LOCUS       NM_025214               4085 bp    mRNA    linear   PRI 08-OCT-2024
DEFINITION  Homo sapiens coiled-coil domain containing 68 (CCDC68), transcript
            variant 1, mRNA.
ACCESSION   NM_025214
VERSION     NM_025214.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4085)
  AUTHORS   Li,Q., Chen,Q., Zheng,T., Wang,F., Teng,J., Zhou,H. and Chen,J.
  TITLE     CCDC68 Maintains Mitotic Checkpoint Activation by Promoting CDC20
            Integration into the MCC
  JOURNAL   Adv Sci (Weinh) 11 (35), e2406009 (2024)
   PUBMED   39018254
  REMARK    GeneRIF: CCDC68 Maintains Mitotic Checkpoint Activation by
            Promoting CDC20 Integration into the MCC.
REFERENCE   2  (bases 1 to 4085)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 4085)
  AUTHORS   Li,X., Li,H., Pei,X., Zhou,Y. and Wei,Z.
  TITLE     CCDC68 Upregulation by IL-6 Promotes Endometrial Carcinoma
            Progression
  JOURNAL   J Interferon Cytokine Res 41 (1), 12-19 (2021)
   PUBMED   33471616
  REMARK    GeneRIF: CCDC68 Upregulation by IL-6 Promotes Endometrial Carcinoma
            Progression.
REFERENCE   4  (bases 1 to 4085)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 4085)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4085)
  CONSRTM   Cross-Disorder Group of the Psychiatric Genomics Consortium
  TITLE     Identification of risk loci with shared effects on five major
            psychiatric disorders: a genome-wide analysis
  JOURNAL   Lancet 381 (9875), 1371-1379 (2013)
   PUBMED   23453885
  REMARK    Erratum:[Lancet. 2013 Apr 20;381(9875):1360]
REFERENCE   7  (bases 1 to 4085)
  CONSRTM   Schizophrenia Psychiatric Genome-Wide Association Study (GWAS)
            Consortium
  TITLE     Genome-wide association study identifies five new schizophrenia
            loci
  JOURNAL   Nat Genet 43 (10), 969-976 (2011)
   PUBMED   21926974
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 4085)
  AUTHORS   Grassi,M.A., Tikhomirov,A., Ramalingam,S., Below,J.E., Cox,N.J. and
            Nicolae,D.L.
  TITLE     Genome-wide meta-analysis for severe diabetic retinopathy
  JOURNAL   Hum Mol Genet 20 (12), 2472-2481 (2011)
   PUBMED   21441570
REFERENCE   9  (bases 1 to 4085)
  AUTHORS   Gerhardt,A., Usener,D., Keese,M., Sturm,J., Schadendorf,D. and
            Eichmuller,S.
  TITLE     Tissue expression and sero-reactivity of tumor-specific antigens in
            colorectal cancer
  JOURNAL   Cancer Lett 208 (2), 197-206 (2004)
   PUBMED   15142679
REFERENCE   10 (bases 1 to 4085)
  AUTHORS   Eichmuller,S., Usener,D., Dummer,R., Stein,A., Thiel,D. and
            Schadendorf,D.
  TITLE     Serological detection of cutaneous T-cell lymphoma-associated
            antigens
  JOURNAL   Proc Natl Acad Sci U S A 98 (2), 629-634 (2001)
   PUBMED   11149944
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC098848.7 and AI823801.1.
