LOCUS       NM_001267723            1817 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens coiled-coil domain containing 61 (CCDC61), mRNA.
ACCESSION   NM_001267723
VERSION     NM_001267723.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1817)
  AUTHORS   Ochi,T., Quarantotti,V., Lin,H., Jullien,J., Rosa E Silva,I.,
            Boselli,F., Barnabas,D.D., Johnson,C.M., McLaughlin,S.H.,
            Freund,S.M.V., Blackford,A.N., Kimata,Y., Goldstein,R.E.,
            Jackson,S.P., Blundell,T.L., Dutcher,S.K., Gergely,F. and van
            Breugel,M.
  TITLE     CCDC61/VFL3 Is a Paralog of SAS6 and Promotes Ciliary Functions
  JOURNAL   Structure 28 (6), 674-689 (2020)
   PUBMED   32375023
  REMARK    GeneRIF: CCDC61/VFL3 Is a Paralog of SAS6 and Promotes Ciliary
            Functions.
REFERENCE   2  (bases 1 to 1817)
  AUTHORS   Pizon,V., Gaudin,N., Poteau,M., Cifuentes-Diaz,C., Demdou,R.,
            Heyer,V., Reina San Martin,B. and Azimzadeh,J.
  TITLE     hVFL3/CCDC61 is a component of mother centriole subdistal
            appendages required for centrosome cohesion and positioning
  JOURNAL   Biol Cell 112 (1), 22-37 (2020)
   PUBMED   31789463
  REMARK    GeneRIF: hVFL3/CCDC61 is the human orthologue of proteins required
            for anchoring distinct sets of cytoskeletal fibers to centrioles in
            unicellular eukaryotes.
REFERENCE   3  (bases 1 to 1817)
  AUTHORS   Barenz,F., Kschonsak,Y.T., Meyer,A., Jafarpour,A., Lorenz,H. and
            Hoffmann,I.
  TITLE     Ccdc61 controls centrosomal localization of Cep170 and is required
            for spindle assembly and symmetry
  JOURNAL   Mol Biol Cell 29 (26), 3105-3118 (2018)
   PUBMED   30354798
  REMARK    GeneRIF: Ccdc61 controls centrosomal localization of Cep170 and is
            required for spindle assembly and symmetry.
REFERENCE   4  (bases 1 to 1817)
  AUTHORS   Jakobsen,L., Vanselow,K., Skogs,M., Toyoda,Y., Lundberg,E.,
            Poser,I., Falkenby,L.G., Bennetzen,M., Westendorf,J., Nigg,E.A.,
            Uhlen,M., Hyman,A.A. and Andersen,J.S.
  TITLE     Novel asymmetrically localizing components of human centrosomes
            identified by complementary proteomics methods
  JOURNAL   EMBO J 30 (8), 1520-1535 (2011)
   PUBMED   21399614
REFERENCE   5  (bases 1 to 1817)
  AUTHORS   Bailey,S.D., Xie,C., Do,R., Montpetit,A., Diaz,R., Mohan,V.,
            Keavney,B., Yusuf,S., Gerstein,H.C., Engert,J.C. and Anand,S.
  CONSRTM   DREAM investigators
  TITLE     Variation at the NFATC2 locus increases the risk of
            thiazolidinedione-induced edema in the Diabetes REduction
            Assessment with ramipril and rosiglitazone Medication (DREAM) study
  JOURNAL   Diabetes Care 33 (10), 2250-2253 (2010)
   PUBMED   20628086
  REMARK    GeneRIF: Observational study of gene-disease association,
            gene-environment interaction, and pharmacogenomic / toxicogenomic.
            (HuGE Navigator)
REFERENCE   6  (bases 1 to 1817)
  AUTHORS   Talmud,P.J., Drenos,F., Shah,S., Shah,T., Palmen,J., Verzilli,C.,
            Gaunt,T.R., Pallas,J., Lovering,R., Li,K., Casas,J.P., Sofat,R.,
            Kumari,M., Rodriguez,S., Johnson,T., Newhouse,S.J., Dominiczak,A.,
            Samani,N.J., Caulfield,M., Sever,P., Stanton,A., Shields,D.C.,
            Padmanabhan,S., Melander,O., Hastie,C., Delles,C., Ebrahim,S.,
            Marmot,M.G., Smith,G.D., Lawlor,D.A., Munroe,P.B., Day,I.N.,
            Kivimaki,M., Whittaker,J., Humphries,S.E. and Hingorani,A.D.
