LOCUS       NM_024098               1851 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens coiled-coil domain containing 86 (CCDC86), mRNA.
ACCESSION   NM_024098
VERSION     NM_024098.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1851)
  AUTHORS   Wang,Z., Zhou,T., Chen,X., Zhu,X., Liao,B., Liu,J., Li,S., Tan,T.
            and Liu,Y.
  TITLE     CCDC86 promotes the aggressive behavior of nasopharyngeal carcinoma
            by positively regulating EGFR and activating the PI3K/Akt signaling
  JOURNAL   Neoplasma 70 (6), 761-776 (2023)
   PUBMED   38247332
  REMARK    GeneRIF: CCDC86 promotes the aggressive behavior of nasopharyngeal
            carcinoma by positively regulating EGFR and activating the PI3K/Akt
            signaling.
REFERENCE   2  (bases 1 to 1851)
  AUTHORS   Stamatiou,K., Chmielewska,A., Ohta,S., Earnshaw,W.C. and
            Vagnarelli,P.
  TITLE     CCDC86 is a novel Ki-67-interacting protein important for cell
            division
  JOURNAL   J Cell Sci 136 (2) (2023)
   PUBMED   36695333
  REMARK    GeneRIF: CCDC86 is a novel Ki-67-interacting protein important for
            cell division.
REFERENCE   3  (bases 1 to 1851)
  AUTHORS   Xie,G., Roshandel,D., Sherva,R., Monach,P.A., Lu,E.Y., Kung,T.,
            Carrington,K., Zhang,S.S., Pulit,S.L., Ripke,S., Carette,S.,
            Dellaripa,P.F., Edberg,J.C., Hoffman,G.S., Khalidi,N.,
            Langford,C.A., Mahr,A.D., St Clair,E.W., Seo,P., Specks,U.,
            Spiera,R.F., Stone,J.H., Ytterberg,S.R., Raychaudhuri,S., de
            Bakker,P.I., Farrer,L.A., Amos,C.I., Merkel,P.A. and
            Siminovitch,K.A.
  TITLE     Association of granulomatosis with polyangiitis (Wegener's) with
            HLA-DPB1*04 and SEMA6A gene variants: evidence from genome-wide
            analysis
  JOURNAL   Arthritis Rheum 65 (9), 2457-2468 (2013)
   PUBMED   23740775
REFERENCE   4  (bases 1 to 1851)
  AUTHORS   Shishkov,R., Chervenkov,T., Yamashima,T. and Tonchev,A.B.
  TITLE     Expression of Cyclon/CCDC86, a novel nuclear protein, in the
            hippocampus of adult non-human primates
  JOURNAL   J Neuroimmunol 258 (1-2), 96-99 (2013)
   PUBMED   23528659
REFERENCE   5  (bases 1 to 1851)
  AUTHORS   Chervenkov,T., Shishkov,R. and Tonchev,A.B.
  TITLE     Expression and differential response to haloperidol treatment of
            Cyclon/CCDC86 mRNA in schizophrenia patients
  JOURNAL   Neurochem Int 62 (6), 870-872 (2013)
   PUBMED   23439384
  REMARK    GeneRIF: Cyclon/CCDC68 levels correlate with the clinical
            presentation of relapsed schizophrenia
REFERENCE   6  (bases 1 to 1851)
  AUTHORS   Oguri,M., Kato,K., Yokoi,K., Yoshida,T., Watanabe,S., Metoki,N.,
            Yoshida,H., Satoh,K., Aoyagi,Y., Nozawa,Y. and Yamada,Y.
  TITLE     Assessment of a polymorphism of SDK1 with hypertension in Japanese
            Individuals
  JOURNAL   Am J Hypertens 23 (1), 70-77 (2010)
   PUBMED   19851296
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (bases 1 to 1851)
  AUTHORS   Hoshino,A. and Fujii,H.
