LOCUS       NM_032251               4934 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens coiled-coil domain containing 88B (CCDC88B), mRNA.
ACCESSION   NM_032251 XM_290514
VERSION     NM_032251.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4934)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 4934)
  AUTHORS   Fodil,N., Moradin,N., Leung,V., Olivier,J.F., Radovanovic,I.,
            Jeyakumar,T., Flores Molina,M., McFarquhar,A., Cayrol,R., Bozec,D.,
            Shoukry,N.H., Kubo,M., Dimitrieva,J., Louis,E., Theatre,E.,
            Dahan,S., Momozawa,Y., Georges,M., Yeretssian,G. and Gros,P.
  TITLE     CCDC88B is required for pathogenesis of inflammatory bowel disease
  JOURNAL   Nat Commun 8 (1), 932 (2017)
   PUBMED   29030607
  REMARK    GeneRIF: A critical function of CCDC88B in colonic inflammation and
            inflammatory bowel disease
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4934)
  AUTHORS   Ham,H., Huynh,W., Schoon,R.A., Vale,R.D. and Billadeau,D.D.
  TITLE     HkRP3 is a microtubule-binding protein regulating lytic granule
            clustering and NK cell killing
  JOURNAL   J Immunol 194 (8), 3984-3996 (2015)
   PUBMED   25762780
  REMARK    GeneRIF: results demonstrate an important role for HkRP3 in
            regulating the clustering of lytic granules and MTOC repositioning
            during the development of NK cell-mediated killing.
REFERENCE   4  (bases 1 to 4934)
  AUTHORS   Liu,H., Irwanto,A., Fu,X., Yu,G., Yu,Y., Sun,Y., Wang,C., Wang,Z.,
            Okada,Y., Low,H., Li,Y., Liany,H., Chen,M., Bao,F., Li,J., You,J.,
            Zhang,Q., Liu,J., Chu,T., Andiappan,A.K., Wang,N., Niu,G., Liu,D.,
            Yu,X., Zhang,L., Tian,H., Zhou,G., Rotzschke,O., Chen,S., Zhang,X.,
            Liu,J. and Zhang,F.
  TITLE     Discovery of six new susceptibility loci and analysis of
            pleiotropic effects in leprosy
  JOURNAL   Nat Genet 47 (3), 267-271 (2015)
   PUBMED   25642632
REFERENCE   5  (bases 1 to 4934)
  AUTHORS   Jostins,L., Ripke,S., Weersma,R.K., Duerr,R.H., McGovern,D.P.,
            Hui,K.Y., Lee,J.C., Schumm,L.P., Sharma,Y., Anderson,C.A.,
            Essers,J., Mitrovic,M., Ning,K., Cleynen,I., Theatre,E.,
            Spain,S.L., Raychaudhuri,S., Goyette,P., Wei,Z., Abraham,C.,
            Achkar,J.P., Ahmad,T., Amininejad,L., Ananthakrishnan,A.N.,
            Andersen,V., Andrews,J.M., Baidoo,L., Balschun,T., Bampton,P.A.,
            Bitton,A., Boucher,G., Brand,S., Buning,C., Cohain,A., Cichon,S.,
            D'Amato,M., De Jong,D., Devaney,K.L., Dubinsky,M., Edwards,C.,
            Ellinghaus,D., Ferguson,L.R., Franchimont,D., Fransen,K.,
            Gearry,R., Georges,M., Gieger,C., Glas,J., Haritunians,T., Hart,A.,
            Hawkey,C., Hedl,M., Hu,X., Karlsen,T.H., Kupcinskas,L.,
            Kugathasan,S., Latiano,A., Laukens,D., Lawrance,I.C., Lees,C.W.,
            Louis,E., Mahy,G., Mansfield,J., Morgan,A.R., Mowat,C., Newman,W.,
            Palmieri,O., Ponsioen,C.Y., Potocnik,U., Prescott,N.J.,
            Regueiro,M., Rotter,J.I., Russell,R.K., Sanderson,J.D., Sans,M.,
            Satsangi,J., Schreiber,S., Simms,L.A., Sventoraityte,J.,
            Targan,S.R., Taylor,K.D., Tremelling,M., Verspaget,H.W., De Vos,M.,
            Wijmenga,C., Wilson,D.C., Winkelmann,J., Xavier,R.J., Zeissig,S.,
            Zhang,B., Zhang,C.K., Zhao,H., Silverberg,M.S., Annese,V.,
            Hakonarson,H., Brant,S.R., Radford-Smith,G., Mathew,C.G.,
            Rioux,J.D., Schadt,E.E., Daly,M.J., Franke,A., Parkes,M.,
            Vermeire,S., Barrett,J.C. and Cho,J.H.