  CONSRTM   ASCOT investigators; NORDIL investigators; BRIGHT Consortium
  TITLE     Gene-centric association signals for lipids and apolipoproteins
            identified via the HumanCVD BeadChip
  JOURNAL   Am J Hum Genet 85 (5), 628-642 (2009)
   PUBMED   19913121
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC011545.4, DR007040.1, BI819372.1, AW453013.1, CB852675.1,
            CA775840.1 and BQ184369.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001267723.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DRR138525.551611.1,
                                           DRR138527.204530.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968832
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000595358.5/ ENSP00000471454.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1                 AC011545.4         27388-27388
            2-550               DR007040.1         28-576
            551-683             BI819372.1         457-589
            684-1014            AW453013.1         1-331               c
            1015-1214           CB852675.1         8-207
            1215-1632           CA775840.1         159-576
            1633-1817           BQ184369.1         18-202              c
FEATURES             Location/Qualifiers
     source          1..1817
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.32"
     gene            1..1817
                     /gene="CCDC61"
                     /gene_synonym="hVFL3; VFL3"
                     /note="coiled-coil domain containing 61"
                     /db_xref="GeneID:729440"
                     /db_xref="HGNC:HGNC:33629"
                     /db_xref="MIM:620676"
     exon            1..38
                     /gene="CCDC61"
                     /gene_synonym="hVFL3; VFL3"
                     /inference="alignment:Splign:2.1.0"
     exon            39..197
                     /gene="CCDC61"
                     /gene_synonym="hVFL3; VFL3"
                     /inference="alignment:Splign:2.1.0"
     CDS             50..1588
                     /gene="CCDC61"
                     /gene_synonym="hVFL3; VFL3"
                     /note="coiled-coil domain-containing protein 61; VFL3
                     homolog; variable flagellar number 3 homolog (C.
                     reinhardtii)"
                     /codon_start=1
                     /product="centrosomal protein CCDC61"
                     /protein_id="NP_001254652.1"
                     /db_xref="CCDS:CCDS46120.2"
                     /db_xref="GeneID:729440"
                     /db_xref="HGNC:HGNC:33629"
                     /db_xref="MIM:620676"
                     /translation="MDQPAGLQVDYVFRGVEHAVRVMVSGQVLELEVEDRMTADQWRG
                     EFDAGFIEDLTHKTGNFKQFNIFCHMLESALTQSSESVTLDLLTYTDLESLRNRKMGG
                     RPGSLAPRSAQLNSKRYLILIYSVEFDRIHYPLPLPYQGKPDPVVLQGIIRSLKEELG
                     RLQGLDGQNTRDTRENEIWHLREQVSRLASEKRELEAQLGRSREEALAGRAARQEAEA
                     LRGLVRGLELELRQERGLGHRVAGRRGQDCRRLAKELEEAKASERSLRARLKTLTSEL
                     ALYKRGRRTPPVQPPPTREDRASSSRERSASRGRGAARSSSRESGRGSRGRGRPARPS
                     PSPTGGRALRFDPTAFVKAKERKQREIQMKQQQRNRLGSGGSGDGPSVSWSRQTQPPA
                     ALTGRGDAPNRSRNRSSSVDSFRSRCSSASSCSDLEDFSESLSRGGHRRRGKPPSPTP
                     WSGSNMKSPPVERSHHQKSLANSGGWVPIKEYSSEHQAADMAEIDARLKALQEYMNRL
                     DMRS"
     exon            198..280
                     /gene="CCDC61"
                     /gene_synonym="hVFL3; VFL3"
                     /inference="alignment:Splign:2.1.0"
     exon            281..438
                     /gene="CCDC61"
                     /gene_synonym="hVFL3; VFL3"
                     /inference="alignment:Splign:2.1.0"
     exon            439..600
                     /gene="CCDC61"
                     /gene_synonym="hVFL3; VFL3"
                     /inference="alignment:Splign:2.1.0"
     exon            601..811
                     /gene="CCDC61"
                     /gene_synonym="hVFL3; VFL3"
                     /inference="alignment:Splign:2.1.0"
