LOCUS       NM_001008391            3395 bp    mRNA    linear   PRI 05-AUG-2024
DEFINITION  Homo sapiens coiled-coil domain containing 73 (CCDC73), mRNA.
ACCESSION   NM_001008391
VERSION     NM_001008391.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3395)
  AUTHORS   Khan,M., Jabeen,N., Khan,T., Hussain,H.M.J., Ali,A., Khan,R.,
            Jiang,L., Li,T., Tao,Q., Zhang,X., Yin,H., Yu,C., Jiang,X. and
            Shi,Q.
  TITLE     The evolutionarily conserved genes: Tex37, Ccdc73, Prss55 and Nxt2
            are dispensable for fertility in mice
  JOURNAL   Sci Rep 8 (1), 4975 (2018)
   PUBMED   29563520
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3395)
  AUTHORS   Lee,S.Y., Obata,Y., Yoshida,M., Stockert,E., Williamson,B.,
            Jungbluth,A.A., Chen,Y.T., Old,L.J. and Scanlan,M.J.
  TITLE     Immunomic analysis of human sarcoma
  JOURNAL   Proc Natl Acad Sci U S A 100 (5), 2651-2656 (2003)
   PUBMED   12601173
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL035400.13, AL049714.6, AL096793.20 and AL078477.5.
            
            On Oct 11, 2020 this sequence version replaced NM_001008391.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK131470.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000335185.10/ ENSP00000335325.5
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-50                AL035400.13        110557-110606
            51-200              AL049714.6         33293-33442
            201-272             AL096793.20        20188-20259
            273-344             AL096793.20        35391-35462
            345-380             AL096793.20        37509-37544
            381-455             AL096793.20        39010-39084
            456-494             AL096793.20        54761-54799
            495-630             AL096793.20        62314-62449
            631-710             AL096793.20        62691-62770
            711-839             AL078477.5         10265-10393
            840-899             AL078477.5         11200-11259
            900-1004            AL078477.5         12010-12114
            1005-1115           AL078477.5         23155-23265
            1116-1250           AL078477.5         29407-29541
            1251-1440           AL078477.5         49108-49297
            1441-2961           AL078477.5         50295-51815
            2962-3095           AL078477.5         53972-54105
            3096-3395           AL078477.5         62217-62516
FEATURES             Location/Qualifiers
     source          1..3395
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11p13"
     gene            1..3395
                     /gene="CCDC73"
                     /gene_synonym="NY-SAR-79"
                     /note="coiled-coil domain containing 73"
                     /db_xref="GeneID:493860"
                     /db_xref="HGNC:HGNC:23261"
                     /db_xref="MIM:612328"
     exon            1..50
                     /gene="CCDC73"
                     /gene_synonym="NY-SAR-79"
                     /inference="alignment:Splign:2.1.0"
     exon            51..200
                     /gene="CCDC73"
                     /gene_synonym="NY-SAR-79"
                     /inference="alignment:Splign:2.1.0"
     CDS             66..3305
                     /gene="CCDC73"
                     /gene_synonym="NY-SAR-79"
                     /note="sarcoma antigen NY-SAR-79"
                     /codon_start=1
                     /product="coiled-coil domain-containing protein 73"
                     /protein_id="NP_001008392.2"
                     /db_xref="CCDS:CCDS41630.1"
                     /db_xref="GeneID:493860"
                     /db_xref="HGNC:HGNC:23261"
                     /db_xref="MIM:612328"
                     /translation="MESNFNTESSSTFTLQSSSETLFSIQLLDFKTSLLEALEELRMR
                     REAEIHYEEQIGKIIVETQELKWQKETLQNQKETLAEQHKEAMAVFKKQLQMKMCALE
                     EEKGKYQLATEIKEKEIEGLKETLKALQVSKYSLQKKVSEMEQKVQLHLLAKEDYHKQ
                     LSEIEKYYATITGQFGLVKENHEKLEQNVREAIQSNKRLSALNKKQEAEICSLKKELK
                     KAASDLIKSKVTCQYKMGEENINLTIKEQKFQELQERLNMELELNEKINEEITHIQEE
                     KQDIIISFQHMQQLLRQQIQANTEMEAELKVLKENNQTLERDNELQREKVKENEEKFL