  CONSRTM   International IBD Genetics Consortium (IIBDGC)
  TITLE     Host-microbe interactions have shaped the genetic architecture of
            inflammatory bowel disease
  JOURNAL   Nature 491 (7422), 119-124 (2012)
   PUBMED   23128233
REFERENCE   6  (bases 1 to 4934)
  AUTHORS   Fischer,A., Schmid,B., Ellinghaus,D., Nothnagel,M., Gaede,K.I.,
            Schurmann,M., Lipinski,S., Rosenstiel,P., Zissel,G., Hohne,K.,
            Petrek,M., Kolek,V., Pabst,S., Grohe,C., Grunewald,J.,
            Ronninger,M., Eklund,A., Padyukov,L., Gieger,C., Wichmann,H.E.,
            Nebel,A., Franke,A., Muller-Quernheim,J., Hofmann,S. and
            Schreiber,S.
  TITLE     A novel sarcoidosis risk locus for Europeans on chromosome 11q13.1
  JOURNAL   Am J Respir Crit Care Med 186 (9), 877-885 (2012)
   PUBMED   22837380
  REMARK    GeneRIF: A genotype dataset found a sarcoidosis risk locus on
            chromosome 11q13.1, a risk region for Crohn disease. An
            allele-dependent expression of CCDC88B was found in bronchoalveolar
            lavage samples of German, Swedish and Czech patients with
            sarcoidosis.
REFERENCE   7  (bases 1 to 4934)
  AUTHORS   Matsushita,E., Asai,N., Enomoto,A., Kawamoto,Y., Kato,T., Mii,S.,
            Maeda,K., Shibata,R., Hattori,S., Hagikura,M., Takahashi,K.,
            Sokabe,M., Murakumo,Y., Murohara,T. and Takahashi,M.
  TITLE     Protective role of Gipie, a Girdin family protein, in endoplasmic
            reticulum stress responses in endothelial cells
  JOURNAL   Mol Biol Cell 22 (6), 736-747 (2011)
   PUBMED   21289099
  REMARK    GeneRIF: Data show that a novel Girdin family protein, Gipie, is
            expressed in endothelial cells, where it interacts with GRP78, a
            master regulator of the UPR, and that Gipie/GRP78 interaction
            controls the IRE1-JNK signaling pathway.
REFERENCE   8  (bases 1 to 4934)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   9  (bases 1 to 4934)
  AUTHORS   Simpson,F., Martin,S., Evans,T.M., Kerr,M., James,D.E.,
            Parton,R.G., Teasdale,R.D. and Wicking,C.
  TITLE     A novel hook-related protein family and the characterization of
            hook-related protein 1
  JOURNAL   Traffic 6 (6), 442-458 (2005)
   PUBMED   15882442
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AP003774.4, BC151222.1,
            BC141866.1, BC140822.1 and BE222756.1.
            
            On Nov 22, 2018 this sequence version replaced NM_032251.5.
            
            Summary: This gene encodes a member of the hook-related protein
            family. Members of this family are characterized by an N-terminal
            potential microtubule binding domain, a central coiled-coiled and a
            C-terminal Hook-related domain. The encoded protein may be involved
            in linking organelles to microtubules. [provided by RefSeq, Oct
            2009].
