LOCUS       NM_001395015            4826 bp    mRNA    linear   PRI 22-SEP-2024
DEFINITION  Homo sapiens coiled-coil domain containing 7 (CCDC7), transcript
            variant 6, mRNA.
ACCESSION   NM_001395015 XM_011519663
VERSION     NM_001395015.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4826)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   2  (bases 1 to 4826)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 4826)
  AUTHORS   Shen,Y.M., Arbman,G., Sandstrom,P., Gullstrand,P., Wei,Y.Q.,
            Zhang,H., Rosell,J., Olsson,B., Peng,F., Yang,H.S., Wang,C.T. and
            Sun,X.F.
  TITLE     Novel gene hBiot2 is an independent prognostic factor in colorectal
            cancer patients
  JOURNAL   Oncol Rep 27 (2), 376-382 (2012)
   PUBMED   22024937
  REMARK    GeneRIF: A higher expression of hBiot2 in primary CRC patients
            independently indicates a poorer prognosis.
REFERENCE   4  (bases 1 to 4826)
  AUTHORS   Shen,Y.M., He,X., Deng,H.X., Xie,Y.P., Wang,C.T., Wei,Y.Q. and
            Zhao,X.
  TITLE     Overexpression of the hBiot2 gene is associated with development of
            human cervical cancer
  JOURNAL   Oncol Rep 25 (1), 75-80 (2011)
   PUBMED   21109960
  REMARK    GeneRIF: Overexpression of hBiot2 is associated with early and
            interim development of human cervical cancer.
REFERENCE   5  (bases 1 to 4826)
  AUTHORS   Argyropoulos,G., Stutz,A.M., Ilnytska,O., Rice,T., Teran-Garcia,M.,
            Rao,D.C., Bouchard,C. and Rankinen,T.
  TITLE     KIF5B gene sequence variation and response of cardiac stroke volume
            to regular exercise
  JOURNAL   Physiol Genomics 36 (2), 79-88 (2009)
   PUBMED   18984674
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   6  (bases 1 to 4826)
  AUTHORS   Wang,C.T., Zhang,P., Wang,Y.S., Ruan,X.Z., Li,Z.Y., Peng,F.,
            Yang,H.S. and Wei,Y.Q.
  TITLE     RNA interference against Biot2, a novel mouse testis-specific gene,
            inhibits the growth of tumor cells
  JOURNAL   Cell Mol Biol Lett 14 (3), 363-376 (2009)
   PUBMED   19277478
REFERENCE   7  (bases 1 to 4826)
  AUTHORS   Grupe,A., Li,Y., Rowland,C., Nowotny,P., Hinrichs,A.L., Smemo,S.,
            Kauwe,J.S., Maxwell,T.J., Cherny,S., Doil,L., Tacey,K., van
            Luchene,R., Myers,A., Wavrant-De Vrieze,F., Kaleem,M.,
            Hollingworth,P., Jehu,L., Foy,C., Archer,N., Hamilton,G.,
            Holmans,P., Morris,C.M., Catanese,J., Sninsky,J., White,T.J.,
            Powell,J., Hardy,J., O'Donovan,M., Lovestone,S., Jones,L.,
            Morris,J.C., Thal,L., Owen,M., Williams,J. and Goate,A.
  TITLE     A scan of chromosome 10 identifies a novel locus showing strong
            association with late-onset Alzheimer disease
  JOURNAL   Am J Hum Genet 78 (1), 78-88 (2006)
   PUBMED   16385451
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL391839.9, AL354750.12, AL356053.14, AL591850.4 and AL365203.19.