                     NLQNEHEKALGTWKRHAEELNGEINKIKNELSSLKETHIKLQEHYNKLCNQKTFEEDK
                     KFQNVPEVNNENSEMSTEKSENTIIQKYNTEQEIREENMENFCSDTEYREKEEKKEGS
                     FIEEIIIDDLQLFEKSFKNEIDTVVSQDENQSEISLSKTLSLDKEVISQGQTSNVTDN
                     RKSVTTEIKDKICLEKDNGCTEFKSPNNHFVVLDTAIETEKIHLERTRGLDVHHTDVN
                     LEVENNKTSFNSILNETAHNTYHNNNKDVSENEPFKQFRLLPGTREHALEKEITNSDQ
                     TKADLDSSLDIKKNPVPCQKYSLRNSSNVMLDDKQCKIKQIQLLTKKSECSILLSKQT
                     SDFLQVCNDTLEKSELTVPCDIVIDHHVSYAAFSANSKLLLKNSDKNVHSMSMLVKPN
                     SSPGGKTMCKNMSDMQNSQFNNCLGYLENTNVNISHLHLNNENSHASQAKDVKTAVHM
                     KTCTETEFSNKKNQIDENQVTEATKNDLFLFVSINERQHTLLNNTEKTESLNDIVSGK
                     MFSEGQLEESHSFHIEPSGDLVNRSGRSTFDLSTSDKKTEKTPVYMNFSDPGPWSKVN
                     HIESQTASSSTPCISLLLKERPLDPSENKKIISMALCKNIGVDDVGKDIGPDTTSINR
                     VADTLNNWSIHPDPKGEPSEEKNAMAKTFYDSSFPTEHVKTKPLISTPLQSHLQAIKT
                     TKNTSGDDDWQSLITNQLNKSENLLSLENDNQPKKRKAEETLEKNNRLK"
     exon            201..272
                     /gene="CCDC73"
                     /gene_synonym="NY-SAR-79"
                     /inference="alignment:Splign:2.1.0"
     exon            273..344
                     /gene="CCDC73"
                     /gene_synonym="NY-SAR-79"
                     /inference="alignment:Splign:2.1.0"
     exon            345..380
                     /gene="CCDC73"
                     /gene_synonym="NY-SAR-79"
                     /inference="alignment:Splign:2.1.0"
     exon            381..455
                     /gene="CCDC73"
                     /gene_synonym="NY-SAR-79"
                     /inference="alignment:Splign:2.1.0"
     exon            456..494
                     /gene="CCDC73"
                     /gene_synonym="NY-SAR-79"
                     /inference="alignment:Splign:2.1.0"
     exon            495..630
                     /gene="CCDC73"
                     /gene_synonym="NY-SAR-79"
                     /inference="alignment:Splign:2.1.0"
     exon            631..710
                     /gene="CCDC73"
                     /gene_synonym="NY-SAR-79"
                     /inference="alignment:Splign:2.1.0"
     exon            711..839
                     /gene="CCDC73"
                     /gene_synonym="NY-SAR-79"
                     /inference="alignment:Splign:2.1.0"
     exon            840..899
                     /gene="CCDC73"
                     /gene_synonym="NY-SAR-79"
                     /inference="alignment:Splign:2.1.0"
     exon            900..1004
                     /gene="CCDC73"
                     /gene_synonym="NY-SAR-79"
                     /inference="alignment:Splign:2.1.0"
     exon            1005..1115
                     /gene="CCDC73"
                     /gene_synonym="NY-SAR-79"
                     /inference="alignment:Splign:2.1.0"
     exon            1116..1250
                     /gene="CCDC73"
                     /gene_synonym="NY-SAR-79"
                     /inference="alignment:Splign:2.1.0"
     exon            1251..1440
                     /gene="CCDC73"
                     /gene_synonym="NY-SAR-79"
                     /inference="alignment:Splign:2.1.0"
     exon            1441..2961
                     /gene="CCDC73"
                     /gene_synonym="NY-SAR-79"
                     /inference="alignment:Splign:2.1.0"
     exon            2962..3095
                     /gene="CCDC73"
                     /gene_synonym="NY-SAR-79"
                     /inference="alignment:Splign:2.1.0"
     exon            3096..3395
                     /gene="CCDC73"
                     /gene_synonym="NY-SAR-79"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3368..3373
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CCDC73"
                     /gene_synonym="NY-SAR-79"
                     /note="hexamer: AATAAA"
     polyA_site      3391
                     /gene="CCDC73"
                     /gene_synonym="NY-SAR-79"
                     /note="major polyA site"
ORIGIN      
        1 aaaaggtgaa ccggaagggc caacaggagc tagaggcgcg cttcgctgag gaaataaata
