LOCUS       NM_001365480            9751 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens coiled-coil domain containing 88A (CCDC88A),
            transcript variant 4, mRNA.
ACCESSION   NM_001365480 XM_011532965
VERSION     NM_001365480.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 9751)
  AUTHORS   Duranti,C., Iorio,J., Bagni,G., Chioccioli Altadonna,G.,
            Fillion,T., Lulli,M., D'Alessandro,F.N., Montalbano,A.,
            Lastraioli,E., Fanelli,D., Coppola,S., Schmidt,T., Piazza,F.,
            Becchetti,A. and Arcangeli,A.
  TITLE     Integrins regulate hERG1 dynamics by girdin-dependent Galphai3:
            signaling and modeling in cancer cells
  JOURNAL   Life Sci Alliance 7 (1), e202302135 (2023)
   PUBMED   37923359
  REMARK    GeneRIF: Integrins regulate hERG1 dynamics by girdin-dependent
            Galphai3: signaling and modeling in cancer cells.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 9751)
  AUTHORS   Lan,Y., Dong,M., Li,Y., Diao,Y., Chen,Z. and Wu,Z.
  TITLE     Upregulation of girdin delays endothelial cell apoptosis via
            promoting engulfment of platelets
  JOURNAL   Mol Biol Rep 50 (10), 8111-8120 (2023)
   PUBMED   37548867
  REMARK    GeneRIF: Upregulation of girdin delays endothelial cell apoptosis
            via promoting engulfment of platelets.
REFERENCE   3  (bases 1 to 9751)
  AUTHORS   Hayashi,Y., Matsuo,Y., Denda,Y., Nonoyama,K., Murase,H., Ueda,G.,
            Aoyama,Y., Kato,T., Omi,K., Imafuji,H., Saito,K., Morimoto,M.,
            Ogawa,R., Takahashi,H., Mitsui,A., Kimura,M. and Takiguchi,S.
  TITLE     Girdin regulates both migration and angiogenesis in pancreatic
            cancer cell lines
  JOURNAL   Oncol Rep 50 (3) (2023)
   PUBMED   37503752
  REMARK    GeneRIF: Girdin regulates both migration and angiogenesis in
            pancreatic cancer cell lines.
REFERENCE   4  (bases 1 to 9751)
  AUTHORS   Zhu,D., Qi,H. and Zhu,H.
  TITLE     hsa-miR-199b-3p suppresses osteosarcoma progression by targeting
            CCDC88A, inhibiting epithelial-to-mesenchymal transition, and
            Wnt/beta-catenin signaling pathway
  JOURNAL   Sci Rep 13 (1), 12544 (2023)
   PUBMED   37532779
  REMARK    GeneRIF: hsa-miR-199b-3p suppresses osteosarcoma progression by
            targeting CCDC88A, inhibiting epithelial-to-mesenchymal transition,
            and Wnt/beta-catenin signaling pathway.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 9751)
  AUTHORS   Weng,L., Enomoto,A., Ishida-Takagishi,M., Asai,N. and Takahashi,M.
  TITLE     Girding for migratory cues: roles of the Akt substrate Girdin in
            cancer progression and angiogenesis
  JOURNAL   Cancer Sci 101 (4), 836-842 (2010)
   PUBMED   20132219
  REMARK    Review article
REFERENCE   6  (bases 1 to 9751)
  AUTHORS   Girard,A., Sachidanandam,R., Hannon,G.J. and Carmell,M.A.
  TITLE     A germline-specific class of small RNAs binds mammalian Piwi
            proteins
  JOURNAL   Nature 442 (7099), 199-202 (2006)
   PUBMED   16751776
REFERENCE   7  (bases 1 to 9751)
  AUTHORS   Enomoto,A., Murakami,H., Asai,N., Morone,N., Watanabe,T., Kawai,K.,
            Murakumo,Y., Usukura,J., Kaibuchi,K. and Takahashi,M.
  TITLE     Akt/PKB regulates actin organization and cell motility via
            Girdin/APE
  JOURNAL   Dev Cell 9 (3), 389-402 (2005)
   PUBMED   16139227
  REMARK    GeneRIF: The Girdin(or Akt-phosphorylation enhancer) is an actin
            binding protein, and Girdin is essential for the integrity of the
            actin cytoskeleton and cell migration and provide a direct link
            between Akt and cell motility.
REFERENCE   8  (bases 1 to 9751)
  AUTHORS   Le-Niculescu,H., Niesman,I., Fischer,T., DeVries,L. and
            Farquhar,M.G.
  TITLE     Identification and characterization of GIV, a novel Galpha
            i/s-interacting protein found on COPI, endoplasmic reticulum-Golgi
            transport vesicles
  JOURNAL   J Biol Chem 280 (23), 22012-22020 (2005)
   PUBMED   15749703
  REMARK    GeneRIF: GIV is a novel Galpha-interacting protein associated with
            COPI transport vesicles that may play a role in Galpha-mediated
            effects on vesicle trafficking within the Golgi and/or between the
            ER and the Golgi
REFERENCE   9  (bases 1 to 9751)
  AUTHORS   Simpson,F., Martin,S., Evans,T.M., Kerr,M., James,D.E.,
            Parton,R.G., Teasdale,R.D. and Wicking,C.
