LOCUS       NM_199511              12301 bp    mRNA    linear   PRI 01-JUL-2024
DEFINITION  Homo sapiens coiled-coil domain containing 80 (CCDC80), transcript
            variant 1, mRNA.
ACCESSION   NM_199511 NR_109779
VERSION     NM_199511.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 12301)
  AUTHORS   Yu,M., Peng,J., Lu,Y., Li,S. and Ding,K.
  TITLE     Silencing immune-infiltrating biomarker CCDC80 inhibits malignant
            characterization and tumor formation in gastric cancer
  JOURNAL   BMC Cancer 24 (1), 724 (2024)
   PUBMED   38872096
  REMARK    GeneRIF: Silencing immune-infiltrating biomarker CCDC80 inhibits
            malignant characterization and tumor formation in gastric cancer.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 12301)
  AUTHORS   Meng,S., Dolo,P.R., Guo,P., Hong,J., Li,C., Zhu,X. and Zhou,D.
  TITLE     The expression of long non-coding RNA LINC01279 in gastric
            adenocarcinoma and its clinical significance
  JOURNAL   Asian J Surg 45 (6), 1231-1236 (2022)
   PUBMED   34507839
  REMARK    GeneRIF: The expression of long non-coding RNA LINC01279 in gastric
            adenocarcinoma and its clinical significance.
REFERENCE   3  (bases 1 to 12301)
  AUTHORS   Christian,J.I., Pastula,A., Herbst,A., Neumann,J., Marschall,M.K.,
            Ofner,A., Zierahn,H., Schneider,M.R., Wolf,E., Quante,M. and
            Kolligs,F.T.
  TITLE     Loss of DRO1/CCDC80 in the tumor microenvironment promotes
            carcinogenesis
  JOURNAL   Oncotarget 13, 615-627 (2022)
   PUBMED   35422964
  REMARK    GeneRIF: Loss of DRO1/CCDC80 in the tumor microenvironment promotes
            carcinogenesis.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 12301)
  AUTHORS   Wang,H.H., Luo,W.Y., Lin,M., Li,X.J., Xiang,G.D. and D Triganti,S.
  TITLE     Plasma asprosin, CCDC80 and ANGPTL4 levels are associated with
            metabolic and cardiovascular risk in patients with inflammatory
            bowel disease
  JOURNAL   Physiol Res 70 (2), 203-211 (2021)
   PUBMED   33676388
  REMARK    GeneRIF: Plasma asprosin, CCDC80 and ANGPTL4 levels are associated
            with metabolic and cardiovascular risk in patients with
            inflammatory bowel disease.
REFERENCE   5  (bases 1 to 12301)
  AUTHORS   Liu,J., Wang,Q., Zhang,R., Zhang,C., Lin,J. and Huang,X.
  TITLE     Identification of LINC01279 as a cell cycle-associated long
            non-coding RNA in endometriosis with GBA analysis
  JOURNAL   Mol Med Rep 18 (4), 3850-3858 (2018)
   PUBMED   30106115
  REMARK    GeneRIF: LINC01279 and MSC-AS1 were upregulated in endometriosis.
            LINC01279 may be associated with the pathogenesis of endometriosis.
REFERENCE   6  (bases 1 to 12301)
  AUTHORS   Oh,J.H., Yang,J.O., Hahn,Y., Kim,M.R., Byun,S.S., Jeon,Y.J.,
            Kim,J.M., Song,K.S., Noh,S.M., Kim,S., Yoo,H.S., Kim,Y.S. and
            Kim,N.S.
  TITLE     Transcriptome analysis of human gastric cancer
  JOURNAL   Mamm Genome 16 (12), 942-954 (2005)
   PUBMED   16341674
REFERENCE   7  (bases 1 to 12301)
  AUTHORS   Cha,S.Y., Sung,Y.K., Im,S., Kwack,M.H., Kim,M.K. and Kim,J.C.
  TITLE     URB expression in human dermal papilla cells
  JOURNAL   J Dermatol Sci 39 (2), 128-130 (2005)
   PUBMED   15998583
  REMARK    GeneRIF: URB is expressed in human dermal papilla cells
REFERENCE   8  (bases 1 to 12301)
  AUTHORS   Bommer,G.T., Jager,C., Durr,E.M., Baehs,S., Eichhorst,S.T.,
            Brabletz,T., Hu,G., Frohlich,T., Arnold,G., Kress,D.C., Goke,B.,
            Fearon,E.R. and Kolligs,F.T.
