LOCUS       NM_005436               5727 bp    mRNA    linear   PRI 17-JUN-2024
DEFINITION  Homo sapiens coiled-coil domain containing 6 (CCDC6), mRNA.
ACCESSION   NM_005436
VERSION     NM_005436.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5727)
  AUTHORS   Qiu,T., Kong,Y., Wei,G., Sun,K., Wang,R., Wang,Y., Chen,Y.,
            Wang,W., Zhang,Y., Jiang,C., Yang,P., Xie,T. and Chen,X.
  TITLE     CCDC6-RET fusion protein regulates Ras/MAPK signaling through the
            fusion- GRB2-SHC1 signal niche
  JOURNAL   Proc Natl Acad Sci U S A 121 (23), e2322359121 (2024)
   PUBMED   38805286
  REMARK    GeneRIF: CCDC6-RET fusion protein regulates Ras/MAPK signaling
            through the fusion- GRB2-SHC1 signal niche.
REFERENCE   2  (bases 1 to 5727)
  AUTHORS   Wang,C., Dong,M., Zhang,X., Wang,X., Zhao,Y. and Cao,Y.
  TITLE     Competitive binding of circCCDC6 to microRNA-128-3p activates
            TXNIP/NLRP3 pathway and promotes cerebral ischemia-reperfusion
            defects
  JOURNAL   Acta Biochim Pol 70 (4), 807-815 (2023)
   PUBMED   37934513
  REMARK    GeneRIF: Competitive binding of circCCDC6 to microRNA-128-3p
            activates TXNIP/NLRP3 pathway and promotes cerebral
            ischemia-reperfusion defects.
REFERENCE   3  (bases 1 to 5727)
  AUTHORS   Khonrak,T., Watcharadetwittaya,S., Chamgramol,Y., Intarawichian,P.
            and Deenonpoe,R.
  TITLE     RET rearrangements are relevant to histopathologic subtypes and
            clinicopathological features in Thai papillary thyroid carcinoma
            patients
  JOURNAL   Pathol Oncol Res 29, 1611138 (2023)
   PUBMED   37188126
  REMARK    GeneRIF: RET rearrangements are relevant to histopathologic
            subtypes and clinicopathological features in Thai papillary thyroid
            carcinoma patients.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5727)
  AUTHORS   Tong,Q., Li,Y., Smanik,P.A., Fithian,L.J., Xing,S., Mazzaferri,E.L.
            and Jhiang,S.M.
  TITLE     Characterization of the promoter region and oligomerization domain
            of H4 (D10S170), a gene frequently rearranged with the ret
            proto-oncogene
  JOURNAL   Oncogene 10 (9), 1781-1787 (1995)
   PUBMED   7753554
REFERENCE   5  (bases 1 to 5727)
  AUTHORS   Grieco,M., Cerrato,A., Santoro,M., Fusco,A., Melillo,R.M. and
            Vecchio,G.
  TITLE     Cloning and characterization of H4 (D10S170), a gene involved in
            RET rearrangements in vivo
  JOURNAL   Oncogene 9 (9), 2531-2535 (1994)
   PUBMED   8058316
REFERENCE   6  (bases 1 to 5727)
  AUTHORS   Jhiang,S.M., Chiu,I.M. and Mazzaferri,E.L.
  TITLE     An STS in the human PTC oncogene located at 10q11.2
  JOURNAL   Nucleic Acids Res 19 (15), 4303 (1991)
   PUBMED   1678508
REFERENCE   7  (bases 1 to 5727)
  AUTHORS   Ishizaka,Y., Ushijima,T., Sugimura,T. and Nagao,M.
  TITLE     cDNA cloning and characterization of ret activated in a human
            papillary thyroid carcinoma cell line
  JOURNAL   Biochem Biophys Res Commun 168 (2), 402-408 (1990)
   PUBMED   2334411
REFERENCE   8  (bases 1 to 5727)
  AUTHORS   Grieco,M., Santoro,M., Berlingieri,M.T., Melillo,R.M., Donghi,R.,
            Bongarzone,I., Pierotti,M.A., Della Porta,G., Fusco,A. and
            Vecchio,G.
  TITLE     PTC is a novel rearranged form of the ret proto-oncogene and is
            frequently detected in vivo in human thyroid papillary carcinomas
  JOURNAL   Cell 60 (4), 557-563 (1990)
   PUBMED   2406025
REFERENCE   9  (bases 1 to 5727)
  AUTHORS   Radice,P., Donghi,R., Pierotti,M.A., Longoni,A., Fusco,A.,
            Grieco,M., Santoro,M., Vecchio,G. and Della Porta,G.
