LOCUS       NM_001286159            1975 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens coiled-coil domain containing 83 (CCDC83), transcript
            variant 2, mRNA.
ACCESSION   NM_001286159 XM_005273840
VERSION     NM_001286159.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1975)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 1975)
  AUTHORS   Song,M.H., Ha,J.M., Shin,D.H., Lee,C.H., Old,L. and Lee,S.Y.
  TITLE     KP-CoT-23 (CCDC83) is a novel immunogenic cancer/testis antigen in
            colon cancer
  JOURNAL   Int J Oncol 41 (5), 1820-1826 (2012)
   PUBMED   22923163
  REMARK    GeneRIF: These data suggest that KP-CoT-23 is a novel CT antigen
            that may be useful for the diagnosis and immunotherapy of cancer.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AP000974.5 and AP003128.2.
            
            On Jan 31, 2020 this sequence version replaced NM_001286159.1.
            
            Transcript Variant: This variant (2) lacks an alternate in-frame
            exon, compared to variant 1. The encoded isoform (2) is shorter
            than isoform 1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC040280.1, AK314036.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2148093
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000342404.8/ ENSP00000344512.3
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-202               AP000974.5         72675-72876
            203-325             AP000974.5         82388-82510
            326-410             AP000974.5         90503-90587
            411-573             AP003128.2         7660-7822
            574-741             AP003128.2         11347-11514
            742-833             AP003128.2         20440-20531
            834-902             AP003128.2         24094-24162
            903-1024            AP003128.2         36428-36549
            1025-1104           AP003128.2         40566-40645
            1105-1310           AP003128.2         41175-41380
            1311-1975           AP003128.2         44496-45160
FEATURES             Location/Qualifiers
     source          1..1975
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q14.1-q14.2"
     gene            1..1975
                     /gene="CCDC83"
                     /gene_synonym="CT148; HSD9; KP-CoT-23"
                     /note="coiled-coil domain containing 83"
                     /db_xref="GeneID:220047"
                     /db_xref="HGNC:HGNC:28535"
     exon            1..202
                     /gene="CCDC83"
                     /gene_synonym="CT148; HSD9; KP-CoT-23"
                     /inference="alignment:Splign:2.1.0"
     exon            203..325
                     /gene="CCDC83"
                     /gene_synonym="CT148; HSD9; KP-CoT-23"
                     /inference="alignment:Splign:2.1.0"
     CDS             231..1472
                     /gene="CCDC83"
                     /gene_synonym="CT148; HSD9; KP-CoT-23"
                     /note="isoform 2 is encoded by transcript variant 2;
                     coiled-coil domain-containing protein 83"
                     /codon_start=1
                     /product="coiled-coil domain-containing protein 83 isoform
                     2"
                     /protein_id="NP_001273088.1"
                     /db_xref="CCDS:CCDS66196.1"
                     /db_xref="GeneID:220047"
                     /db_xref="HGNC:HGNC:28535"
                     /translation="MENSGKANKKDTHDGPPKEIKLPTSEALLDYQCQIKEDAVEQFM
                     FQIKTLRKKNQKYHERNSRLKEEQIWHIRHLLKELSEEKAEGLPVVTREDVEEAMKEK
                     WKFERDQEKNLRDMRMQISNAEKLFLEKLSEKEYWEEYKNVGSERHAKLITSLQNDIN
                     TVKENAEKMSEHYKITLEDTRKKIIKETLLQLDQKKEWATQNAVKLIDKGSYLEIWEN
                     DWLKKEVAIHRKEVEELKNAIHELEAENLVLIDQLSNCRLVDLKIPRRLYLTQAAGLE
                     VPPEEMSLELPETHIEEKSELQPTEVESRDLMSSSDESTILHLSHENSIEDLQYVKID
                     KEENSGTEFGDTDMKYLLYEDEKDFKDYVNLGPLGVKLMSVESKKMPIHFQEKEIPVK
                     LYKDVRSPESHITYKMMKSFL"
     exon            326..410
                     /gene="CCDC83"
                     /gene_synonym="CT148; HSD9; KP-CoT-23"
                     /inference="alignment:Splign:2.1.0"
     exon            411..573
