag ctgctggaag aaaacatggt
     1381 ccttgagatt gcacagaagc agagcatgaa cgaatctgcc caccttggct gggagctgga
     1441 gcagctgtcc aagaacgcag acttgtcaga cgcctccagg aagtcgtttg tgtttgagct
     1501 gaacgaatgt gcgtccagcc gcatcctgaa gctggagaag gagaatcaga gcctccagag
     1561 caccatccag gggctgcggg acgcgtccct ggtgttggag gagagcggcc tcaagtgcgg
     1621 ggagctggag aaggagaacc accagctcag caagaagatt gaaaagttac aaacccagct
     1681 ggagagagaa aagcagagca accaagatct ggagaccctc agtgaggagc tgatcagaga
     1741 gaaggagcag ctgcagagtg acatggagac cctgaaggct gacaaagcca ggcagatcaa
     1801 ggaccttgag caggaaaagg accacctcaa ccgagccatg tggtcgctgc gggagaggtc
     1861 gcaggtcagc agtgaggccc gcatgaaaga cgtggagaag gagaacaaag ccctccacca
     1921 gacggtgacg gaggccaatg gcaagctcag ccagttggag tttgagaagc ggcagctgca
     1981 cagggacttg gagcaggcca aggagaaggg ggagcgggca gagaagctgg agagggagct
     2041 acagcgactc caggaggaga acgggaggct ggccaggaag gtgacctccc tggagacagc
     2101 caccgagaaa gtcgaggccc tggagcatga gagccagggc ctgcagctgg agaaccggac
     2161 tctgaggaag tctctggaca ccttgcagaa cgtgtccctg cagcttgagg gcctggagcg
     2221 tgacaacaag cagctggacg cagagaacct ggagctgcgc aggctggtgg agaccatgcg
     2281 cttcaccagc accaagctgg cacagatgga gagggagaac cagcagctgg agcgtgagaa
     2341 ggaggagctg aggaagaacg tggatctgct caaggcgctg ggcaagaagt cagagcgcct
     2401 ggagctcagc taccagagcg tgagcgctga gaacctccgg ctgcagcaga gcctggagag
     2461 cagcagccac aagacgcaga ccttggagag tgagctgggc gagctggagg ctgagcgcca
     2521 ggcgctgcgg cgggacctgg aggccctccg gctggccaat gcacagttgg agggggccga
     2581 gaaggacagg aaggccctgg agcaggaggt ggcccagctc gagaaggata agaagctgct
     2641 ggagaaggag gccaagcggc tgtggcagca ggtggagctc aaggatgcag tcttggacga
     2701 tagcactgcc aaactgtccg ccgttgagaa ggagagccgc gcgctggaca aggagctggc
     2761 ccgctgcagg gacgcagccg gcaagctgaa ggagctggag aaggacaacc gggacctcac
     2821 caagcaagtc accgtgcatg caaggacact gacaactctg agggaggacc tggtgctcga
     2881 gaagctgaag agccagcagc tcagcagtga gctggacaag ctgagccagg aactggagaa
     2941 ggtcggcctc aacagggagc tgctgttgca ggaggacgac agcggcagtg acacaaaata
     3001 caagattttg gagggcagaa atgaatcagc attaaaaaca acactagcca tgaaagaaga
     3061 aaagattgtg ctcttagaag cacagatgga agagaaagcg agcctaaatc gccagttaga
     3121 gagtgagctg cagatgctaa agaaggagtg tgagaccctc aggcagaacc agggagaggg
     3181 gcagcacttg cagaactctt tcaagcaccc tgcggggaag acagccgcca gtcaccaggg
     3241 gaaggaggcc tgggggcccg gccataagga agccaccatg gagcttctcc gagtgaagga
     3301 ccgggccatc gagctggagc ggaataatgc agctctgcag gctgagaagc agctgctaaa
     3361 ggaacagctg cagcacctgg agacccagaa cgtgaccttc agcagccaga tcttgacact