  TITLE     A novel hook-related protein family and the characterization of
            hook-related protein 1
  JOURNAL   Traffic 6 (6), 442-458 (2005)
   PUBMED   15882442
  REMARK    GeneRIF: HkRP1 is involved in the process of tubulation of sorting
            nexin-1 positive membranes from early endosome subdomains
            GeneRIF: A novel Hook-related protein family and the
            characterisation of Hook-related protein 1.
REFERENCE   10 (bases 1 to 9751)
  AUTHORS   Anai,M., Shojima,N., Katagiri,H., Ogihara,T., Sakoda,H., Onishi,Y.,
            Ono,H., Fujishiro,M., Fukushima,Y., Horike,N., Viana,A.,
            Kikuchi,M., Noguchi,N., Takahashi,S., Takata,K., Oka,Y.,
            Uchijima,Y., Kurihara,H. and Asano,T.
  TITLE     A novel protein kinase B (PKB)/AKT-binding protein enhances PKB
            kinase activity and regulates DNA synthesis
  JOURNAL   J Biol Chem 280 (18), 18525-18535 (2005)
   PUBMED   15753085
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC019198.12, AC092176.4 and
            AC012358.9.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Aug 29, 2018 this sequence version replaced XM_011532965.3.
            
            Summary: This gene encodes a member of the Girdin family of
            coiled-coil domain containing proteins. The encoded protein is an
            actin-binding protein that is activated by the serine/threonine
            kinase Akt and plays a role in cytoskeleton remodeling and cell
            migration. The encoded protein also enhances Akt signaling by
            mediating phosphoinositide 3-kinase (PI3K)-dependent activation of
            Akt by growth factor receptor tyrosine kinases and G
            protein-coupled receptors. Increased expression of this gene and
            phosphorylation of the encoded protein may play a role in cancer
            metastasis. Alternatively spliced transcript variants encoding
            multiple isoforms have been observed for this gene. [provided by
            RefSeq, Dec 2011].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA1965299, SAMEA1966682
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            MANE Ensembl match        :: ENST00000436346.7/ ENSP00000410608.1
            RefSeq Select criteria    :: based on manual assertion,
                                         conservation, expression, longest
                                         protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-840               AC019198.12        47972-48811         c
            841-941             AC019198.12        47771-47871         c
            942-1050            AC019198.12        17733-17841         c
            1051-1120           AC019198.12        3769-3838           c
            1121-1179           AC019198.12        1407-1465           c
            1180-1263           AC092176.4         8206-8289           c
            1264-1404           AC092176.4         6564-6704           c
            1405-1411           AC092176.4         1-7                 c
            1412-1577           AC012358.9         159986-160151       c
            1578-1659           AC012358.9         153925-154006       c
            1660-1818           AC012358.9         150582-150740       c
            1819-1965           AC012358.9         148775-148921       c
            1966-2110           AC012358.9         148055-148199       c
            2111-2295           AC012358.9         143871-144055       c
            2296-2433           AC012358.9         141088-141225       c
            2434-3504           AC012358.9         138501-139571       c
            3505-3632           AC012358.9         136973-137100       c
            3633-3774           AC012358.9         132701-132842       c
            3775-3939           AC012358.9         126935-127099       c
            3940-4101           AC012358.9         123250-123411       c
            4102-4379           AC012358.9         121971-122248       c
            4380-4523           AC012358.9         121613-121756       c
            4524-4710           AC012358.9         120335-120521       c
            4711-4856           AC012358.9         116841-116986       c
            4857-4949           AC012358.9         113569-113661       c
