LOCUS       NM_015621               3398 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens coiled-coil domain containing 69 (CCDC69), mRNA.
ACCESSION   NM_015621
VERSION     NM_015621.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3398)
  AUTHORS   Li,J., Zhang,P. and Xia,Y.
  TITLE     Study on <em>CCDC69</em> interfering with the prognosis of patients
            with breast cancer through PPAR signal pathway
  JOURNAL   Eur J Histochem 65 (1), 3207 (2021)
   PUBMED   33634680
  REMARK    GeneRIF: Study on <em>CCDC69</em> interfering with the prognosis of
            patients with breast cancer through PPAR signal pathway.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3398)
  AUTHORS   Cui,L., Zhou,F., Chen,C. and Wang,C.C.
  TITLE     Overexpression of CCDC69 activates p14ARF/MDM2/p53 pathway and
            confers cisplatin sensitivity
  JOURNAL   J Ovarian Res 12 (1), 4 (2019)
   PUBMED   30651135
  REMARK    GeneRIF: CCDC69 could play an important role in regulating
            chemoresistance in ovarian cancer through activation of
            p14ARF/MDM2/p53 signaling pathway
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3398)
  AUTHORS   Wade,T.D., Gordon,S., Medland,S., Bulik,C.M., Heath,A.C.,
            Montgomery,G.W. and Martin,N.G.
  TITLE     Genetic variants associated with disordered eating
  JOURNAL   Int J Eat Disord 46 (6), 594-608 (2013)
   PUBMED   23568457
REFERENCE   4  (bases 1 to 3398)
  AUTHORS   Comuzzie,A.G., Cole,S.A., Laston,S.L., Voruganti,V.S., Haack,K.,
            Gibbs,R.A. and Butte,N.F.
  TITLE     Novel genetic loci identified for the pathophysiology of childhood
            obesity in the Hispanic population
  JOURNAL   PLoS One 7 (12), e51954 (2012)
   PUBMED   23251661
REFERENCE   5  (bases 1 to 3398)
  AUTHORS   Pal,D., Wu,D., Haruta,A., Matsumura,F. and Wei,Q.
  TITLE     Role of a novel coiled-coil domain-containing protein CCDC69 in
            regulating central spindle assembly
  JOURNAL   Cell Cycle 9 (20), 4117-4129 (2010)
   PUBMED   20962590
  REMARK    GeneRIF: Results indicate that CCDC69 acts as a scaffold to
            regulate the recruitment of midzone components and the assembly of
            central spindles.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL713742.1, BC016647.1 and BM927471.1.
            
            On Nov 22, 2018 this sequence version replaced NM_015621.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK225826.1, SRR1803616.221928.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000355417.7/ ENSP00000347586.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-170               AL713742.1         2-171
            171-617             BC016647.1         10-456
            618-1348            BM927471.1         136-866
            1349-3057           BC016647.1         1162-2870
            3058-3398           AL713742.1         2980-3320
FEATURES             Location/Qualifiers
     source          1..3398
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q33.1"
     gene            1..3398
                     /gene="CCDC69"
                     /note="coiled-coil domain containing 69"
                     /db_xref="GeneID:26112"
                     /db_xref="HGNC:HGNC:24487"
                     /db_xref="MIM:619288"
