LOCUS       NM_001156474            2627 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens coiled-coil domain containing 81 (CCDC81), transcript
            variant 1, mRNA.
ACCESSION   NM_001156474
VERSION     NM_001156474.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2627)
  AUTHORS   Burroughs,A.M., Kaur,G., Zhang,D. and Aravind,L.
  TITLE     Novel clades of the HU/IHF superfamily point to unexpected roles in
            the eukaryotic centrosome, chromosome partitioning, and biologic
            conflicts
  JOURNAL   Cell Cycle 16 (11), 1093-1103 (2017)
   PUBMED   28441108
REFERENCE   2  (bases 1 to 2627)
  AUTHORS   Firat-Karalar,E.N., Sante,J., Elliott,S. and Stearns,T.
  TITLE     Proteomic analysis of mammalian sperm cells identifies new
            components of the centrosome
  JOURNAL   J Cell Sci 127 (Pt 19), 4128-4133 (2014)
   PUBMED   25074808
REFERENCE   3  (bases 1 to 2627)
  AUTHORS   Kottyan,L.C., Davis,B.P., Sherrill,J.D., Liu,K., Rochman,M.,
            Kaufman,K., Weirauch,M.T., Vaughn,S., Lazaro,S., Rupert,A.M.,
            Kohram,M., Stucke,E.M., Kemme,K.A., Magnusen,A., He,H.,
            Dexheimer,P., Chehade,M., Wood,R.A., Pesek,R.D., Vickery,B.P.,
            Fleischer,D.M., Lindbad,R., Sampson,H.A., Mukkada,V.A.,
            Putnam,P.E., Abonia,J.P., Martin,L.J., Harley,J.B. and
            Rothenberg,M.E.
  TITLE     Genome-wide association analysis of eosinophilic esophagitis
            provides insight into the tissue specificity of this allergic
            disease
  JOURNAL   Nat Genet 46 (8), 895-900 (2014)
   PUBMED   25017104
REFERENCE   4  (bases 1 to 2627)
  AUTHORS   Draber,P., Vonkova,I., Stepanek,O., Hrdinka,M., Kucova,M.,
            Skopcova,T., Otahal,P., Angelisova,P., Horejsi,V., Yeung,M.,
            Weiss,A. and Brdicka,T.
  TITLE     SCIMP, a transmembrane adaptor protein involved in major
            histocompatibility complex class II signaling
  JOURNAL   Mol Cell Biol 31 (22), 4550-4562 (2011)
   PUBMED   21930792
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK131331.1, AP001148.4 and BC126412.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001156474.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC126412.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2144333
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000445632.7/ ENSP00000415528.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-524               AK131331.1         155-678
            525-575             AP001148.4         96476-96526
            576-1533            BC126412.1         571-1528
            1534-2627           AK131331.1         1418-2511
FEATURES             Location/Qualifiers
     source          1..2627
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q14.2"
     gene            1..2627
                     /gene="CCDC81"
                     /note="coiled-coil domain containing 81"
                     /db_xref="GeneID:60494"
                     /db_xref="HGNC:HGNC:26281"
     exon            1..356
                     /gene="CCDC81"
                     /inference="alignment:Splign:2.1.0"
     CDS             278..2236
                     /gene="CCDC81"
                     /note="isoform 1 is encoded by transcript variant 1;
                     coiled-coil domain-containing protein 81"