            
            On May 25, 2021 this sequence version replaced XM_011519663.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA1968968,
                              SAMEA2148874 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000639629.2/ ENSP00000491655.1
            NMD candidate          :: translation inferred from conservation
            RefSeq Select criteria :: based on manual assertion, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-258               AL391839.9         152367-152624
            259-588             AL391839.9         157819-158148
            589-681             AL391839.9         159571-159663
            682-765             AL391839.9         162478-162561
            766-786             AL354750.12        6419-6439
            787-819             AL354750.12        6753-6785
            820-986             AL354750.12        14800-14966
            987-1048            AL354750.12        16217-16278
            1049-1105           AL354750.12        17703-17759
            1106-1181           AL354750.12        35658-35733
            1182-1212           AL354750.12        61681-61711
            1213-1302           AL354750.12        62152-62241
            1303-1388           AL354750.12        87036-87121
            1389-1443           AL354750.12        87983-88037
            1444-1506           AL354750.12        109294-109356
            1507-1728           AL354750.12        111406-111627
            1729-1763           AL354750.12        115595-115629
            1764-2037           AL354750.12        126770-127043
            2038-2110           AL354750.12        127968-128040
            2111-2221           AL354750.12        177990-178100
            2222-2323           AL354750.12        178793-178894
            2324-2431           AL356053.14        21034-21141
            2432-2542           AL356053.14        42950-43060
            2543-2653           AL356053.14        46033-46143
            2654-2767           AL356053.14        51859-51972
            2768-2878           AL356053.14        68600-68710
            2879-2977           AL356053.14        83714-83812
            2978-3088           AL356053.14        85867-85977
            3089-3214           AL356053.14        86312-86437
            3215-3322           AL356053.14        135957-136064
            3323-3406           AL356053.14        161995-162078
            3407-3490           AL356053.14        171350-171433
            3491-3577           AL591850.4         7143-7229
            3578-3661           AL591850.4         17440-17523
            3662-3745           AL591850.4         27868-27951
            3746-3829           AL591850.4         28168-28251
            3830-3913           AL591850.4         28501-28584
            3914-3997           AL591850.4         29001-29084
            3998-4051           AL591850.4         30458-30511
            4052-4081           AL365203.19        2001-2030
            4082-4204           AL365203.19        2710-2832
            4205-4330           AL365203.19        5921-6046
            4331-4420           AL365203.19        8514-8603
            4421-4654           AL365203.19        30461-30694
            4655-4826           AL365203.19        36807-36978
FEATURES             Location/Qualifiers
     source          1..4826
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10p11.22"
     gene            1..4826
                     /gene="CCDC7"
                     /gene_synonym="BIOT2; BioT2-A; BioT2-B; BioT2-C; C10orf68"
                     /note="coiled-coil domain containing 7"