  TITLE     RFLP for TaqI of the human thyroid papillary carcinoma (PTC)
            oncogene
  JOURNAL   Nucleic Acids Res 16 (18), 9062 (1988)
   PUBMED   2902563
REFERENCE   10 (bases 1 to 5727)
  AUTHORS   Fusco,A., Grieco,M., Santoro,M., Berlingieri,M.T., Pilotti,S.,
            Pierotti,M.A., Della Porta,G. and Vecchio,G.
  TITLE     A new oncogene in human thyroid papillary carcinomas and their
            lymph-nodal metastases
  JOURNAL   Nature 328 (6126), 170-172 (1987)
   PUBMED   3600795
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK292593.1, BC022284.1,
            AC060231.8 and BM672399.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_005436.4.
            
            Summary: This gene encodes a coiled-coil domain-containing protein.
            The encoded protein is ubiquitously expressed and may function as a
            tumor suppressor. A chromosomal rearrangement resulting in the
            expression of a fusion gene containing a portion of this gene and
            the intracellular kinase-encoding domain of the ret proto-oncogene
            is the cause of thyroid papillary carcinoma.[provided by RefSeq,
            Sep 2010].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC036757.2, SRR1803616.139003.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000263102.7/ ENSP00000263102.6
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-428               AK292593.1         101-528
            429-429             BC022284.1         423-423
            430-1457            AK292593.1         530-1557
            1458-5452           AC060231.8         74354-78348
            5453-5727           BM672399.1         16-290              c
FEATURES             Location/Qualifiers
     source          1..5727
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q21.2"
     gene            1..5727
                     /gene="CCDC6"
                     /gene_synonym="D10S170; H4; PTC; PTC1; TPC; TST1"
                     /note="coiled-coil domain containing 6"
                     /db_xref="GeneID:8030"
                     /db_xref="HGNC:HGNC:18782"
                     /db_xref="MIM:601985"
     exon            1..435
                     /gene="CCDC6"
                     /gene_synonym="D10S170; H4; PTC; PTC1; TPC; TST1"
                     /inference="alignment:Splign:2.1.0"
     CDS             133..1557
                     /gene="CCDC6"
                     /gene_synonym="D10S170; H4; PTC; PTC1; TPC; TST1"
                     /note="papillary thyroid carcinoma-encoded protein;
                     transforming sequence, thyroid-1"
                     /codon_start=1
                     /product="coiled-coil domain-containing protein 6"
                     /protein_id="NP_005427.2"
                     /db_xref="CCDS:CCDS7257.1"
                     /db_xref="GeneID:8030"
                     /db_xref="HGNC:HGNC:18782"
                     /db_xref="MIM:601985"
                     /translation="MADSASESDTDGAGGNSSSSAAMQSSCSSTSGGGGGGGGGGGGG
                     KSGGIVISPFRLEELTNRLASLQQENKVLKIELETYKLKCKALQEENRDLRKASVTIQ
                     ARAEQEEEFISNTLFKKIQALQKEKETLAVNYEKEEEFLTNELSRKLMQLQHEKAELE
                     QHLEQEQEFQVNKLMKKIKKLENDTISKQLTLEQLRREKIDLENTLEQEQEALVNRLW
                     KRMDKLEAEKRILQEKLDQPVSAPPSPRDISMEIDSPENMMRHIRFLKNEVERLKKQL
                     RAAQLQHSEKMAQYLEEERHMREENLRLQRKLQREMERREALCRQLSESESSLEMDDE