  TITLE     DRO1, a gene down-regulated by oncogenes, mediates growth
            inhibition in colon and pancreatic cancer cells
  JOURNAL   J Biol Chem 280 (9), 7962-7975 (2005)
   PUBMED   15563452
REFERENCE   9  (bases 1 to 12301)
  AUTHORS   Liu,Y., Monticone,M., Tonachini,L., Mastrogiacomo,M., Marigo,V.,
            Cancedda,R. and Castagnola,P.
  TITLE     URB expression in human bone marrow stromal cells and during mouse
            development
  JOURNAL   Biochem Biophys Res Commun 322 (2), 497-507 (2004)
   PUBMED   15325258
  REMARK    GeneRIF: Downregulated during osteoblastic differentiation of bone
            marrow stromal cells.  Suggests role in skeletogenesis.
REFERENCE   10 (bases 1 to 12301)
  AUTHORS   Aoki,K., Sun,Y.J., Aoki,S., Wada,K. and Wada,E.
  TITLE     Cloning, expression, and mapping of a gene that is upregulated in
            adipose tissue of mice deficient in bombesin receptor subtype-3
  JOURNAL   Biochem Biophys Res Commun 290 (4), 1282-1288 (2002)
   PUBMED   11812002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC048334.21.
            
            On or before Nov 30, 2019 this sequence version replaced
            NR_109779.1, NM_199511.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Both variants 1 and 2 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC116178.1, AY548106.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000206423.8/ ENSP00000206423.3
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-817               AC048334.21        137687-138503
            818-2706            AC048334.21        138914-140802
            2707-2863           AC048334.21        148561-148717
            2864-3000           AC048334.21        159726-159862
            3001-3149           AC048334.21        161972-162120
            3150-3253           AC048334.21        168749-168852
            3254-3334           AC048334.21        171574-171654
            3335-12301          AC048334.21        173067-182033
FEATURES             Location/Qualifiers
     source          1..12301
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q13.2"
     gene            1..12301
                     /gene="CCDC80"
                     /gene_synonym="CL2; DRO1; LINC01279; okuribin; SSG1; URB"
                     /note="coiled-coil domain containing 80"
                     /db_xref="GeneID:151887"
                     /db_xref="HGNC:HGNC:30649"
                     /db_xref="MIM:608298"
     exon            1..817
                     /gene="CCDC80"
                     /gene_synonym="CL2; DRO1; LINC01279; okuribin; SSG1; URB"
                     /inference="alignment:Splign:2.1.0"
     exon            818..2706
                     /gene="CCDC80"
                     /gene_synonym="CL2; DRO1; LINC01279; okuribin; SSG1; URB"
                     /inference="alignment:Splign:2.1.0"
     CDS             829..3681
                     /gene="CCDC80"
                     /gene_synonym="CL2; DRO1; LINC01279; okuribin; SSG1; URB"
                     /note="coiled-coil domain-containing protein 80; steroid
                     sensitive gene 1; nuclear envelope protein okuribin;
                     down-regulated by oncogenes protein 1; up-regulated in