            4950-5164           AC012358.9         113216-113430       c
            5165-5248           AC012358.9         107476-107559       c
            5249-5449           AC012358.9         106279-106479       c
            5450-5521           AC012358.9         105613-105684       c
            5522-5602           AC012358.9         104246-104326       c
            5603-5868           AC012358.9         100665-100930       c
            5869-6328           AC012358.9         100004-100463       c
            6329-6428           AC012358.9         96083-96182         c
            6429-9751           AC012358.9         92249-95571         c
FEATURES             Location/Qualifiers
     source          1..9751
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p16.1"
     gene            1..9751
                     /gene="CCDC88A"
                     /gene_synonym="APE; GIRDIN; GIV; GRDN; HkRP1; KIAA1212;
                     PEHO; PEHOL"
                     /note="coiled-coil domain containing 88A"
                     /db_xref="GeneID:55704"
                     /db_xref="HGNC:HGNC:25523"
                     /db_xref="MIM:609736"
     exon            1..840
                     /gene="CCDC88A"
                     /gene_synonym="APE; GIRDIN; GIV; GRDN; HkRP1; KIAA1212;
                     PEHO; PEHOL"
                     /inference="alignment:Splign:2.1.0"
     CDS             778..6393
                     /gene="CCDC88A"
                     /gene_synonym="APE; GIRDIN; GIV; GRDN; HkRP1; KIAA1212;
                     PEHO; PEHOL"
                     /note="isoform 4 is encoded by transcript variant 4;
                     Hook-related protein 1; AKT-phosphorylation enhancer;
                     girders of actin filaments; g alpha-interacting
                     vesicle-associated protein"
                     /codon_start=1
                     /product="girdin isoform 4"
                     /protein_id="NP_001352409.1"
                     /db_xref="CCDS:CCDS92755.1"
                     /db_xref="GeneID:55704"
                     /db_xref="HGNC:HGNC:25523"
                     /db_xref="MIM:609736"
                     /translation="MENEIFTPLLEQFMTSPLVTWVKTFGPLAAGNGTNLDEYVALVD
                     GVFLNQVMLQINPKLESQRVNKKVNNDASLRMHNLSILVRQIKFYYQETLQQLIMMSL
                     PNVLIIGKNPFSEQGTEEVKKLLLLLLGCAVQCQKKEEFIERIQGLDFDTKAAVAAHI
                     QEVTHNQENVFDLQWMEVTDMSQEDIEPLLKNMALHLKRLIDERDEHSETIIELSEER
                     DGLHFLPHASSSAQSPCGSPGMKRTESRQHLSVELADAKAKIRRLRQELEEKTEQLLD
                     CKQELEQMEIELKRLQQENMNLLSDARSARMYRDELDALREKAVRVDKLESEVSRYKE
                     RLHDIEFYKARVEELKEDNQVLLETKTMLEDQLEGTRARSDKLHELEKENLQLKAKLH
                     DMEMERDMDRKKIEELMEENMTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSL
                     GHEVNELTSSRLLKLEMENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVE
                     ILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQT
                     VSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKG
                     ERAEELENELHHLEKENELLQKKITNLKITCEKIEALEQENSELERENRKLKKTLDSF
                     KNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKG
                     LELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQK
                     NLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENN
                     VKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSE
                     KLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDSRYKLLESKLESTLKKSLEIK
                     EEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSPPISGEDNKW
                     ERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQR
                     QTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKER
                     EDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQ
                     LLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQLLKETE
                     VLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQLKGNL
                     EEENRHLLDQIQTLMLQNRTLLEQNMESKDLFHVEQRQYIDKLNELRRQKEKLEEKIM
                     DQYKFYDPSPPRRRGNWITLKMRKLIKSKKDINRERQKSLTLTPTRSDSSEGFLQLPH
                     QDSQDSSSVGSNSLEDGQTLGTKKSSMVALKRLPFLRNRPKDKDKMKACYRRSMSMND