                     /gene="CCDC83"
                     /gene_synonym="CT148; HSD9; KP-CoT-23"
                     /inference="alignment:Splign:2.1.0"
     exon            574..741
                     /gene="CCDC83"
                     /gene_synonym="CT148; HSD9; KP-CoT-23"
                     /inference="alignment:Splign:2.1.0"
     exon            742..833
                     /gene="CCDC83"
                     /gene_synonym="CT148; HSD9; KP-CoT-23"
                     /inference="alignment:Splign:2.1.0"
     exon            834..902
                     /gene="CCDC83"
                     /gene_synonym="CT148; HSD9; KP-CoT-23"
                     /inference="alignment:Splign:2.1.0"
     exon            903..1024
                     /gene="CCDC83"
                     /gene_synonym="CT148; HSD9; KP-CoT-23"
                     /inference="alignment:Splign:2.1.0"
     exon            1025..1104
                     /gene="CCDC83"
                     /gene_synonym="CT148; HSD9; KP-CoT-23"
                     /inference="alignment:Splign:2.1.0"
     exon            1105..1310
                     /gene="CCDC83"
                     /gene_synonym="CT148; HSD9; KP-CoT-23"
                     /inference="alignment:Splign:2.1.0"
     exon            1311..1975
                     /gene="CCDC83"
                     /gene_synonym="CT148; HSD9; KP-CoT-23"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1949..1954
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CCDC83"
                     /gene_synonym="CT148; HSD9; KP-CoT-23"
                     /note="hexamer: AATAAA"
     polyA_site      1975
                     /gene="CCDC83"
                     /gene_synonym="CT148; HSD9; KP-CoT-23"
                     /note="major polyA site"
ORIGIN      
        1 gtccacgaag cgccgttctt gggccgttag gagctgctgg gaagggctct gataggccca
       61 ctcctcttct ccacccagga gatgagaagg agggcaggcc tttttaatct gatcagaatg
      121 ttaacccatc tctccgcctt gcggtagaac ccctggatac attatttgcc ctctcgaaag
      181 gcaggctctg aatttgattc aggtatattt cttcatagct aaccagcaca atggaaaact
      241 cagggaaagc aaataaaaag gatacacatg acgggccacc aaaagaaatt aaactgccta
      301 ccagtgaagc acttctagac tatcaatgtc aaataaagga agatgccgtg gagcaattca
      361 tgtttcaaat aaagacactt aggaaaaaga accaaaaata tcatgaaaga aatagccgct
      421 taaaagaaga acagatttgg cacatacggc atctactaaa ggaactgagt gaagagaagg
      481 cagagggatt gccagttgta acaagagagg atgttgaaga agcgatgaag gaaaaatgga
      541 agtttgaaag agaccaggaa aaaaacttga gagatatgcg catgcaaata agtaatgctg
      601 agaaactatt tcttgagaaa ctcagtgaaa aggaatattg ggaggagtac aagaatgtag
      661 ggagtgaacg acatgctaaa ctcattacct ccttacaaaa tgacatcaac acagttaaag
      721 agaatgcaga gaaaatgtca gaacactata aaatcactct ggaagatact agaaagaaaa
      781 taatcaagga aactttgttg caactggacc aaaagaagga atgggccaca cagaatgctg
      841 taaagctcat tgacaagggc agttatctag agatctggga gaatgactgg ctcaaaaaag
      901 aggttgcaat tcacaggaag gaagttgaag aattaaaaaa tgctattcat gaactggaag
      961 cagaaaattt ggtgcttatt gatcaactat ccaactgtag acttgtggat ctcaagatac
     1021 ccaggcgact atatcttacc caagctgctg gactagaagt gccacctgaa gaaatgtctt
     1081 tggaattgcc agaaacacat atagaagaga agtcagaatt gcaacccaca gaagtagaaa
     1141 gtagagactt gatgtcctca tcagatgaga gcactatctt acatcttagt catgaaaata
     1201 gcatcgaaga tctccagtat gtgaagatag ataaagagga aaactcaggc acagagtttg
     1261 gggacactga tatgaagtac ttactatatg aggatgagaa ggatttcaag gattatgtaa
     1321 acttgggccc cctgggagtg aagcttatga gtgtggagag caagaaaatg cccattcatt
     1381 ttcaagagaa ggaaattcca gtcaaactct ataaagatgt caggagccca gaaagccaca
     1441 tcacatataa gatgatgaag tcttttctct aagacggaaa gctgcaaagg aaacacaact
     1501 tttccttata aatgttcttt gggaactgaa gtatatccgt tgcccatttt acttacactt
     1561 tggctcattt ttaaaccagc tgttatttct aaaggtcata tttacattta aaatcaaagg
     1621 tattcagcta ttcatttact tgcatggtat gagtgaccaa aacggaagca cgctttgtat
     1681 ttctacactg aagtattcag aagcatgaca gtgggttcaa ggtagtctct gaggttcctt
     1741 ttcacacaca aaaaattcac tgattaatct gtgattccag tatgaaatag ttccattaga
     1801 aatgtttcta agaaaaactt agaagtttgc atagcattgt ctacacatct ttccctctga
     1861 ggatgctcaa tgtgatagac agccagtcta taatgcaagc caattctccg tagtttaacc
     1921 ctgtgtatta gtctgttctc atgctgctaa taaagacata attgaaactg ggtaa
//
