LOCUS       NM_001144995           16564 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens coiled-coil domain containing 85C (CCDC85C), mRNA.
ACCESSION   NM_001144995 XM_001723910 XM_001724833 XM_001726444 XR_040689
            XR_040690 XR_040691
VERSION     NM_001144995.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 16564)
  AUTHORS   Han,Y.W., Xu,S.X., Zhang,J., Li,Y.F., Xu,P., Lee,S.C. and Zhao,J.Z.
  TITLE     Cadmium promotes the binding and centrosomal translocation of
            CCDC85C and PLK4 via ROS-GCLM pathway to trigger centrosome
            amplification in colon cancer cells
  JOURNAL   Toxicol Lett 392, 84-93 (2024)
   PUBMED   38185225
REFERENCE   2  (bases 1 to 16564)
  AUTHORS   Yadav,L., Tamene,F., Goos,H., van Drogen,A., Katainen,R.,
            Aebersold,R., Gstaiger,M. and Varjosalo,M.
  TITLE     Systematic Analysis of Human Protein Phosphatase Interactions and
            Dynamics
  JOURNAL   Cell Syst 4 (4), 430-444 (2017)
   PUBMED   28330616
REFERENCE   3  (bases 1 to 16564)
  AUTHORS   Boldt,K., van Reeuwijk,J., Lu,Q., Koutroumpas,K., Nguyen,T.M.,
            Texier,Y., van Beersum,S.E., Horn,N., Willer,J.R., Mans,D.A.,
            Dougherty,G., Lamers,I.J., Coene,K.L., Arts,H.H., Betts,M.J.,
            Beyer,T., Bolat,E., Gloeckner,C.J., Haidari,K., Hetterschijt,L.,
            Iaconis,D., Jenkins,D., Klose,F., Knapp,B., Latour,B.,
            Letteboer,S.J., Marcelis,C.L., Mitic,D., Morleo,M., Oud,M.M.,
            Riemersma,M., Rix,S., Terhal,P.A., Toedt,G., van Dam,T.J., de
            Vrieze,E., Wissinger,Y., Wu,K.M., Apic,G., Beales,P.L.,
            Blacque,O.E., Gibson,T.J., Huynen,M.A., Katsanis,N., Kremer,H.,
            Omran,H., van Wijk,E., Wolfrum,U., Kepes,F., Davis,E.E., Franco,B.,
            Giles,R.H., Ueffing,M., Russell,R.B. and Roepman,R.
  CONSRTM   UK10K Rare Diseases Group
  TITLE     An organelle-specific protein landscape identifies novel diseases
            and molecular mechanisms
  JOURNAL   Nat Commun 7, 11491 (2016)
   PUBMED   27173435
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 16564)
  AUTHORS   Tanaka,N., Izawa,T., Takenaka,S., Yamate,J. and Kuwamura,M.
  TITLE     Ccdc85C, a causative protein for hydrocephalus and subcortical
            heterotopia, is expressed in the systemic epithelia with
            proliferative activity in rats
  JOURNAL   Histol Histopathol 30 (7), 823-832 (2015)
   PUBMED   25644709
REFERENCE   5  (bases 1 to 16564)
  AUTHORS   Wang,X., Lopez,O., Sweet,R.A., Becker,J.T., DeKosky,S.T.,
            Barmada,M.M., Feingold,E., Demirci,F.Y. and Kamboh,M.I.
  TITLE     Genetic Determinants of Survival in Patientswith Alzheimer's
            Disease
  JOURNAL   J Alzheimers Dis 45 (2), 651-658 (2015)
   PUBMED   25649651
  REMARK    GeneRIF: Genome-wide SNP analysis identified multiple suggestive
            novel loci and two of them were also significant in gene-based
            analysis (CCDC85C and NARS2) that survived after controlling for
            false-discovery rate at 0.05.
REFERENCE   6  (bases 1 to 16564)
  AUTHORS   Markham,N.O., Doll,C.A., Dohn,M.R., Miller,R.K., Yu,H.,
            Coffey,R.J., McCrea,P.D., Gamse,J.T. and Reynolds,A.B.
  TITLE     DIPA-family coiled-coils bind conserved isoform-specific head
            domain of p120-catenin family: potential roles in hydrocephalus and
            heterotopia
  JOURNAL   Mol Biol Cell 25 (17), 2592-2603 (2014)
   PUBMED   25009281
REFERENCE   7  (bases 1 to 16564)
  AUTHORS   Mori,N., Kuwamura,M., Tanaka,N., Hirano,R., Nabe,M., Ibuki,M. and
            Yamate,J.
