LOCUS       NM_001141947            3134 bp    mRNA    linear   PRI 20-FEB-2025
DEFINITION  Homo sapiens coiled-coil domain containing 66 (CCDC66), transcript
            variant 1, mRNA.
ACCESSION   NM_001141947 NM_001130911
VERSION     NM_001141947.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3134)
  AUTHORS   Chen,X., Tong,P., Jiang,Y., Cheng,Z., Zang,L., Yang,Z., Lan,W.,
            Xia,K., Hu,Z. and Tian,Q.
  TITLE     CCDC66 mutations are associated with high myopia through affected
            cell mitosis
  JOURNAL   J Med Genet 61 (3), 262-269 (2024)
   PUBMED   37852749
  REMARK    GeneRIF: CCDC66 mutations are associated with high myopia through
            affected cell mitosis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3134)
  AUTHORS   Odabasi,E., Conkar,D., Deretic,J., Batman,U., Frikstad,K.M.,
            Patzke,S. and Firat-Karalar,E.N.
  TITLE     CCDC66 regulates primary cilium length and signaling via
            interactions with transition zone and axonemal proteins
  JOURNAL   J Cell Sci 136 (3) (2023)
   PUBMED   36606424
  REMARK    GeneRIF: CCDC66 regulates primary cilium length and signaling via
            interactions with transition zone and axonemal proteins.
REFERENCE   3  (bases 1 to 3134)
  AUTHORS   Batman,U., Deretic,J. and Firat-Karalar,E.N.
  TITLE     The ciliopathy protein CCDC66 controls mitotic progression and
            cytokinesis by promoting microtubule nucleation and organization
  JOURNAL   PLoS Biol 20 (7), e3001708 (2022)
   PUBMED   35849559
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3134)
  AUTHORS   Mo,Y., Lu,Q., Zhang,Q., Chen,J., Deng,Y., Zhang,K., Tao,R., Liu,W.
            and Wang,Y.
  TITLE     Circular RNA CCDC66 Improves Murine Double Minute 4 (MDM4)
            Expression through Targeting miR-370 in Colorectal Cancer
  JOURNAL   Comput Math Methods Med 2022, 7723995 (2022)
   PUBMED   35069793
  REMARK    GeneRIF: Circular RNA CCDC66 Improves Murine Double Minute 4 (MDM4)
            Expression through Targeting miR-370 in Colorectal Cancer.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3134)
  AUTHORS   Qi,L., Wang,W., Zhao,G., Jiang,H., Zhang,Y., Zhao,D., Jin,H., Xu,H.
            and Yu,H.
  TITLE     Circular RNA circCCDC66 promotes glioma proliferation by acting as
            a ceRNA for miR-320a to regulate FOXM1 expression
  JOURNAL   Aging (Albany NY) 13 (13), 17673-17689 (2021)
   PUBMED   34252882
  REMARK    GeneRIF: Circular RNA circCCDC66 promotes glioma proliferation by
            acting as a ceRNA for miR-320a to regulate FOXM1 expression.
REFERENCE   6  (bases 1 to 3134)
  AUTHORS   Conkar,D., Culfa,E., Odabasi,E., Rauniyar,N., Yates,J.R. 3rd and
            Firat-Karalar,E.N.
  TITLE     The centriolar satellite protein CCDC66 interacts with CEP290 and
            functions in cilium formation and trafficking
  JOURNAL   J Cell Sci 130 (8), 1450-1462 (2017)
   PUBMED   28235840
  REMARK    GeneRIF: this study identifies CCDC66 as a targeting factor for
            centrosome and cilium proteins
REFERENCE   7  (bases 1 to 3134)
  AUTHORS   Gupta,G.D., Coyaud,E., Goncalves,J., Mojarad,B.A., Liu,Y., Wu,Q.,
            Gheiratmand,L., Comartin,D., Tkach,J.M., Cheung,S.W., Bashkurov,M.,
            Hasegan,M., Knight,J.D., Lin,Z.Y., Schueler,M., Hildebrandt,F.,
            Moffat,J., Gingras,A.C., Raught,B. and Pelletier,L.
  TITLE     A Dynamic Protein Interaction Landscape of the Human
            Centrosome-Cilium Interface
  JOURNAL   Cell 163 (6), 1484-1499 (2015)
   PUBMED   26638075
REFERENCE   8  (bases 1 to 3134)
  AUTHORS   Al-Balool,H.H., Weber,D., Liu,Y., Wade,M., Guleria,K., Nam,P.L.,
            Clayton,J., Rowe,W., Coxhead,J., Irving,J., Elliott,D.J.,
            Hall,A.G., Santibanez-Koref,M. and Jackson,M.S.