            
            On Nov 23, 2018 this sequence version replaced NM_025214.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Both variants 1 and 2 encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803615.126689.1,
                                           SRR1660805.6218.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000591504.6/ ENSP00000466690.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-126               AC098848.7         78758-78883         c
            127-216             AC098848.7         64810-64899         c
            217-345             AC098848.7         62097-62225         c
            346-432             AC098848.7         60419-60505         c
            433-573             AC098848.7         57379-57519         c
            574-699             AC098848.7         56255-56380         c
            700-828             AC098848.7         54242-54370         c
            829-911             AC098848.7         48222-48304         c
            912-1017            AC098848.7         38693-38798         c
            1018-1101           AC098848.7         37335-37418         c
            1102-1178           AC098848.7         27208-27284         c
            1179-3634           AC098848.7         21382-23837         c
            3635-4085           AI823801.1         5-455               c
FEATURES             Location/Qualifiers
     source          1..4085
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="18"
                     /map="18q21.2"
     gene            1..4085
                     /gene="CCDC68"
                     /gene_synonym="SE57-1"
                     /note="coiled-coil domain containing 68"
                     /db_xref="GeneID:80323"
                     /db_xref="HGNC:HGNC:24350"
                     /db_xref="MIM:616909"
     exon            1..126
                     /gene="CCDC68"
                     /gene_synonym="SE57-1"
                     /inference="alignment:Splign:2.1.0"
     exon            127..216
                     /gene="CCDC68"
                     /gene_synonym="SE57-1"
                     /inference="alignment:Splign:2.1.0"
     exon            217..345
                     /gene="CCDC68"
                     /gene_synonym="SE57-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             229..1236
                     /gene="CCDC68"
                     /gene_synonym="SE57-1"
                     /note="CTCL tumor antigen se57-1; cutaneous T-cell
                     lymphoma associated antigen; CTCL-associated antigen
                     se57-1; cutaneous T-cell lymphoma-associated antigen
                     se57-1"
                     /codon_start=1
                     /product="coiled-coil domain-containing protein 68"
                     /protein_id="NP_079490.1"
                     /db_xref="CCDS:CCDS11959.1"
                     /db_xref="GeneID:80323"
                     /db_xref="HGNC:HGNC:24350"
                     /db_xref="MIM:616909"
                     /translation="MTTVTVTTEIPPRDKMEDNSALYESTSAHIIEETEYVKKIRTTL
                     QKIRTQMFKDEIRHDSTNHKLDAKHCGNLQQGSDSEMDPSCCSLDLLMKKIKGKDLQL
                     LEMNKENEVLKIKLQASREAGAAALRNVAQRLFENYQTQSEEVRKKQEDSKQLLQVNK
                     LEKEQKLKQHVENLNQVAEKLEEKHSQITELENLVQRMEKEKRTLLERKLSLENKLLQ
                     LKSSATYGKSCQDLQREISILQEQISHLQFVIHSQHQNLRSVIQEMEGLKNNLKEQDK
                     RIENLREKVNILEAQNKELKTQVALSSETPRTKVSKAVSTSELKTEGVSPYLMLIRLR
                     K"
     exon            346..432
                     /gene="CCDC68"