                     LVQSMVLAGQWTGSTENLEVPDDISTGKRRKELGAMAFSTTAINFSTVNSSAGFRSKQ
                     LVNNKDTTSFEDISPQGVSDDSSTGSRVHASRPASLDSGRTSTSNSNNNASLHEVKAG
                     AVNNQSRPQSHSSGEFSLLHDHEAWSSSGSSPIQYLKRQTRSSPVLQHKISETLESRH
                     HKIKTGSPGSEVVTLQQFLEESNKLTSVQIKSSSQENLLDEVMKSLSVSSDFLGKDKP
                     VSCGLARSVSGKTPGDFYDRRTTKPEFLRPGPRKTEDTYFISSAGKPTPGTQGKIKLV
                     KESSLSRQSKDSNPYATLPRASSVISTAEGTTRRTSIHDFLTKDSRLPISVDSPPAAA
                     DSNTTAASNVDKVQESRNSKSRSREQQSS"
     exon            841..941
                     /gene="CCDC88A"
                     /gene_synonym="APE; GIRDIN; GIV; GRDN; HkRP1; KIAA1212;
                     PEHO; PEHOL"
                     /inference="alignment:Splign:2.1.0"
     exon            942..1050
                     /gene="CCDC88A"
                     /gene_synonym="APE; GIRDIN; GIV; GRDN; HkRP1; KIAA1212;
                     PEHO; PEHOL"
                     /inference="alignment:Splign:2.1.0"
     exon            1051..1120
                     /gene="CCDC88A"
                     /gene_synonym="APE; GIRDIN; GIV; GRDN; HkRP1; KIAA1212;
                     PEHO; PEHOL"
                     /inference="alignment:Splign:2.1.0"
     exon            1121..1179
                     /gene="CCDC88A"
                     /gene_synonym="APE; GIRDIN; GIV; GRDN; HkRP1; KIAA1212;
                     PEHO; PEHOL"
                     /inference="alignment:Splign:2.1.0"
     exon            1180..1263
                     /gene="CCDC88A"
                     /gene_synonym="APE; GIRDIN; GIV; GRDN; HkRP1; KIAA1212;
                     PEHO; PEHOL"
                     /inference="alignment:Splign:2.1.0"
     exon            1264..1404
                     /gene="CCDC88A"
                     /gene_synonym="APE; GIRDIN; GIV; GRDN; HkRP1; KIAA1212;
                     PEHO; PEHOL"
                     /inference="alignment:Splign:2.1.0"
     exon            1405..1577
                     /gene="CCDC88A"
                     /gene_synonym="APE; GIRDIN; GIV; GRDN; HkRP1; KIAA1212;
                     PEHO; PEHOL"
                     /inference="alignment:Splign:2.1.0"
     exon            1578..1659
                     /gene="CCDC88A"
                     /gene_synonym="APE; GIRDIN; GIV; GRDN; HkRP1; KIAA1212;
                     PEHO; PEHOL"
                     /inference="alignment:Splign:2.1.0"
     exon            1660..1818
                     /gene="CCDC88A"
                     /gene_synonym="APE; GIRDIN; GIV; GRDN; HkRP1; KIAA1212;
                     PEHO; PEHOL"
                     /inference="alignment:Splign:2.1.0"
     exon            1819..1965
                     /gene="CCDC88A"
                     /gene_synonym="APE; GIRDIN; GIV; GRDN; HkRP1; KIAA1212;
                     PEHO; PEHOL"
                     /inference="alignment:Splign:2.1.0"
     exon            1966..2110
                     /gene="CCDC88A"
                     /gene_synonym="APE; GIRDIN; GIV; GRDN; HkRP1; KIAA1212;
                     PEHO; PEHOL"
                     /inference="alignment:Splign:2.1.0"
     exon            2111..2295
                     /gene="CCDC88A"
                     /gene_synonym="APE; GIRDIN; GIV; GRDN; HkRP1; KIAA1212;
                     PEHO; PEHOL"
                     /inference="alignment:Splign:2.1.0"
     exon            2296..2433
                     /gene="CCDC88A"
                     /gene_synonym="APE; GIRDIN; GIV; GRDN; HkRP1; KIAA1212;
                     PEHO; PEHOL"
                     /inference="alignment:Splign:2.1.0"
     exon            2434..3504
                     /gene="CCDC88A"
                     /gene_synonym="APE; GIRDIN; GIV; GRDN; HkRP1; KIAA1212;
                     PEHO; PEHOL"
                     /inference="alignment:Splign:2.1.0"
     exon            3505..3632
                     /gene="CCDC88A"
                     /gene_synonym="APE; GIRDIN; GIV; GRDN; HkRP1; KIAA1212;
                     PEHO; PEHOL"
                     /inference="alignment:Splign:2.1.0"
     exon            3633..3774
                     /gene="CCDC88A"
                     /gene_synonym="APE; GIRDIN; GIV; GRDN; HkRP1; KIAA1212;
                     PEHO; PEHOL"