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC140824.1, SRR14038192.1463423.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000356786.10/ ENSP00000349238.5
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-14                AP003774.4         21205-21218
            15-35               BC151222.1         1-21
            36-2719             BC141866.1         1-2684
            2720-2807           AP003774.4         30372-30459
            2808-2891           AP003774.4         30552-30635
            2892-3785           BC141866.1         2857-3750
            3786-4908           BC140822.1         3761-4883
            4909-4934           BE222756.1         13-38               c
FEATURES             Location/Qualifiers
     source          1..4934
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q13.1"
     gene            1..4934
                     /gene="CCDC88B"
                     /gene_synonym="BRLZ; CCDC88; gipie; HKRP3"
                     /note="coiled-coil domain containing 88B"
                     /db_xref="GeneID:283234"
                     /db_xref="HGNC:HGNC:26757"
                     /db_xref="MIM:611205"
     exon            1..123
                     /gene="CCDC88B"
                     /gene_synonym="BRLZ; CCDC88; gipie; HKRP3"
                     /inference="alignment:Splign:2.1.0"
     CDS             64..4494
                     /gene="CCDC88B"
                     /gene_synonym="BRLZ; CCDC88; gipie; HKRP3"
                     /note="78 kDa glucose-regulated protein
                     [GRP78]-interacting protein induced by ER stress; brain
                     leucine zipper protein; hook-related protein 3; brain
                     leucine zipper domain-containing protein;
                     GRP78-interacting protein induced by ER stress;
                     coiled-coil domain containing 88"
                     /codon_start=1
                     /product="coiled-coil domain-containing protein 88B"
                     /protein_id="NP_115627.6"
                     /db_xref="CCDS:CCDS8072.2"
                     /db_xref="GeneID:283234"
                     /db_xref="HGNC:HGNC:26757"
                     /db_xref="MIM:611205"
                     /translation="MEGGKGPRLRDFLSGSLATWALGLAGLVGEAEDSEGEEEEEEEE
                     PPLWLEKRFLRLSDGALLLRVLGIIAPSSRGGPRMLRGLDGPAAWRVWNLNHLWGRLR
                     DFYQEELQLLILSPPPDLQTLGFDPLSEEAVEQLEGVLRLLLGASVQCEHRELFIRHI
                     QGLSLEVQSELAAAIQEVTQPGAGVVLALSGPDPGELAPAELEMLSRSLMGTLSKLAR
                     ERDLGAQRLAELLLEREPLCLRPEAPSRAPAEGPSHHLALQLANAKAQLRRLRQELEE
                     KAELLLDSQAEVQGLEAEIRRLRQEAQALSGQAKRAELYREEAEALRERAGRLPRLQE
                     ELRRCRERLQAAEAYKSQLEEERVLSGVLEASKALLEEQLEAARERCARLHETQRENL
                     LLRTRLGEAHAELDSLRHQVDQLAEENVELELELQRSLEPPPGSPGEAPLAGAAPSLQ
                     DEVREAEAGRLRTLERENRELRGLLQVLQGQPGGQHPLLEAPREDPVLPVLEEAPQTP
                     VAFDHSPQGLVQKARDGGPQALDLAPPALDSVLEASAECPQAPDSDPQEAESPLQAAA
                     MDPQASDWSPQESGSPVETQESPEKAGRRSSLQSPASVAPPQGPGTKIQAPQLLGGET
                     EGREAPQGELVPEAWGLRQEGPEHKPGPSEPSSVQLEEQEGPNQGLDLATGQAEAREH
                     DQRLEGTVRDPAWQKPQQKSEGALEVQVWEGPIPGESLASGVAEQEALREEVAQLRRK
                     AEALGDELEAQARKLEAQNTEAARLSKELAQARRAEAEAHREAEAQAWEQARLREAVE
                     AAGQELESASQEREALVEALAAAGRERRQWEREGSRLRAQSEAAEERMQVLESEGRQH
                     LEEAERERREKEALQAELEKAVVRGKELGDRLEHLQRELEQAALERQEFLREKESQHQ
                     RYQGLEQRLEAELQAAATSKEEALMELKTRALQLEEELFQLRQGPAGLGPKKRAEPQL
                     VETQNVRLIEVERSNAMLVAEKAALQGQLQHLEGQLGSLQGRAQELLLQSQRAQEHSS
                     RLQAEKSVLEIQGQELHRKLEVLEEEVRAARQSQEETRGQQQALLRDHKALAQLQRRQ
                     EAELEGLLVRHRDLKANMRALELAHRELQGRHEQLQAQRASVEAQEVALLAERERLMQ
