LOCUS       NM_001080433            4114 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens coiled-coil domain containing 85A (CCDC85A),
            transcript variant 2, mRNA.
ACCESSION   NM_001080433 XM_055636
VERSION     NM_001080433.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4114)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 4114)
  AUTHORS   Perry,J.R., Day,F., Elks,C.E., Sulem,P., Thompson,D.J.,
            Ferreira,T., He,C., Chasman,D.I., Esko,T., Thorleifsson,G.,
            Albrecht,E., Ang,W.Q., Corre,T., Cousminer,D.L., Feenstra,B.,
            Franceschini,N., Ganna,A., Johnson,A.D., Kjellqvist,S.,
            Lunetta,K.L., McMahon,G., Nolte,I.M., Paternoster,L., Porcu,E.,
            Smith,A.V., Stolk,L., Teumer,A., Tsernikova,N., Tikkanen,E.,
            Ulivi,S., Wagner,E.K., Amin,N., Bierut,L.J., Byrne,E.M.,
            Hottenga,J.J., Koller,D.L., Mangino,M., Pers,T.H.,
            Yerges-Armstrong,L.M., Zhao,J.H., Andrulis,I.L., Anton-Culver,H.,
            Atsma,F., Bandinelli,S., Beckmann,M.W., Benitez,J., Blomqvist,C.,
            Bojesen,S.E., Bolla,M.K., Bonanni,B., Brauch,H., Brenner,H.,
            Buring,J.E., Chang-Claude,J., Chanock,S., Chen,J.,
            Chenevix-Trench,G., Collee,J.M., Couch,F.J., Couper,D.,
            Coveillo,A.D., Cox,A., Czene,K., D'adamo,A.P., Smith,G.D., De
            Vivo,I., Demerath,E.W., Dennis,J., Devilee,P., Dieffenbach,A.K.,
            Dunning,A.M., Eiriksdottir,G., Eriksson,J.G., Fasching,P.A.,
            Ferrucci,L., Flesch-Janys,D., Flyger,H., Foroud,T., Franke,L.,
            Garcia,M.E., Garcia-Closas,M., Geller,F., de Geus,E.E., Giles,G.G.,
            Gudbjartsson,D.F., Gudnason,V., Guenel,P., Guo,S., Hall,P.,
            Hamann,U., Haring,R., Hartman,C.A., Heath,A.C., Hofman,A.,
            Hooning,M.J., Hopper,J.L., Hu,F.B., Hunter,D.J., Karasik,D.,
            Kiel,D.P., Knight,J.A., Kosma,V.M., Kutalik,Z., Lai,S.,
            Lambrechts,D., Lindblom,A., Magi,R., Magnusson,P.K., Mannermaa,A.,
            Martin,N.G., Masson,G., McArdle,P.F., McArdle,W.L., Melbye,M.,
            Michailidou,K., Mihailov,E., Milani,L., Milne,R.L., Nevanlinna,H.,
            Neven,P., Nohr,E.A., Oldehinkel,A.J., Oostra,B.A., Palotie,A.,
            Peacock,M., Pedersen,N.L., Peterlongo,P., Peto,J., Pharoah,P.D.,
            Postma,D.S., Pouta,A., Pylkas,K., Radice,P., Ring,S.,
            Rivadeneira,F., Robino,A., Rose,L.M., Rudolph,A., Salomaa,V.,
            Sanna,S., Schlessinger,D., Schmidt,M.K., Southey,M.C., Sovio,U.,
            Stampfer,M.J., Stockl,D., Storniolo,A.M., Timpson,N.J., Tyrer,J.,
            Visser,J.A., Vollenweider,P., Volzke,H., Waeber,G.,
            Waldenberger,M., Wallaschofski,H., Wang,Q., Willemsen,G.,
            Winqvist,R., Wolffenbuttel,B.H., Wright,M.J., Boomsma,D.I.,
            Econs,M.J., Khaw,K.T., Loos,R.J., McCarthy,M.I., Montgomery,G.W.,
            Rice,J.P., Streeten,E.A., Thorsteinsdottir,U., van Duijn,C.M.,
            Alizadeh,B.Z., Bergmann,S., Boerwinkle,E., Boyd,H.A., Crisponi,L.,
            Gasparini,P., Gieger,C., Harris,T.B., Ingelsson,E., Jarvelin,M.R.,
            Kraft,P., Lawlor,D., Metspalu,A., Pennell,C.E., Ridker,P.M.,
            Snieder,H., Sorensen,T.I., Spector,T.D., Strachan,D.P.,
            Uitterlinden,A.G., Wareham,N.J., Widen,E., Zygmunt,M., Murray,A.,
            Easton,D.F., Stefansson,K., Murabito,J.M. and Ong,K.K.