  TITLE     Redundant promoter elements mediate IL-3-induced expression of a
            novel cytokine-inducible gene, cyclon
  JOURNAL   FEBS Lett 581 (5), 975-980 (2007)
   PUBMED   17300783
  REMARK    GeneRIF: cyclon gene encodes a phosphorylated nuclear protein
            consisting of repetitive sequences in the amino-terminus and a
            coiled-coil domain in the carboxyl-terminus
REFERENCE   8  (bases 1 to 1851)
  AUTHORS   Girard,A., Sachidanandam,R., Hannon,G.J. and Carmell,M.A.
  TITLE     A germline-specific class of small RNAs binds mammalian Piwi
            proteins
  JOURNAL   Nature 442 (7099), 199-202 (2006)
   PUBMED   16751776
REFERENCE   9  (bases 1 to 1851)
  AUTHORS   Ahn,J., Chung,K.S., Kim,D.U., Won,M., Kim,L., Kim,K.S., Nam,M.,
            Choi,S.J., Kim,H.C., Yoon,M., Chae,S.K. and Hoe,K.L.
  TITLE     Systematic identification of hepatocellular proteins interacting
            with NS5A of the hepatitis C virus
  JOURNAL   J Biochem Mol Biol 37 (6), 741-748 (2004)
   PUBMED   15607035
REFERENCE   10 (bases 1 to 1851)
  AUTHORS   Beausoleil,S.A., Jedrychowski,M., Schwartz,D., Elias,J.E.,
            Villen,J., Li,J., Cohn,M.A., Cantley,L.C. and Gygi,S.P.
  TITLE     Large-scale characterization of HeLa cell nuclear phosphoproteins
  JOURNAL   Proc Natl Acad Sci U S A 101 (33), 12130-12135 (2004)
   PUBMED   15302935
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AP000777.4.
            
            On Nov 23, 2018 this sequence version replaced NM_024098.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC001378.1, AK025974.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000227520.10/ ENSP00000227520.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-770               AP000777.4         69785-70554
            771-900             AP000777.4         75596-75725
            901-975             AP000777.4         77612-77686
            976-1851            AP000777.4         77878-78753
FEATURES             Location/Qualifiers
     source          1..1851
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q12.2"
     gene            1..1851
                     /gene="CCDC86"
                     /gene_synonym="Cgr1"
                     /note="coiled-coil domain containing 86"
                     /db_xref="GeneID:79080"
                     /db_xref="HGNC:HGNC:28359"
                     /db_xref="MIM:611293"
     exon            1..770
                     /gene="CCDC86"
                     /gene_synonym="Cgr1"
                     /inference="alignment:Splign:2.1.0"
     CDS             13..1095
                     /gene="CCDC86"
                     /gene_synonym="Cgr1"
                     /note="cyclon; cytokine-induced protein with coiled-coil
                     domain"
                     /codon_start=1
                     /product="coiled-coil domain-containing protein 86"
                     /protein_id="NP_077003.1"
                     /db_xref="CCDS:CCDS7993.1"
                     /db_xref="GeneID:79080"
                     /db_xref="HGNC:HGNC:28359"
                     /db_xref="MIM:611293"
                     /translation="MDTPLRRSRRLGGLRPESPESLTSVSRTRRALVEFESNPEETRE
                     PGSPPSVQRAGLGSPERPPKTSPGSPRLQQGAGLESPQGQPEPGAASPQRQQDLHLES
                     PQRQPEYSPESPRCQPKPSEEAPKCSQDQGVLASELAQNKEELTPGAPQHQLPPVPGS
                     PEPYPGQQAPGPEPSQPLLELTPRAPGSPRGQHEPSKPPPAGETVTGGFGAKKRKGSS