  TITLE     Ccdc85c encoding a protein at apical junctions of radial glia is
            disrupted in hemorrhagic hydrocephalus (hhy) mice
  JOURNAL   Am J Pathol 180 (1), 314-327 (2012)
   PUBMED   22056358
REFERENCE   8  (bases 1 to 16564)
  AUTHORS   Heilig,R., Eckenberg,R., Petit,J.L., Fonknechten,N., Da Silva,C.,
            Cattolico,L., Levy,M., Barbe,V., de Berardinis,V., Ureta-Vidal,A.,
            Pelletier,E., Vico,V., Anthouard,V., Rowen,L., Madan,A., Qin,S.,
            Sun,H., Du,H., Pepin,K., Artiguenave,F., Robert,C., Cruaud,C.,
            Bruls,T., Jaillon,O., Friedlander,L., Samson,G., Brottier,P.,
            Cure,S., Segurens,B., Aniere,F., Samain,S., Crespeau,H., Abbasi,N.,
            Aiach,N., Boscus,D., Dickhoff,R., Dors,M., Dubois,I., Friedman,C.,
            Gouyvenoux,M., James,R., Madan,A., Mairey-Estrada,B., Mangenot,S.,
            Martins,N., Menard,M., Oztas,S., Ratcliffe,A., Shaffer,T.,
            Trask,B., Vacherie,B., Bellemere,C., Belser,C., Besnard-Gonnet,M.,
            Bartol-Mavel,D., Boutard,M., Briez-Silla,S., Combette,S.,
            Dufosse-Laurent,V., Ferron,C., Lechaplais,C., Louesse,C.,
            Muselet,D., Magdelenat,G., Pateau,E., Petit,E.,
            Sirvain-Trukniewicz,P., Trybou,A., Vega-Czarny,N., Bataille,E.,
            Bluet,E., Bordelais,I., Dubois,M., Dumont,C., Guerin,T.,
            Haffray,S., Hammadi,R., Muanga,J., Pellouin,V., Robert,D.,
            Wunderle,E., Gauguet,G., Roy,A., Sainte-Marthe,L., Verdier,J.,
            Verdier-Discala,C., Hillier,L., Fulton,L., McPherson,J.,
            Matsuda,F., Wilson,R., Scarpelli,C., Gyapay,G., Wincker,P.,
            Saurin,W., Quetier,F., Waterston,R., Hood,L. and Weissenbach,J.
  TITLE     The DNA sequence and analysis of human chromosome 14
  JOURNAL   Nature 421 (6923), 601-607 (2003)
   PUBMED   12508121
  REMARK    Erratum:[Nature. 2023 Aug;620(7973):E17. doi:
            10.1038/s41586-023-06403-y.. PMID: 37491470]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL160313.4 and AL110504.6.
            
            On Nov 23, 2018 this sequence version replaced NM_001144995.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803612.496694.1, BQ918944.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA2142670
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000380243.9/ ENSP00000369592.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1041              AL160313.4         107483-108523
            1042-1115           AL110504.6         114747-114820
            1116-1223           AL110504.6         128595-128702
            1224-1319           AL110504.6         133652-133747
            1320-1418           AL110504.6         134549-134647
            1419-16564          AL110504.6         135500-150645
FEATURES             Location/Qualifiers
     source          1..16564
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q32.2"
     gene            1..16564
                     /gene="CCDC85C"
                     /note="coiled-coil domain containing 85C"
                     /db_xref="GeneID:317762"
                     /db_xref="HGNC:HGNC:35459"
     exon            1..1041
                     /gene="CCDC85C"
                     /inference="alignment:Splign:2.1.0"
     CDS             249..1508
                     /gene="CCDC85C"
                     /codon_start=1
                     /product="coiled-coil domain-containing protein 85C"
                     /protein_id="NP_001138467.1"
                     /db_xref="CCDS:CCDS45161.1"
                     /db_xref="GeneID:317762"
                     /db_xref="HGNC:HGNC:35459"
                     /translation="MAKPAATAAAASEELSQVPDEELLRWSKEELARRLRRAEGEKVG
                     LMLEHGGLMRDVNRRLQQHLLEIRGLKDVNQRLQDDNQELRELCCFLDDDRQKGRKLA
                     REWQRFGRHAAGAVWHEVARSQQKLRELEARQEALLRENLELKELVLLLDEERAALAA