  CONSRTM   Australian Ovarian Cancer Study; GENICA Network; kConFab; LifeLines
            Cohort Study; InterAct Consortium; Early Growth Genetics (EGG)
            Consortium
  TITLE     Parent-of-origin-specific allelic associations among 106 genomic
            loci for age at menarche
  JOURNAL   Nature 514 (7520), 92-97 (2014)
   PUBMED   25231870
REFERENCE   3  (bases 1 to 4114)
  AUTHORS   Markham,N.O., Doll,C.A., Dohn,M.R., Miller,R.K., Yu,H.,
            Coffey,R.J., McCrea,P.D., Gamse,J.T. and Reynolds,A.B.
  TITLE     DIPA-family coiled-coils bind conserved isoform-specific head
            domain of p120-catenin family: potential roles in hydrocephalus and
            heterotopia
  JOURNAL   Mol Biol Cell 25 (17), 2592-2603 (2014)
   PUBMED   25009281
REFERENCE   4  (bases 1 to 4114)
  AUTHORS   Elks,C.E., Perry,J.R., Sulem,P., Chasman,D.I., Franceschini,N.,
            He,C., Lunetta,K.L., Visser,J.A., Byrne,E.M., Cousminer,D.L.,
            Gudbjartsson,D.F., Esko,T., Feenstra,B., Hottenga,J.J.,
            Koller,D.L., Kutalik,Z., Lin,P., Mangino,M., Marongiu,M.,
            McArdle,P.F., Smith,A.V., Stolk,L., van Wingerden,S.H., Zhao,J.H.,
            Albrecht,E., Corre,T., Ingelsson,E., Hayward,C., Magnusson,P.K.,
            Smith,E.N., Ulivi,S., Warrington,N.M., Zgaga,L., Alavere,H.,
            Amin,N., Aspelund,T., Bandinelli,S., Barroso,I., Berenson,G.S.,
            Bergmann,S., Blackburn,H., Boerwinkle,E., Buring,J.E., Busonero,F.,
            Campbell,H., Chanock,S.J., Chen,W., Cornelis,M.C., Couper,D.,
            Coviello,A.D., d'Adamo,P., de Faire,U., de Geus,E.J., Deloukas,P.,
            Doring,A., Smith,G.D., Easton,D.F., Eiriksdottir,G., Emilsson,V.,
            Eriksson,J., Ferrucci,L., Folsom,A.R., Foroud,T., Garcia,M.,
            Gasparini,P., Geller,F., Gieger,C., Gudnason,V., Hall,P.,
            Hankinson,S.E., Ferreli,L., Heath,A.C., Hernandez,D.G., Hofman,A.,
            Hu,F.B., Illig,T., Jarvelin,M.R., Johnson,A.D., Karasik,D.,
            Khaw,K.T., Kiel,D.P., Kilpelainen,T.O., Kolcic,I., Kraft,P.,
            Launer,L.J., Laven,J.S., Li,S., Liu,J., Levy,D., Martin,N.G.,
            McArdle,W.L., Melbye,M., Mooser,V., Murray,J.C., Murray,S.S.,
            Nalls,M.A., Navarro,P., Nelis,M., Ness,A.R., Northstone,K.,
            Oostra,B.A., Peacock,M., Palmer,L.J., Palotie,A., Pare,G.,
            Parker,A.N., Pedersen,N.L., Peltonen,L., Pennell,C.E., Pharoah,P.,
            Polasek,O., Plump,A.S., Pouta,A., Porcu,E., Rafnar,T., Rice,J.P.,
            Ring,S.M., Rivadeneira,F., Rudan,I., Sala,C., Salomaa,V., Sanna,S.,
            Schlessinger,D., Schork,N.J., Scuteri,A., Segre,A.V.,
            Shuldiner,A.R., Soranzo,N., Sovio,U., Srinivasan,S.R.,
            Strachan,D.P., Tammesoo,M.L., Tikkanen,E., Toniolo,D., Tsui,K.,
            Tryggvadottir,L., Tyrer,J., Uda,M., van Dam,R.M., van Meurs,J.B.,
            Vollenweider,P., Waeber,G., Wareham,N.J., Waterworth,D.M.,
            Weedon,M.N., Wichmann,H.E., Willemsen,G., Wilson,J.F., Wright,A.F.,
            Young,L., Zhai,G., Zhuang,W.V., Bierut,L.J., Boomsma,D.I.,
            Boyd,H.A., Crisponi,L., Demerath,E.W., van Duijn,C.M., Econs,M.J.,
            Harris,T.B., Hunter,D.J., Loos,R.J., Metspalu,A., Montgomery,G.W.,
            Ridker,P.M., Spector,T.D., Streeten,E.A., Stefansson,K.,
            Thorsteinsdottir,U., Uitterlinden,A.G., Widen,E., Murabito,J.M.,
            Ong,K.K. and Murray,A.