                     /inference="alignment:Splign:2.1.0"
     exon            3775..3939
                     /gene="CCDC88A"
                     /gene_synonym="APE; GIRDIN; GIV; GRDN; HkRP1; KIAA1212;
                     PEHO; PEHOL"
                     /inference="alignment:Splign:2.1.0"
     exon            3940..4101
                     /gene="CCDC88A"
                     /gene_synonym="APE; GIRDIN; GIV; GRDN; HkRP1; KIAA1212;
                     PEHO; PEHOL"
                     /inference="alignment:Splign:2.1.0"
     exon            4102..4379
                     /gene="CCDC88A"
                     /gene_synonym="APE; GIRDIN; GIV; GRDN; HkRP1; KIAA1212;
                     PEHO; PEHOL"
                     /inference="alignment:Splign:2.1.0"
     exon            4380..4523
                     /gene="CCDC88A"
                     /gene_synonym="APE; GIRDIN; GIV; GRDN; HkRP1; KIAA1212;
                     PEHO; PEHOL"
                     /inference="alignment:Splign:2.1.0"
     exon            4524..4710
                     /gene="CCDC88A"
                     /gene_synonym="APE; GIRDIN; GIV; GRDN; HkRP1; KIAA1212;
                     PEHO; PEHOL"
                     /inference="alignment:Splign:2.1.0"
     exon            4711..4856
                     /gene="CCDC88A"
                     /gene_synonym="APE; GIRDIN; GIV; GRDN; HkRP1; KIAA1212;
                     PEHO; PEHOL"
                     /inference="alignment:Splign:2.1.0"
     exon            4857..4949
                     /gene="CCDC88A"
                     /gene_synonym="APE; GIRDIN; GIV; GRDN; HkRP1; KIAA1212;
                     PEHO; PEHOL"
                     /inference="alignment:Splign:2.1.0"
     exon            4950..5164
                     /gene="CCDC88A"
                     /gene_synonym="APE; GIRDIN; GIV; GRDN; HkRP1; KIAA1212;
                     PEHO; PEHOL"
                     /inference="alignment:Splign:2.1.0"
     exon            5165..5248
                     /gene="CCDC88A"
                     /gene_synonym="APE; GIRDIN; GIV; GRDN; HkRP1; KIAA1212;
                     PEHO; PEHOL"
                     /inference="alignment:Splign:2.1.0"
     exon            5249..5449
                     /gene="CCDC88A"
                     /gene_synonym="APE; GIRDIN; GIV; GRDN; HkRP1; KIAA1212;
                     PEHO; PEHOL"
                     /inference="alignment:Splign:2.1.0"
     exon            5450..5521
                     /gene="CCDC88A"
                     /gene_synonym="APE; GIRDIN; GIV; GRDN; HkRP1; KIAA1212;
                     PEHO; PEHOL"
                     /inference="alignment:Splign:2.1.0"
     exon            5522..5602
                     /gene="CCDC88A"
                     /gene_synonym="APE; GIRDIN; GIV; GRDN; HkRP1; KIAA1212;
                     PEHO; PEHOL"
                     /inference="alignment:Splign:2.1.0"
     exon            5603..5868
                     /gene="CCDC88A"
                     /gene_synonym="APE; GIRDIN; GIV; GRDN; HkRP1; KIAA1212;
                     PEHO; PEHOL"
                     /inference="alignment:Splign:2.1.0"
     exon            5869..6328
                     /gene="CCDC88A"
                     /gene_synonym="APE; GIRDIN; GIV; GRDN; HkRP1; KIAA1212;
                     PEHO; PEHOL"
                     /inference="alignment:Splign:2.1.0"
     exon            6329..6428
                     /gene="CCDC88A"
                     /gene_synonym="APE; GIRDIN; GIV; GRDN; HkRP1; KIAA1212;
                     PEHO; PEHOL"
                     /inference="alignment:Splign:2.1.0"
     exon            6429..9751
                     /gene="CCDC88A"
                     /gene_synonym="APE; GIRDIN; GIV; GRDN; HkRP1; KIAA1212;
                     PEHO; PEHOL"
                     /inference="alignment:Splign:2.1.0"
     regulatory      9482..9487
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CCDC88A"
                     /gene_synonym="APE; GIRDIN; GIV; GRDN; HkRP1; KIAA1212;
                     PEHO; PEHOL"
                     /note="hexamer: ATTAAA"
     polyA_site      9504
                     /gene="CCDC88A"
                     /gene_synonym="APE; GIRDIN; GIV; GRDN; HkRP1; KIAA1212;
                     PEHO; PEHOL"