                     TGAASGGGGGGGGAGSRSSIDSQASLSGPLSGGAPGAGARDVGDGSSTSSAGSGGSPD
                     HHHHVPPPLLPPGPHKAPDGKAGATRRSLDDLSAPPHHRSIPNGLHDPSSTYIRQLES
                     KVRLLEGDKLLAQQAGSGEFRTLRKGFSPYHSESQLASLPPSYQDSLQNGPACPAPEL
                     PSPPSAGYSPAGQKPEAVVHAMKVLEVHENLDRQLQDSCEEDLSEKEKAIVREMCNVV
                     WRKLGDAASSKPSIRQHLSGNQFKGPL"
     exon            1042..1115
                     /gene="CCDC85C"
                     /inference="alignment:Splign:2.1.0"
     exon            1116..1223
                     /gene="CCDC85C"
                     /inference="alignment:Splign:2.1.0"
     exon            1224..1319
                     /gene="CCDC85C"
                     /inference="alignment:Splign:2.1.0"
     exon            1320..1418
                     /gene="CCDC85C"
                     /inference="alignment:Splign:2.1.0"
     exon            1419..16564
                     /gene="CCDC85C"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4644..4649
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CCDC85C"
                     /note="hexamer: AGTAAA"
     polyA_site      4664
                     /gene="CCDC85C"
                     /note="major polyA site"
     regulatory      4696..4701
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CCDC85C"
                     /note="hexamer: AATAAA"
     polyA_site      4722
                     /gene="CCDC85C"
                     /note="major polyA site"
     regulatory      5336..5341
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CCDC85C"
                     /note="hexamer: AATATA"
     polyA_site      5357
                     /gene="CCDC85C"
     regulatory      5466..5471
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CCDC85C"
                     /note="hexamer: AATACA"
     polyA_site      5492
                     /gene="CCDC85C"
     regulatory      16545..16550
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CCDC85C"
                     /note="hexamer: AATAAA"
     polyA_site      16564
                     /gene="CCDC85C"
ORIGIN      
        1 agaaccctga gagcgcccgg caccgcggcc gccgacgcag cagccgcctc cgctcgtcaa
       61 ccccgaggcg cgcgggctcc cgggcggccc cggcgggcgc ggcgagagga cgcgccaggc
      121 ggcgcggggc gggccgcacg cgcccccggc cgccccccgc ccgcgcgcgg accggcccag
      181 cggagccccg gcgcggggaa gcgccggccg ggcgagggcg agggcgatgc cgcggtgacg
      241 gccccgccat ggctaagccc gcggcgacgg cggcggcggc gtcggaggag ctgagccagg
      301 tgccggacga ggagctgctg cgctggagca aggaggagct ggcgcggcgg ctgcggcgcg
      361 ccgagggcga gaaggtgggc ctcatgctgg agcacggcgg cctgatgcgc gacgtgaacc
      421 ggcggctgca gcagcacctg ctggagatcc gcggcctcaa ggacgtgaac cagcggctgc
      481 aggacgacaa ccaggagctg cgcgagctct gctgcttcct cgacgacgac cggcagaagg
      541 ggcgcaagct ggcgcgcgag tggcagcgct tcgggcgcca cgcggccggc gccgtgtggc
      601 acgaggtggc ccgctcgcag cagaagctgc gcgagctcga ggcgcgccag gaggccctgc
      661 tgcgcgagaa cctggagctc aaggagctgg tgctgctgct ggacgaggag cgcgcggcac
      721 tggcggcgac gggggccgca agcggtggcg gcggcggcgg gggcggcgcc ggctcccgca
      781 gctccatcga cagccaggcc agcctgagcg ggccgctgtc gggtggcgcg cccggcgcgg
      841 gggcccgcga cgtgggcgac ggcagcagta cgtccagcgc gggcagcggc ggcagccccg
      901 accaccacca ccacgtccca cccccgctgc tgccccccgg gccgcacaag gcccccgacg
      961 gcaaggcagg agccacacgt cggtccctgg acgacttgtc ggcgccgccg caccaccgca
     1021 gcatccccaa cggcctgcac gatccctcat ccacctacat caggcaactg gagagcaaag
     1081 tgaggctgct ggagggtgac aagctcctcg cacagcaggc aggctccgga gagttccgca
     1141 cgctgcggaa aggcttctcg ccctaccact cggagtccca gcttgcgtcc ctgccgccct
     1201 cctaccagga ctccctgcag aacggcccgg cctgccccgc acctgagctg ccctcgcccc
     1261 cctctgctgg ctacagccct gcaggacaga agcccgaggc tgtcgtgcat gccatgaagg
     1321 tcctggaggt acacgagaat ctggaccggc agctccagga cagctgtgag gaggacctga