                     DGHRQRGLEEELRRLQSEHDRAQMLLAELSRERGELQGERGELRGRLARLELERAQLE
                     MQSQQLRESNQQLDLSACRLTTQCELLTQLRSAQEEENRQLLAEVQALSRENRELLER
                     SLESRDHLHREQREYLDQLNALRREKQKLVEKIMDQYRVLEPVPLPRTKKGSWLADKV
                     KRLMRPRREGGPPGGLRLGADGAGSTESLGGPPETELPEGREADGTGSPSPAPMRRAQ
                     SSLCLRDETLAGGQRRKLSSRFPVGRSSESFSPGDTPRQRFRQRHPGPLGAPVSHSKG
                     PGVGWENSAETLQEHETDANREGPEVQEPEKRPLTPSLSQ"
     exon            124..269
                     /gene="CCDC88B"
                     /gene_synonym="BRLZ; CCDC88; gipie; HKRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            270..381
                     /gene="CCDC88B"
                     /gene_synonym="BRLZ; CCDC88; gipie; HKRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            382..451
                     /gene="CCDC88B"
                     /gene_synonym="BRLZ; CCDC88; gipie; HKRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            452..510
                     /gene="CCDC88B"
                     /gene_synonym="BRLZ; CCDC88; gipie; HKRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            511..594
                     /gene="CCDC88B"
                     /gene_synonym="BRLZ; CCDC88; gipie; HKRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            595..738
                     /gene="CCDC88B"
                     /gene_synonym="BRLZ; CCDC88; gipie; HKRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            739..884
                     /gene="CCDC88B"
                     /gene_synonym="BRLZ; CCDC88; gipie; HKRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            885..966
                     /gene="CCDC88B"
                     /gene_synonym="BRLZ; CCDC88; gipie; HKRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            967..1125
                     /gene="CCDC88B"
                     /gene_synonym="BRLZ; CCDC88; gipie; HKRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1126..1272
                     /gene="CCDC88B"
                     /gene_synonym="BRLZ; CCDC88; gipie; HKRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1273..1381
                     /gene="CCDC88B"
                     /gene_synonym="BRLZ; CCDC88; gipie; HKRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1382..1518
                     /gene="CCDC88B"
                     /gene_synonym="BRLZ; CCDC88; gipie; HKRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1519..2679
                     /gene="CCDC88B"
                     /gene_synonym="BRLZ; CCDC88; gipie; HKRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            2680..2807
                     /gene="CCDC88B"
                     /gene_synonym="BRLZ; CCDC88; gipie; HKRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            2808..2925
                     /gene="CCDC88B"
                     /gene_synonym="BRLZ; CCDC88; gipie; HKRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            2926..3021
                     /gene="CCDC88B"
                     /gene_synonym="BRLZ; CCDC88; gipie; HKRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            3022..3162
                     /gene="CCDC88B"
                     /gene_synonym="BRLZ; CCDC88; gipie; HKRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            3163..3419
                     /gene="CCDC88B"
                     /gene_synonym="BRLZ; CCDC88; gipie; HKRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            3420..3563
                     /gene="CCDC88B"
                     /gene_synonym="BRLZ; CCDC88; gipie; HKRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            3564..3750
                     /gene="CCDC88B"
                     /gene_synonym="BRLZ; CCDC88; gipie; HKRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            3751..3896