                     SQAPASKKLNKEELPVIPKGKPKSGRVWKDRSKKRFSQMLQDKPLRTSWQRKMKERQE
                     RKLAKDFARHLEEEKERRRQEKKQRRAENLKRRLENERKAEVVQVIRNPAKLKRAKKK
                     QLRSIEKRDTLALLQKQPPQQPAAKI"
     exon            771..900
                     /gene="CCDC86"
                     /gene_synonym="Cgr1"
                     /inference="alignment:Splign:2.1.0"
     exon            901..975
                     /gene="CCDC86"
                     /gene_synonym="Cgr1"
                     /inference="alignment:Splign:2.1.0"
     exon            976..1851
                     /gene="CCDC86"
                     /gene_synonym="Cgr1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1833..1838
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CCDC86"
                     /gene_synonym="Cgr1"
                     /note="hexamer: AATAAA"
     polyA_site      1851
                     /gene="CCDC86"
                     /gene_synonym="Cgr1"
                     /note="major polyA site"
ORIGIN      
        1 accggctgag ccatggatac accgttaagg cgcagccgac ggctgggagg cctaaggccc
       61 gaatcccccg agagcctcac ctcagtttcg cggacgagac gggcccttgt ggagttcgag
      121 tcgaacccag aagaaacgag ggagcccggg tctcctccga gtgtgcagcg ggctggcctg
      181 gggtcccccg aaaggccgcc gaagacaagc ccaggatcac cccgtctgca gcagggtgca
      241 ggcttggagt caccccaagg gcagccagag ccaggcgcag cgtcccccca gcgtcagcaa
      301 gacctacacc tggagtcgcc tcaaagacag ccagagtaca gtcctgaatc cccacgatgt
      361 cagccgaagc caagtgagga ggcaccaaag tgttctcagg accagggagt actggcctcg
      421 gagttggccc agaataagga ggagctgacc ccgggggccc cccagcatca gctaccgccg
      481 gtcccaggat caccagagcc ttaccccggt cagcaagctc ccggtccgga gccctctcag
      541 ccactactgg agctgacacc cagggcacct ggctcccccc ggggtcagca tgagccgagc
      601 aagccacctc cagctgggga gacggtgaca ggcggcttcg gggcaaagaa gcgaaaaggt
      661 tcttcatccc aggccccagc gtccaagaag ttgaataaag aggagcttcc tgtaatcccg
      721 aaggggaagc ccaaatcggg gcgagtgtgg aaggaccgct ccaagaaaag attctcccag
      781 atgcttcagg acaagcccct gcgcacatcg tggcagcgga agatgaagga acgacaggag
      841 aggaagctgg ccaaggactt tgcccgtcac ctggaggagg agaaggagag gcgccgccag
      901 gagaagaaac agcgccgggc tgagaacctg aaacgccgcc tggagaatga gcggaaggca
      961 gaggtcgtcc aagtgatccg aaaccccgcc aagctcaagc gggcaaagaa gaagcagctg
     1021 cgctccattg agaagcggga caccctggcc ctgctgcaga agcagccgcc ccagcagccg
     1081 gcagccaaga tctgagctca ggacggcccg aggccttcca tggccaacaa ccatgtcaga
     1141 cacagcacct caggccgctg ctcagatgcc tctgctggag ctggcactcc aaacccatgg
     1201 ctccagaaca gggaccccca ccccgaccgg ggctcctcgg cctttgaagg cttccaggca
     1261 ggtctgtgtg ggacagaagc ccagaggggg cctgggacct ggcagagatg ggggcgggaa
     1321 gagattcagc tcccatccct ccttcctctc cttctccaag tgccttcaaa ccaagaactg
     1381 tacattcttc tggttcctca gtgagctggt gactggcagg tgactccctc agcagtgtat
     1441 gccctttctc agcatcctag gtccatccca ggcctggagg ctgacagttg ggaatccagc
     1501 ttcccccaca ccttcccaaa ggctgctctg agcacctcca caccccactg cctctgtccc
     1561 cagcagactg aatccggttc ctctccactt ttcaatactg aaagattaaa atggggaggt
     1621 tgcagggagc agagcttttc cctagcaccc actttcccaa accagtctct gcagaagccc
     1681 cagagaatct aactcatgcc tgtccagtct acagcaaaaa tatttattga gtgcctgttg
     1741 catacaggca caatcctagg caccggcaaa tacagacaat agaccaaagt ccctgccctc
     1801 gaggagcttt cattctgatg gagagaaaac ataataaaca agcaaaatgc a
//