                     BRS-3 deficient mouse homolog; TCONS_00006930; long
                     intergenic non-protein coding RNA 1279"
                     /codon_start=1
                     /product="coiled-coil domain-containing protein 80
                     precursor"
                     /protein_id="NP_955805.1"
                     /db_xref="CCDS:CCDS2968.1"
                     /db_xref="GeneID:151887"
                     /db_xref="HGNC:HGNC:30649"
                     /db_xref="MIM:608298"
                     /translation="MTWRMGPRFTMLLAMWLVCGSEPHPHATIRGSHGGRKVPLVSPD
                     SSRPARFLRHTGRSRGIERSTLEEPNLQPLQRRRSVPVLRLARPTEPPARSDINGAAV
                     RPEQRPAARGSPREMIRDEGSSARSRMLRFPSGSSSPNILASFAGKNRVWVISAPHAS
                     EGYYRLMMSLLKDDVYCELAERHIQQIVLFHQAGEEGGKVRRITSEGQILEQPLDPSL
                     IPKLMSFLKLEKGKFGMVLLKKTLQVEERYPYPVRLEAMYEVIDQGPIRRIEKIRQKG
                     FVQKCKASGVEGQVVAEGNDGGGGAGRPSLGSEKKKEDPRRAQVPPTRESRVKVLRKL
                     AATAPALPQPPSTPRATTLPPAPATTVTRSTSRAVTVAARPMTTTAFPTTQRPWTPSP
                     SHRPPTTTEVITARRPSVSENLYPPSRKDQHRERPQTTRRPSKATSLESFTNAPPTTI
                     SEPSTRAAGPGRFRDNRMDRREHGHRDPNVVPGPPKPAKEKPPKKKAQDKILSNEYEE
                     KYDLSRPTASQLEDELQVGNVPLKKAKESKKHEKLEKPEKEKKKKMKNENADKLLKSE
                     KQMKKSEKKSKQEKEKSKKKKGGKTEQDGYQKPTNKHFTQSPKKSVADLLGSFEGKRR
                     LLLITAPKAENNMYVQQRDEYLESFCKMATRKISVITIFGPVNNSTMKIDHFQLDNEK
                     PMRVVDDEDLVDQRLISELRKEYGMTYNDFFMVLTDVDLRVKQYYEVPITMKSVFDLI
                     DTFQSRIKDMEKQKKEGIVCKEDKKQSLENFLSRFRWRRRLLVISAPNDEDWAYSQQL
                     SALSGQACNFGLRHITILKLLGVGEEVGGVLELFPINGSSVVEREDVPAHLVKDIRNY
                     FQVSPEYFSMLLVGKDGNVKSWYPSPMWSMVIVYDLIDSMQLRRQEMAIQQSLGMRCP
                     EDEYAGYGYHSYHQGYQDGYQDDYRHHESYHHGYPY"
     exon            2707..2863
                     /gene="CCDC80"
                     /gene_synonym="CL2; DRO1; LINC01279; okuribin; SSG1; URB"
                     /inference="alignment:Splign:2.1.0"
     exon            2864..3000
                     /gene="CCDC80"
                     /gene_synonym="CL2; DRO1; LINC01279; okuribin; SSG1; URB"
                     /inference="alignment:Splign:2.1.0"
     exon            3001..3149
                     /gene="CCDC80"
                     /gene_synonym="CL2; DRO1; LINC01279; okuribin; SSG1; URB"
                     /inference="alignment:Splign:2.1.0"
     exon            3150..3253
                     /gene="CCDC80"
                     /gene_synonym="CL2; DRO1; LINC01279; okuribin; SSG1; URB"
                     /inference="alignment:Splign:2.1.0"
     exon            3254..3334
                     /gene="CCDC80"
                     /gene_synonym="CL2; DRO1; LINC01279; okuribin; SSG1; URB"
                     /inference="alignment:Splign:2.1.0"
     exon            3335..12301
                     /gene="CCDC80"
                     /gene_synonym="CL2; DRO1; LINC01279; okuribin; SSG1; URB"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3811..3816
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CCDC80"
                     /gene_synonym="CL2; DRO1; LINC01279; okuribin; SSG1; URB"