     1381 gtgagaagga gaaggccatc gttcgcgaga tgtgcaacgt ggtctggaga aagctgggag
     1441 atgcagccag ctccaagccc tccatacggc agcacctgtc tgggaaccag ttcaaggggc
     1501 ctttgtaggg ccactcttct gtggacgtgg actggccctg ctgggggtcc ccagggggag
     1561 tttcaggccc cagacacggg caggacctcc agcccagccc ctgtcttctt cctctgtggt
     1621 gaactgtaca taggacgctg cccgccctgg cccagctgcc atgggtccga tgcactggcc
     1681 caagccgcca tctcccgcct catacaccag caacctggga agacgagacg ctgcgactgt
     1741 tcctgcagca gagcggcccg gacgcctcat tccccctctg ggccctgggc tccatgagca
     1801 agaggctgca ggctgcttct gagatccagc ctgggaactg tccaggctcc tctgtcctgc
     1861 ctgggatgga ggggccactc atcaaaccct ctactccccg gctgccaccc acactggaca
     1921 gagaccacca ctacctgggt cttgacgcag gtggcaccac ttcttgccca aatgccgtgg
     1981 cctggcccca ggccccccaa gcactgggtc cccggcatgt ggacaaggcc actcaccaca
     2041 tctgtggctg gctggaggct gccctgggcc cttcctgtga ccctcagcct tggaggtcag
     2101 ggtgccctca cacctgggga tctgtgctca gccacccgat gcccgctgct ccttgctttt
     2161 ggaggtcatc cccctccccc ccagtctctg caatgtcccc ctgccaccct gtccaggcta
     2221 tgcccttctt gggctcctcc tgccccatgc ctgaggcacg tcccttttcg tggtttacat
     2281 gacaggccag taacaggaag ggcctgggga gagtttctgg gctgagccac atgtgatttt
     2341 cctgatgggc agcactgggc cacagctggg gctctggttg gctgtgacct cccccagggc
     2401 ctggctgcat cttgggtccc tgtggacaga gctgtgtagg ctgcagatga gagttctgtt
     2461 ctttttggga aggagcgtgt ctggccaggt tctgccttta gtttgtggtg tgacctttag
     2521 cagttcactc agcctgtctg ggctcttggt ggaaacaggt ctctgaggtt ccttttcggc
     2581 catgcttatg gctccaggtc atccagcgcc acagggcagg ggtcctcact gagggggcgt
     2641 gagccaacag ccgacggctg agggcgggcc gggtggagct gagttctgct gccttgcagt
     2701 cgctgcgggt ggagagttgc ctccccactc tgagcccgtg tcctcagtag taaaatgggc
     2761 agcataaggc cctcctcaca ggattctggc atcaagtgag atcttcagtg taaatgacca
     2821 tgtataaact gtaaagtgca atagaaaact gtgtgtgtga ggaaagtaag gcctagaggg
     2881 ggtgatgtgt ggcacatgac agggattttg atcccacagc tgcagcacgg ggacaggccg
     2941 cttccccaca tccgctcatg ccactgtaag cagccctagc tcttgggtcc aggacctcac
     3001 caggtcctcg tcagactcct gtgctcttcc aggggctgct cagccccacc tgaagagccc
     3061 agagaggctg tcttcctacc cagcaggtct catgcaggcc cagggctggg gatgcaggca
     3121 agaggaggga gatggccgcc ctgtccctct ccctagctgg cggctctatt ctgagcagtt
     3181 cttgctgccc gtttgctctc aggggaaagg ctcacgcccc ccatcttagc cccagggggg
     3241 taagtgggtg ctggtgatgg gatggtgtgg cgctcctgcc gtgggtgttg ccaggaggct
     3301 ctttgggaag gagtgtcgcc cggtcaggtg gtgcgctccc ggtcactagg ggtgtacacg
     3361 tgaagttggg tgaacacctg ctgctcatgg tacccagtga ttcttgcccg agtgggcagc
     3421 tgagcagagg cccctctggg tcttgcagtc caaagaaccg cagagtagcc caagggctgt
     3481 gggtccattt tgagtggcag ccaagtctgg gagcccgtgt gcatcatgtt tgggtcaggt
     3541 tggcgtggcc accactgaaa taagcaataa gtacgggctc ctggtacctg cggatctcct
     3601 gcaaacaggc ccagagaaca gccttgaagc cacctttccc ctcaagggga ctgaccctgt
     3661 ctttaatgct gcagtggcat ccagggatca gtggaacatt gctttgagaa ccctcctgct
     3721 gttacggagg cagcacaaag ctggtgaccc ctgagccaac acggcactgg gatggctttc
     3781 taggacagaa ccctgtcggc gactgtcaca tctcaaacta atagctgatt ttaaaagcca
     3841 gcagcagcga cgccatgtac ctgagtacag gtggcagttg cagagccgtg ggctgtagaa
     3901 ggtcagatgg ggcttcccac aggggaaatc tgggcatgct gtagctcagg gtgactccca
     3961 gctccgtcac tagcagggcg acccccttcc ttctggagcc ttagctctga aagcccccag
     4021 tgggggtgcc ctttcagatg ccccctttcc atttcaaagg ctctgactct tgatcttgaa
     4081 gccggacgcg gcactggcac tcggcttcag tttccactgt gacagatgga ggtctccttt
     4141 cgccccagcc caggtggcca agcccatcct ggcctcagaa catgctgagc acattttgta
     4201 gggtggcacc tttttatcca agttactagc tacacatcag tgtttaaaga gaaaaaagtg
     4261 acctttcatt ttttttttct tgaaacttga ggaaacaaga tacatactac tgattttttt
     4321 tttttcttaa aactaaatgc atgactgcag agcggtagag gtgtatattt ttcatactgt
     4381 ggggcaaagt atttgtgctg ctttttggag atggactgga acgtctggtt tctgtccccg