                     /db_xref="GeneID:79741"
                     /db_xref="HGNC:HGNC:26533"
                     /db_xref="MIM:619444"
     exon            1..258
                     /gene="CCDC7"
                     /gene_synonym="BIOT2; BioT2-A; BioT2-B; BioT2-C; C10orf68"
                     /inference="alignment:Splign:2.1.0"
     exon            259..588
                     /gene="CCDC7"
                     /gene_synonym="BIOT2; BioT2-A; BioT2-B; BioT2-C; C10orf68"
                     /inference="alignment:Splign:2.1.0"
     CDS             310..4467
                     /gene="CCDC7"
                     /gene_synonym="BIOT2; BioT2-A; BioT2-B; BioT2-C; C10orf68"
                     /note="isoform c is encoded by transcript variant 6;
                     coiled-coil domain-containing protein 7; uncharacterized
                     protein C10orf68; epididymis secretory sperm binding
                     protein"
                     /codon_start=1
                     /product="uncharacterized protein C10orf68 isoform c"
                     /protein_id="NP_001381944.1"
                     /db_xref="CCDS:CCDS86081.1"
                     /db_xref="GeneID:79741"
                     /db_xref="HGNC:HGNC:26533"
                     /db_xref="MIM:619444"
                     /translation="MKPVKHLLTTSNKSANVPALTTKKGLHNLPLSPELKEKHNAKLI
                     HDKIEPMVLRSPPTGESILRYALPIPSSKTKNLLPEDEMIGKIIKHLKMVVSTLEETY
                     GHCDQNGEEPFVKHEHEELSLSVGDDMNSFLTYCSQFAAQLEEALKEEQNILESLFKW
                     FQWQVNQMEEISKDQTLLQAEPPKPDKTVILNIAEIVRLVQRFEELKNRLKQRSKSSV
                     KVMLSKTMDKENRPEAVKSCEALAQKIEEFLEAHSTDEFKDVSATEPQTAHSMTNRFN
                     AMLKVFENQANMLERAVNDQVLLDAEYKQMQCDFQLLSEEKLVLENELQKLKDKEKTK
                     PTNNRTKKAVKTVKKKDKGKSEDSEKKMSPEKEFKIKEDLDQVQKVARLEIENKVLQE
                     QLKQALQEAEKAKHQLNYFLNQEKLLKSEGKTETTMQVGNSQTKVKGEDSKNIPLEKE
                     TRKSLVSDSGGQRTSDKIQEYPQITAQSGRLIEKSSEKKRSSPAISDLSQILKSQDES
                     AFLESSNEVSVAENQSYKSPSETHDKSLTTVSSSKEVQDSLSVGTLAQKNETVISPFI
                     LPPVLTESKKADVSEEQLQKMTEEQTYQAAEKSQADSEVPDENLMVENKDSVTKVQIE
                     QMKQRTSSMERHEETLTTPQLPEDMVLVSRIQSETKNLKATRNESFHSHNDVPEENLM
                     LEQDTKSKTEVEVKKQKSFQDNQLSTHNEVPNERLVVEHQESLSKTKLQIKKQETSTE
                     QPLTTPDKEPNENLILRHQDSMSKSEMQVKEQRTLKGQRIITHDEEPGKNLVLEHQDS
                     VSKLEMQIEKTKKLPREKRHSTHDEESGENPMLKHQDSVSKIQVQLEIQETSEGEGRS
                     IPDKNSMFVHQDSVSKLQMQEKKKITPGRERRNTRIVVPNENVISVHQDSKSKLQMQE
                     KKQINSGVERHKTFPLEIKKKDISLEHLLPEEKVLLSRSESQTKKLQAKVTSRKIKNE
                     AASELPDTAENLPAMYPSISDLIIQFDLNKVVETDIESLRGALGRRLLNDEFKTQSKS
                     FPGPDIEQLTDAFGRDILKDEFKTRSKSLPETDERLHSTTERGTINDAIKTQLKRKSY
                     PETVLKHLKGVNGKDIIKHLINIQSKSHGETDKEHLADDTGRGIIKGSINAQLKGHQK
                     TDKNFFAYATGRGLMKESTTTQLKSHPETDKEFLADAIGRGIIIGPITTQLKSHRETD
                     KELLKDAIGRDIIKGPISAQLKSHQETDVEPLTNAIGSSKTIGEIKTQLRTHYDVNLF
                     KNKDMSVQRQEGIFTRSITPSKFPTKVINLSPFENKEETYEYSSPYVTAPSKAIYRTY
                     RAGPSFSKDIHLPLLNQLPSGHSKVVTLSQKTIEFTLPTVTNTVGKPTYKVLHAAARK
                     SVPHPYF"
     exon            589..681
                     /gene="CCDC7"
                     /gene_synonym="BIOT2; BioT2-A; BioT2-B; BioT2-C; C10orf68"
                     /inference="alignment:Splign:2.1.0"
     exon            682..765
                     /gene="CCDC7"
                     /gene_synonym="BIOT2; BioT2-A; BioT2-B; BioT2-C; C10orf68"
                     /inference="alignment:Splign:2.1.0"
     exon            766..786
