LOCUS       NM_152591               1966 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens coiled-coil domain containing 63 (CCDC63), transcript
            variant 1, mRNA.
ACCESSION   NM_152591
VERSION     NM_152591.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1966)
  AUTHORS   Sarkar,S., Yadav,S., Mehta,P., Gupta,G. and Rajender,S.
  TITLE     Histone Methylation Regulates Gene Expression in the Round
            Spermatids to Set the RNA Payloads of Sperm
  JOURNAL   Reprod Sci 29 (3), 857-882 (2022)
   PUBMED   35015293
REFERENCE   2  (bases 1 to 1966)
  AUTHORS   Young,S.A., Miyata,H., Satouh,Y., Kato,H., Nozawa,K., Isotani,A.,
            Aitken,R.J., Baker,M.A. and Ikawa,M.
  TITLE     CRISPR/Cas9-Mediated Rapid Generation of Multiple Mouse Lines
            Identified Ccdc63 as Essential for Spermiogenesis
  JOURNAL   Int J Mol Sci 16 (10), 24732-24750 (2015)
   PUBMED   26501274
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1966)
  AUTHORS   Yang,X., Lu,X., Wang,L., Chen,S., Li,J., Cao,J., Chen,J., Hao,Y.,
            Li,Y., Zhao,L., Li,H., Liu,D., Wang,L., Lu,F., Shen,C., Yu,L.,
            Wu,X., Zhao,Q., Ji,X., Guo,D., Peng,X., Huang,J. and Gu,D.
  TITLE     Common variants at 12q24 are associated with drinking behavior in
            Han Chinese
  JOURNAL   Am J Clin Nutr 97 (3), 545-551 (2013)
   PUBMED   23364009
REFERENCE   4  (bases 1 to 1966)
  AUTHORS   Baik,I., Cho,N.H., Kim,S.H., Han,B.G. and Shin,C.
  TITLE     Genome-wide association studies identify genetic loci related to
            alcohol consumption in Korean men
  JOURNAL   Am J Clin Nutr 93 (4), 809-816 (2011)
   PUBMED   21270382
REFERENCE   5  (bases 1 to 1966)
  AUTHORS   Takeuchi,F., Isono,M., Nabika,T., Katsuya,T., Sugiyama,T.,
            Yamaguchi,S., Kobayashi,S., Ogihara,T., Yamori,Y., Fujioka,A. and
            Kato,N.
  TITLE     Confirmation of ALDH2 as a Major locus of drinking behavior and of
            its variants regulating multiple metabolic phenotypes in a Japanese
            population
  JOURNAL   Circ J 75 (4), 911-918 (2011)
   PUBMED   21372407
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK302207.1, DB036197.1, AK093162.1 and BC064580.1.
            
            On May 17, 2019 this sequence version replaced NM_152591.2.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC044815.1, AK093162.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2148093
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000308208.10/ ENSP00000312399.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-20                AK302207.1         28-47
            21-82               DB036197.1         1-62
            83-1723             AK093162.1         63-1703
            1724-1966           BC064580.1         1409-1651
FEATURES             Location/Qualifiers
     source          1..1966
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q24.11"
     gene            1..1966
                     /gene="CCDC63"
                     /gene_synonym="ODA5"
                     /note="coiled-coil domain containing 63"
                     /db_xref="GeneID:160762"
                     /db_xref="HGNC:HGNC:26669"
                     /db_xref="MIM:617969"
     exon            1..119
                     /gene="CCDC63"
                     /gene_synonym="ODA5"
                     /inference="alignment:Splign:2.1.0"
     exon            120..224
                     /gene="CCDC63"
                     /gene_synonym="ODA5"
                     /inference="alignment:Splign:2.1.0"
     CDS             216..1907
                     /gene="CCDC63"
                     /gene_synonym="ODA5"
                     /note="isoform 1 is encoded by transcript variant 1;
                     coiled-coil domain-containing protein 63; outer row dynein
                     assembly 5 homolog"
                     /codon_start=1
                     /product="coiled-coil domain-containing protein 63 isoform
                     1"
                     /protein_id="NP_689804.1"
                     /db_xref="CCDS:CCDS9151.1"
                     /db_xref="GeneID:160762"
                     /db_xref="HGNC:HGNC:26669"
                     /db_xref="MIM:617969"
                     /translation="MSVLKKNRRKDSDTPQEPSEKAKEQQAEAELRKLRQQFRKMVES
                     RKSFKFRNQQKIASQYKEIKTLKTEQDEITLLLSLMKSSRNMNRSEKNYMELRLLLQT
                     KEDYEALIKSLKVLLAELDEKILQMEKKIANQKQIFAKMQEANNPRKLQKQIHILETR
                     LNLVTVHFDKMLTTNAKLRKEIEDLRFEKAAYDNVYQQLQHCLLMEKKTMNLAIEQSS
                     QAYEQRVEAMARMAAMKDRQKKDTSQYNLEIRELERLYAHESKLKSFLLVKLNDRNEF
                     EEQAKREEALKAKKHVKKNRGESFESYEVAHLRLLKLAESGNLNQLIEDFLAKEEKNF
                     ARFTYVTELNNDMEMMHKRTQRIQDEIILLRSQQKLSHDDNHSVLRQLEDKLRKTTEE
