LOCUS       NM_006848                963 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens coiled-coil domain containing 85B (CCDC85B), mRNA.
ACCESSION   NM_006848
VERSION     NM_006848.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 963)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 963)
  AUTHORS   Feng,Y., Gao,Y., Yu,J., Jiang,G., Zhang,X., Lin,X., Han,Q.,
            Rong,X., Xu,H., Li,Q., Qiu,X. and Wang,E.
  TITLE     CCDC85B promotes non-small cell lung cancer cell proliferation and
            invasion
  JOURNAL   Mol Carcinog 58 (1), 126-134 (2019)
   PUBMED   30242906
  REMARK    GeneRIF: High CCDC85B expression is associated with non-small cell
            lung cancer.
REFERENCE   3  (bases 1 to 963)
  AUTHORS   Zhong,Q., Pevzner,S.J., Hao,T., Wang,Y., Mosca,R., Menche,J.,
            Taipale,M., Tasan,M., Fan,C., Yang,X., Haley,P., Murray,R.R.,
            Mer,F., Gebreab,F., Tam,S., MacWilliams,A., Dricot,A., Reichert,P.,
            Santhanam,B., Ghamsari,L., Calderwood,M.A., Rolland,T.,
            Charloteaux,B., Lindquist,S., Barabasi,A.L., Hill,D.E., Aloy,P.,
            Cusick,M.E., Xia,Y., Roth,F.P. and Vidal,M.
  TITLE     An inter-species protein-protein interaction network across vast
            evolutionary distance
  JOURNAL   Mol Syst Biol 12 (4), 865 (2016)
   PUBMED   27107014
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 963)
  AUTHORS   Markham,N.O., Doll,C.A., Dohn,M.R., Miller,R.K., Yu,H.,
            Coffey,R.J., McCrea,P.D., Gamse,J.T. and Reynolds,A.B.
  TITLE     DIPA-family coiled-coils bind conserved isoform-specific head
            domain of p120-catenin family: potential roles in hydrocephalus and
            heterotopia
  JOURNAL   Mol Biol Cell 25 (17), 2592-2603 (2014)
   PUBMED   25009281
REFERENCE   5  (bases 1 to 963)
  AUTHORS   Navarini,A.A., Simpson,M.A., Weale,M., Knight,J., Carlavan,I.,
            Reiniche,P., Burden,D.A., Layton,A., Bataille,V., Allen,M.,
            Pleass,R., Pink,A., Creamer,D., English,J., Munn,S., Walton,S.,
            Willis,C., Deret,S., Voegel,J.J., Spector,T., Smith,C.H.,
            Trembath,R.C. and Barker,J.N.
  CONSRTM   Acne Genetic Study Group
  TITLE     Genome-wide association study identifies three novel susceptibility
            loci for severe Acne vulgaris
  JOURNAL   Nat Commun 5, 4020 (2014)
   PUBMED   24927181
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 963)
  AUTHORS   Lim,J., Hao,T., Shaw,C., Patel,A.J., Szabo,G., Rual,J.F.,
            Fisk,C.J., Li,N., Smolyar,A., Hill,D.E., Barabasi,A.L., Vidal,M.
            and Zoghbi,H.Y.
  TITLE     A protein-protein interaction network for human inherited ataxias
            and disorders of Purkinje cell degeneration
  JOURNAL   Cell 125 (4), 801-814 (2006)
   PUBMED   16713569
REFERENCE   7  (bases 1 to 963)
  AUTHORS   Bezy,O., Elabd,C., Cochet,O., Petersen,R.K., Kristiansen,K.,
            Dani,C., Ailhaud,G. and Amri,E.Z.
  TITLE     Delta-interacting protein A, a new inhibitory partner of
            CCAAT/enhancer-binding protein beta, implicated in adipocyte
            differentiation
  JOURNAL   J Biol Chem 280 (12), 11432-11438 (2005)
   PUBMED   15644333
  REMARK    GeneRIF: DIPA is a novel partner of C/EBP beta that down-regulates
            early events of adipogenesis.
REFERENCE   8  (bases 1 to 963)
  AUTHORS   Long,M., de Souza,S.J. and Gilbert,W.
  TITLE     Delta-interacting protein A and the origin of hepatitis delta
            antigen
  JOURNAL   Science 276 (5313), 824-825 (1997)
   PUBMED   9115212
REFERENCE   9  (bases 1 to 963)
  AUTHORS   Robertson,H.D.
  TITLE     How did replicating and coding RNAs first get together?
  JOURNAL   Science 274 (5284), 66-67 (1996)
   PUBMED   8848724
REFERENCE   10 (bases 1 to 963)
  AUTHORS   Brazas,R. and Ganem,D.