                     /note="hexamer: AATAAA"
     polyA_site      3833
                     /gene="CCDC80"
                     /gene_synonym="CL2; DRO1; LINC01279; okuribin; SSG1; URB"
                     /note="major polyA site"
     regulatory      12284..12289
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CCDC80"
                     /gene_synonym="CL2; DRO1; LINC01279; okuribin; SSG1; URB"
                     /note="hexamer: AATAAA"
     polyA_site      12301
                     /gene="CCDC80"
                     /gene_synonym="CL2; DRO1; LINC01279; okuribin; SSG1; URB"
ORIGIN      
        1 agccttctca ctcctcactg agtccactct gaacgtgcta aaatgggaag gaggcggtgt
       61 tttgctgatc tgttaaattc ttagtgaagt ttccttgatt tccagtggct gctgttgttt
      121 gagtttggtt tggagcaaaa ctgaggtagt cctaacattt ctgggactga atccaggcaa
      181 gagaaagaag aaaaagaaga agaaaaagag gaggaaaaag gtagggagaa ataaagggag
      241 gagagaagca cagtgaaaga aaaaaaaagt cccttttcga catcacattc ctgtgttttc
      301 cctcagcctg gaaaacatat taatcccagt gcttttacgc ccggaaacaa agagactaag
      361 ccagactatg ggggaaaggg agataagaag gatcctggaa ctttaaagag ggaaagagtg
      421 agattcagaa atcgccagga ctggacttta agggacgtcc tgtgtcagca caagggactg
      481 gcacacacag acacacgaga ccgaggagaa actgcagaca aatggagata caaagactta
      541 gaaggacagc tcctttcacc tcatcctact tgtccagaag gtaaaaagac acagccagaa
      601 agaaaaggca tcggctcagc tctcagatca ggacaggctg tggatctgtg gcggtactct
      661 gaaagctgga gctgcagcac accccttttg tattgctcac cctcggtaaa gagagagagg
      721 gctgggagga aaagtagttc atctaggaaa ctgtcctggg aaccaaactt ctgatttctt
      781 ttgcaaccct ctgcattcca tctctatgag ccaccattgg attacacaat gacatggaga
      841 atgggacccc gtttcactat gctgttggcc atgtggctag tgtgtggatc agaaccccac
      901 ccccatgcca ctattagagg cagccacgga ggacggaaag tgcctttggt ttctccggac
      961 agcagtaggc cagctcggtt tctgaggcac actgggaggt ctcgcggaat tgagagatcc
     1021 actctggagg aaccaaacct tcagcctctc cagagaagga ggagtgtgcc cgtgttgaga
     1081 ctagctcgcc caacagagcc gccagcccgc tcggacatca atggggccgc cgtgagacct
     1141 gagcaaagac cagcagccag gggctctccg cgtgagatga tcagagatga ggggtcctca
     1201 gctcggtcaa gaatgttgcg tttcccttcg gggtccagct ctcccaacat ccttgccagc
     1261 tttgcaggga agaacagagt atgggtcatc tcagcccctc atgcctcgga aggctactac
     1321 cgcctcatga tgagcctgct gaaggacgat gtgtactgtg agctggcgga gaggcacatc
     1381 caacagattg tgctcttcca ccaggcaggt gaggaaggag gcaaggtgag aaggatcacc
     1441 agcgagggcc agatcctgga gcagcccctg gaccctagcc tcatccctaa gctgatgagc
     1501 ttcctgaagc tggagaaggg caagtttggc atggtgctgc tgaagaagac gctgcaggtg
     1561 gaggagcgct atccatatcc cgttaggctg gaagccatgt acgaggtcat cgaccaaggc
     1621 cccatccgta ggatcgagaa gatcaggcag aagggctttg tccagaaatg taaggcctct
     1681 ggtgtagagg gccaggtggt ggcggagggg aatgacggtg gagggggagc aggaaggcca
     1741 agcctgggca gcgagaagaa gaaagaggac ccaaggagag cacaagtccc accaaccaga
     1801 gagagtcggg tgaaggtcct gagaaaactg gccgccactg caccagcttt gccccaacct
     1861 ccctcaaccc ccagagccac cacccttcct cctgccccag ccacaacagt gactcggtcc
     1921 acgtcccggg cggtaacagt tgctgcaaga cctatgacca ccactgcctt tcccaccacg
     1981 cagaggccct ggaccccctc accctcccac aggcccccta caaccactga ggtgatcact
     2041 gccaggagac cctcagtttc agagaatctt taccctccat cccggaagga tcagcacagg