  CONSRTM   GIANT Consortium
  TITLE     Thirty new loci for age at menarche identified by a meta-analysis
            of genome-wide association studies
  JOURNAL   Nat Genet 42 (12), 1077-1085 (2010)
   PUBMED   21102462
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC007743.3 and AC007744.2.
            
            On Nov 22, 2018 this sequence version replaced NM_001080433.1.
            
            Transcript Variant: This variant (2) lacks an alternate in-frame
            exon compared to variant 1. The resulting isoform (2) has the same
            N- and C-termini but is shorter compared to isoform 1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB067499.2, SRR1660809.152318.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145743, SAMEA2151741
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000407595.3/ ENSP00000384040.2
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-133               AC007743.3         79125-79257         c
            134-911             AC007743.3         78347-79124         c
            912-1875            AC007743.3         69807-70770         c
            1876-1952           AC007744.2         119310-119386       c
            1953-2087           AC007744.2         89787-89921         c
            2088-2207           AC007744.2         86330-86449         c
            2208-4114           AC007744.2         76093-77999         c
FEATURES             Location/Qualifiers
     source          1..4114
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p16.1"
     gene            1..4114
                     /gene="CCDC85A"
                     /note="coiled-coil domain containing 85A"
                     /db_xref="GeneID:114800"
                     /db_xref="HGNC:HGNC:29400"
     exon            1..911
                     /gene="CCDC85A"
                     /inference="alignment:Splign:2.1.0"
     CDS             636..2297
                     /gene="CCDC85A"
                     /note="isoform 2 is encoded by transcript variant 2;
                     coiled-coil domain-containing protein 85A"
                     /codon_start=1
                     /product="coiled-coil domain-containing protein 85A
                     isoform 2"
                     /protein_id="NP_001073902.1"
                     /db_xref="CCDS:CCDS46290.1"
                     /db_xref="GeneID:114800"
                     /db_xref="HGNC:HGNC:29400"
                     /translation="MSKAAGGAAAAAAAAESCSPAPAGSSAAPPAPVEDLSKVSDEEL
                     LQWSKEELIRSLRRAEAEKVSAMLDHSNLIREVNRRLQLHLGEIRGLKDINQKLQEDN
                     QELRDLCCFLDDDRQKGKRVSREWQRLGRYTAGVMHKEVALYLQKLKDLEVKQEEVVK
                     ENMELKELCVLLDEEKGAGCAGSRCSIDSQASLCQLTASTAPYVRDVGDGSSTSSTGS
                     TDSPDHHKHHASSGSPEHLQKPRSEGSPEHSKHRSASPEHPQKPRACGTPDRPKALKG
                     PSPEHHKPLCKGSPEQQRHPHPGSSPETLPKHVLSGSPEHFQKHRSGSSPEHARHSGG
                     SPEHLQKHALGGSLEHLPRARGTSPEHLKQHYGGSPDHKHGGGSGGSGGSGGGSREGT
                     LRRQAQEDGSPHHRNVYSGMNESTLSYVRQLEARVRQLEEENRMLPQASQNRRQPPTR