                     /gene="CCDC7"
                     /gene_synonym="BIOT2; BioT2-A; BioT2-B; BioT2-C; C10orf68"
                     /inference="alignment:Splign:2.1.0"
     exon            787..819
                     /gene="CCDC7"
                     /gene_synonym="BIOT2; BioT2-A; BioT2-B; BioT2-C; C10orf68"
                     /inference="alignment:Splign:2.1.0"
     exon            820..986
                     /gene="CCDC7"
                     /gene_synonym="BIOT2; BioT2-A; BioT2-B; BioT2-C; C10orf68"
                     /inference="alignment:Splign:2.1.0"
     exon            987..1048
                     /gene="CCDC7"
                     /gene_synonym="BIOT2; BioT2-A; BioT2-B; BioT2-C; C10orf68"
                     /inference="alignment:Splign:2.1.0"
     exon            1049..1105
                     /gene="CCDC7"
                     /gene_synonym="BIOT2; BioT2-A; BioT2-B; BioT2-C; C10orf68"
                     /inference="alignment:Splign:2.1.0"
     exon            1106..1181
                     /gene="CCDC7"
                     /gene_synonym="BIOT2; BioT2-A; BioT2-B; BioT2-C; C10orf68"
                     /inference="alignment:Splign:2.1.0"
     exon            1182..1212
                     /gene="CCDC7"
                     /gene_synonym="BIOT2; BioT2-A; BioT2-B; BioT2-C; C10orf68"
                     /inference="alignment:Splign:2.1.0"
     exon            1213..1302
                     /gene="CCDC7"
                     /gene_synonym="BIOT2; BioT2-A; BioT2-B; BioT2-C; C10orf68"
                     /inference="alignment:Splign:2.1.0"
     exon            1303..1388
                     /gene="CCDC7"
                     /gene_synonym="BIOT2; BioT2-A; BioT2-B; BioT2-C; C10orf68"
                     /inference="alignment:Splign:2.1.0"
     exon            1389..1443
                     /gene="CCDC7"
                     /gene_synonym="BIOT2; BioT2-A; BioT2-B; BioT2-C; C10orf68"
                     /inference="alignment:Splign:2.1.0"
     exon            1444..1506
                     /gene="CCDC7"
                     /gene_synonym="BIOT2; BioT2-A; BioT2-B; BioT2-C; C10orf68"
                     /inference="alignment:Splign:2.1.0"
     exon            1507..1728
                     /gene="CCDC7"
                     /gene_synonym="BIOT2; BioT2-A; BioT2-B; BioT2-C; C10orf68"
                     /inference="alignment:Splign:2.1.0"
     exon            1729..1763
                     /gene="CCDC7"
                     /gene_synonym="BIOT2; BioT2-A; BioT2-B; BioT2-C; C10orf68"
                     /inference="alignment:Splign:2.1.0"
     exon            1764..2037
                     /gene="CCDC7"
                     /gene_synonym="BIOT2; BioT2-A; BioT2-B; BioT2-C; C10orf68"
                     /inference="alignment:Splign:2.1.0"
     exon            2038..2110
                     /gene="CCDC7"
                     /gene_synonym="BIOT2; BioT2-A; BioT2-B; BioT2-C; C10orf68"
                     /inference="alignment:Splign:2.1.0"
     exon            2111..2221
                     /gene="CCDC7"
                     /gene_synonym="BIOT2; BioT2-A; BioT2-B; BioT2-C; C10orf68"
                     /inference="alignment:Splign:2.1.0"
     exon            2222..2323
                     /gene="CCDC7"
                     /gene_synonym="BIOT2; BioT2-A; BioT2-B; BioT2-C; C10orf68"
                     /inference="alignment:Splign:2.1.0"
     exon            2324..2431
                     /gene="CCDC7"
                     /gene_synonym="BIOT2; BioT2-A; BioT2-B; BioT2-C; C10orf68"
                     /inference="alignment:Splign:2.1.0"
     exon            2432..2542