     2101 gagaggccac agacaaccag gaggcccagc aaggccacca gcttggagag cttcacaaat
     2161 gcccctccca ccaccatctc agaacccagc acaagggctg ctggcccagg ccgtttccgg
     2221 gacaaccgca tggacaggcg ggaacatggc caccgagacc caaatgtggt gccaggtcct
     2281 cccaagccag caaaggagaa acctcccaaa aagaaggccc aggacaaaat tcttagtaat
     2341 gagtatgagg agaagtatga cctcagccgg cctactgcct ctcagctgga ggacgagctg
     2401 caggtgggga atgttcccct taaaaaagca aaggagtcta aaaagcatga aaagcttgag
     2461 aaaccagaga aggagaagaa aaaaaagatg aagaatgaga acgcagacaa gttacttaag
     2521 agtgaaaagc aaatgaagaa gtctgagaaa aagagcaagc aagagaaaga gaagagcaag
     2581 aagaaaaaag gaggtaaaac agaacaggat ggctatcaga aacccaccaa caaacacttc
     2641 acgcagagtc ccaagaagtc agtggccgac ctgctggggt cctttgaagg caaacgaaga
     2701 ctccttctga tcactgctcc caaggctgag aacaatatgt atgtgcaaca acgtgatgaa
     2761 tatctggaaa gtttctgcaa gatggctacc aggaaaatct ctgtgatcac catcttcggc
     2821 cctgtcaaca acagcaccat gaaaatcgac cactttcagc tagataatga gaagcccatg
     2881 cgagtggtgg atgatgaaga cttggtagac cagcgtctca tcagcgagct gaggaaagag
     2941 tacggaatga cctacaatga cttcttcatg gtgctaacag atgtggatct gagagtcaag
     3001 caatactatg aggtaccaat aacaatgaag tctgtgtttg atctgatcga tactttccag
     3061 tcccgaatca aagatatgga gaagcagaag aaggagggca ttgtttgcaa agaggacaaa
     3121 aagcagtccc tggagaactt cctatccagg ttccggtgga ggaggaggtt gctggtgatc
     3181 tctgctccta acgatgaaga ctgggcctat tcacagcagc tctctgccct cagtggtcag
     3241 gcgtgcaatt ttggtctgcg ccacataacc attctgaagc ttttaggcgt tggagaggaa
     3301 gttgggggag tgttagaact gttcccaatt aatgggagct ctgttgttga gcgagaagac
     3361 gtaccagccc atttggtgaa agacattcgt aactattttc aagtgagccc ggagtacttc
     3421 tccatgcttc tagtcggaaa agacggaaat gtcaaatcct ggtatccttc cccaatgtgg
     3481 tccatggtga ttgtgtacga tttaattgat tcgatgcaac ttcggagaca ggaaatggcg
     3541 attcagcagt cactggggat gcgctgccca gaagatgagt atgcaggcta tggttaccat
     3601 agttaccacc aaggatacca ggatggttac caggatgact accgtcatca tgagagttat
     3661 caccatggat acccttactg agcagaaata tgtaacctta gactcagcca gtttcctctg
     3721 cagctgctaa aactacatgt ggccagctcc attcttccac actgcgtact acatttcctg
     3781 cctttttctt tcagtgtttt tctaagacta aataaatagc aaactttcac ctattcatga
     3841 gttattattg aaacctcaaa tcataaagac atttaaaaga attgtttttc taactggagg
     3901 ggctctagtg ctaaataata gtactgaaaa ttgatattat tttccttttc ttatatgaag
     3961 gaccttattt ggcatataaa attttataaa atatgtattt aaagcttttt cttatttttt
     4021 gtattaattg gtaagtgaaa actctgttaa agatcacacc acaatgtttt caagaaacat
     4081 ctgaaaagat aaaacaaaga acaaataact tataatactt acttaaattg acactttttg
     4141 aaatgccagt ctgaaaataa ttaagatatc tctgctttgt atgagtttct tttatgaaac
     4201 ttgataccac gggagtccag taatattggc cacaaaagcc agagaaagta ccaagcccag
     4261 ctttgttatc atagccactt cctgccctgc ttctgttatt tttagtgttt tttcagatat
     4321 aaatcggggt ccaggaaatc ctcaccagaa tctggcactg cagccaaagg cgatacttcc
     4381 agagttctag taggctgcta tggaatttct ggcatgaaaa ttcttgaccc ctcacacttt
     4441 accccctgta cagcacaggc ataccatgga gatattacag gatcagttcc agaccaccat
     4501 aataaagtgg atatcgcaat aaagtgagtc acacaaaatt tttggtttct cagtgcatat
     4561 aaaagttatg tttacactct ttagtagtct attaagtgta taatagcttt atgtccaaaa