                     /gene="CCDC88B"
                     /gene_synonym="BRLZ; CCDC88; gipie; HKRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            3897..3995
                     /gene="CCDC88B"
                     /gene_synonym="BRLZ; CCDC88; gipie; HKRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            3996..4162
                     /gene="CCDC88B"
                     /gene_synonym="BRLZ; CCDC88; gipie; HKRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            4163..4369
                     /gene="CCDC88B"
                     /gene_synonym="BRLZ; CCDC88; gipie; HKRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            4370..4438
                     /gene="CCDC88B"
                     /gene_synonym="BRLZ; CCDC88; gipie; HKRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            4439..4934
                     /gene="CCDC88B"
                     /gene_synonym="BRLZ; CCDC88; gipie; HKRP3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4909..4914
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CCDC88B"
                     /gene_synonym="BRLZ; CCDC88; gipie; HKRP3"
                     /note="hexamer: AATAAA"
     polyA_site      4934
                     /gene="CCDC88B"
                     /gene_synonym="BRLZ; CCDC88; gipie; HKRP3"
                     /note="major polyA site"
ORIGIN      
        1 gacttcctct tcctctcagg gcaggtgcag ctgccacagt gagacgggca ccccgacccg
       61 ggcatggagg ggggcaaggg gcccaggctc agagacttcc tgagtgggag tctggctacc
      121 tgggcgctgg gactggccgg gctggtcggg gaggcggagg actcggaggg ggaagaagag
      181 gaagaggagg aagagccgcc cctttggttg gagaagagat tcctgcgcct cagcgatggg
      241 gccctgctcc tccgggtgct gggcatcatt gcccccagct cccgaggggg acctcggatg
      301 ctcagaggcc ttgacggacc tgctgcctgg cgagtgtgga acctgaacca cctgtggggc
      361 cgactgaggg acttctacca ggaggagctg cagctgctga tcctgtcgcc acccccagac
      421 ctccagacat tgggatttga ccctctctca gaagaagcgg tggagcagct ggaaggcgtt
      481 cttcggctac tgttgggagc gtcagtacag tgtgagcacc gggaactctt catccgccac
      541 atccagggcc tcagtctcga ggtccagagc gagctggccg ctgccatcca ggaggtgacc
      601 cagccggggg ccggcgtggt gctggcactg tctgggccag atcctgggga gctggcacct
      661 gccgagctgg agatgctgtc ccggagcctg atggggacac tgtcgaagct ggcacgggag
      721 cgtgacctgg gggcccagcg gctggctgaa ctgctgctgg agcgagaacc cctctgcttg
      781 aggcctgagg ctccctctag ggctcccgcc gagggcccct cgcaccatct ggccctgcag
      841 ctggccaacg ccaaggctca gctgcggcgt ctgcggcagg agctggagga gaaggccgag
      901 ctgctgctag actcccaggc cgaggtgcag ggtttggagg ccgaaataag aaggctccgc
      961 caggaggccc aggcgctgtc gggacaggcc aagcgggccg agctgtaccg cgaggaggca
     1021 gaggcgctgc gggagcgggc cggccgcctg ccccgcctgc aggaggagct gaggcgctgc
     1081 cgcgagcggc tgcaggcggc tgaggcctac aagagtcagc tggaggagga gcgggtgctc
     1141 tcgggggtgc tggaggcgtc caaggcgctg ctggaagagc agctggaggc tgcccgagag
     1201 cgctgcgccc ggctgcacga gacccagcgc gagaacctgc tgctgcgaac ccggctgggc
     1261 gaggcccatg cggagctgga ctctctgcgg catcaggtgg accagctggc tgaggagaat
     1321 gtggagctgg agctggagct tcagcggagc ttggagccac ctccaggatc ccctggggag
     1381 gcacccctag caggagcggc cccctcgctg caagatgagg tgagggaggc agaggctggg
     1441 cggcttcgga cccttgagag ggagaaccgg gagcttcggg ggctgcttca ggtgcttcag
     1501 gggcagccag ggggccagca ccccctgctg gaggcaccga gagaggaccc tgttcttcca
     1561 gtgctggagg aggctcccca gactcctgtg gccttcgacc acagccctca gggcttggtt
     1621 cagaaggcaa gggatggagg cccccaggcc ttggacttgg ctcccccggc attagactca
     1681 gtgctcgagg catcagctga gtgtccccag gcacctgatt cagacccaca ggaggcagag
     1741 agtccccttc aggcagctgc catggacccc caggcctcag actggtcccc gcaagagtca
     1801 ggctctcctg tggagacaca ggagtccccg gagaaggctg gccgtagatc ctctctccag
     1861 agccctgcct ctgtggcccc acctcagggt ccagggacca aaattcaggc cccgcagttg