  TITLE     Post-transcriptional exon shuffling events in humans can be
            evolutionarily conserved and abundant
  JOURNAL   Genome Res 21 (11), 1788-1799 (2011)
   PUBMED   21948523
REFERENCE   9  (bases 1 to 3134)
  AUTHORS   Gerding,W.M., Schreiber,S., Schulte-Middelmann,T., de Castro
            Marques,A., Atorf,J., Akkad,D.A., Dekomien,G., Kremers,J.,
            Dermietzel,R., Gal,A., Rulicke,T., Ibrahim,S., Epplen,J.T. and
            Petrasch-Parwez,E.
  TITLE     Ccdc66 null mutation causes retinal degeneration and dysfunction
  JOURNAL   Hum Mol Genet 20 (18), 3620-3631 (2011)
   PUBMED   21680557
REFERENCE   10 (bases 1 to 3134)
  AUTHORS   Dekomien,G., Vollrath,C., Petrasch-Parwez,E., Boeve,M.H.,
            Akkad,D.A., Gerding,W.M. and Epplen,J.T.
  TITLE     Progressive retinal atrophy in Schapendoes dogs: mutation of the
            newly identified CCDC66 gene
  JOURNAL   Neurogenetics 11 (2), 163-174 (2010)
   PUBMED   19777273
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA017177.1, BC132827.1, CU456552.1, AL833326.1, AC098478.2,
            BU674751.1 and BM874633.1.
            
            On May 17, 2019 this sequence version replaced NM_001141947.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803617.58651.1,
                                           SRR1803611.98213.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000394672.8/ ENSP00000378167.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-14                DA017177.1         20-33
            15-412              BC132827.1         1-398
            413-657             CU456552.1         384-628
            658-1054            BC132827.1         644-1040
            1055-1215           AL833326.1         1111-1271
            1216-1216           AC098478.2         197492-197492
            1217-1886           BC132827.1         1203-1872
            1887-2987           BC132827.1         1876-2976
            2988-3133           BU674751.1         1-146               c
            3134-3134           BM874633.1         226-226
FEATURES             Location/Qualifiers
     source          1..3134
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p14.3"
     gene            1..3134
                     /gene="CCDC66"
                     /note="coiled-coil domain containing 66"
                     /db_xref="GeneID:285331"
                     /db_xref="HGNC:HGNC:27709"
                     /db_xref="MIM:619287"
     exon            1..79
                     /gene="CCDC66"
                     /inference="alignment:Splign:2.1.0"
     CDS             69..2915
                     /gene="CCDC66"
                     /note="isoform 1 is encoded by transcript variant 1;
                     coiled-coil domain-containing protein 66"
                     /codon_start=1
                     /product="coiled-coil domain-containing protein 66 isoform
                     1"
                     /protein_id="NP_001135419.1"
                     /db_xref="CCDS:CCDS46852.1"
                     /db_xref="GeneID:285331"
                     /db_xref="HGNC:HGNC:27709"
                     /db_xref="MIM:619287"
                     /translation="MNLGDGLKLETELLDGKTKLILSPYEHKSKISVKMGNKAKIAKC
                     PLRTKTGHILKSTQDTCIGSEKLLQKKPVGSETSQAKGEKNGMTFSSTKDLCKQCIDK
                     DCLHIQKEISPATPNMQKTRNTVNTSLVGKQKPHKKHITAENMKSSLVCLTQDQLQQI
                     LMTVNQGNRSLSLTENGKEAKSQYSLYLNSISNQPKDENIMGLFKKTEMVSSVPAENK
                     SVLNEHQETSKQCEQKIAIENEWKPADIFSTLGERECDRSSLEAKKAQWRKELDEQVA
                     LKKKEKEVSEKWNDPWKKSESDKIIWEKHQILDQSRETVLLEHPFSAVKQELQRKWIE
                     ELNKQIEDDRQRKIEEKIIYSKGEEHDRWAMHFDSLKSYPGSQSQLFSQSTHKQPEYF