                     RYFNEMSAQGLRPRTVSSPIPYTPSPSSSRPISPGLSYASHTVGFTPPTSLTRAGMSY
                     YNSPGLHVQHMGTSHGITRPSPRRSNSPDKFKRPTPPPSPNTQTPVQPPPPPPPPPMQ
                     PTVPSAATSQPTPSQHSAHPSSQP"
     exon            436..585
                     /gene="CCDC6"
                     /gene_synonym="D10S170; H4; PTC; PTC1; TPC; TST1"
                     /inference="alignment:Splign:2.1.0"
     exon            586..714
                     /gene="CCDC6"
                     /gene_synonym="D10S170; H4; PTC; PTC1; TPC; TST1"
                     /inference="alignment:Splign:2.1.0"
     exon            715..818
                     /gene="CCDC6"
                     /gene_synonym="D10S170; H4; PTC; PTC1; TPC; TST1"
                     /inference="alignment:Splign:2.1.0"
     exon            819..979
                     /gene="CCDC6"
                     /gene_synonym="D10S170; H4; PTC; PTC1; TPC; TST1"
                     /inference="alignment:Splign:2.1.0"
     exon            980..1136
                     /gene="CCDC6"
                     /gene_synonym="D10S170; H4; PTC; PTC1; TPC; TST1"
                     /inference="alignment:Splign:2.1.0"
     exon            1137..1237
                     /gene="CCDC6"
                     /gene_synonym="D10S170; H4; PTC; PTC1; TPC; TST1"
                     /inference="alignment:Splign:2.1.0"
     exon            1238..1362
                     /gene="CCDC6"
                     /gene_synonym="D10S170; H4; PTC; PTC1; TPC; TST1"
                     /inference="alignment:Splign:2.1.0"
     exon            1363..5727
                     /gene="CCDC6"
                     /gene_synonym="D10S170; H4; PTC; PTC1; TPC; TST1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2693..2698
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CCDC6"
                     /gene_synonym="D10S170; H4; PTC; PTC1; TPC; TST1"
                     /note="hexamer: AATAAA"
     polyA_site      2724
                     /gene="CCDC6"
                     /gene_synonym="D10S170; H4; PTC; PTC1; TPC; TST1"
                     /note="major polyA site"
     regulatory      2992..2997
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CCDC6"
                     /gene_synonym="D10S170; H4; PTC; PTC1; TPC; TST1"
                     /note="hexamer: ATTAAA"
     polyA_site      3014
                     /gene="CCDC6"
                     /gene_synonym="D10S170; H4; PTC; PTC1; TPC; TST1"
     regulatory      3294..3299
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CCDC6"
                     /gene_synonym="D10S170; H4; PTC; PTC1; TPC; TST1"
                     /note="hexamer: AATACA"
     polyA_site      3317
                     /gene="CCDC6"
                     /gene_synonym="D10S170; H4; PTC; PTC1; TPC; TST1"
     regulatory      5687..5692
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CCDC6"
                     /gene_synonym="D10S170; H4; PTC; PTC1; TPC; TST1"
                     /note="hexamer: AATAAA"
     polyA_site      5727
                     /gene="CCDC6"
                     /gene_synonym="D10S170; H4; PTC; PTC1; TPC; TST1"
ORIGIN      
        1 gtctgcgccc tggtgccagg cgctcagctc ggcgctcccc tgtgctcgcc cggcgcccac
       61 tcattcgcag cccggccttc gtcgccgccg cctccctgct gctcctcctc ctttccccag
      121 cccgccgcgg ccatggcgga cagcgccagc gagagcgaca cggacggggc ggggggcaac
      181 agcagcagct cggccgccat gcagtcgtcc tgctcgtcga cctcgggcgg cggcggtggc