                     ADMYESKYGEVSKTLDLLKNSVEKLFKKINCDATKILVQLGETGKVTDINLPQYFAII
                     EKKTNDLLLLETYRRILEVEGAEAEIPPPFINPFWGGSALLKPPEPIKVIPPVLGADP
                     FSDRLDDVEQPLDHSSLRQLVLDNYILKENRSKEVRGDSLPEKVDDFRSRKKVTM"
     exon            225..394
                     /gene="CCDC63"
                     /gene_synonym="ODA5"
                     /inference="alignment:Splign:2.1.0"
     exon            395..584
                     /gene="CCDC63"
                     /gene_synonym="ODA5"
                     /inference="alignment:Splign:2.1.0"
     exon            585..704
                     /gene="CCDC63"
                     /gene_synonym="ODA5"
                     /inference="alignment:Splign:2.1.0"
     exon            705..886
                     /gene="CCDC63"
                     /gene_synonym="ODA5"
                     /inference="alignment:Splign:2.1.0"
     exon            887..1068
                     /gene="CCDC63"
                     /gene_synonym="ODA5"
                     /inference="alignment:Splign:2.1.0"
     exon            1069..1289
                     /gene="CCDC63"
                     /gene_synonym="ODA5"
                     /inference="alignment:Splign:2.1.0"
     exon            1290..1364
                     /gene="CCDC63"
                     /gene_synonym="ODA5"
                     /inference="alignment:Splign:2.1.0"
     exon            1365..1557
                     /gene="CCDC63"
                     /gene_synonym="ODA5"
                     /inference="alignment:Splign:2.1.0"
     exon            1558..1761
                     /gene="CCDC63"
                     /gene_synonym="ODA5"
                     /inference="alignment:Splign:2.1.0"
     exon            1762..1966
                     /gene="CCDC63"
                     /gene_synonym="ODA5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1947..1952
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CCDC63"
                     /gene_synonym="ODA5"
                     /note="hexamer: AATAAA"
     polyA_site      1966
                     /gene="CCDC63"
                     /gene_synonym="ODA5"
                     /note="major polyA site"
ORIGIN      
        1 gtggcgcagc gaggccgcgc agcaagcagt cctcccggca ccgtcggaag cgcagttgca
       61 gcagccgtcg gacaagcggc cggagcagcc acggacaagc agtccgggcc ccgccactgg
      121 gcattgcaga gagacagaga gagagaggaa ggctcactgg ctttgagctc tctgggtaca
      181 gtgtctgagt ggaggcaaag tgcggttcct tcaagatgtc tgtgttgaag aagaacagga
      241 gaaaagactc cgacactccc caggaacctt cggagaaggc caaagagcag caggcggagg
      301 cagagctccg gaagctaagg cagcagttca ggaagatggt ggaaagccgg aagtctttta
      361 agttccgaaa ccagcagaag attgcgagtc agtacaagga gatcaagacc ctgaagacag
      421 agcaggatga gatcacccta ctgttgagtc tcatgaaatc ctcgaggaac atgaatcgga
      481 gtgagaagaa ctacatggag ctgcgactcc tgctccaaac taaggaggac tatgaggcat
      541 tgattaaatc cctgaaagtg ctgttggctg aactggatga gaagattctt cagatggaaa
      601 aaaaaatcgc aaaccaaaaa cagattttcg caaaaatgca ggaggccaat aacccccgga
      661 aactgcagaa acagattcac attttggaaa cccgtttgaa tctcgtcact gttcactttg
      721 acaagatgct gaccactaat gccaagctcc ggaaggagat tgaagaccta cgatttgaga
      781 aggctgctta tgacaatgtc taccagcagc tccagcactg cctgttgatg gagaagaaaa
      841 ccatgaactt ggccattgag caatcttctc aggcctatga gcagagggtg gaggccatgg
      901 ctcgaatggc tgccatgaaa gaccgccaga agaaggacac ctctcagtac aacctggaga
      961 tccgagagct ggagcgtctc tatgcccatg agagcaagct caagtccttc ctgctcgtca
     1021 agctgaatga tcgcaatgaa ttcgaggagc aggccaaaag ggaggaagct ctcaaggcaa
     1081 agaagcatgt caagaagaac aggggagaga gttttgagag ctatgaggtg gcccacctcc
     1141 ggctgctgaa gctggctgag agtgggaacc taaaccagct cattgaagat tttctggcca
     1201 aggaggagaa gaattttgct cggttcacgt atgtcacgga gctcaacaac gacatggaga
     1261 tgatgcacaa gaggacccaa cgaatccagg acgagatcat cctcttgcga tcccagcaga
     1321 aattgtccca cgatgacaac cactctgtcc tgagacagct ggaggataaa ctgaggaaga
     1381 ccacggagga ggcagatatg tatgagagca agtacgggga ggtcagcaag accttggatc
     1441 tattgaagaa ctcagtggag aaactgttca agaagataaa ctgtgacgcc accaagatcc
     1501 tggtgcagtt aggggagacg gggaaagtca ctgacatcaa ccttccgcag tattttgcca
     1561 tcattgaaaa gaagaccaac gacctgctgc tgttggagac ctacaggcgc atcctggaag
     1621 tggaaggggc agaggctgag atcccgccac ccttcatcaa ccctttctgg ggtggctctg
     1681 ccctcctcaa gcccccagaa cccatcaaag tcatcccccc agtgctgggg gctgacccct
     1741 tcagcgacag gttggatgat gtggaacagc ccctggacca cagcagcctt cggcagctgg
     1801 ttctcgacaa ttatatcctg aaggagaatc ggagtaagga agtgcgcgga gacagcctgc
     1861 ctgagaaggt ggatgacttc agatccagga agaaagtaac catgtgaggt gcatgcatgg
     1921 ggccaccttt gcaacataac cgaaagaata aatgttttgt tctgta
//