     1921 ctgggaggag agacagaggg aagagaggct ccccaaggcg agttggtgcc tgaggcctgg
     1981 gggttgagac aggagggccc tgagcacaag ccagggcctt cggagcccag ctctgtgcag
     2041 ctggaggagc aggagggccc aaaccagggc ctggacctgg ccacgggaca agcagaggcc
     2101 agagagcatg accagaggct ggaagggacg gtcagggacc cagcctggca aaaaccacag
     2161 cagaagtcag aaggggctct tgaggtccag gtctgggaag gcccaatccc aggggagagc
     2221 ctggccagtg gtgtcgcaga gcaggaggcc ctcagggagg aggtggcaca gttgaggaga
     2281 aaggctgagg cccttggaga tgagctggaa gcccaggccc gcaagctgga ggcccaaaac
     2341 acggaggctg cccgcctctc caaggagctg gcccaagcgc gaagggcaga ggccgaggcc
     2401 caccgggagg cagaggccca ggcctgggag caagcccggc tgcgggaggc agtggaggct
     2461 gctggccagg agctggagtc tgcgtcccag gaacgggagg cgctggtgga ggcgctggca
     2521 gcagcgggcc gggagcggag gcagtgggag cgtgaggggt ccaggctgcg ggcccagtcg
     2581 gaggccgccg aggaacggat gcaggtgctg gagagcgagg gccgccagca cttggaggag
     2641 gctgagaggg agcgccggga gaaggaggcc ctccaggcgg agctggagaa agctgtggtg
     2701 cggggcaagg agttggggga ccggctggag catttgcagc gtgagctgga gcaggcggct
     2761 ctcgagcgcc aggaatttct gcgagaaaag gaaagccagc accagaggta ccagggcttg
     2821 gagcagcggc tggaagctga gctgcaggcg gcggcgacca gcaaggagga ggcgctgatg
     2881 gagctcaaga ccagggccct gcagctggaa gaggagctgt tccagctgcg ccagggcccc
     2941 gcggggctgg ggcccaaaaa gcgtgcggag cctcagctgg tggagaccca gaatgtgcgg
     3001 cttattgagg tggagcgcag taatgcgatg ctggtggcag agaaggcagc tttgcagggg
     3061 cagctgcagc acctggaggg gcagctgggg agcctgcagg gccgtgccca ggagctgctg
     3121 ctgcagagcc agcgggcgca ggagcacagc agccgcctgc aggccgagaa gtctgtgctg
     3181 gagattcagg gccaggagct gcaccggaag ctggaggtgc tggaggagga ggtgcgggcg
     3241 gcacggcagt cccaggagga gacccgcggg cagcagcagg ccctgcttcg ggaccacaag
     3301 gccctggcac agctgcagcg gcggcaggag gccgagctag agggactgct ggtgcggcac
     3361 cgagacctca aggccaacat gcgggcactg gagctggccc accgggagct gcagggccgg
     3421 cacgagcagc tgcaggccca gcgggccagc gtggaggcac aggaggtggc cctgctggca
     3481 gagcgtgaac gcctgatgca agatgggcat cggcagcggg gcctggagga ggagctgcgg
     3541 aggcttcaga gcgagcacga cagggctcag atgctgctgg cagagttgtc tcgggagcgg
     3601 ggtgagctgc agggtgaacg cggggagcta cggggccggc tggcgcggct ggagctggag
     3661 cgggcacagc tggagatgca gagccagcag ctgcgcgagt ccaaccagca gctggacctg
     3721 agcgcctgcc ggctgaccac gcagtgtgag ctattgacac agctgcgaag tgcccaggaa
     3781 gaggagaacc ggcagctgct ggctgaagtt caggccctga gccgggagaa cagggagctc
     3841 ctggagcgca gcctggagag tcgggaccac ctgcaccgcg aacagcggga gtacctggac
     3901 cagcttaatg ccctgcgccg cgagaagcag aagctcgtgg agaagatcat ggaccaatac
     3961 cgcgtgctgg agcctgtgcc cctgccccgg accaagaagg gcagctggct ggcagacaag
     4021 gtgaagaggc tgatgcggcc ccggcgggag gggggccccc ctggggggct gcgcctgggg
     4081 gccgatgggg ctggcagcac cgagagcctg gggggccccc cggagacgga gcttcctgag
     4141 ggcagggagg cagatgggac agggtcccct tccccggcac ccatgcgccg ggcccagagc
     4201 tccctctgcc tgcgggatga gaccttggca ggcgggcagc ggcggaaact cagctcaagg
     4261 ttcccggtgg ggcgaagctc tgagtcattc agccctgggg acacccctag gcaacgattc
     4321 cgacagcgcc atccaggccc cctgggggcg cccgtctccc acagcaaagg acctggtgtg
     4381 ggatgggaga actccgctga gaccctgcag gaacacgaaa cagatgccaa ccgagagggc
     4441 cctgaggtac aggaaccgga gaaacgtccc ctcaccccat ccctcagcca gtgacaccgt
     4501 gggaacagca ggcttgggag tgcagccttc tcggcactgg agtgtcagcg gaggccccag
     4561 gcagcccaag agctcaggga gccagggacc ccaaggggag tccttggaca aggaggcctg
     4621 ggccctgaga tcctccacgg tcagcgccgg ggcccggaga tggagctggg acgagtgtgt
     4681 ggacaggggg gatggctggc ccccacgagc agctccaggc tggagttctg gttcttccag
     4741 gtggctcccg ctgaggcagc ggtctctggg ggatccccca gctgaaggag gctggcagga
     4801 gttggcaaga gaaccccctg ccctgtccag gtgggaagct gagtcccagt gctgggggac
     4861 tgtggcctgg gctgatcttg agccttaact ggacatgagg ggcatgagaa taaagctgaa
     4921 ctgcagcctc ctga
//