     3421 gcagaaacag agcgccttcc tgcaggagca caacaccaca ctgcagaccc agaccgccaa
     3481 gctgcaggtg gagaactcca cgctgagttc ccagagcgca gcgctcaccg cgcagtacac
     3541 gctgctgcag aaccaccaca cggccaagga gacggagaac gaaagcctgc agaggcagca
     3601 ggagcaactt acagcggcct acgaggccct gctgcaggac cacgagcacc tgggcacgct
     3661 gcacgagcgg caatcggccg agtacgaggc cctcatccgc cagcacagct gcctaaagac
     3721 actgcatcgg aatctggagc tggagcacaa ggagctcggg gagaggcacg gtgacatgct
     3781 gaagcgcaag gcggagctgg aggagcggga gaaggtcttg accactgagc gagaggcgct
     3841 gcagcaggag cagaggacaa acgccctcgc catgggcgag aaccagaggc tgcggggcga
     3901 gctggacagg gtcaatttcc tgcaccacca gctgaagggg gagtacgagg agctgcacgc
     3961 ccacaccaag gagctgaaaa cctcactgaa caacgcgcag ctggagctca accgctggca
     4021 ggcccgcttc gacgagctga aggagcagca ccagaccatg gacatctcgc tgaccaagct
     4081 ggacaaccac tgtgagctgc tctcccgtct caaggggaac ttggaggaag aaaatcatca
     4141 cctcctgagc cagatccagc tgttgagcca gcagaaccag atgcttctgg agcagaacat
     4201 ggagaacaag gagcagtacc atgaggagca gaagcagtac atagacaaat taaatgcctt
     4261 acgaagacat aaggaaaagc tggaagaaaa aatcatggat caatacaagt tctatgatcc
     4321 tcctccaaag aagaagaacc actggattgg agccaaagcc ttagtcaaac tcatcaaacc
     4381 aaagaaagag ggttcgaggg aacgcttaaa atccaccgtg gacagccctc cctggcagct
     4441 ggagtcctca gaccccgcct cgccggcggc ctctcagccg ctcagatcac aggccgagaa
     4501 ccccgacacc cccgcactgg gctccaactg tgcagaagag cgcgacgccc acaacgggtc
     4561 tgtggggaaa ggccctgggg atctaaaacc aaagcgaggc tccccacaca gaggcagcct
     4621 tgaccgcaca gatgcctcca ccgatctggc catgaggtcc tggccctcgg agctgggctc
     4681 ccggacttgc tcaacttcag ccaccactac agccccttcc aactccaccc ccatcgcccg
     4741 gcacccaggc cgcaccaaag gctataactc agatgacaac ctctgtgagc catccctgga
     4801 gtttgaggtc cccaaccaca ggcagtacgt gtcgcggcca agtagcttag agagcagtag
     4861 aaacacatcc agcaacagct cacctcttaa cctaaaaggc tcctccgagc agctccatgg
     4921 ccggtctgag agcttcagca gcgaagacct gatccccagc agggacctgg ccactttgcc
     4981 ccgggaagcc agcacaccgg gacgcaacgc cctcggccgc cacgagtacc ccttgcctcg
     5041 gaacgggcct ctcccacagg agggtgccca gaagaggggc acagcccctc cctacgtcgg
     5101 agtgcggccc tgctcggcct cccccagcag tgagatggtc accttggagg agttcctgga
     5161 ggagagcaac cgcagctccc ccacccatga cactcccagt tgccgggatg acctgctgag
     5221 tgactacttc cgaaaggcca gcgatccccc agccatcgga ggccaaccag gaccacctgc
     5281 caagaaagaa ggggccaaga tgcccaccaa ctttgtggcc cccaccgtca aaatggccgc
     5341 ccccacctcg gaggggaggc cgctgaagcc cgggcagtac gtaaagccaa acttcagact
     5401 gactgaggcc gaggccccac ccagcgtggc cccgagacag gcccagcctc cccagagcct