     4441 ggcccggcag ctacgtctat tttctgtaga aggtgccaca gtgagacctg gagccacccc
     4501 ttcctgccct ggcgccgttt agagctggga gcccgtggac tcccggcctg tttctacctt
     4561 ctattcaacc actctgacgt ggggagacaa gaagaaatag aactttttga tagtgtggta
     4621 aaaacattga tttgaactat tttagtaaaa ggagtaacaa acaagattgt gatagtgtct
     4681 actttgagct agataaataa aggcctcttt gtgagcctcc tggctgggtg ctcagtgctt
     4741 gtttctgtcg tgggtggcag ggtcagcagg cagagacagg gccaaggccc ctcaagcacc
     4801 gcagatgggg gctcagtcgg ggccccttcc acagacagag ccgtggcccc tcaaggtgga
     4861 cagtgaggcc gctgctcctc cagctgcctc tgtctcatca caggccagaa gtggaaaggg
     4921 tttcaaatcc aagcccccgg gttcctgtgt gcgttctacg cagcaaggct tcaaagtttc
     4981 aaactggttt ggaactcaac caggtcctcc aaaggaaacc aaggcaggca caggatgggg
     5041 gcaggctggc ttggcaggca gctgtgcgga tccacccaga gtgccttggg aggcagtggg
     5101 gttggctgtg gctgctgtga gctgcagcca ggcctctccc gcgtccccag ggtctggaag
     5161 gagggcctct gcacatttta taagccacag actgcgaagg cctggagccc caccttccac
     5221 ccataacaaa gaaagggata gtttcagaac tgcttttatt tggataactg actgaaggag
     5281 tctcatttgt aaccaagatg gaattcacag tatgttgtta cattcacact taaaaaatat
     5341 atctctatgt acaggaattt gcaaagagat gtaaacatac attaatttcc aagtacattt
     5401 ctccccttct ccctggagga aaaaaaaaaa gccatccaat gaggcaaccc cttcaaaata
     5461 attttaatac aaaggatgca aacatctata aatgaaaaat gtggttcttc tgccccttct
     5521 gggtgtcatg ggagagaatg tcaccgaatg aaaatgacaa cagcttggct tcagatggaa
     5581 ttggactatt taaaattgag tttccaggaa aaataggcac tgatttctag aaggaaatta
     5641 actccttacc gaagctattt attgagccaa tatggctggt taacgtcctc actagtataa
     5701 agtaacccag tgcaggactc tcagacatta gctgaaccaa gtgtacacag tcagactgca
     5761 agggcactga tgaggctact ctgaaagctg gttgtccccg tcctctaggt gtgaggacca
     5821 ctctgatttt atcccagggg cccggtccat tcttcccata ctgcaactgt cgtgcattat
     5881 acaaggtacc ctgctgctta cccacttcaa ctactctgca agtcgattag aaaatcttgt
     5941 taaaaaaaca aagagggaaa aaaggctcac gttatctcat ccaggctgcc cgccccagcc
     6001 ccccaactgg aggcatgccg ggtgggggaa tgggcggggg cacaggaggc tgtcctccag
     6061 gggggacggc aggaggtggg tagctggctg gcggcaggcc caaccctgga ggaggatgag
     6121 gggggactgc gtgggtaggc gggaggcgtg ggggtggggg tgggaagttg gggttgtagg
     6181 tgggtggggg tggggggtag ccaggagtag ggggtgggat ggcaggtggg gggaaggagg
     6241 ctgggggagg aggcacaggt ggcgggggcg ggttgggcgg gtagacatgg gggtggtagg
     6301 gcaggtgtgc aggtgggccg taggcggggg gcagggcacc gtaggagggt ccctcggtct
     6361 tcatcatgga ctgcaggctc tggtagccct ctccagacat gtaggagctg gtggtggaca
     6421 tcccggtcat gtagctggag gggggtgggg gcgggggccg gtgtggcagc ggcggtggct
     6481 ggtgcacagg ggccgggtgg gccggagggg gaatctggac tttggggagg tcagtggcat
     6541 ccacagggcc cggcggctca gcctcaccta aggcagcagc gaggggaggc ttccggtctg
     6601 caggagagag acgcatcagt gcccggcctc cgccagcaat ggttgctttt tcagtgcctc
     6661 ctggcccttc agggccatct ttacagagga gcagggagca gctgcccgcc tcctctgtgg
     6721 cccaacgcat gggcccatgc cccatgtcct gatgccacca gatgtctccc caccatctgt
     6781 caagaaggcc ctccaccctg tctgcgacga cctggggttt tccctccctc agccctgacc
     6841 acaccaccta caggcagtct cggcagcacc cgaagccccc ttgtgccctg gccccagccc
     6901 cctcttccta gtgcaaaacg tgtgggggct cctctgtttt tctgccttca gaaactgacc
     6961 ccaggggtca gggccacact gaactcctgt ctgcagcagt ggcattttgc agaaaacctc
     7021 agagttagtc aaatgaatgt gatggcactt aaaacaattc tgtacaagtc tctgacattc
     7081 ccggtgtacc catcgaagca gcaattcagg ttctattcta ctcaagagag gctacatcaa
     7141 accccactgt gtgctctcag atagcagcct ccttgagagg agtgtgtgca tgtgtgtgcg
     7201 tgtgcgtgct gcgtgcgtgc tgcatgtctg tgcgtgctgc gtgtgtgtgc gtgctgcgtg
     7261 tgcagcaggg acaggcagca ctaggtgttg agcacgccca agatactcgt gctcagaacc
     7321 agcctcaggc ccctcccaca gcgcctccca acccatgagc cctcacgccc ccttctgcca
     7381 aagccttatt taacatgttt tggcctgtga tcccgggtca ccgtcagacc actggaaaat