     exon            1..170
                     /gene="CCDC69"
                     /inference="alignment:Splign:2.1.0"
     CDS             123..1013
                     /gene="CCDC69"
                     /codon_start=1
                     /product="coiled-coil domain-containing protein 69"
                     /protein_id="NP_056436.2"
                     /db_xref="CCDS:CCDS4312.1"
                     /db_xref="GeneID:26112"
                     /db_xref="HGNC:HGNC:24487"
                     /db_xref="MIM:619288"
                     /translation="MGCRHSRLSSCKPPKKKRQEPEPEQPPRPEPHELGPLNGDTAIT
                     VQLCASEEAERHQKDITRILQQHEEEKKKWAQQVEKERELELRDRLDEQQRVLEGKNE
                     EALQVLRASYEQEKEALTHSFREASSTQQETIDRLTSQLEAFQAKMKRVEESILSRNY
                     KKHIQDYGSPSQFWEQELESLHFVIEMKNERIHELDRRLILMETVKEKNLILEEKITT
                     LQQENEDLHVRSRNQVVLSRQLSEDLLLTREALEKEVQLRRQLQQEKEELLYRVLGAN
                     ASPAFPLAPVTPTEVSFLAT"
     exon            171..246
                     /gene="CCDC69"
                     /inference="alignment:Splign:2.1.0"
     exon            247..353
                     /gene="CCDC69"
                     /inference="alignment:Splign:2.1.0"
     exon            354..441
                     /gene="CCDC69"
                     /inference="alignment:Splign:2.1.0"
     exon            442..515
                     /gene="CCDC69"
                     /inference="alignment:Splign:2.1.0"
     exon            516..617
                     /gene="CCDC69"
                     /inference="alignment:Splign:2.1.0"
     exon            618..737
                     /gene="CCDC69"
                     /inference="alignment:Splign:2.1.0"
     exon            738..835
                     /gene="CCDC69"
                     /inference="alignment:Splign:2.1.0"
     exon            836..3398
                     /gene="CCDC69"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3374..3379
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CCDC69"
                     /note="hexamer: ACTAAA"
     polyA_site      3381
                     /gene="CCDC69"
                     /note="major polyA site"
     polyA_site      3398
                     /gene="CCDC69"
                     /note="major polyA site"
ORIGIN      
        1 agtttcaggg tctcgccggc agccccagcc ggcgggcgcg gagcgggcag cggggcccgg
       61 atcgcaggct cctctggggg ccccggagtt gggaagcggc gtccgggagc ccccggagga
      121 ggatgggctg cagacacagc aggctgagca gctgcaaacc cccgaaaaag aagcgccaag
      181 aaccagaacc agaacagcca cccagaccag agccccatga attaggtccc ctcaatgggg
      241 acacagctat aactgtccag ctctgtgcat cagaggaggc tgagcggcac cagaaggata
      301 taaccagaat tctccagcaa catgaggagg aaaagaagaa atgggcacaa caggtggaga
      361 aggaaaggga gctagagctt cgagacagac tggatgagca gcaaagggtc ctggaaggaa
      421 agaatgaaga ggccctgcaa gtcctccggg cctcatatga acaggagaaa gaagcgctta
      481 cccactcttt ccgggaggcc agttctaccc agcaggagac catagacaga ctgacctcac
      541 agctggaggc tttccaggcc aaaatgaaga gggtggagga gtccattctg agccgaaact
      601 ataagaaaca tatccaggat tatgggagcc ccagccagtt ctgggagcag gagctggaga
      661 gcttacactt tgtcatcgag atgaagaatg agcgtattca tgagctggac aggcggctga
      721 tcctcatgga aacagtgaaa gagaaaaatc tgatattgga ggaaaaaatt acgaccctgc