                     /gene="CCDC7"
                     /gene_synonym="BIOT2; BioT2-A; BioT2-B; BioT2-C; C10orf68"
                     /inference="alignment:Splign:2.1.0"
     exon            2543..2653
                     /gene="CCDC7"
                     /gene_synonym="BIOT2; BioT2-A; BioT2-B; BioT2-C; C10orf68"
                     /inference="alignment:Splign:2.1.0"
     exon            2654..2767
                     /gene="CCDC7"
                     /gene_synonym="BIOT2; BioT2-A; BioT2-B; BioT2-C; C10orf68"
                     /inference="alignment:Splign:2.1.0"
     exon            2768..2878
                     /gene="CCDC7"
                     /gene_synonym="BIOT2; BioT2-A; BioT2-B; BioT2-C; C10orf68"
                     /inference="alignment:Splign:2.1.0"
     exon            2879..2977
                     /gene="CCDC7"
                     /gene_synonym="BIOT2; BioT2-A; BioT2-B; BioT2-C; C10orf68"
                     /inference="alignment:Splign:2.1.0"
     exon            2978..3088
                     /gene="CCDC7"
                     /gene_synonym="BIOT2; BioT2-A; BioT2-B; BioT2-C; C10orf68"
                     /inference="alignment:Splign:2.1.0"
     exon            3089..3214
                     /gene="CCDC7"
                     /gene_synonym="BIOT2; BioT2-A; BioT2-B; BioT2-C; C10orf68"
                     /inference="alignment:Splign:2.1.0"
     exon            3215..3322
                     /gene="CCDC7"
                     /gene_synonym="BIOT2; BioT2-A; BioT2-B; BioT2-C; C10orf68"
                     /inference="alignment:Splign:2.1.0"
     exon            3323..3406
                     /gene="CCDC7"
                     /gene_synonym="BIOT2; BioT2-A; BioT2-B; BioT2-C; C10orf68"
                     /inference="alignment:Splign:2.1.0"
     exon            3407..3490
                     /gene="CCDC7"
                     /gene_synonym="BIOT2; BioT2-A; BioT2-B; BioT2-C; C10orf68"
                     /inference="alignment:Splign:2.1.0"
     exon            3491..3577
                     /gene="CCDC7"
                     /gene_synonym="BIOT2; BioT2-A; BioT2-B; BioT2-C; C10orf68"
                     /inference="alignment:Splign:2.1.0"
     exon            3578..3661
                     /gene="CCDC7"
                     /gene_synonym="BIOT2; BioT2-A; BioT2-B; BioT2-C; C10orf68"
                     /inference="alignment:Splign:2.1.0"
     exon            3662..3745
                     /gene="CCDC7"
                     /gene_synonym="BIOT2; BioT2-A; BioT2-B; BioT2-C; C10orf68"
                     /inference="alignment:Splign:2.1.0"
     exon            3746..3829
                     /gene="CCDC7"
                     /gene_synonym="BIOT2; BioT2-A; BioT2-B; BioT2-C; C10orf68"
                     /inference="alignment:Splign:2.1.0"
     exon            3830..3913
                     /gene="CCDC7"
                     /gene_synonym="BIOT2; BioT2-A; BioT2-B; BioT2-C; C10orf68"
                     /inference="alignment:Splign:2.1.0"
     exon            3914..3997
                     /gene="CCDC7"
                     /gene_synonym="BIOT2; BioT2-A; BioT2-B; BioT2-C; C10orf68"
                     /inference="alignment:Splign:2.1.0"
     exon            3998..4081
                     /gene="CCDC7"
                     /gene_synonym="BIOT2; BioT2-A; BioT2-B; BioT2-C; C10orf68"
                     /inference="alignment:Splign:2.1.0"
     exon            4082..4204
                     /gene="CCDC7"
                     /gene_synonym="BIOT2; BioT2-A; BioT2-B; BioT2-C; C10orf68"
                     /inference="alignment:Splign:2.1.0"