     7441 gacatcgcaa caccccacca caggtagcca aacacacaga atgagtgtcc tttcccaagg
     7501 cagcccagga gacagaccac aggagcaaca tttctggttc cagagaacat agagaggaca
     7561 aagccacgaa gatgcttctg gttccccagg cacttgggtt aggcaaggca cagcacgaca
     7621 tcctggttgg gtagacgtgg ccattggcac acaacccgtt tgatcttgcc aaagcgagca
     7681 tgagcaggat ttcatcaggt cggtaacagg tgtgccactg gtgtgccaca tcagcacccc
     7741 gccagcctac cgggtaggaa ggtcatatgt gcctggcctt agataactgg ctttggctcc
     7801 aggtcagggc cagatgccct gtggttctag gagctgacta aaaaagaggt gcagaaaagt
     7861 gctgacaccc ttcaatgcct cctgtgtgtc actccacagc cacctgggcc cacaggcctg
     7921 ctcctccacc ttgcagaaat caacttttcc aacactcgac cctgtagcct gaatcttcaa
     7981 gtcaccagtg tgcctgccct tgtgctgtgt gactgagctg gaacagcaag tgggggtctc
     8041 tcctgggcac cccattccct ctctgtacac ttgctcctga ccaagtccca cacactgcca
     8101 ccaaactgct ccctaaacat cactgctgac ctgaatgcct cttcccatgg cctagggcct
     8161 cccaggaagc gtacttccct cccttcctca cggcccagct ttactgcgcc tcccaggccc
     8221 tgctctcttc agccatggcc tcctggcagt gtatctggca cccaggtccc actcaagtcc
     8281 caggcctact cctggctatc tgtaatgggg gagggagcag agctctgagg cctccacagc
     8341 agctactcag tgccctggag gtagcagcac ccctgtggct gccccaggct ccccagataa
     8401 accacccatc tcctcagtga aggcacagcc ccaggctcgg accaggggaa ctgcacttgg
     8461 cgaggaggtg ctccataaat gcttcatgag caaccacagg catttaagta aggttcatat
     8521 tgaattgggg gttttgggat ttggccccaa agtggaaaat gacgcctctg ttctcccaaa
     8581 gcacaaacac tatcatgatt gagtaggaac agaaatgtaa tctgtggcac atctgttacg
     8641 ggcacacagt gctgtcagcc ccagtgtgag ccacgtgcac cgaccaacag tgagtgtagc
     8701 aggctggagg agctgctgac agaggcttgg aagcctccgg agtatcgacc accttttgga
     8761 gagcaagcac aggtcactct ggccttctct agcgcatcac cttctgaaat ggtgccacag
     8821 gtaaagaatg ccatctactt tacagctttt ctcctctatt gccagcggta tcagagaggc
     8881 tttccagctt accatgtact acttgttgag aacttttcac tctttcattt actctctgta
     8941 caattgctta ttcttcagaa tgcactaaga cgacacactg ccaataggaa gcaggtgtag
     9001 gggcggccgg agcctagtag ccacagtaac cctgcctcta tctcagaagg cggggtttgg
     9061 ctttctttcc taaaactgat tctaatacaa tgtgtagttt agcatttctg gatgtgagag
     9121 gtcggaaaat attcagatat acttaacaat ttacaacatt ctcaaaatac ctggtcaaaa
     9181 tcagaacttt gagacacggt ctccctctca cccaggctgg agtacggtgg tgcaatcata
     9241 gctcactgca gccttgactg cccagggctc aaatgatctt cccatctcag actcctaagt
     9301 agttgggact acaggtgtgt gctaccacac ctggctaatt ttttagacag ggtctcactt
     9361 tgttgcccag gctgacctcg aactcctggg gtcaggtgat tctcctgcct ccgcctccca
     9421 aagtgctggg atcaaaaaca caagccattg tgcccagccc aagaacaatt ttgcaaagat
     9481 tcctgcctgt ggctgacatt gtcaatctgg gccccagtct cccttttcta agttcccagg
     9541 acctgctgcg tccaacattc agaggcgatg tgcacagctg gccaagctgc ttcagcagat
     9601 gcttacctgg aggtgggtgg gctggaggca acggtggatg agtggtctca attttgggga
     9661 ttttaggtgg tggtggttct acaaagaaaa agcagattag aaaaccactc atacttcttc
     9721 acatgaataa gcatgtcata aagaaaaatg tactggcaga gatttctttg ggagaaaaac
     9781 aacagagatg accaaggctt taagggaact tgaagaaggt ttcagctaaa ccattatgca
     9841 tgaatcctgt taacaaatta aatgccacct ccctccaaaa gacctgcgag cttcccacag
     9901 gcagcccatt ttccatgtct acctaagttt ccttgctgac cacttcactc aagtccttcc
     9961 gaccatgtga gaccagcaga gcaacgtctt catgagcatg tatgacctat ctggagtcct
    10021 ccctggtaca gaggacacaa agaagggtcc agagtagcaa catcatgtca ctgagtcccc
    10081 tgagggttcc acaagagaat ctctatcttt tcattcttag acatagttta ttctctcttt
    10141 cccaaatact gacttccagt tggcagcatg tcagaagcag cacattaact ggagtcagca
    10201 gagctctgga ggttgacaca ctgatggcag gaagaatgtg ccgctcacaa aagcccagca
    10261 gtcaggaccc cttgaggtgg aggaaacagc ccacccttcc ggggtcaggc agcggcacgc
    10321 agccagaatc cacaatgaca gcactaggtc tccaaggcag cccaagggaa gtccaatctc
    10381 atccgtttaa gaaggcagcg tgcacatcac aactgaaaaa gaaccctatt tttctgtttg
    10441 catgctgagg ctttttcttc ctgaaatgta ctttcttctg gcttgtacac cactcagatc