     5461 gtctctgggc agaccccggc aggctccggt gcccccagct tcccatgcac ctgccagccg
     5521 cagtgcctcc ttgagccggg ccttcagcct ggcctcagct gaccttctcc gggccagcgg
     5581 gccagaggcc tgcaaacagg agtcccctca gaagctgggg gctcctgagg ccttaggggg
     5641 cagagagaca ggcagccaca ccctgcaaag ccccgcaccc cccagctccc atagcctggc
     5701 ccgggagcgg accccacttg tgggaaaggc tggcagctcc tgtcagggcc caggtccccg
     5761 cagccggccg ctggacacga ggcgcttctc cctggctccc ccaaaggagg agaggctggc
     5821 ccccctgcat cagtctgcca cagcccccgc cattgccact gcaggtgctg gtgctgctgc
     5881 tgctggcagt ggcagcaact cccagctcct gcacttctca cctgctgcag ccccggctgc
     5941 caggaccaag cccaaggcgc ccccacgctc aggggaggtg gccaccatca cccctgtccg
     6001 ggcagggctc agcctctcag agggagacgg ggtcccgggg cagggctgca gtgaggggct
     6061 tccggccaag agcccaggtc ggtctcccga tttggctccc cacctcggcc gggccctgga
     6121 ggactgcagt cgagggagcg tctcaaagag cagtccggcc tccccggagc ccggcgggga
     6181 tccgcagacc gtgtggtatg agtacggctg tgtgtgactg tctcgtggtt gagctcgcaa
     6241 acctgaaaac tactgacgcg ccttccgact ctcacggcct tttctcttgc ttgcctgcgg
     6301 tgccaggaga gggtttggaa tgaggaaagg ggttcccacg catttctgct gtttgttctg
     6361 tgaatggaaa cactgtgcca agccccaaga ggattacgct tccaggtgtg taacgtgttt
     6421 tctgtgtctg ccgcttccag cagctgatat ctttggaaca aataatccac gtcagcatgg
     6481 ggaccaatta ggatgcaatg acaaactgac ttcccccaaa gcagacacta ctccagtatg
     6541 tcccagtaga acactcattt gcaatgtgtt gagctccgtt aagcacacac acactcacac
     6601 aacaggctta cgaggctcag gcctggcggg tcagaaagcc cactccctct cccaaggcca
     6661 ctggatccca ggagaagccc agactggcga tactacaaag gtctccaggg cctggcagac
     6721 cccagagtca ggcctgctgt taaaaagtga gagtgctgct gttccattcc tggggtccca
     6781 agcacttccc tttaccccag gacccagggc agcctgcagg gcagctggcg gtggccttgg
     6841 ccatttgccc ccagcctcca gctggctcct gagctctgca ccagggggtt tggggaccac
     6901 acaggcacct gccttcctag atttccctgg ctcacttttc tgcaaacact ggatctgcca
     6961 ggcctgggga ttggggggca ggaaagaggc ccccatccag ccccctccag gccagtgtgc
     7021 acagtgcacc gaggggtcat ccgcacagag cgaggtgcaa gctcgatgtg taacctggct
     7081 gcggcacccg acatccccgg tctcggggtg ttgatttatt tctgaataac tttttgggta
     7141 tagaaaccaa ttttttttaa tatatgacat gtatatgtac acactcatgt gaaatatgta
     7201 tactttgggg ggatctattt atgttccagt gggagtcact ctcttctgtc gggaatctta
     7261 tctgctgctt tgtgtctttg gtcagattcc tgacaattta gtttcctgtt gtaaaggtgc
     7321 ttttcctggg gtgaactaaa cctattgatt tttttttttt aagatttttt tttccttttg
     7381 atttaatata ctgagaaaga aatgggagac ttttgaatgt taacaagatc cattttagga
     7441 gtgtttgggg ttgtgtatta aatagccatt cattctggaa ctcaaggaca ggactgtaat
     7501 aaaatggaat ggaaccgaa
//