                     NSSNMEKGWGSRARRVLQWWQGCRGIGRCLPTLPGSFRLSSGADGSNSSPNSAASFSG
                     HATPSQQPEPVVHSLKVVWRKLGDAAGSCPGIRQHLSGNQYKGPM"
     exon            912..1875
                     /gene="CCDC85A"
                     /inference="alignment:Splign:2.1.0"
     exon            1876..1952
                     /gene="CCDC85A"
                     /inference="alignment:Splign:2.1.0"
     exon            1953..2087
                     /gene="CCDC85A"
                     /inference="alignment:Splign:2.1.0"
     exon            2088..2207
                     /gene="CCDC85A"
                     /inference="alignment:Splign:2.1.0"
     exon            2208..4114
                     /gene="CCDC85A"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4096..4101
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CCDC85A"
                     /note="hexamer: AATAAA"
     polyA_site      4114
                     /gene="CCDC85A"
                     /note="major polyA site"
ORIGIN      
        1 cttctcgact ccgctctgca aatcgaaggc tttccggagc agcctaggag cggccgcggg
       61 cgcagcgaag gcggcaggag gagcgcagca gccttcgggc agccgcggcg gcgtcgctag
      121 agcagccggg gaggcgccgc ggtgcccggc gcgccctcca agctaggaga ggggagaagc
      181 cgggggctgc agctgggcaa gggggaggaa agtgcgtgtg cgtgcacgcc tgtgtgcagg
      241 gcagagagtg cggggggcga cagtctcggc ttagggcgga ggagagggca ggggaacggc
      301 ggtgcagctc ccccgctgtc cccgaggatt tcccgcggca gccccgggct ccccagtgcc
      361 cctcaccatg gacttgcgcg gagttgggac gggcctcggc agcagcaagc ggctggctgc
      421 cgggccctgg gggagcgcgg gcgcgcgcgc ggggatggcg aggtaggatg gccacccagc
      481 gcgacccccg ccgccccaac ccagcggccc ctgggcggtg ccgctgactc gccggagcgc
      541 acaggggtgt gggcggaggc ggcctcgccg cgcccgcgcc ttcgggagtc gcctcgcctc
      601 ttccacccac ttgcacctgc caccccgcgg ataccatgtc gaaggcggcc ggaggcgcgg
      661 cggcggctgc ggcggcggcg gaaagttgtt ccccagcccc ggccggctcg tccgcggccc
      721 cgcccgcgcc ggtggaggac ctgtccaaag tgtcggacga ggagctgctg cagtggagca
      781 aggaggagct gatccgcagc ctgcggcgcg ccgaggcgga gaaggtgagc gcgatgctgg
      841 accacagcaa cctcatccgc gaggtgaacc gccgcctgca gctgcacctc ggcgagatcc
      901 gcggcctcaa ggatatcaac cagaaactcc aggaagacaa ccaggaactg agggacctct
      961 gctgtttcct ggatgatgac cggcagaaag gcaagagggt gtctcgggag tggcagagac
     1021 tgggtcgcta cactgccggg gtgatgcaca aggaagtggc cttatacctg cagaagctga
     1081 aagacctgga ggtgaagcag gaggaagtgg tgaaggagaa catggagctc aaggagctct
     1141 gtgtgctact agatgaggag aagggtgcag gctgcgcagg cagccgctgc tccatcgaca
     1201 gccaggccag cctgtgccaa ctcacagcct ccaccgcacc ctacgtgcgg gatgtgggtg
     1261 acggcagcag cacctccagc actggcagca ctgacagccc ggaccaccac aagcaccacg
     1321 cgagcagtgg cagcccggag cacctgcaga agccccggag cgagggcagc ccggagcact
     1381 ccaagcacag gagcgccagc cccgagcatc cacagaaacc cagagcctgt ggaaccccag
     1441 atcgccccaa agcactcaaa ggacctagcc cggagcacca caaacccttg tgcaagggca
     1501 gccccgaaca gcaaaggcac ccgcatccag ggagcagccc cgaaacgctg cccaagcacg
     1561 tgctgagtgg gagcccggaa cacttccaga agcaccggtc agggagcagc cctgaacacg
     1621 ccaggcacag tggagggagc ccggagcatc ttcagaaaca cgctcttggg gggagcctag