                     /gene_synonym="SE57-1"
                     /inference="alignment:Splign:2.1.0"
     exon            433..573
                     /gene="CCDC68"
                     /gene_synonym="SE57-1"
                     /inference="alignment:Splign:2.1.0"
     exon            574..699
                     /gene="CCDC68"
                     /gene_synonym="SE57-1"
                     /inference="alignment:Splign:2.1.0"
     exon            700..828
                     /gene="CCDC68"
                     /gene_synonym="SE57-1"
                     /inference="alignment:Splign:2.1.0"
     exon            829..911
                     /gene="CCDC68"
                     /gene_synonym="SE57-1"
                     /inference="alignment:Splign:2.1.0"
     exon            912..1017
                     /gene="CCDC68"
                     /gene_synonym="SE57-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1018..1101
                     /gene="CCDC68"
                     /gene_synonym="SE57-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1102..1178
                     /gene="CCDC68"
                     /gene_synonym="SE57-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1179..4085
                     /gene="CCDC68"
                     /gene_synonym="SE57-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4013..4018
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CCDC68"
                     /gene_synonym="SE57-1"
                     /note="hexamer: CATAAA"
     polyA_site      4032
                     /gene="CCDC68"
                     /gene_synonym="SE57-1"
                     /note="major polyA site"
     regulatory      4064..4069
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CCDC68"
                     /gene_synonym="SE57-1"
                     /note="hexamer: ATTAAA"
     polyA_site      4085
                     /gene="CCDC68"
                     /gene_synonym="SE57-1"
                     /note="major polyA site"
ORIGIN      
        1 ggagccaagc ctgcgggcgg tggcggctgc actcgcaggg ccctggcagc cgaccctggc
       61 cccaaggtcc gatcgcccag gggaggagca gcaccgggac cccgcgtcgg ctgggcgccc
      121 cacaagggaa gccagtctta atatgatgga aacatctctg aacttctaaa agaccaaggt
      181 tggcgtttta gctctattaa ttttacttcg tcttggccag aattcacaat gacaacagtg
      241 acagtgacca cagaaattcc cccaagggat aagatggaag ataattctgc cttgtatgag
      301 tctacgtccg ctcacattat tgaagaaacc gagtatgtga aaaagattcg aactactctg
      361 caaaagatca ggacccagat gtttaaagat gaaataagac atgacagtac aaatcacaaa
      421 ctagatgcaa agcactgtgg aaaccttcaa cagggctctg attctgaaat ggatccttct
      481 tgttgcagtt tggatttgct tatgaaaaag ataaaaggaa aagacctaca gctcttagaa
      541 atgaacaaag agaatgaagt attgaaaatc aagctgcaag cctccagaga agcaggagca
      601 gcagctctga gaaacgtggc ccagagatta tttgaaaact accaaacgca atctgaagaa
      661 gtgagaaaga agcaggagga cagtaaacaa ttactccagg ttaacaagct tgaaaaagaa
      721 cagaaattga aacaacatgt tgaaaatctg aatcaagttg ctgaaaaact tgaagaaaaa
      781 cacagtcaaa ttacagaatt ggagaacctt gtacagagaa tggaaaagga aaagagaaca
      841 ctactagaaa gaaaactgtc tttggaaaac aagctactgc aactcaaatc cagtgctaca
      901 tatggaaaaa gttgccagga tcttcagagg gagatttcca ttctccagga gcagatctct
      961 catctgcagt ttgtgattca ctcccaacat cagaacctgc gcagtgtcat ccaggagatg
     1021 gaaggattaa aaaataattt aaaagaacaa gacaaaagaa ttgaaaatct cagagaaaag
     1081 gttaacatac ttgaagccca gaataaagaa ctaaaaaccc aggtagcact ttcatctgaa
     1141 actcctagga caaaggtatc taaggctgtc tctacaagtg aattgaagac cgaaggtgtt
     1201 tccccttatt taatgttgat taggttacgg aaatgaactg gctggatgaa gatctgattt