     exon            4205..4330
                     /gene="CCDC7"
                     /gene_synonym="BIOT2; BioT2-A; BioT2-B; BioT2-C; C10orf68"
                     /inference="alignment:Splign:2.1.0"
     exon            4331..4420
                     /gene="CCDC7"
                     /gene_synonym="BIOT2; BioT2-A; BioT2-B; BioT2-C; C10orf68"
                     /inference="alignment:Splign:2.1.0"
     exon            4421..4654
                     /gene="CCDC7"
                     /gene_synonym="BIOT2; BioT2-A; BioT2-B; BioT2-C; C10orf68"
                     /inference="alignment:Splign:2.1.0"
     exon            4655..4826
                     /gene="CCDC7"
                     /gene_synonym="BIOT2; BioT2-A; BioT2-B; BioT2-C; C10orf68"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4807..4812
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CCDC7"
                     /gene_synonym="BIOT2; BioT2-A; BioT2-B; BioT2-C; C10orf68"
                     /note="hexamer: AACAAA"
     polyA_site      4826
                     /gene="CCDC7"
                     /gene_synonym="BIOT2; BioT2-A; BioT2-B; BioT2-C; C10orf68"
                     /note="major polyA site"
ORIGIN      
        1 aacggcccca tccggcgccg gcggcgggtg cccggcggtc tttgctgccg cccgggggcg
       61 cagaggccgg gccttttctt tcagcacaaa cgtcagtttg taaaagggag gtgctggagt
      121 ctgaggagtt ttcaggcttc cgtctcgaag gaagtctggc aggctcggaa ttgtcatctt
      181 cctcaggcaa atagtttttc accttagagc cagcaaggcc aaaccgccca gtcacccgac
      241 ttcccacagt ctcagcaggg aggaataagt ttttttcatc tgtaatttgg aagccaagtc
      301 agtaacaaaa tgaaaccagt aaagcatctg ttgaccacca gtaacaaatc ggcaaatgtt
      361 ccagcattaa ctactaaaaa aggactacat aatttaccat tatcacctga gctaaaggaa
      421 aaacataatg caaaattaat tcatgataaa attgaaccaa tggtcctaag atctccacca
      481 acaggagaat ccattttacg gtatgctttg cccattccat cgagtaagac aaagaactta
      541 ctaccagaag atgaaatgat cggaaaaatt atcaaacatc tgaagatggt tgtttccact
      601 ttggaagaaa cctatggaca ttgcgatcag aatggagaag aaccatttgt aaagcatgaa
      661 catgaagaat tatctttatc tgttggggat gatatgaatt cattcttgac atattgttcg
      721 caatttgcag ctcagctaga agaagcactt aaagaagaac aaaatatttt ggaatctctt
      781 tttaagtggt ttcagtggca ggtcaatcag atggaagaaa taagtaaaga tcaaactctt
      841 ttacaagcag agcctccaaa acctgacaaa acagtcattt taaatattgc agaaatagta
      901 aggcttgtac aaagatttga agaactgaag aatcgcctta aacagaggtc taaatcctcc
      961 gtgaaagtca tgttgtctaa aactatggat aaagaaaatc gaccagaagc agtgaaaagt
     1021 tgtgaagctc tggcacagaa aattgaagaa ttcttagaag cccactcaac tgatgaattt
     1081 aaagatgttt ctgcaacaga accacaaact gctcattcaa tgactaatcg atttaatgcc
     1141 atgttgaaag tatttgaaaa ccaggcaaat atgttggaga gagctgtaaa tgatcaagtt
     1201 ttgttagatg ctgaatacaa acagatgcag tgtgattttc agttgttatc agaagagaag
     1261 ttggtgctgg aaaatgaact acaaaagttg aaggacaaag agaaaactaa gcctacaaat
     1321 aatcgaacaa agaaagctgt gaaaacagtg aagaaaaaag acaaaggaaa atctgaggat
     1381 tcagaaaaga agatgtctcc agaaaaagag tttaaaataa aagaagattt ggatcaagta
     1441 cagaaagtag cacgtctgga aattgagaac aaagtccttc aggagcaatt gaaacaggct
     1501 ttacaggaag ctgaaaaagc taagcatcaa cttaactatt tcctaaatca agagaagtta
     1561 cttaaaagtg aggggaaaac tgagacaaca atgcaagtgg gtaatagtca aacaaaagtt
     1621 aaaggtgaag attcaaaaaa tataccattg gagaaagaaa caagaaaatc actggtttca
     1681 gattcaggtg gacaaaggac aagtgataaa atccaagaat atccacagat cactgcccaa
     1741 agcggaagac tgattgaaaa gagctcagag aagaaacgat ctagccctgc tatttcagat
     1801 ctttcacaga tccttaagtc tcaagatgaa tcagcatttt tagagagttc aaatgaagtt
     1861 tcagttgctg aaaaccaatc ctataaatct ccatcagaga cccatgataa atcacttaca