     1681 agcatctccc cagagccagg ggcaccagcc cggagcacct caaacaacat tatggaggga
     1741 gccctgatca caaacacgga ggaggcagtg gaggaagtgg aggcagcggc ggaggcagca
     1801 gggagggcac cctcagacgg caggcacagg aggacgggtc accccatcac cggaatgtct
     1861 acagtggcat gaacgaatca accttgtcct atgttaggca gctggaggca agagtaagac
     1921 agctggagga agaaaatcgc atgctgcccc aggccagcca gaatagaagg caacctccaa
     1981 ctagaaacag ctcaaatatg gagaaaggct gggggtccag agcccggcgg gtcttgcagt
     2041 ggtggcaagg gtgccgagga ataggacgat gcctgcctac tctcccgggt tcttttaggt
     2101 tgtcatcagg ggctgatggg agtaacagtt cacccaactc tgcagctagc ttcagtggac
     2161 atgccacacc ttcccagcag cctgaacctg tggtacattc tcttaaggtt gtgtggagga
     2221 aacttggaga tgctgcaggt tcgtgtcctg gaattaggca acatttgtca ggaaaccagt
     2281 acaaaggacc aatgtgagat gcactctttt tcaaacagga gatcaccact gccagaaagt
     2341 gatagaagac aagaagaaaa aggaaagagt gggtttccac aaacctggac tcatggaata
     2401 acatggagtg attgtacatt gcacatatct cccctctaaa acctgtagta caacttctcc
     2461 cctcaagctg atattctgtg tctctcacct caatgtccac aacagtcaat ctcaaacaag
     2521 gtagctttga acatctcaaa cagagtagct ttgaaaatca acattttggt accagtgttt
     2581 tcattagaaa taagtgtttt taactcccca gatataatat tgtaattggg aaacctgaat
     2641 agttttaaga gtccagtgga gcctcagtgt tttgaataga gatgactcat tacacataat
     2701 ggtaggagtt ttctaccata tcatattgaa gatatgaaga ggtattttcc agcttcccaa
     2761 gtttgagagt tgggcattta cctcttacac ttcagtcaac aaacaaacta gtaattccta
     2821 atgcataatt aatttggatg caagataaga ttaagtttct ggagttttgt tttgacttct
     2881 gaggtgctaa aaaataccat gtaaattctc cctaccagct agaagggtag caagacgttg
     2941 tagagtgctt atcagagagt accatttact tcaattgatc aatataaata tatctttttt
     3001 tttcatctta atgagtttct cataaagaca catcttgggg cataccaacc ttcatattca
     3061 ttcagtgtat ccattggtgt taatattaac aatttcaact aaaaacaaca aacataattt
     3121 ttctaagtgt ttcgagctgt gagatgtcaa tttctacaat ttagtttcta gacatgctgt
     3181 atatttaata aactttatgt aaactttaaa atattgcact gcatttatga aaaaagcttt
     3241 ctttgcctac tgcagctatc taacatttta tgaaactgac gcatgtcctt cattattgag
     3301 gctaaaagct cttgttcaga ttgcttgagg tttgaaaaag aggtgtgcta gctttgctta
     3361 gtttatttct tatttttggt atacatatac atatatataa cattagaatg tgtgtactgg
     3421 aaatgctatg ataggtattt tgtgttaatc caaatgcaat gatagtttct tgtatgaatg
     3481 tgcaagaggc ctgtgaccga atgctacgtt tttatggtag tttaagatta taaaagtaga
     3541 aatgcaacaa ttcccagttt ttggataggt tctaaatttc tgagatttga ttcatggcag
     3601 atattctctg ttgttgttgt tttagatggg ctcattacat aacgagttaa ttgtcactag
     3661 taggagactg tgaaggaatt ttgttatact ttcaaaaatg ttactgtgat gaaaaatcat
     3721 ctattttcag aaaatattta tgaattaatt tactatagaa ttatctctct aattatcata
     3781 attgggttac aatttaagct ccccttttaa atgttatatt ttaaaatgtt attactctat
     3841 aaaagaaaat tgcttgctat atttacacct tctttcctag gaaagctttc atccttaaat
     3901 tgttgtattc ctaccctctg aagacattta aaataagctt ttgtgcctgc agcagagcct
     3961 gcagaagcta atacaaggga cactggtctt ttgacaaaat aaacttgtgt aaattttgat
     4021 actgtattaa aactattttt ttaaagttct gcataaaatt gagtattaag tatatgtgtt
     4081 catcttagca atggtaataa attatttaat ctca
//