                     /codon_start=1
                     /product="coiled-coil domain-containing protein 81 isoform
                     1"
                     /protein_id="NP_001149946.1"
                     /db_xref="CCDS:CCDS53691.1"
                     /db_xref="GeneID:60494"
                     /db_xref="HGNC:HGNC:26281"
                     /translation="MLDTIARALQDLGRQVLPTLPSLSQEEVSIIWGNVSEFVRRQLT
                     LHKGVQIPAFGTFTFIRQKLEVGNNKFILIQRPVFIMVEKLVQIHGLKQNKVYTPGEI
                     PIVPLNFVMISLEGPFNRDVVEGCVKETLLFLSRSISMKQNVEFTFKGIGVLMIRDSK
                     VKMRFYKDFLCTMDGSGALAKALANRPGTVDSVLSSREALRKWPSSVLAFPRIELKEM
                     ENKLPMETLVEECGENRERKCKLKDQSDKEEGTRDISSPKRLRDRQALFPAKVTNVSL
                     LEKFERSESGGKIMTPESLSYPSCLKHDSEMKPQTSPACQDHNKAGQEMCYVCLQRAQ
                     RNSLLYYSEERRREIEDERLIQQYQMLKDQEALFRHQMKSLATREQNQKNAAYNLGVA
                     EAIRNHKNEKPEFYKSFLFDKRPLSPALNALKQEEYSRSLLKQMDNRQENEIKQRQYR
                     ELMDRLEQVQLTEELAAQRAKFLKDKMEETQCYKRALDAQIKNKPSRLPPFEPDSSEP
                     IFGKNEGELMVEKQKREQNYMKHQLEAAANHKRKAILHQLVDQRRDLQMLQRTQREHL
                     ADRTAELERVNRVNQCLQEDWERSAAMKKQRDLEDKAFERASDKLFLLDQCEKYRRCK
                     QCQRRTSNVGESNLWPLNKFLPGSRLLV"
     exon            357..418
                     /gene="CCDC81"
                     /inference="alignment:Splign:2.1.0"
     exon            419..575
                     /gene="CCDC81"
                     /inference="alignment:Splign:2.1.0"
     exon            576..832
                     /gene="CCDC81"
                     /inference="alignment:Splign:2.1.0"
     exon            833..912
                     /gene="CCDC81"
                     /inference="alignment:Splign:2.1.0"
     exon            913..1034
                     /gene="CCDC81"
                     /inference="alignment:Splign:2.1.0"
     exon            1035..1158
                     /gene="CCDC81"
                     /inference="alignment:Splign:2.1.0"
     exon            1159..1246
                     /gene="CCDC81"
                     /inference="alignment:Splign:2.1.0"
     exon            1247..1390
                     /gene="CCDC81"
                     /inference="alignment:Splign:2.1.0"
     exon            1391..1495
                     /gene="CCDC81"
                     /inference="alignment:Splign:2.1.0"
     exon            1496..1668
                     /gene="CCDC81"
                     /inference="alignment:Splign:2.1.0"
     exon            1669..1747
                     /gene="CCDC81"
                     /inference="alignment:Splign:2.1.0"
     exon            1748..1968
                     /gene="CCDC81"
                     /inference="alignment:Splign:2.1.0"
     exon            1969..2094
                     /gene="CCDC81"
                     /inference="alignment:Splign:2.1.0"
     exon            2095..2627
                     /gene="CCDC81"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2607..2612
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CCDC81"
                     /note="hexamer: AATAAA"
     polyA_site      2627
                     /gene="CCDC81"
                     /note="major polyA site"
ORIGIN      