     4621 aatgtacatg ttttatttta aaaatacttt attgctaaaa attgctaatg atcataatct
     4681 ttttgcattg atgttgatgg ctgctgaatg atcagggtgg tggttactga aggttggggg
     4741 tgatggtggc aatttcttaa aataagacag caatgaagtt tgccacttcg attgactttt
     4801 tcttcatgaa agatttctct gcagcatgtg atgctgtatg atagcatttt accagtagta
     4861 caacttcttt tgaaattgga gccaatcctc tcaaaccctg ttgctgcttt attaatgaaa
     4921 tttatgtaat gttgtaaatc ctttgttgtc atttcaataa tgtacatagc aacttacgcg
     4981 agtagattcc atctcaagaa atcactttct tcgttcattc ataagaagca agtcttcatc
     5041 tattaaactt ttgtaatgag attgcagcaa ttcagtcaca tcttcaggct ccacttctaa
     5101 ttccagttct cttgctattt ccactatgtc tatagcagag cttcctccaa tgaagtcttg
     5161 ggcctcttaa aatcatccat gagggatgga atcagtttcc gaactcattg atcttcctat
     5221 tttgaccttc tcccatgaat cacgatgttc ttaacagcat ctagaatggt gaatcctttc
     5281 caggttttta atttgctttg cccagatcca ttagcgggat cacaatctgt gacagttata
     5341 gtcttacgaa aagtgcaaat gactccttga ttcctgtgct gcacaatagg tattgtgtta
     5401 gcaggcacga aaatattaat ctccttgtat atctctatcc aagttcttgg gtgactgggt
     5461 atattgtcag tgaacagcta tatatatata tattatagtg gtctggaact gatcatttat
     5521 atatatattt tatatacata tataaaatat ataatatata ttatatatat atatattttt
     5581 ttcgagatgg agtctcgctc tgtcacccag gctggagtgc agtggtgcga tcttggctca
     5641 ctgcaacctc tgcctccggg gttcaagtga ttctcctgcc tcagacccct gagtagctgg
     5701 atttacaggc gcccaccact acacccagct tatttttgta tttttagtag agatggggtt
     5761 tcaccatgtt agtcagggtg gtctcgaact actgactttg gcctcggcct cccaaagtgc
     5821 tgggattaca ggcatgagcc actgcgcccg gcccgaacag caatattttt aaaagattct
     5881 ttttttttct gagcagtaag actcaaaaag tgagcttaaa atgtccagta aaccatgctg
     5941 tccatagaca tgctgtcatt caggctttgt tgctccattt atagagcaca ggcagattag
     6001 atttagcata attctgaaaa gtcgtaggat ttggggaaat ggtaaatgag cattgatttc
     6061 aacttaaaat caccagctgc gttaacttct aacaaggagt aagcctgttg gttgaagctt
     6121 tgaagtgagg cattgactac tcctctctag atacgtaagt ctgagatggc atcttcttcc
     6181 aatataaggc tgtttcatct cttttgaaaa tctattgttt agtgtagcca ctttcattaa
     6241 ttatcttaac tagatcttct ggataactta ctgcagcttc tacatcaaca tttgctgctt
     6301 tactttgcac ttttatggat gcacaaggct tcttttcttc aaactcatga accagactct
     6361 gctaccttca aacttttttt ctgaagcttc ctcacctccc tttagctttc atagaattga
     6421 agagagttag ggccttgctc tgaactaggc tttggcttaa gggaattttg tggctggctt
     6481 gatcttctat tcagatgact caaagtttct ccatatcagc agtaaggctg ttttactttt
     6541 ttatcattca tgcattcaca aagtagcact tttaatttcc ttcaagaact tttcctttgc
     6601 atttacaact tggttgtttg gcataagagg cttagctttc agcctgtctc agcttttgac
     6661 acaccttcct cactaagctt attcatttct agcttttgat ttaaagtgaa agattgcaac
     6721 ttcctctcac ttgaaatacc tggaggctat tttagggtta ttaattgatc tactttcaat
     6781 attgtgtctc agggactaag gaggcctgag aagaaggaga aagattggag aaaggttggt
     6841 tgttggagca atcagaacat acacacattt attaagttta ctgtgttata taagtgtggt
     6901 tcatggtgcc cccagtaatt ataatagcaa catcaaagat cgttgactac agattttaat
     6961 aacagagata ataatgaaac agtgtgaaat atggcaagaa ttaccaaaat gtgacacaga
     7021 gacataaagt gagtacatac tattgcaaaa atgatgtcaa cagacttcct tgatgcaggg
     7081 ttgccacaaa ccttcaattt gtaaaaaatg cagtatctga gaagtataat aaaataagat
     7141 gtgcctgtac ttacttgcta atggacctat taccatactg gcatcttata aaaaaaatta