       61 ttaatatgga aagcaacttc aatactgagt catcatctac ttttactctt caaagttctt
      121 cagagacatt gttttctatt cagctattag atttcaaaac aagtttactg gaggcattag
      181 aagaattgcg tatgagaagg gaagcagaaa ttcattatga agagcagatt ggtaaaatta
      241 ttgtggagac acaggaactt aaatggcaaa aggaaactct tcagaatcaa aaggaaacat
      301 tggcagagca acacaaggaa gcaatggcag tttttaaaaa gcagttgcag atgaagatgt
      361 gtgccctgga agaagaaaag ggaaaatatc aacttgctac agaaataaag gaaaaagaaa
      421 tagaaggatt gaaggaaaca ttaaaagcac tacaggtttc taaatactct ttacagaaga
      481 aagtgagtga aatggaacaa aaggtccagt tacatcttct ggctaaagaa gactatcata
      541 agcaactgag tgaaattgag aaatattatg ccacaataac aggtcaattt ggattggtaa
      601 aagagaatca tgaaaagtta gaacaaaatg tacgggaagc aatacaatca aacaaaagac
      661 tttcagcttt aaataaaaaa caagaagctg aaatatgcag tttaaagaag gaactaaaaa
      721 aagcagcctc agacttgata aagtccaaag tcacatgtca atataagatg ggagaagaaa
      781 acatcaatct aacaattaaa gaacaaaaat ttcaagaact tcaagaaaga ctcaacatgg
      841 aattggaatt aaatgagaag attaatgaag agattaccca tattcaagaa gaaaaacagg
      901 atatcatcat ttctttccaa catatgcagc agttacttcg gcaacaaatt caagctaata
      961 ctgaaatgga ggcagaattg aaggtgctaa aagaaaataa tcagaccctt gaaagagata
     1021 atgagctgca aagggagaag gtaaaagaaa atgaagaaaa gtttcttaat cttcaaaatg
     1081 agcatgaaaa agcactagga acttggaaaa gacatgctga agaacttaat ggagaaatta
     1141 ataagattaa aaatgaatta tcatccctta aagaaactca tattaagtta caagaacatt
     1201 ataacaaatt atgcaatcaa aaaacatttg aggaagacaa aaagtttcag aatgttccag
     1261 aagtaaataa tgaaaacagt gaaatgtcaa ctgaaaaatc agaaaacacc attatacaga
     1321 aatataatac tgagcaagaa ataagggaag aaaatatgga gaatttttgt tcagatactg
     1381 aatacagaga aaaagaagaa aaaaaagaag gctcatttat agaggaaata attatagatg
     1441 atttacagct ttttgaaaaa agcttcaaga atgaaattga tactgttgtt tctcaggatg
     1501 aaaatcaaag tgaaatctcc ttaagcaaaa ccctctcctt agataaagaa gtaattagtc
     1561 aaggacaaac ctcgaatgtt acggacaaca gaaaatcagt tactacagaa ataaaagaca
     1621 agatatgctt ggaaaaagac aatggatgta cagaatttaa atcaccaaat aatcattttg
     1681 tagtgttaga tacagcaata gaaacagaaa aaatacatct agaaagaacc agaggattag
     1741 atgttcacca tacagatgta aatctggagg ttgaaaataa caaaacatca tttaacagta
     1801 ttttaaatga gacagcacac aatacatatc acaataataa taaagatgtt tctgaaaatg
     1861 agccattcaa acaattcaga ttgcttccag ggactcgaga acatgctcta gagaaggaaa
     1921 ttacaaatag tgaccaaacc aaagcagatt tggactcgtc tctagatata aaaaaaaatc
     1981 ctgttccatg tcagaaatat agtttacgga attcaagtaa tgttatgtta gatgataaac
     2041 aatgtaaaat aaaacaaata caactgttaa ctaaaaaaag tgagtgcagc atattacttt
     2101 ctaaacaaac ttcagatttt ctgcaagtct gtaatgatac tttagagaaa tctgaactaa
     2161 ctgttccctg tgatatagta atcgaccacc atgtttcata tgctgctttt agtgctaatt
     2221 caaaactact tctgaagaac tcagataaaa atgtccatag tatgtctatg ttggtgaaac
     2281 ctaactcaag ccctggggga aaaactatgt gtaaaaatat gagtgatatg caaaacagtc
     2341 aatttaataa ctgtttggga tacttagaaa acactaatgt gaacatttcc catcttcatc
     2401 ttaacaatga gaatagtcat gcttcacaag ccaaagatgt gaaaactgct gttcacatga
     2461 aaacttgcac agaaacagag ttttccaata aaaagaatca gattgatgag aatcaggtaa
     2521 ctgaagccac aaaaaatgac ctcttccttt ttgtgagcat taatgaaaga cagcatacat
     2581 tgttaaataa tacagagaaa acagaatcat taaatgacat tgtttcagga aaaatgttca
     2641 gtgaaggaca gctggaggaa tcacattcat ttcacataga gccatctgga gatttagtaa
     2701 acagaagcgg aaggtcaacc tttgatcttt caacttcaga taaaaaaact gagaaaactc
     2761 cagtatacat gaatttttca gaccccggtc cttggtcaaa agtaaatcac attgaaagtc
     2821 aaacagcgag cagttcgacc ccttgcattt ctttgttgct gaaggagaga ccactagatc
     2881 catcagaaaa caaaaagatc atttcaatgg ctctttgtaa aaatattggt gtggatgatg
     2941 ttggaaagga tattggacca gatactacca gcattaacag agttgctgac actttgaata
     3001 actggagtat ccatccagat cccaagggag aacccagtga agagaagaat gcaatggcaa
     3061 agacttttta tgattcctct tttcccacag aacatgtgaa aacaaagcct ctgatatcaa
     3121 ctccactaca aagccatttg caggcaatca agacgactaa aaatacttct ggtgatgatg
     3181 actggcagag cctcattacg aatcaactaa ataaaagtga aaatttacta agtttagaaa
     3241 atgacaacca gccaaagaaa agaaaagcag aagagacgtt ggaaaaaaac aacagattaa
     3301 aataatgtag ataagtgctt tcagtagtga aattatgtaa ctgaaattct ggtatagttt
     3361 ttactagaat aaaatgactg ttgtatttaa agctc
//