  TITLE     A cellular homolog of hepatitis delta antigen: implications for
            viral replication and evolution
  JOURNAL   Science 274 (5284), 90-94 (1996)
   PUBMED   8810253
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AI583181.1 and BC008796.2.
            
            On May 17, 2019 this sequence version replaced NM_006848.2.
            
            Summary: Hepatitis delta virus (HDV) is a pathogenic human virus
            whose RNA genome and replication cycle resemble those of plant
            viroids. Delta-interacting protein A (DIPA), a cellular gene
            product, has been found to have homology to hepatitis delta virus
            antigen (HDAg). DIPA interacts with the viral antigen, HDAg, and
            can affect HDV replication in vitro. [provided by RefSeq, Jul
            2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: BC008796.2, SRR1163658.240507.1
                                        [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000312579.4/ ENSP00000311695.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-13                AI583181.1         208-220             c
            14-963              BC008796.2         48-997
FEATURES             Location/Qualifiers
     source          1..963
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q13.1"
     gene            1..963
                     /gene="CCDC85B"
                     /gene_synonym="DIPA"
                     /note="coiled-coil domain containing 85B"
                     /db_xref="GeneID:11007"
                     /db_xref="HGNC:HGNC:24926"
                     /db_xref="MIM:605360"
     exon            1..963
                     /gene="CCDC85B"
                     /gene_synonym="DIPA"
                     /inference="alignment:Splign:2.1.0"
     CDS             112..720
                     /gene="CCDC85B"
                     /gene_synonym="DIPA"
                     /note="hepatitis delta antigen-interacting protein A;
                     delta-interacting protein A"
                     /codon_start=1
                     /product="coiled-coil domain-containing protein 85B"
                     /protein_id="NP_006839.2"
                     /db_xref="CCDS:CCDS8120.1"
                     /db_xref="GeneID:11007"
                     /db_xref="HGNC:HGNC:24926"
                     /db_xref="MIM:605360"
                     /translation="MEAEAGGLEELTDEEMAALGKEELVRRLRREEAARLAALVQRGR
                     LMQEVNRQLQGHLGEIRELKQLNRRLQAENRELRDLCCFLDSERQRGRRAARQWQLFG
                     TQASRAVREDLGGCWQKLAELEGRQEELLRENLALKELCLALGEEWGPRGGPSGAGGS
                     GAGPAPELALPPCGPRDLGDGSSSTGSVGSPDQLPLACSPDD"
     regulatory      942..947
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CCDC85B"
                     /gene_synonym="DIPA"
                     /note="hexamer: AATAAA"
     polyA_site      963
                     /gene="CCDC85B"
                     /gene_synonym="DIPA"
                     /note="major polyA site"
ORIGIN      
        1 cactgcctgc cgcgtgcgga gccggagccc gagcctgagt ggcgccgggc ccgacgtggg
       61 gctcctgggc cgcggcggcg ggcgggcgat gctccagagg cctgaccagc catggaggcc
      121 gaggcaggcg gcctggagga gctgacggac gaggagatgg cggcgctagg caaggaagag
      181 ctagtgcggc gcctgcggcg ggaggaggcg gcgcgcctgg cggcactggt gcagcgcggc
      241 cgcctcatgc aggaggtgaa tcggcagctg cagggccacc tgggcgagat ccgcgagctc
      301 aagcagctca accggcgtct gcaggcagag aaccgtgagc tgcgcgacct ctgctgcttc
      361 ctggactcgg agcgccagcg cgggcggcgc gccgcacgcc agtggcagct cttcgggacc
      421 caagcatccc gggccgtgcg cgaggacctg ggcggctgtt ggcagaagct ggccgagctg
      481 gagggccgcc aggaggagct gctgcgggag aacctagcgc ttaaggagct ctgcctggcg
      541 ctgggcgaag aatggggccc ccgcggcggc cccagcggcg ccgggggatc aggagccggg
      601 ccagcacccg agcttgcctt gcccccgtgc gggccccgcg acctaggcga tggaagctcc
      661 agcactggca gcgtgggcag tccggatcag ttgcccctgg cctgttcccc cgatgattga
      721 aggcactgct tcctccacgc cgacgcccgc ccggattgct ccccgagccc cgggaccgct
      781 gtggacctcg ggacctggac gccgtcctgg ctgcgcagga ggggccgctg gcatggacta
      841 agaaatcctg acaccaagaa gggcccctcg ctcttgctgg cagggcagca gggggactga
      901 aggctggagc ggagggactt gctgggggtt ggattggggg taataaaccc ggacggaagc
      961 gga
//