     7201 caaggaagga gattatatcc agggattctt tttgttttca aggcaaaggt taccaagtta
     7261 caatggacca aagtagctgg aatgcaaagg agtataatcc ttgtctttga aaaaagagca
     7321 tttgtttcaa tcatatggca tatcaaagta aactttctcc cttcctccct cctttcgttg
     7381 ctgctgcttc ttttttttct cttttttttt ttcttttttt ggagagggtc tcactctgtc
     7441 acccaggctg cagtgcagta gtgcaatctt ggctcactgc aaactcagct tccctcaaac
     7501 aatcctccca cctcagcatc ccaagttagc tgggaccaca gccatgctcc accatgccca
     7561 gccatccttg cttctttact acatttcttt tttcaacaaa tatttatcaa gtaatattgt
     7621 caagtaatat ttatgagctt cccctcagat aggcatttag catcatgatg gcaccatcct
     7681 ctaacaataa tgggaaggct attttccact gttattaatc attaattctc caaatcattt
     7741 tagtattatt attaattcta ataagtacag agattaataa atgcattcaa accacatgtg
     7801 aatatttgct ataggtttat ctgtgcctac tgtatgttca gatttttctt tatatctgaa
     7861 ctttgttata aataaatgac agtaaaaatg gaatttatag ttcaatgaac ttgacaaatc
     7921 acttattctg ccattcattt tccataaaga ccattcattc ttccttgttt tacaggtaac
     7981 tgagctccag aaagctcaag tgactttaga actcagttct tagtgtgtga attatgctcc
     8041 catctcatcc ctcttccttg atggagcact ttcctcctca ttttttcttg gatagtctgt
     8101 acaagctgcc tgaggtgtgc aggaaagtga gccacgtcga agtgtactgc ttttaaattt
     8161 ttgccaggat gaagcatagc ccaaagttgc caataaaaat ggatttcttt acctttctga
     8221 aattgtgtga tgacaatttc taagtaaagg acccaaatca tgtcaacttc aggaaatata
     8281 ataatgaggg agccaggagc agtgaggggc tcacacctgt aatcccagca ctttgggagg
     8341 ccaaggtgag cgggtcgctt gagcccagga cttcgagacc agcctgggca acacggcaaa
     8401 accctgtctc tacaaaaaaa tacaaaaaat tagctgggta aggtggtgtg tgtctgtggt
     8461 cccagctatt caggaggctg aagtgagaga atcgcttgag cctaggaggt cgaggcttca
     8521 gtgtgccgtg atcgtgccac agcactccat catcatcatc ctgggtgaca aagtgagacc
     8581 ctgtctcccc accaaaaaaa agagggagtt tcatctccca agaaaatgaa ttagatagga
     8641 ataatagaaa atttactctc agaataatag ggttctagct cctgcaacca aaaaaagata
     8701 gttctttttt acaacctgag attacttttt caagcatttc tccagttcca ctggcattga
     8761 aataatagtt agcaatgcat ctgagctttt cttcctctaa tgagcaggca gagaagtcat
     8821 agatcatcat ttggaggact ataaaataag acatagctta gcaaaaggac caaaatacat
     8881 tcagaggagg atgctattgg tgaatgtcct caaagcctat aatctggaaa aatacaaggc
     8941 atatctctga aactgtgagg attagcaaac tagctaacct gaatctctgt cttctggtag
     9001 tataaactag gtagtttcaa atctgagtag tttctccata aaagcatttc ttcccaaacg
     9061 tttcttacca aactcccaaa taaatgagaa aaataaaata cagttttata atttttgaga
     9121 aagattatgg gattatggta tttaaaaaga aaagcattct gtagagttgg ggaaatctgg
     9181 aagactcttg aggacatagc tttgccgaaa ttgctggttg tcacaagact cttcaaaaac
     9241 tacttttcat cagacatctc ccagggctct gaggtgaata ttaattcagc agaaagatcc
     9301 ttttctgcta cataggcagg aggtccagac acaggggagt gggtgcaacc cagctggtcc
     9361 cattttctgt aatataatta acaatgaagc tcatactttc tcaacttcta gaagcctgga
     9421 ggatggaagc agcccgagag tagggtgaat gatggcctca gtgggccctt cttaatgtgt
     9481 ctcagtactg aatgtgtgga gattgtagaa aaatagaagg cccttggaaa aaacctctgt
     9541 tcgtttctct gttcgtttcg ctccctgatc tccctgccgg attgcttttc tttcctttct
     9601 cttccttggc tgtcctttac ctcatggtgt ggggtgtgca gatagcaggt tgtggcttgg
     9661 tgagtgctct tcacttcagg tcaaggtgag gcacagttaa catgctaact actttcctca
     9721 gttctctctg agttgtgtaa agctcccgat gccagacttc ctcttaattt tgcacattat