    10501 tgagtctcct ctgccatcac tggcctcttt ctctggattt cctccatctc aaatacaggc
    10561 tcaatttaag ttccagggac ttcctctctc ttcaccctct tcctcagagt ccaaagcccc
    10621 tctctaagtg gacaactaca aacctacatt tctagcgtcc atcttgccac caaaaccatg
    10681 gcccatccct agacccacca atcagcacct cacactctac cttttgcctc tgtatcctat
    10741 aactgctatt actctcacct cagggaccca cctcctgcct ttttccacag ctggtaatag
    10801 ttagctaaag ccgtctacat cagggctgtc caacagcaat ataactgaga gccacatatc
    10861 tacaatttta aactttccag gagccatttt attttttgag acagggtctc gctctgtcac
    10921 ccaggctgga gtgtagtaat gtaatcatgg ctcactgcag cttcaaccaa ccaggctcaa
    10981 gtgatcttgc tgcctgagtc tcccaagtag ctgggaccat aggtgtggcg ccaccacgcc
    11041 gagctgattt ttaagttttg tgtagtgatg gggtcaccct atgtggccca gtctggcctg
    11101 gaactcctgg gctcaaagca tgccttggcc tcccaaagtg ctgggattac aagtgtgcca
    11161 ggaaccactt taacaagaaa aaggagcact ccagcctgca ttaacagagc aagactctgg
    11221 aaataaaagg aaaaaggata aaatttattt aacccgatag atcgaaaatt ttatttcaac
    11281 atgtaaccaa tataaagctt tactaatgag atgtcttacg ttctcctttc ttggaaatct
    11341 ctgtgtattt tgcattgtca gtgcttcaga atttgaccca gtcacatttc gagtgcttgc
    11401 agccctctgc agccagtagc cttcggcatg gcacagtgca gctgagttcc tctataaagc
    11461 ttcctccgga tctgcccttc ctgccccgca gccagcatgc tgaggccacc atgtttccca
    11521 tgagtgccag caagattctc cccattccta accacttgcc ctatttactg ctgccagggg
    11581 actccttctc aaatgaattt agactctgcc attcccctgc taaatctcca atggcttccc
    11641 ttgcctctgc caaactcaca gtcctccagg taaactctgt gatctggtcc taacccacat
    11701 tttagatcct atcagaagct attgcctttc aattcatcac attccagaaa gactcctctc
    11761 catttcccct gattctcaat tcctttgctc acttgcgtac ttccaactta ttgctccatc
    11821 ctccccctct gctctcgctg ctcaaatgca actcttcctt caaggtcata tatagtttgt
    11881 ttcctgcctc tgacagacct gcacgtcaac tcaattgcat ttcatgtggc atggagtgta
    11941 gcccgttctt gtgtctaaca tttaatgtcg gtcaatttga agctaattaa aaaattcacc
    12001 tgtaggctgg gcacggtggc tcatgcctgt aatcgcagca ctttgggagg ctggggcgag
    12061 cagatcacct gaggtcggga gtttgacacc tgcctgacca acatggagaa accctgtctc
    12121 tactaaaaat acaaaattag ccaggcctgg tggtgcatgc ctgtaatccc agctactcgg
    12181 gaggctgagg caggagaatt gcttgaaccc aggaggcgga ggttgtggtg agttaagatt
    12241 gcaccgctgc actccagcct gggcaacaag agtgaaactc tgtctcaaaa aaaaaaaaaa
    12301 aattcacctg tactgaactc atcattccct caaatatact ggaaaaaaaa aaaaagtagc
    12361 tctatcataa ctggaagatt tcacagcagt ttaatgaatg gaactaagaa ccgagaacat
    12421 ggttctaaga accaggaact actggaacta agaaccaagt aacaaagaaa gacaaatgag
    12481 tcaatagggt ctgtgccttc aaagagttca gtatgatagg tggactgacc ctgtgacaaa
    12541 acatttctaa ctttctgttt tgtaattgtt ccaattttgc tcactccttc tgtttatttc
    12601 caatattgac atgaactaac tttgggttct agacatgtga cagcacctca acccaagtgt
    12661 gtttcaaaga ggccttgcct gcaagggcag ctgggctggg ccgggctggt gctgtccggg
    12721 cagcacacca ccccctactg cccccccgca tctgctgtgg cttggtgctt gggagaggac
    12781 tcctgctgct gtgatggggg taaatagtct ctaaaaataa aattgcagca acagttctcc
    12841 tacagccata attatacttt tatatatgtt actgagtaca tttttattgc cagtaatgtt
    12901 ttctgtactg atagcttcgt aagagcacaa ttttagaatc tatgatcagg tgatgaacag
    12961 aaagacaatg ctgatggaaa agttttgtat gagctctaaa gttaagattt aaggccaatt
    13021 tagatctgaa aagaaacaat gttggctaag aatttaaagt tttgcatata aacacataaa
    13081 actaaaaaaa catcagaaca ggaaattacc tgctgctttg ttctcttctt tgggagaaac
    13141 aacctgttac aaaagaaaat acacaattgt taactgggat cctgagtatg atgagaaaaa
    13201 aatggattat ccaggtacca ccagaatcag cgacggcagt cactgtgaac agcctcggac
    13261 aaaaattatt tctagcctga actttcaggg caaaccacgg cacctaccag atcatcattt
    13321 ctgctccctt cctctttcca tttaccaaat aagacagaat gactagcttt cctgaatggt
    13381 gagttctgag taaacactaa gtttcaggac cacttgggtg caggaaacgg tccactgttt
    13441 ggggtcaggc agctgcacag aagcagcatg cacaacgaca ctgctaggac acggcaacga
    13501 caccgacagg cttcagaacc ctggcaggga tgaaacaggc agcagggctg gagccgggca