                     /note="major polyA site"
     regulatory      9722..9727
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CCDC88A"
                     /gene_synonym="APE; GIRDIN; GIV; GRDN; HkRP1; KIAA1212;
                     PEHO; PEHOL"
                     /note="hexamer: AATAAA"
     polyA_site      9751
                     /gene="CCDC88A"
                     /gene_synonym="APE; GIRDIN; GIV; GRDN; HkRP1; KIAA1212;
                     PEHO; PEHOL"
ORIGIN      
        1 gttactccgg cttctccata gagggcggag aaggctggag cgcggcggtg attttgtgcc
       61 agggattccc agagacgcgc tgaaaggctg gcagggctta ggaagctggg gggttaggga
      121 cacacattca agcccccacc cccgggaggg gaagggggct ggaggcgagg cttgagggcg
      181 gcggaggaat ggtgtctgct cggggggaag gggcgagccc tgcctgttgg tactgagggg
      241 ctgcgggcag tggaggctcc gcgggtcgaa agcggctcca tgcccatcgg tgggtggaac
      301 gtgtagaggt cggaacgccg aggtcgagtc tggtggcgcc tcggtatcct taacgtggtc
      361 tctgtttaac gtatttcatt tagcccccgt tgggattgat tcattgggag cagtttcgct
      421 ggtctggatc ctccaggagc tggacaacct tgacgggctt tttgtcttgg gttccagccc
      481 cctttccctt cctcctcctc cagatgcctt ttctctgccc ctcctcgccc ggtacagaca
      541 tttccagcgc aggctgctgc tcgtggtgtc cgtcgtcgaa gccacttctt gggatttcgg
      601 ctcgtttcac tctggggtgt tttttgagga gggagagtgc ccccctcctc cacgatggga
      661 tttttctccc ttgccgaaat ggactttcat tgatttctac ttacttccac gtttagtgac
      721 caattcccta ggcgtatttt tgtggtagtt ccttttttca aatacatact ctgtaaaatg
      781 gagaacgaaa tttttactcc ccttctggag cagttcatga ccagcccttt ggtcacttgg
      841 gttaaaacgt ttggacctct ggccgcagga aatgggacca accttgatga atatgtggct
      901 ttggtggatg gggtattctt gaaccaggtc atgctccaaa ttaatcctaa attggagagt
      961 cagagagtaa ataaaaaagt caataatgat gcctcactta gaatgcacaa tctatccatt
     1021 ttggtgagac agataaaatt ttattaccag gagactttgc agcaattgat catgatgtcg
     1081 ttgccaaatg tcttaatcat tggcaaaaat cccttttctg aacaaggcac agaagaagtt
     1141 aaaaaactgc ttttactttt attgggttgt gcagttcagt gtcagaaaaa agaggaattt
     1201 attgaaagaa ttcaaggttt agattttgat acaaaagcag cggttgccgc acatattcaa
     1261 gaggtaactc ataatcagga aaatgtgttt gacctgcaat ggatggaagt gactgatatg
     1321 tcgcaggagg acatagaacc actcttgaaa aatatggcat tgcatctaaa aagacttata
     1381 gatgagagag atgaacattc agagactatc atagaactct ctgaagagcg ggatggtctc
     1441 cattttctac cccatgcctc ttcatctgca cagtcaccct gtggttctcc aggcatgaag
     1501 cgaacagaaa gtcgacaaca tctgtcggtg gaactggcag atgctaaagc caagataaga
     1561 aggcttaggc aggaattgga ggaaaagact gagcagttgt tggattgtaa acaagaactt
     1621 gagcaaatgg aaatagaact caaaaggctg caacaagaga acatgaattt gctttcggat
     1681 gctcgctctg ccagaatgta ccgagatgaa ttagatgcac ttcgagagaa agcagtcaga
     1741 gtcgataagc ttgaaagtga agtcagcaga tataaagaga gactacatga tattgaattt
     1801 tataaggcaa gagttgagga attaaaagaa gacaatcaag ttttattaga aacaaaaacc
     1861 atgttggaag accaactaga gggaactcgt gctcgttctg ataaattaca tgaattagaa
     1921 aaagagaact tacaactgaa agctaaactt catgatatgg aaatggaacg agatatggat
     1981 agaaaaaaga ttgaagaatt aatggaagaa aatatgactt tggaaatggc acagaaacaa
     2041 agtatggatg aatcattaca tcttggctgg gaactggaac agatatccag aactagtgaa
     2101 ctttccgaag caccccagaa atccctgggc catgaggtga atgagttgac atcaagtaga
     2161 ttattgaagc tagagatgga aaatcaaagt ttgacaaaaa ccgtagaaga gcttcggact
     2221 actgtggatt ctgtagaagg caatgcttcc aaaatcctga aaatggaaaa agaaaatcaa
     2281 aggctcagta aaaaggttga gattcttgaa aatgagattg ttcaagaaaa gcaaagtctt
     2341 cagaattgtc agaatttaag caaggatcta atgaaggaga aagctcagct tgaaaaaaca
     2401 atagaaacac tgagagaaaa ttcagagaga cagattaaga tactggaaca ggaaaatgaa
     2461 catctgaatc aaacagtgtc ttccttaagg cagcggtccc agataagtgc agaagcaaga
     2521 gtgaaagaca ttgaaaaaga aaacaaaatt cttcatgaat ctatcaaaga aacaagtagc
     2581 aagctaagca agattgaatt tgaaaaaaga caaattaaaa aagaattgga acattataaa
     2641 gaaaaaggag aacgagctga agaacttgaa aatgaattgc atcatcttga aaaagaaaat
     2701 gaattattac agaaaaaaat aactaattta aaaattactt gtgaaaaaat tgaggcctta
     2761 gaacaagaaa attcagagct agaaagagaa aatagaaaat taaaaaaaac attggatagc
     2821 tttaaaaatc tgacctttca gttagaatcc ctagaaaaag agaattccca acttgatgag
     2881 gaaaacttag aactgcgaag gaatgtagaa tctttgaagt gtgcaagcat gaaaatggct
     2941 cagctacagc tagaaaacaa agaactggaa agtgaaaaag agcaacttaa gaagggtttg