     9781 taaagtccaa agagttaaga tttggtgatg aggggcaaag ggccagctgt cacagaaatc
     9841 aatgaaatga tacacagaaa tgggtatcat gaaaaggcca ctggacttgg gaaaactggg
     9901 tgcctgtcct tgccctgcca tgtacttacc tgtgtgactg gaggtgagat gttttaccta
     9961 tgggcctcag tttctcatta caaaatgaca gagaagacta gatacctaag ttcctaagtt
    10021 tgtgacattt gtgaattttt cttggccctc tgtgagtaga gtgctaaatt tagaggcttc
    10081 ctgtggttga actgatgtcc aattctcagg gaacccagac ttctcagttc agaacccagt
    10141 tccagatttt tgtgggaata gggaaaggta ttaaataact ccattgaatt ctttcctgca
    10201 taatgccctg ctgtggctga gactcaatga ggtcatcacc tccaacacac agaacccctc
    10261 atcatctcct tacagccaga ctggagcttc caaggacatc aggttggcaa ggattgtgag
    10321 taccctaaac atctaaagag gccctctaat aagggacata tttgttcttc aacagtttcc
    10381 taacttgaga ccacaaatgc gtaatctctc taatatccta aagcttggac aaactgggca
    10441 gcccctgagc agaccgcaca gagcttaaat gtcagtgctt tccttccaga aagaaaaaga
    10501 atggtcctac acctcccaat ccatgggctg atacatatgc caagggagcc ggatgaagaa
    10561 gtgggtgatt ttaaatagct aagactgccc atgggcaaac gttctttggc ttttctcctc
    10621 tgcaataagt ataccttcct ctctcctggt ccttttctcc tttcccaggc ccctctatca
    10681 ataataattc tggctctcag atgactacag ttgattaggt ggaactgata ggataaaggt
    10741 gacacccttc ccaaggctat ctataatgca aaaagatatc caagaaaaag agaggtaggg
    10801 aacaccttgg gaaaccattt ctggaagaca gccagtccct gctgtagaca agcctcattt
    10861 tccttccccc aaatgttaaa gagtaaattc ctcctgtagc cttagctctc ttttctatct
    10921 ttggcttgct ttttatgaac tatctttaga gtgccaaatt agaacagggt aggcagaggc
    10981 aggaatatgc ccaaatttgg gaagacctgg ttgggaatag tcgaaagcct tgatatgtgc
    11041 aaagaaagaa ccatttgatc aacccagttc ttaatacagg atactaactt aaaatttaga
    11101 ctcaagttat acgataattc aaacatttat tgtatttata ctattctata tgtacttttc
    11161 caggaaccag gaatacaaaa ctgacatttc tctgtacaga ggctcagact agtagagaac
    11221 agttaggtac gccgttaatt ataaactaat atgtatcatc aattatgggt ttttatgggg
    11281 gtttggcagg tggaagggac cagggagaga tgatgagtga tgatggttat gtagtcttta
    11341 ggaggatgca attataacat tgctcttcct ttcacgcacc acatgattta gcaagtactt
    11401 catattggct ccaccattaa catggtcaat ggcttctgga tactcacagt tcaggcacag
    11461 tttctcctga agatttttta cctctcccat ctttaagaaa ttgtctggat gtccatgaaa
    11521 gatgctgaca cttgtattaa ttcattaaaa aacaccaccc cctccctgaa ataaactaaa
    11581 aagtaatgaa ttcatagaaa aaaatttcac caagattgaa actagagaat atacctagac
    11641 ttgcactttg agctttgaga aatgtgtacc tattcaccat tccaacgtga agaagctctg
    11701 cagtaggaaa aataattaac acacttatag tctactgccc atgtaaggat cagctccggc
    11761 taagaggcca aagatgggtg acatcgttat gctctgcctt tattttttct ttcttaccca
    11821 cttagcttcc taattggagg aaggaggcgt ggtaaaggta tatgaagact atggtttaat
    11881 tagaccagaa aacactgtca taatctctgg ggtcatcaga atgtccagtt ttgtctttgg
    11941 gccaagataa gggcagtggg atttatgatg tgttgtttat agtctgaaac tactctggtg
    12001 atcaccaggg tcagtttctt taatgatggt ttccaactgg cctaatacat taagtaagac
    12061 tggctgataa catgaccaga cagacataaa gaccctgttg ggaatgacat tgaactctca
    12121 aagtcaagat ttcttacaca aatctatcag ctggagaaaa tgaaggcagt gtggtatatg
    12181 tgtgcaaata aggacattat gaagcttaaa tatggaatgt ctcttggacc cccgatgtca
    12241 tctgtattct ctttttcttc ttgtactata tcctttgcct gtaaataaaa ggtttatttg
    12301 a
//