     1921 acagtatcat ccagcaaaga agttcaagat tcactgtctg ttggaacatt ggctcaaaaa
     1981 aacgaaacag tgatatcacc attcatttta cctcctgttc ttacagaaag taaaaaggct
     2041 gatgtttcag aagaacaatt acaaaagatg actgaagaac aaacttacca agcagcagaa
     2101 aaatctcaag ctgacagtga agttccagat gaaaatctta tggttgaaaa taaagattca
     2161 gtaacaaaag tccaaataga acaaatgaaa caaagaactt ctagtatgga aagacatgag
     2221 gagactctta caaccccaca attgcctgag gacatggttt tagtttcaag aatccaatct
     2281 gaaactaaaa atcttaaagc taccagaaat gagagttttc attctcataa tgatgtacca
     2341 gaagaaaatc ttatgcttga acaagacaca aagtcaaaaa cggaagtaga agtaaagaaa
     2401 caaaaatctt tccaagataa tcaactcagt actcataatg aagtaccaaa tgaaaggctt
     2461 gtagttgagc atcaagaatc attgtcaaaa accaaattac aaataaagaa acaagaaact
     2521 tctacagagc aaccactcac cactcctgat aaagaaccaa atgaaaatct tatacttagg
     2581 catcaagact caatgtcaaa atcagaaatg caagtgaagg aacaaagaac tctcaaaggg
     2641 caaagaatta ttactcatga tgaagaacca ggcaaaaatc ttgtgcttga acatcaagat
     2701 tcagtgtcaa aactggaaat gcaaattgaa aaaaccaaaa aacttcctag agagaaaaga
     2761 catagtactc atgatgaaga atcaggtgaa aatcctatgc ttaaacatca agattcagtg
     2821 tcaaaaatcc aagtgcaatt agagattcaa gaaacttctg aaggagaagg acgtagcata
     2881 ccagataaaa attctatgtt tgttcatcaa gattcagtgt caaaactcca aatgcaagaa
     2941 aagaaaaaaa taactcctgg aagggaaagg cgtaatactc gtattgtagt accaaatgaa
     3001 aatgtgattt ctgttcatca agattcaaag tcaaaactcc aaatgcaaga aaagaaacaa
     3061 ataaattctg gagtggaaag acacaagacg tttcctttag aaatcaaaaa aaaggatata
     3121 tcacttgaac atctgttgcc tgaggagaaa gttttattat caagaagcga atctcaaacg
     3181 aagaaacttc aagctaaagt aacttcaaga aaaattaaaa atgaagcagc ctcagaactt
     3241 ccagatacag cagaaaatct tccagcaatg tacccgtcaa ttagcgacct aataattcaa
     3301 tttgatttaa acaaagtggt cgagactgat atagaaagct tgagaggtgc tttgggaaga
     3361 cgcttattaa atgatgaatt caagacacag tcaaagagtt tccctgggcc tgatatagaa
     3421 caattgacag atgcatttgg aagagatata ctaaaggatg aattcaagac acgatcaaag
     3481 agtctccctg agactgatga acgattgcat agtacaactg agagaggtac aataaatgat
     3541 gcaattaaga cgcagttaaa gagaaagagt taccctgaga ctgtcttaaa acacttgaaa
     3601 ggtgttaatg gaaaagatat aataaagcat ctaatcaaca tacagtcaaa gagtcatgga
     3661 gagactgata aggaacactt agcagatgat actggaagag gtataataaa gggatcaatc
     3721 aatgcacaac taaagggtca ccaaaagact gataagaact tctttgccta tgctactgga
     3781 agaggtctaa tgaaggagtc aaccacgaca caattaaaaa gtcacccaga gactgataag
     3841 gaattcttgg cagatgctat tggaagaggt ataataatag ggccaatcac tacacaactg
     3901 aagagtcacc gagagactga taaagaactc ttaaaagatg ctattggaag agatataata
     3961 aagggaccaa tcagtgcaca attaaagagt caccaggaga ctgatgtaga acccttgaca
     4021 aatgccattg gttcaagtaa aacaattggt gagataaaga cacaactaag gactcactat
     4081 gatgtgaact tatttaaaaa caaagatatg tccgtacaac gtcaagaagg tatctttact
     4141 aggagcatta caccaagtaa attcccaaca aaagtgatca atttatcacc ctttgaaaat
     4201 aaagaggaaa cttatgagta ctcttcaccc tatgtgactg caccttcaaa agcaatttat
     4261 agaacatata gggctggtcc aagcttttct aaagacatcc accttccttt actgaatcaa
     4321 ctcccttcag ggcattcgaa agttgttacc ttaagccaaa aaactattga atttactctg
     4381 cctactgtga ccaatacagt tggaaaacct acctataaag tgttacatgc tgctgcccga
     4441 aaatctgtac cacacccata cttttgagaa tgaaggaaat tctgagcaag ataagcaaca
     4501 tgacaaattc agaaatgcag gaaaggaaat tgcaagtata gaagcctttt gaaaataata
     4561 ctgactcgtg tggatggtgc ttattgaaaa acagctggaa atacagtgga tcaacagggt
     4621 aggcccagat cacagaaggc ctgaccaggc agtgaatgtg tctttaccat atggaacaat
     4681 tttgaacttc taagatcaag cctttttgtt gctgagggta agaaaggagc tctgtgatga
     4741 ggttccagct tacttctatt cgccagtgtc cctgtaatgc tttctggtgt gatgtaaaat
     4801 caattaaaca aaacttgtgc tctgca
//