     3001 gagctcctga aagcatcttt caagaaaaca gaacgcttag aagttagcta ccagggttta
     3061 gatatagaaa atcaaagact gcaaaaaact ttagagaaca gcaataaaaa aatccagcaa
     3121 ttagagagtg aactacaaga cttagagatg gaaaatcaaa cattgcagaa aaacctagaa
     3181 gaactaaaaa tatctagcaa aagactagaa cagctggaaa aagaaaataa atcattagag
     3241 caagagactt ctcaactgga aaaggataag aaacaattgg agaaggaaaa taagagactc
     3301 cgacaacaag cagaaattaa agataccaca ttagaagaaa ataatgtgaa gattggaaat
     3361 ttggaaaaag aaaacaaaac cctatccaaa gaaattggta tatataaaga atcttgtgtc
     3421 cgtctgaaag aactagaaaa agaaaataag gagcttgtga aaagagcaac tattgatata
     3481 aaaacgttgg ttacactacg tgaggatttg gtgagtgaaa agttgaagac ccaacagatg
     3541 aacaatgatc tcgaaaaatt aactcatgag cttgagaaga tagggttaaa taaggagcga
     3601 ctcttacatg atgaacaaag tactgatgac agtaggtata aacttttgga atcaaaatta
     3661 gaatccactc ttaagaagtc tcttgaaata aaagaagaaa aaattgctgc tttagaagct
     3721 cgattagaag aatccacgaa ttataaccag caattgcgcc aagaacttaa aacagtgaaa
     3781 aaaaattatg aagctctcaa acagagacaa gatgaggaaa ggatggtaca gagctctcct
     3841 ccaatatctg gtgaagacaa caaatgggag cgagaaagtc aagaaacgac tagagaactt
     3901 ctgaaagtta aagacagatt aattgaagta gaaagaaata atgctacact gcaagcagag
     3961 aagcaagcgt tgaaaactca actgaagcaa cttgagacac agaacaataa tttgcaggct
     4021 cagattcttg cacttcagag gcagacagtg tcattacaag aacagaatac cactcttcaa
     4081 acacagaatg ccaagcttca ggttgaaaat tccaccctta attcccaaag tacctcactc
     4141 atgaaccaga atgcccaact cctaatccag cagtcttcct tagaaaatga aaatgaatct
     4201 gtaatcaaag agcgagaaga cctaaaatct ctctatgatt ctctgatcaa agatcatgaa
     4261 aagctggaac ttcttcatga acgtcaggct tcagagtatg aatctcttat ctctaaacat
     4321 ggaactctga agtctgccca caaaaatctt gaggtggaac atagagacct tgaagaccgt
     4381 tacaatcagt tattaaaaca gaaaggacag ttggaagatt tggaaaaaat gctcaaagta
     4441 gaacaggaaa aaatgctgct tgaaaataaa aatcatgaaa cagtagctgc agaatacaag
     4501 aaactttgtg gtgaaaatga taggctgaat catacctata gtcaactttt aaaagagact
     4561 gaagttttac aaactgacca taaaaatttg aaaagtcttc tgaataattc caaactggaa
     4621 caaacaagat tagaagctga attttcaaaa ctaaaggaac aataccaaca attggatatt
     4681 acatcaacca agctgaataa ccagtgtgag ttgctaagcc aacttaaagg aaatttagaa
     4741 gaagaaaatc ggcatctact agatcaaatt cagacattaa tgctacagaa cagaacactt
     4801 ttggagcaga atatggaaag caaggatctt tttcatgttg aacaaagaca gtacattgat
     4861 aagttaaatg aattaagacg tcagaaggag aaactagaag agaaaattat ggatcaatac
     4921 aaattttatg acccatctcc tcctagaagg agaggcaact ggattactct aaaaatgaga
     4981 aaattgataa agtctaagaa agatattaat cgggaacgcc agaaatctct aacattaaca
     5041 cccacccgct cagactccag tgaaggattt cttcagctcc ctcatcaaga cagtcaagat
     5101 agttcttcag taggttcaaa ctctttagaa gatggccaga ccttggggac caagaaaagc
     5161 agcatggttg cactgaaaag actgcccttt ttgaggaaca gaccgaagga taaagacaaa
     5221 atgaaggcct gctaccgtcg ttccatgtcc atgaatgacc tggtgcagtc catggtccta
     5281 gcaggacagt ggacaggtag tactgagaat ttggaggttc ctgatgatat ttcaacgggt
     5341 aaaaggagaa aagaattggg agctatggcc ttctctacta cagccatcaa cttttcaact
     5401 gtcaactctt ctgcaggctt cagatccaag cagttggtta ataataaaga tactacatcc
     5461 tttgaagaca taagtccaca aggtgttagt gatgattcta gtacgggatc aagagttcat
     5521 gcttcaagac cagccagcct tgatagtggc agaacatcca ctagcaatag caataataat
     5581 gcttcactac atgaagtcaa agcaggtgca gttaataacc aaagcaggcc acaaagccac
     5641 agcagtggag aatttagcct gcttcatgac catgaggctt ggtccagcag tggtagcagt
     5701 ccaatccagt acttgaaaag acagaccaga tcaagcccag tgctccagca caaaatatct
     5761 gaaacactgg agagtcgaca tcacaagatc aaaactggtt cccctggaag tgaagttgtt
     5821 actctacaac agtttttgga agaaagcaat aagcttacct cagtacagat aaagtcctca
     5881 agtcaagaga atcttttaga tgaagtaatg aaaagtttgt ctgtctcttc tgactttttg
     5941 ggaaaagaca aaccagttag ctgtggtctg gccaggtcag taagtggaaa aaccccaggg
     6001 gacttctatg atagacggac aactaagcct gagtttttga gacctggtcc tcgaaaaact
     6061 gaagatacct acttcattag ttctgcggga aaacctacac caggcactca aggaaaaata
     6121 aaattagtaa aagaatcttc tctgtcacga caatcaaaag atagtaaccc ttatgcaact
     6181 ttacctcgtg caagcagcgt gatctcaact gccgaaggaa ctacacgaag gacaagcatc
     6241 catgattttt tgaccaagga cagtagactg cctatatcag ttgattcacc accagctgct
     6301 gctgacagca acaccactgc agcatctaat gtggacaaag tacaagaaag cagaaattca