      241 ggcgggggag gcggcggcgg tgggaagtcg gggggcattg tcatctcgcc gttccgcctg
      301 gaggagctca ccaaccgcct ggcctcgctg cagcaagaga acaaggtgct gaagatagag
      361 ctggagacct acaaactgaa gtgcaaggca ctgcaggagg agaaccgcga cctgcgcaaa
      421 gccagcgtga ccatccaagc cagggctgag caggaagaag aattcattag taacacttta
      481 ttcaagaaaa ttcaggcttt gcagaaggag aaagaaaccc ttgctgtaaa ttatgagaaa
      541 gaagaagaat tcctcactaa tgagctctcc agaaaattga tgcagttgca gcatgagaaa
      601 gccgaactag aacagcatct tgaacaagag caggaatttc aggtcaacaa actgatgaag
      661 aaaattaaaa aactggagaa tgacaccatt tctaagcaac ttacattaga acagttgaga
      721 cgggagaaga ttgaccttga aaatacattg gaacaagaac aagaagcact agttaatcgc
      781 ctctggaaaa ggatggataa gcttgaagct gaaaagcgaa tcctgcagga aaaattagac
      841 cagcccgtct ctgctccacc atcgcctaga gatatctcca tggagattga ttctccagaa
      901 aatatgatgc gtcacatcag gtttttaaag aatgaagtgg aacggctgaa gaagcaactg
      961 agagctgctc agttacagca ttcagagaaa atggcacagt atctggagga ggaacgtcac
     1021 atgagagaag agaacttgag gctccagagg aagctgcaga gggagatgga gagaagagaa
     1081 gccctctgtc gacagctctc cgagagtgag tccagcttag aaatggacga cgaaaggtat
     1141 tttaatgaga tgtctgcaca aggattaaga cctcgcactg tgtccagccc gatcccttac
     1201 acaccttctc cgagttcaag caggcctata tcacctggtc tatcatatgc aagtcacacg
     1261 gttggtttca cgccaccaac ttcactgact agagctggaa tgtcttatta caattccccg
     1321 ggtcttcacg tgcagcacat gggaacatcc catggtatca caaggccttc accacggaga
     1381 agcaacagtc ctgacaaatt caaacggccc acgccgcctc catctcccaa cacacagacc
     1441 ccagtccagc cacctccgcc tccacctccg ccacccatgc agcccacggt cccctcagca
     1501 gccacctcgc agcctactcc ttcgcaacat tcggcgcacc cctcctccca gccttaatgc
     1561 atgagcttag tctgaatttc aagttgggac tcatccaatg gagccgtcta ctcaacgcca
     1621 aaggcttcct tctctggcat atttggatat gacttatttg cactgaggtt atctaggctt
     1681 cactatccat tgtgttgtaa atgtttgtca gaaatgcagc cagtgttgtg ggtctacaac
     1741 actaaccaga cgactttttc catcagtgtt ttacttgaat cttcatgtac gtccattccc
     1801 tggctggaac cttcgctgtt tggtatttgg tatttcagca gcagtgtgca atttttgctt
     1861 ggcccagagc ttcattctcc tggcttttag gtttgtaaaa gaaaaaggga tatctttttt
     1921 atattttttt ccatgaatct gcagaaaatt actgagctgt tgttaccctc ctctcattat
     1981 aatagtgttt accaaacata ccaataattc agcactacaa ttcagacctt tgaaaatctg
     2041 gctttcagtg tagaacagaa agttagatga atcagtgccc aagacatatt ttctgtttaa
     2101 cagaactttc tacagataca ttttttacag gttattttca ttgtgttatt gacatccatg
     2161 tctctcgtaa aacagatggc ccaaagtaat gaatcatgtg gctgtacctt ctccacataa
     2221 atgggatgga taattatcgt atattaagat gtgattctct tttttatcct taatgttaat
     2281 ctacttaacc tggccccctc taacatgagt cgataaatgt tgtcctactc accggtggtt
     2341 tcaatggcta attagaatgt gttatttgat ttctgctgca gaaggcagtg tgattgtaac
     2401 aaaaacaatg cggcttcccc ctttcgtact tcatttgtgt tctcttaaaa tagagtttga
     2461 acaaatattt taaaggtgca aaataccatt agaaaatact atttgaaatg gacattatcg
     2521 cattatcttg gcataatggc cagaaaatat tgtattgctt ggcagaaaag aaaataaggt
     2581 ctaaaggaaa gtagcacatt agcattgatg gctgttcatt tcacccagta taagcaagtg
     2641 cagtgtacaa agaagtatat tctgaataca ttatttccat tcatttagca caaataaatc
     2701 atttggtttc actttgcagt ggaacactga gtcactcttt tcttaacacg tgcaacatct
     2761 taatttttgt ttttcagcag ttgctgtttt gtactttggt agtaaagtga tttttaccac
     2821 ctgtgtttgc atatttatat atgctgtgga tgaaaataac ttactagaga atgtatattt
     2881 tatgacaaga atgtgtatct gttggatata atcagagaac tgaaaagtaa tttatcagta
     2941 atttttaaga gtccatgttt tgtgacaacc atctctaata gccaactctt tattaaacac