      781 aacaggaaaa tgaggacctc catgtccgaa gccgcaacca ggtggtcctg tcaaggcagc
      841 tgtcagaaga cctgcttctc acgcgtgagg ccctggagaa ggaggtgcag ctgcggcgac
      901 agctccagca ggagaaggag gagctgttgt accgggtcct tggggccaat gcctcgcctg
      961 ccttccctct ggcccctgtc actcccactg aggtctcttt cctcgccaca tagggtgcag
     1021 ggcctgggcc caccacgacg cctgaagtca cagctccttc caaggttttt ctggagaaga
     1081 cagcaggagc ctctcagttc ttttccagga aggaacgagg gtgggagcga gatggagatc
     1141 ctgggtgtgt gcccagtgag ccctggggcc ttgagttaca tggaatcacc cacagggttt
     1201 tggaggcccc gagaagcgtc ttcccttgag ttggccaagg gaataagcaa gaggagacat
     1261 ttcctccctg ccccagcact ctgtcccaat ccgagaagtt ccgaggcttt cccaggggca
     1321 gtctgtgtca cgctggccat ttgacataaa ggagacagcc cctggtccca gcttgtcagc
     1381 tctgctgccg acttgctgac ttatcaactt cctctaggtg tttccactcc accctggcct
     1441 gctcagagcc tcagtttacc cctgcattaa aatggtgggg ggactggtca aaggactctt
     1501 atgtcactgc agtgtcccat tctaggattg tctgaaggcc agagtagggg ttggggggag
     1561 tgtggacaaa ccccgcaaat cagagtgggg aaggtgagtg gtagagaggg ggtctctgaa
     1621 ggcccttggg gctgacaggg ccaggcagcc tccccagctg aggcatcatt cctgggccag
     1681 agtcgtgtcc accaagggac agtagccaga gctcctcttc ctttaccagg caaggtgcat
     1741 cccctcagcc ctcctggccc ttcagtcttg gtgccacctg ggcacagggg caagcttggt
     1801 ggttgtgagt ccattcatct atcagagctg gaacctcatc cctgcacaga tgaggaaacc
     1861 aaggcatgga gcagttccca gagtcgaatc tagatctcat ctgtcatccg ggtcttatcc
     1921 tttgctctgt ttttctcttc aggctctgga aaatcagatc tgtgacttaa tcttcctctc
     1981 cctggccctc acccacttag tttctttttc attcctgctc cctgccttaa ctcctcctcc
     2041 cactgcccct gatcccaggc ccaggctttt acaacctggt gctcagcttc cccatcagtg
     2101 aaaaggggtg gctagagtaa ctaacctcag caggccgtcc agtcctgata gtctgtggat
     2161 ttcggatcct tctcaggaag cttcatgtct aatggagact ataattataa ctcctgttct
     2221 gcatagagca tttgcatcaa aggctttcca tacccctccc tcccctggtc ctcataagat
     2281 ccttgaagca ggttcctatt cctcattggc aacatggcaa acagatcaca ggagtcaaag
     2341 ggccttgctc aaggtcccca gcttcagccc caggccctaa gccagcgtca gaacagtcaa
     2401 tctgcatttt tcatcagtca ttctatagtg acatcatccc agactgcctt ctgtattccc
     2461 ctgtgtacag tctccttctg tttctaggtt tagaagttca gaggtgactg tgtttctcca
     2521 tttccacagc caaatggggg aagaggtgag gctaggggag tgctgtgctg attctccagc
     2581 catggtcaga caggtcaccc aggagcctcg aggaaagccc tggagggaat cacatgtgta
     2641 ctttttcatg aagctttttg caaagcacat ctgcgataca ctagtttatt gaactaatgt
     2701 ccaggagtag acatgattgg tggccaagtt atttggggac acctaaacag atcagtgacc
     2761 tgaatgactt ctcagaacct ttaatatgcc aatgtgtgtg gcaaacttac aagaagggag
     2821 ctaagtatcc agcctctccc aaacctcttt gaacaaagct tctgtccctc ccacacctct
     2881 cacctcacag gcacatcagg ctgcagaatg cgctttagaa agcattgttt tagtccaggc
     2941 acagtggctc acgcctgtaa tcccagcact ttgggaggcc gaggtgggtg gatcacaagg
     3001 ttgggagatt gagaccatcc tggctaacac agtgaaaccc tgtctctact aaaaaaatac
     3061 aaaaaattag cttggcgtgg tggtgggcgc ctgtagtccc agcagcttgg gaggctgagg
     3121 ctggagaatg gtgtgaaccc aggaggcgga gcttgcagtg agccaagatc gcgccactgc
     3181 actccagccc gggtgacaga gcaagactcc gtctcaaaaa aaagaaaaga aaaaagaaag
     3241 cattgtttta attgagaggg gcagggctgg agaaggagca agttgtgggg agccaggctt
     3301 ccctcacgca gcctgtggtg gatgtgggaa ggagatcaac ttctcctcac tctgggacag
     3361 acgatgtatg gaaactaaaa agaacatgcg gcacctta
//