     6361 aaaagcaggt ctagggagca acaaagctcc taattctatt acccactaca tgacatgtgg
     6421 gccaagtgag agaaaagtgt ccttcagttt ctcagtatga agcctttatt tctgaagtaa
     6481 caagacacct agcaactata ggaatcattt ttaaaaatct ttaaggagac ttttaacagt
     6541 ccttcgtgaa tagagcaggc aagaaataca aaccttcatt ccttgaatca aggagcacta
     6601 ctggattcaa ctgccaaaat tttttaaagg ttttaggact tactatacct tgtactgtta
     6661 agatctactg aataaaggac gttctctcac taaggaccag gtgttttaag gttaagtgtt
     6721 taaagaagta ctccaagaac aatctgcttt tttcatcatt tgttttatga atttatccat
     6781 gtttgcttaa tgcttctgct aagtgttagc caaaatctag ccatttatat ttagttgtgt
     6841 aaacctaaat taaatgctgt agtattttgt ggaatgtact atatagcaag atacagagaa
     6901 aattgttttg gcatgtcaga gccttatttg gttagcagac tgcatgtgtt gatacttttt
     6961 ttttcttaaa gccaattatt ttgatgcaaa agaaattcag tttataagat aaatctgaaa
     7021 aatccataat gaaataggag ttataaaaaa tttatagtga tattaatctt tccatatttc
     7081 ccattaagca acactaagca ttcataagtt aacccatggt aaagagtgtt tttctgaaac
     7141 ttttttttag taagatggtt tttcagcaaa tggcattccc aagataaagc tgttgtgctt
     7201 taactcattt cttttctttg gtattgggtt atgtatgcgt gtgcattttt ttaacttgag
     7261 agctgactgt tgcttaagaa gttttcttat ggcaaaaata atgtaaataa gttactatga
     7321 tctgcatttt gccagaaact catttataat taaggctatc atttattaat gatttttttc
     7381 tcctttatga tattacatta aagttgataa ctgttattgg tacttttgaa atatttgtat
     7441 gcatttgtta cctttaaaca tttggaagaa gcacaaaaaa atagatttag ttaacccagg
     7501 gaaacatcaa tttttttagt agttccaatt ttatatcaca gttttatttt cttatgaaat
     7561 caaaaaatgc attgatactc attaatgcaa attcattatt taacatcaat atcagagtaa
     7621 tcttcaaggt ctgaaatgag aaacatactg actttttaaa attttaacag tgtacttctt
     7681 aggctttcat taccagctct gaagaacttt ttggaataat tccatattcc atagtgtgtg
     7741 gtttatgagt tgtgggtttc atcactaacc cagtaaccat aagaaaagtc tctctctctc
     7801 tctctctctc tctctctttc tctctccctc tttctctctc tctttcgtag gccagtagca
     7861 atgttgtgtt cacagtctaa tttccaaaag accatcaata aaaaagagag catgtttaaa
     7921 ttgaaatgga acttagagaa cttgagctta cttacgtact tcaatgccac cggtaactta
     7981 ggttttacca ccaaatgctg ttaacgttaa atcattttga aaatcttgga tgaaaggtgc
     8041 tatgtaaatg gaaatacaaa ggattcttac taacatacaa aaataatgca caacagaaat
     8101 atctaaaacc ttttccgtag actttgaaac atctctctct ctcataactc cctggattca
     8161 agtagcacat tggtaatagg tatcagagca gtctagagac aattgcatgt caaaaaatgt
     8221 acattcattt ttaggtggat aaaagtaaac atagaaatta tgttatggct aaatacagtt
     8281 agtgggtaac ttagatttat attagctagc atctaatttg cacaactaga acacatccca
     8341 gaacaattac tgaaaagctg aaatttaatg ggtggtgatg tagcccaatg agggcgaatg
     8401 acattacagc ttgacctctc cagaacacta atatcctaaa atacagaaca tgctgggtta
     8461 agtgcattag tgcttcaagc agaaaatgct gaaaacaacg tgtaaagtac tgaatctgag
     8521 taggctgacc ctgagaaggg acaattaaag agacaaccaa gggaacacat tgagactaca
     8581 aaaatatgaa taatctcaat tatattcatc acactttttt cataccattt caagaaacga
     8641 ctagacagta gtaaccacat gaatatttta ctttctccag tataccttga gaagcaaact
     8701 ttgtaggaag ccactcttct cccctaaaca acttctgcca aacaataata aagccaactg
     8761 gaaacgaatc ggagccattt tcattttcct aaccggggcc tgacatgctt taaattatct
     8821 ggctgtattc taaatcaaca cctaacccct caaggaaact gaagaatcaa tatacagggt
     8881 aatagctttg gctcagagct ccaataatgt gcttcagatc tgtccatgtg gaaatgcttt
     8941 catccaaatt tttaaattgg tggttaccaa agagttcaca aaacaggttt gtatgtagca
     9001 cctttcatgc aaggcatgca aaaagcctat tttaaaatca ctgtgcatat tatagagttg
     9061 tagccacctc acaatgaagt actacagcct gtgctgtctt aatggtttat gtcaggaaat
     9121 gaaaaagata ctgtaccaaa tctggaatta caatggggag taataatgta tactaaatga
     9181 cttttgtatt ttaagttact ttttgtgagt ggtgaatttt tgtgtttttc ttttcagcta
     9241 cacttagtcc tgagatgtat tttttcttta agtcttgaat gaatacaaaa ggagcccatt
     9301 ttataatata aaccttgatg tacatgttga gatatttgga caatgaaaat gccttaaaag
     9361 gaatgcatat ggataaagtt gcacttataa cacccttcaa caaaatctaa ttttaaattg
     9421 tctttttctt ttctattaag ggttttcttt ttcagtgtct accattgtac ttataactgt
     9481 tattaaatac caaatcaaat aatataaaag ctgtaacatt tcctttaaaa ctaatgctaa
     9541 taagggattt agagttgaat ggcaaaatgt ttattacttg gcaatacctg atgtcagtca
     9601 caggcatcca actcatgaca agagatacca ctgtttgttt tttaaaaaac atttttcatt
     9661 ttgtttctcc ttcaaaaatt aagttggact aacattcacg tatcaaacta atataaaaag
     9721 aaataaaacc aagaggtgat ttttgtaaca a
//