     3001 actcctaaaa ataaggaacc atgacattgt agatatttaa tattgtacag tatagaaacc
     3061 tccatttttg ccttcgaatg catatttaag agttaacaga atgaaaaaaa aaagtcttgt
     3121 tggataatag tgtttgacta gcgttttaag aacttgagag taaaagcaac aataagattt
     3181 tttcacctct tcctgcttcc acccccaaac tgagaacatc actcaattgt ttggaagaaa
     3241 ctgtaggtct atataaattt tatttataat gtatgtgtaa tatacataat cataatacag
     3301 ttctcagatg cagggaagaa gtttggcatt taatcattga ggctttaggt ttttgatgtg
     3361 atcagactgg gccatgtcaa acccggaatt ttcaccaaca gttcactcac cctcctggta
     3421 cattgccatt ccaaggaatt ctgagagtag gcaaacaaat tttgccttca tggtacagtt
     3481 ctcagttttt cttataggag aaatatggta tatgtttata agaatctttt atgagattat
     3541 agatttcaat gctgtggata gtgtcttgca cccaaacaag aaagtccata atggaatgat
     3601 cttccctcag cttcctatcg atttagttac ctcttgaaag cacaaaaatt aaaacattgc
     3661 catatgttga atttttaaaa agcacttgga gtgagcgaac atttcctgat aaatgccttt
     3721 tagagatagg ttcttgatat tcagacatct gcagaaatgt tctggttccc aaagtcattt
     3781 cacttcgaaa taaaacacag ctccttcaaa cagcactttt tccacataaa tctagttgcc
     3841 tctccctgtg gacattcaga actgatagaa caaacactac tcttttgaat ttgatggttc
     3901 gtgtccttta aagtgtttga ggacctatgc agagcctgta acacttgggt agtacctgct
     3961 aggacaattt cttggcaatt gtcttactac tagggatcag taagatttag attctgagcc
     4021 cataatggca acagccccct cacctatggg aagctgactt ccctcagtcg ggcacttctc
     4081 atgggggctg aacatggttc ctgccattct gttacccact ctcccaggtg agccctggat
     4141 tggctcccag aaggcctttg taaaatcagt agccgtcctg caggcaggtg ggagcaacag
     4201 gggcttcagt agcttcattt tcctgtcttg cagacagaga cccttggcta ccactgtgct
     4261 gctaatagga taagtactct gttgccagat taccatgcct tttatacaaa accaaattaa
     4321 cttacctaat acctgacacc tctttgggct ctgaactgct ttctctcatc aagcatgcta
     4381 gcactctaga cagaattcta gaaatttggc agatagtgga agcctttaat tgaacttact
     4441 ccttcgttga ctgaaaggag ttttaaattc tgagctcctg agatactgac tagcaaccat
     4501 ggaatgaatg tgtgaccaga aagtggcttt gacaccaagt gctactgtcc ctttgtaatt
     4561 ggcttctaac agaattcaac cagaaataat tgataatgtg aatttttgtt aattgttcac
     4621 ttgtaggaaa atagaacatg tatcaccctt tgttaggtag acatgaactt ttcctgcaca
     4681 aagccttgct tttagagaat gcccaataag gcaagaaaaa gcatagtaac ttgtgctttg
     4741 agagctcaat atttgtatct tatcagtaca gaagaaatat ttctgtgtaa cttgatcttc
     4801 tgtctagtac ttgtcttata ggtaaccaac actgaaaact ttgtagtgat gactaccaaa
     4861 gaaatacata gtaaaacaac cttttatttc caaattgtta aagagccagc cattgatgct
     4921 gctacatgag ttccatgctc aagagccatt gtaagagatt aaggggtttc taggtttttg
     4981 gtgatttttt gtttgttttt ttctttgttt tttagggttt ttttttcttc tttaattttt
     5041 tgattaaaac atacacacag ctgttagcat aaagtcgtgg ggggcatttt ctggaatgct
     5101 cagcagttct gattaactgc caagcccagg ttgcctctca tgaggcaact gaaaaaatcc
     5161 tgtgtcttga tagcatgggt gctgtgtgtg tgcatgtgtg tgtctgcatt catgccttaa
     5221 ctcgggttac tgcacaactt tagttcttga cttagtctgc accgtcatct agattgtatt
     5281 gtacatctcg gtctgaactt catcctggca aaaacaaagt tgcaggcaca acagtttaag
     5341 aatgcattcc tccagaagag tatctggtca ggttgacccc tgagccttct ttggacttga
     5401 tttggaactt agcctggaaa gcgaaagtgg actgtccaac agaaagatgt caacaaggaa
     5461 aagaggagag ccaagcgcta gcatgccttt tgcctctgca tatctgtgca cactgtatgt
     5521 tgttcatgat agcttgtcta caacttgact aggttggagt tctggtaata gtggcaatct
     5581 tgacattctt ggtcagagtt tagagagatg taagactttc aattaatgtc ttatttactc
     5641 ctttatgttg attagtcttt gatacatgtg ctgaatcaga aacctaaata aagataattt
     5701 tttaaaatgt acctcttgag ccttaaa
//