                     CVSPDTQELADVSSVCTPTTGSQVEPSEEEHIAKPIKDVVMANSKKTNFLRSMTALLD
                     PAQIEERDRRRQKQLEHQKAITAQVEEKRRKKQLEEEQRKKEEQEEELRLAQEREEMQ
                     KQYEEDILKQKQKEEIMTLKTNELFQTMQRAQELAQRLKQEQRIRELAQKGHDTSRLI
                     KNLGVDTIQMEYNASNISNSRHDSDEISGKMNTYMNSTTSKKDTGVQTDDLNIGIFTN
                     AESHCGSLMERDITNCSSPEISAELIGQFSTKKNKQELTQDKGASLEKENNRCNDQCN
                     QFTRIEKQTKHMKKYPKRPDWNINKPPKRYIPASEKYPKQLQKQREEKKVRRQMELLH
                     LVEKNNPGHLSQNRGISPEIFHSSHQETESKLRWHLVKKEEEPLNIHSFSKERSPSSP
                     VPVVKNRTQQTQNTLHLPLKNSSYERENLISGSNQTELSSGISESSHFIPYVRTNEIY
                     YLDPDAPLSGPSTQDPQYQNSQDCGQKRQLFDSDCVRDPLLNPNMVKNRDRQQAILKG
                     LSELRQGLLQKQKELESSLLPLAENQEESFGSSF"
     exon            80..144
                     /gene="CCDC66"
                     /inference="alignment:Splign:2.1.0"
     exon            145..170
                     /gene="CCDC66"
                     /inference="alignment:Splign:2.1.0"
     exon            171..612
                     /gene="CCDC66"
                     /inference="alignment:Splign:2.1.0"
     exon            613..778
                     /gene="CCDC66"
                     /inference="alignment:Splign:2.1.0"
     exon            779..882
                     /gene="CCDC66"
                     /inference="alignment:Splign:2.1.0"
     exon            883..1004
                     /gene="CCDC66"
                     /inference="alignment:Splign:2.1.0"
     exon            1005..1136
                     /gene="CCDC66"
                     /inference="alignment:Splign:2.1.0"
     exon            1137..1387
                     /gene="CCDC66"
                     /inference="alignment:Splign:2.1.0"
     exon            1388..1472
                     /gene="CCDC66"
                     /inference="alignment:Splign:2.1.0"
     exon            1473..1634
                     /gene="CCDC66"
                     /inference="alignment:Splign:2.1.0"
     exon            1635..1779
                     /gene="CCDC66"
                     /inference="alignment:Splign:2.1.0"
     exon            1780..1911
                     /gene="CCDC66"
                     /inference="alignment:Splign:2.1.0"
     exon            1912..2405
                     /gene="CCDC66"
                     /inference="alignment:Splign:2.1.0"
     exon            2406..2446
                     /gene="CCDC66"
                     /inference="alignment:Splign:2.1.0"
     exon            2447..2703
                     /gene="CCDC66"
                     /inference="alignment:Splign:2.1.0"
     exon            2704..2828
                     /gene="CCDC66"
                     /inference="alignment:Splign:2.1.0"
     exon            2829..3134
                     /gene="CCDC66"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3031..3036
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CCDC66"
                     /note="hexamer: ATTAAA"
     polyA_site      3059
                     /gene="CCDC66"
                     /note="major polyA site"
     regulatory      3079..3084
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CCDC66"
                     /note="hexamer: AATAAA"
     polyA_site      3105
                     /gene="CCDC66"
                     /note="major polyA site"
ORIGIN      
        1 gagcggcggc ggcaaccgac gtacacaagg ggcttgagcg ttctgtggag agagtgcgag
       61 gtcaggccat gaacttggga gatggtttaa agcttgaaac tgaattactg gatggaaaaa
      121 ccaagctaat attgtctcca tatgaacata aatcaaaaat ttctgtgaag atgggaaata
      181 aggccaagat tgcaaaatgt cctttaagaa caaaaactgg gcacattcta aaatcaacac