     1261 agaaagactg cgtgagtctt atttattctc tgaaacacag cccaagtttc atgttaaaat
     1321 ggcaaaatgc cattatttaa atggaactta ttacatacca atggctttgc aagaagatga
     1381 catttcagaa aatcaaacaa atctatattt aatggatgga ctcttcaaaa cttaccaaat
     1441 agttgaagaa accaggtgcc ttctcatgat ggaagacaga ttctgcttta aattaaaaaa
     1501 aaaaaaaaat ctgaatcttg ttttcagatt tttttttcta ctgggattgt tttaagattg
     1561 tcaattctga cttttttata gtggttttta agagtataaa tagaagggag agtgtatatg
     1621 tgtatgaatg aacatacatt tcctgcatat atatgtatga agggcatgta tatgtatgaa
     1681 tgagcaaaca tatttgaaag ttaacttttg gatgatagga aagatcgtac agtgacataa
     1741 gttcatctcc tgatccattg tttgtgggag aattatactt gactgaatta tgggcaggag
     1801 aaagagcaga ttccttttag ctaattcccc aacccatatg cccctctgaa gttgagaatc
     1861 atggctgcct caccacacat cagagaatga ctgttcttct tagttctggg attaaaaatt
     1921 ggtttctaga ggtaacctgt acacacaaac gcacagggat gcacatggtt tcctctgcct
     1981 ttgtgactaa ttttcttctt gatagttatt aatagtatct aaataaaata ttggggggat
     2041 agaaaaataa tgctgttagc tcatacttcc atgaaaatgt atatattata ggctcaaagg
     2101 aataatgact gctgtctgca gccagaaaga atctgaattt atgaattgga aagatatata
     2161 tagtgtattt gtgaaagttt gcttaaattc tgatacatgc cttctttgta ggtggagttt
     2221 gtgattgcag tgaatagaac aaattctgac ttgcagaaat gcagacatac agtcaggaaa
     2281 gaacaaactt caattaaatg tataatgaga gaccttggtc cccctaaagg atgaatttcc
     2341 tttaggcctt tgatcttcct ctctagtgta taactttaaa tatttgctca gaaaagatgc
     2401 tgactctttc attatggaat gtgaaatatc agtgttgtct ataaatattt gaaggtatat
     2461 aaaaatgaga tgatgtaatg tatttataaa tttatccaag tactgtaatc cttgaattgt
     2521 tgtgtaactg tgtgtgagtt ttacgcttca tggtattttt ggaaacattt ttattgcttg
     2581 cttattttga aggtatattt atctgttaac atttagggca tagttacctt ataccagcaa
     2641 caagtctaag cactttactt gtattaattt attttatctt ccccaaggcc ctcagaagca
     2701 gattattcct gttttacaga gaaagatact gagagtggtt gagtaatttg cccagctgct
     2761 aactgtgaag caaaaatttg aaccttttga cttggctatt gatattcatt ctacttgctc
     2821 acatggtggt ctaagaaatt tcccagctat agaaatctct ctatttttgc cactttaatc
     2881 aacacatagc ttcctggatg actgcctgtg ttattttgtg gatgacagta agaaacaaca
     2941 aatactgata aaatcaatat tttgctgaaa tgagttgatc tttcaccagc tggactacca
     3001 ttgtgagaac tcagttcaga caaacttccc tgctaaaaat ctgtttatca tacatttatt
     3061 atttatgact ttatgtcaca ttgaagaatt tcttcatgat acattttcag gcacacttgt
     3121 aggaaaatta ggatcatgag tcctgcttta agtatttgca gtgtagtaag agaatccatc
     3181 ttttactagg agaccagatt ccttttatac ctcattcatc atgctggatt gtaataaatt
     3241 tcagattttg gaatgggctt atttaactga cctgacaatc ttgatgattt ccattagaat
     3301 aacttattct aaggtcaaaa gtggaaagac actgttggtt tttattttga tttcactata
     3361 ctcatttttg aacatggaaa tacagtggtg aaaccaccta tgcaaaaatg ataacagtga
     3421 ggaaattatg acagtgaaag agatctgacc taactatcta tcttgcctcg aaactgccct
     3481 tggtcgttcc tgagtgtggg ccaagctaac tttgggagaa atttacttta taggttaaat
     3541 tataatagcc cttcccaaaa ctaaacgatt ctcctgcctc agcctcccga gtagctgtct
     3601 ttataatacc atcagcctta tcatttattc gtcatgtatg gattgtttcc tatatccact
     3661 atcataaaat tatcatttga aatatttttt tatgaaaaaa aaaacacttc tcagtgaaaa
     3721 aacaagatta caagggggaa taatatttat tcagctaaaa tagtacttca caggaaatat
     3781 aggaaaagaa acactagttc agttttattc caaataatgt acttctaatt atactcttga
     3841 atttattgga taagaaggtc tgaggtgggt ctgaaattca tacatgaagt caggaaaaga
     3901 aaagaaactt agttctacct tgattacata tgttgttaca aattatcatt ataaaatgtt
     3961 taaacaatta gtatagtata tcttttgaat aattgcttat aatatgcctt accataaaga
     4021 aaattgatgc tacattgtgt gaattgtttg gttttctttt tatattaaaa ttatgcataa
     4081 atgaa
//