     exon            812..894
                     /gene="CCDC61"
                     /gene_synonym="hVFL3; VFL3"
                     /inference="alignment:Splign:2.1.0"
     exon            895..1064
                     /gene="CCDC61"
                     /gene_synonym="hVFL3; VFL3"
                     /inference="alignment:Splign:2.1.0"
     exon            1065..1140
                     /gene="CCDC61"
                     /gene_synonym="hVFL3; VFL3"
                     /inference="alignment:Splign:2.1.0"
     exon            1141..1280
                     /gene="CCDC61"
                     /gene_synonym="hVFL3; VFL3"
                     /inference="alignment:Splign:2.1.0"
     exon            1281..1359
                     /gene="CCDC61"
                     /gene_synonym="hVFL3; VFL3"
                     /inference="alignment:Splign:2.1.0"
     exon            1360..1417
                     /gene="CCDC61"
                     /gene_synonym="hVFL3; VFL3"
                     /inference="alignment:Splign:2.1.0"
     exon            1418..1490
                     /gene="CCDC61"
                     /gene_synonym="hVFL3; VFL3"
                     /inference="alignment:Splign:2.1.0"
     exon            1491..1817
                     /gene="CCDC61"
                     /gene_synonym="hVFL3; VFL3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1795..1800
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CCDC61"
                     /gene_synonym="hVFL3; VFL3"
                     /note="hexamer: AATAAA"
     polyA_site      1817
                     /gene="CCDC61"
                     /gene_synonym="hVFL3; VFL3"
                     /note="major polyA site"
ORIGIN      
        1 agttgaaccg ctcgcgagga gggttgctag tggagaagca accttggcca tggaccagcc
       61 ggctggcctg caggtggact acgtcttccg gggtgtggag catgccgtgc gggtgatggt
      121 ttctgggcag gtgctggagc tggaggtgga ggaccggatg acggctgacc agtggcgggg
      181 cgagttcgat gctggcttca ttgaagattt gactcacaag acagggaact tcaaacagtt
      241 caacatcttc tgtcatatgc tggagtcagc cctcactcag agtagtgagt cagtcaccct
      301 ggacctgctg acctacacag acctggagtc cctgcggaac cgcaagatgg ggggccgccc
      361 aggctccttg gcccccaggt cggcccagct caactccaag cgctacctga tcctcatcta
      421 ctccgtggag tttgacagga ttcactaccc gctgcccctc ccgtaccagg gcaagccaga
      481 ccccgtggtt ctgcagggca tcatccggtc actgaaggag gaactgggcc gcctgcaagg
      541 gctggatggc cagaacactc gggacacccg ggagaatgag atctggcatc tgcgggagca
      601 ggtgtcgcgc ctggcgtccg agaagcggga gctggaggcg cagctgggcc gatcgcgcga
      661 ggaggcgctg gccgggcgcg cggcacgcca ggaggccgag gcgctgcgcg ggctggtgcg
      721 cgggctggag ctggagctgc ggcaggagcg cggcctcggg cacagggtgg ccggccgtcg
      781 cggccaggac tgccgccgtc tggccaagga gctcgaggag gcgaaggcat cggagcggag
      841 cctgcgcgcc cggctgaaga cgctgaccag cgagctggca ttgtacaaga gggggaggcg
      901 gactccgccg gtgcagccgc ccccgacgcg ggaggaccgg gcctcatcgt cccgggagcg
      961 ctccgcgtcg cgaggccgcg gcgccgcgcg ctcctcatcc cgggagagcg gccgcgggag
     1021 ccggggtcgg ggccgccctg cgcgcccctc gccctcgccc acaggtggtc gcgcgctccg
     1081 cttcgacccc acggcctttg tgaaagccaa ggaaaggaag cagagagaga tccagatgaa
     1141 gcagcagcag cggaaccgct taggcagtgg gggaagcggg gacggtccgt ccgtctcctg
     1201 gtctcgccag acccagcccc ctgctgcctt gactggccga ggggacgccc ctaaccgctc
     1261 ccgaaaccgc agctcctcag tggacagttt ccgcagccgc tgctcgtctg ccagctcctg
     1321 cagcgatttg gaggatttct ctgagtcgct ctccagaggg ggtcaccgcc gccgtgggaa
     1381 gcctcccagc ccaacgccct ggagtgggtc caatatgaag tctccccccg tggaacgcag
     1441 ccaccatcag aaatctctgg ccaactccgg gggctgggtc cccatcaaag agtacagctc
     1501 ggagcaccag gcggctgaca tggccgaaat agacgcacgc ctgaaggcct tgcaggagta
     1561 catgaaccga ctggacatgc ggtcataacg tggagaaggg gtactacccc tccatccccc
     1621 acccacttgc tgggtatggt gtggggggtg gggccagggt ggcctccagc cctgcccagt
     1681 ccctgccctg gccccgtccc tcctgctgcc cctggggtct caggtgtgtg aggccctgac
     1741 cctgccctct ccccaggcag tgcatgctgg gagggaggat gtgtgcattt tgtaaataaa
     1801 catatttgcc ctgggga
//