      241 aagatacttg tattgggagt gaaaaacttt tgcaaaagaa gccagttggt tcagaaacat
      301 cacaggcaaa aggtgaaaaa aatggaatga ctttttcatc cactaaggat ttatgtaaac
      361 aatgtataga taaagactgt cttcatatcc agaaagagat ttcacctgca acccctaata
      421 tgcagaagac tagaaacacc gtaaatacat ctctagtagg taaacagaag cctcacaaaa
      481 aacacatcac agctgaaaac atgaagagca gtttggtgtg tctaacacaa gaccaactac
      541 aacagatttt gatgactgta aaccaaggaa atagatctct ttccctgact gagaatggaa
      601 aggaggcaaa aagtcaatat agtctatatt taaacagtat ttctaatcag ccaaaggatg
      661 agaacattat gggattattc aaaaaaactg aaatggtttc atctgtccca gctgaaaata
      721 aatctgtctt aaatgaacat caggagacat ctaaacagtg tgagcaaaaa attgccatag
      781 agaatgaatg gaaaccagct gatatattca gtactctggg ggaaagggaa tgtgatagaa
      841 gttcgttgga agcaaaaaaa gcccagtgga ggaaagagct agatgaacag gttgctttaa
      901 agaagaaaga aaaagaagtt tctgaaaaat ggaatgatcc ttggaaaaaa tctgaaagtg
      961 ataaaataat atgggaaaaa catcaaattc ttgaccaatc tagggaaaca gtactgctgg
     1021 agcacccttt cagtgctgtg aaacaagaac tgcaaagaaa atggattgaa gagttgaata
     1081 agcaaataga agatgaccgt caaagaaaaa tagaggaaaa aattatatat tcaaagggtg
     1141 aggaacatga cagatgggca atgcactttg attcattaaa gagttatcct ggttctcaat
     1201 ctcagctgtt ctctcagtca acacacaaac aacctgagta cttctgtgtc tctcctgaca
     1261 ctcaggagct ggctgatgtc agcagtgttt gtacacctac aaccggaagc caggttgaac
     1321 cttcagagga ggagcatata gcaaaaccta ttaaggatgt ggttatggca aacagtaaga
     1381 aaacaaactt tctccgttct atgactgctc tcttggaccc agctcagatt gaggaacgag
     1441 acagacgacg acaaaaacaa ttagagcatc agaaagccat cactgcccag gtagaagaga
     1501 agcgcaggaa gaaacaactg gaggaagagc aaagaaagaa ggaagaacaa gaagaggagc
     1561 ttcgcttagc acaggaacgt gaagagatgc agaaacagta tgaagaagac atacttaagc
     1621 aaaaacaaaa ggaagaaatc atgactctca agacaaatga gctattccag acaatgcagc
     1681 gagcacagga actggcacag agactaaaac aagaacaaag aatccgagaa ttggcgcaaa
     1741 agggacatga cacttctaga ctgattaaaa atcttggtgt tgatacaata caaatggaat
     1801 ataatgcatc taacatttca aattcaagac atgattctga tgaaatcagt ggtaaaatga
     1861 atacatatat gaattctacg acttctaaga aggatactgg tgtgcaaaca gatgacttaa
     1921 atataggaat attcaccaat gcagaatcac attgtggatc attaatggag agggacatca
     1981 caaattgttc atctcctgag atttcggcag aacttattgg acagtttagc accaagaaaa
     2041 acaagcaaga actaactcag gataaaggag ccagcttaga aaaagaaaac aatcggtgta
     2101 atgaccagtg taatcagttc acaagaatag agaaacaaac aaaacacatg aagaaatatc
     2161 ctaaaaggcc tgattggaat ataaataagc cacctaaaag gtatattcca gcatcagaaa
     2221 agtaccctaa acagcttcaa aagcagagag aagaaaaaaa agtaaggagg cagatggaat
     2281 tgcttcattt ggtagaaaaa aataatcctg ggcacctctc tcaaaacaga ggcatttcac
     2341 cagaaatttt tcattcatct catcaagaaa cggagtcaaa gttgaggtgg catctagtca
     2401 aaaaggaaga agagcctctg aatattcatt cattcagcaa ggaaaggtct ccatcatcac
     2461 cagttccagt agtgaaaaac agaacccaac aaactcaaaa tacattacat ttaccactaa
     2521 aaaacagtag ctatgagaga gagaatttga tctcaggaag taatcaaaca gaattatcat
     2581 ctgggatttc tgaatcatcc cattttattc cgtatgttcg aacaaatgag atctattacc
     2641 ttgatcccga tgcaccattg tctgggcctt caacccagga ccctcagtac caaaattcac
     2701 aagactgtgg ccaaaaacga cagctatttg attctgactg tgtcagggat ccacttctta
     2761 atcctaacat ggtgaaaaat agggatcgac agcaagcaat ccttaaggga ctttcagaac
     2821 tgagacaggg ccttctccag aagcaaaagg agttggaaag tagtctcctg cctttagctg
     2881 aaaatcaaga agagagtttt ggttcttcat tttaaatgta gaaaatcaaa tccttcacat
     2941 ttgatttgtg tcttccaaat tataaaatgt gctcactggc tcaactgtat ttttcaaata
     3001 gcctagattt acttattttt ttaaatgctc attaaaaact tgtatactat gtagtaaaat
     3061 gctgtacttg ttctatacaa taaaacagat acttcttttg taaaagctta gtagtaaaaa
     3121 aaaaaaaaaa aaaa
//