    13561 gagagccccc tcctggttct cagaggcagc ctgtccttgg agcacctttg ttttcaggct
    13621 ccccaccgac aagcagtcgg actgcgagtt tcggcgaaca ccccctgctt ccggtgttcc
    13681 ctgtgctcgc ttagaaatgg gaacagtgct caggtgttgc cgccacctgg aaagcctgct
    13741 ctacccaggg cctgctttag cccactcacc acggctcgct taacctgtcg gggagaactg
    13801 ggctgcggag agggtttctt gggctgttgg gctggctgct gctgctgggc tggttgctgg
    13861 gggtccttct gctggggctg ggatggttcg gagctttgag acggctgtga ctgctgtact
    13921 tgcggcactt gtggtgtagg ctgaagagat gggggctgtt gcagctgatg gggggtgtga
    13981 tgaggcatct gttgttttcc ttgtgagtaa agatccagga tttggtggca gatgtctaaa
    14041 tgatagccaa caattacatt ttacacaaat tggtatttta aataaaattt tacctggata
    14101 aagaatcagt tatgataccc ctacgaggac ctaagcatga atcacattta caactcaccc
    14161 catcttcgtt gtgtgcaaca ctggtgtgta tttttagttt accaaaagta tgtgtttgga
    14221 caaagtggaa actattagat aatttaatta atgatgcttc tgaaatattg ctcacatatg
    14281 tctatctggg aaaatccatt cttgggactc agggtacaca tggaagaatc atctcaacat
    14341 ggaacaccct cacgagaacg cttagcatgc ctggtacctt ccaaaacgtc gaccgggaca
    14401 tcttgaacaa actgctccca ccatctccta tacatgggtt tggaggtcca ttcttgtatt
    14461 tcaaatttgc acaaacgtcc tgcgagatac atcactgcta ctgctatgat ctctggttcc
    14521 cactgcagtg acaaggtggt gcagagacta gttcaacaag aaaaaaaaag gttagataat
    14581 atgatctaat atttatgatt aaaccagtgc atggagatgc cataactaac cattaatttg
    14641 cttattctcc cctaaattta attaaagtac tataaataaa taaactcaag tctttactct
    14701 tctaaaggta cccgactaag ttactttaac catagttagt aatttctcta ttccttaaag
    14761 aatcagaaga attctagcac atccaaaaat tgctacacca atgaaaatga cttatgttat
    14821 ttaaactgtt gaaatcctag ccactcaact gtttcttcaa atgaaatctt atggaggaag
    14881 tcaaatgtaa gagaagcttc actgactgca gtgggatggg gctggcagca actccattca
    14941 caggcattct gtttcccacc acggcccctc attagatccc tggcctctca aaagagtgtt
    15001 aaggctctaa aactatacca ggaagtatat ttttgcaaaa ccaaatgggc tctaagtaat
    15061 tagttttcaa aattctccag tgtattgttt tggacttatg tttcagactg gtgataaaat
    15121 ttcagcacct cacaacacca tgacacggca gggcagaagg aaaccctctg ccgggaagca
    15181 gatgacctgg acgtcagccc cagctttgcc attaactggc tcctcaagcc agggcaagtc
    15241 agtttcttct gacacaaaat gaggggttta gatgaaatgg tccataaagt ctctgcctat
    15301 tttaaaatac tgtaattaat caacatttga acatgtatac ctgtcattta caaatgtcca
    15361 tgccatttga accaactttt gaattttgtt tttatcacct agaaatgggg acaaaaaggt
    15421 aaattaatag caatagaaaa attcacaggc agcatcaagt atttattaaa aacctaccac
    15481 gtgttcagca ccactcaaat acacagcaaa gagcttttgc gtgggaaaca aggatgaatg
    15541 atgtgggtcc acatcctacc ccttcttcct cctcatgacc tacgctgaac caccatgtat
    15601 ggaaaacctg gctccaaggc taagtttatt agtccattta aaaaattctg cctcattttc
    15661 ctgcctctcc catcacttgg caactggatg acagagcctg tttatacata aaaggaaaca
    15721 gcattagcag ctgcaatgct gaattgactg agcaagccat gcccttggta tttcacacat
    15781 caaactttgt tttccgcttt tgagaagcgt aatttgagtg tcatcaaatt ataaagactt
    15841 gatttcagaa tgaaaaaatt cttctgaaaa ctttcttctt acctttgagt tgctttgcat
    15901 attttagtag gaactggtat ggatgttcta cctgtaaatc aaacttgatg gtctgcagta
    15961 agattctctc cagaaccatt acttcctcct aaaaatcaat cacaaatgtt aggacagtaa
    16021 ttacaattgc aggtctcaag cagcattaca aaagtgagct ttcctgtcta tttattctct
    16081 cttcaagtta tattttagca actgcctttc cttcctttct ctcccactca gacttttaac
    16141 atgctcagag acactgataa attctgaaaa gatctcaaac aggaagacaa agcagaggtg
    16201 taatgtaaaa aaaaatactg aaaacaaaag atccttaaaa atattattat tttcaataca
    16261 tacatgagtc tccctttaca aaacagatct ttacgttatt gataatttga ctaaattgta
    16321 atttctttca agacctcaaa ttttaaaaat gcaatctttt aggaattttc attgaaaaca
    16381 ttttaagcaa gaaagagttt atgatagcca gcctcatgaa aactcagaga taaattgtac
    16441 cagtgtgtgt gtatgtgtgt gtatatatac tcatgtacac atatagtgta ttacgtgcaa
    16501 atgggggcaa atcaattttg tgtttaaatc tttcatttat ttgaaataaa tcatcccaac
    16561 aaca
//