        1 actcggtgcc ggacatcagt tcctgcggct cttgctgtgg gagctgcccg agagccagag
       61 cagtggggag ggacggcgag aaccaatgtt taagtttatt taagaaagaa gaaaaagagt
      121 caagaagttc aagattttcg tcactcttat ttttaaggca catccaaagc tccgtggaga
      181 aggggctgga gggtgggaaa attatttttg tgcacattcc atataagaaa gaagagaccc
      241 atcgaacatt cagtacggag tcacctggaa attggagatg ttggatacga tcgcccgtgc
      301 cctgcaggac ctgggcaggc aggtgctgcc cactctgccc tcgctgagcc aggaggaagt
      361 ctctattatc tgggggaatg tatcagaatt tgtgagacgg cagttaaccc tgcacaaggg
      421 ggttcagatt ccagcatttg gaactttcac tttcataaga caaaagcttg aggtgggaaa
      481 caacaaattt atcttaatcc agaggcctgt gtttatcatg gtggagaagc tagtgcagat
      541 tcatggactc aaacaaaaca aagtatatac tcctggtgaa atcccaattg ttccacttaa
      601 ttttgtcatg atatccctgg agggtccatt taacagagat gtagtggaag gatgtgtgaa
      661 ggagacgttg ctttttttat cgcgttccat ttccatgaaa caaaatgtgg agtttacatt
      721 caaaggaatt ggggtcctca tgatcagaga cagcaaagtg aagatgaggt tttataaaga
      781 cttcctttgt accatggatg gaagtggggc tttggcaaag gccctagcaa ataggcctgg
      841 cactgtggac tcggtgttgt ctagcagaga ggccttgagg aagtggccca gcagtgtgct
      901 tgcgtttcca aggattgagc tcaaggagat ggaaaacaaa ctgcctatgg agacccttgt
      961 agaagaatgt ggagagaata gagaaaggaa gtgcaagtta aaagaccagt cagacaaaga
     1021 agaaggcacc agagatatct catcacccaa aagacttcga gatagacaag ctttgttccc
     1081 tgccaaagtg acaaatgtca gcttgctgga aaagtttgaa cgaagtgaga gtggtgggaa
     1141 gattatgacc cctgaaagct tatcatatcc aagttgtctg aaacacgaca gtgagatgaa
     1201 gccccaaaca tctccagctt gccaggatca taacaaggca ggacaggaaa tgtgctatgt
     1261 atgtttgcaa cgagcacaac gaaattccct gttgtactac agtgaggaaa ggaggagaga
     1321 gatagaagat gagagactca tacagcagta tcagatgtta aaggatcagg aggctctctt
     1381 cagacaccag atgaaaagtc tggctactag agaacagaat cagaaaaatg ctgcctataa
     1441 tcttggagtt gctgaagcta taagaaacca caagaatgag aaaccggaat tttataaatc
     1501 cttcctattt gacaaacggc cactcagtcc tgcgcttaat gctcttaagc aagaggaata
     1561 ttcccggagt ctcctgaaac aaatggataa cagacaggaa aacgaaataa agcaaagaca
     1621 atacagagag ttgatggacc gcctggaaca agtgcaactc acagaggaac ttgctgcgca
     1681 aagagcgaaa tttttaaaag ataagatgga agaaacacag tgttacaaga gagctttgga
     1741 tgcacagata aagaacaaac cctctcggct gccccccttt gagccagact cctctgagcc
     1801 catctttggt aagaatgagg gtgaactgat ggtggaaaag caaaagcgag aacaaaatta
     1861 catgaaacac cagctggagg cagctgctaa ccacaagagg aaagccatcc tgcatcaact
     1921 agtggaccag aggcgggatt tgcaaatgct tcagaggaca caaagagagc acttggcaga
     1981 cagaaccgct gagctggagc gagtaaatag agtcaaccaa tgcttacagg aggactggga
     2041 aaggagtgct gcgatgaaga agcagcgaga cctggaggac aaggcttttg aacgggcttc
     2101 agacaagctg tttctcctag accagtgtga gaagtatcgg cgctgcaagc aatgccagag
     2161 gcgcacctcc aacgtgggcg agagcaacct gtggcccctg aacaagttcc tgcctggctc
     2221 ccggttgctt gtgtaaaact caaagtttgg ctcttcgttt cccggggaaa gtttttatct
     2281 tttacatgtt tgggggtgat tgtgaaactg cgtattttta cctcagagaa aaaaatcatt
     2341 gtttaggttt ggtgctttca ttagattgct tgttaagccc ttattgaatt cactcctgct
     2401 ttcctcccac ccccaattat ttcctatact agtttctgat ggcagtgaag gtgtctgaat
     2461 ggtcctgagg gctagaacct gctgcacagg ggctgggaat gggatccagc ttcattatgg
     2521 ctgctggggt gctgctgacc cagccctgct gctgctccat gactttgtgt acaaaacttt
     2581 tttcatctgt aatgaatagt ggcaataata aatatttttt aagcgcc
//
