LOCUS       NM_014167               1585 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens coiled-coil domain containing 59 (CCDC59), transcript
            variant 1, mRNA.
ACCESSION   NM_014167
VERSION     NM_014167.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1585)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 1585)
  AUTHORS   Geller,F., Feenstra,B., Carstensen,L., Pers,T.H., van Rooij,I.A.,
            Korberg,I.B., Choudhry,S., Karjalainen,J.M., Schnack,T.H.,
            Hollegaard,M.V., Feitz,W.F., Roeleveld,N., Hougaard,D.M.,
            Hirschhorn,J.N., Franke,L., Baskin,L.S., Nordenskjold,A., van der
            Zanden,L.F. and Melbye,M.
  TITLE     Genome-wide association analyses identify variants in developmental
            genes associated with hypospadias
  JOURNAL   Nat Genet 46 (9), 957-963 (2014)
   PUBMED   25108383
REFERENCE   3  (bases 1 to 1585)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   4  (bases 1 to 1585)
  AUTHORS   Yang,M.C., Guo,Y., Liu,C.C., Weissler,J.C. and Yang,Y.S.
  TITLE     The TTF-1/TAP26 complex differentially modulates surfactant
            protein-B (SP-B) and -C (SP-C) promoters in lung cells
  JOURNAL   Biochem Biophys Res Commun 344 (2), 484-490 (2006)
   PUBMED   16630564
REFERENCE   5  (bases 1 to 1585)
  AUTHORS   Oh,J.H., Yang,J.O., Hahn,Y., Kim,M.R., Byun,S.S., Jeon,Y.J.,
            Kim,J.M., Song,K.S., Noh,S.M., Kim,S., Yoo,H.S., Kim,Y.S. and
            Kim,N.S.
  TITLE     Transcriptome analysis of human gastric cancer
  JOURNAL   Mamm Genome 16 (12), 942-954 (2005)
   PUBMED   16341674
REFERENCE   6  (bases 1 to 1585)
  AUTHORS   Yang,M.C., Wang,B., Weissler,J.C., Margraf,L.R. and Yang,Y.S.
  TITLE     BR22, a 26 kDa thyroid transcription factor-1 associated protein
            (TAP26), is expressed in human lung cells
  JOURNAL   Eur Respir J 22 (1), 28-34 (2003)
   PUBMED   12882447
REFERENCE   7  (bases 1 to 1585)
  AUTHORS   Yang,Y.S., Yang,M.C., Wang,B. and Weissler,J.C.
  TITLE     BR22, a novel protein, interacts with thyroid transcription
            factor-1 and activates the human surfactant protein B promoter
  JOURNAL   Am J Respir Cell Mol Biol 24 (1), 30-37 (2001)
   PUBMED   11152647
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BG538660.1, BC020647.1 and AC083811.22.
            
            On Nov 23, 2018 this sequence version replaced NM_014167.4.
            
            Transcript Variant: This variant (1) encodes the functional
            protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF213377.1, SRR1660805.127505.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000256151.8/ ENSP00000256151.7
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4                 BG538660.1         39-42
            5-1042              BC020647.1         1-1038
            1043-1585           AC083811.22        114870-115412
FEATURES             Location/Qualifiers
     source          1..1585
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q21.31"
     gene            1..1585
                     /gene="CCDC59"
                     /gene_synonym="BR22; HSPC128; TAP26"
                     /note="coiled-coil domain containing 59"
                     /db_xref="GeneID:29080"
                     /db_xref="HGNC:HGNC:25005"
                     /db_xref="MIM:619280"
     exon            1..165
                     /gene="CCDC59"
                     /gene_synonym="BR22; HSPC128; TAP26"
                     /inference="alignment:Splign:2.1.0"
     CDS             12..737
                     /gene="CCDC59"
                     /gene_synonym="BR22; HSPC128; TAP26"
                     /note="TTF-1-associated protein 26; TTF-1-associated
                     protein BR2; coiled-coil domain-containing protein 59"
                     /codon_start=1
                     /product="thyroid transcription factor 1-associated
                     protein 26"
                     /protein_id="NP_054886.2"
                     /db_xref="CCDS:CCDS9023.1"
                     /db_xref="GeneID:29080"
                     /db_xref="HGNC:HGNC:25005"
                     /db_xref="MIM:619280"
                     /translation="MAPVRRSAKWRPGGIEARGEGVSTVGYRNKNVRQKTWRPNHPQA
                     FVGSVREGQGFAFRRKLKIQQSYKKLLRKEKKAQTSLESQFTDRYPDNLKHLYLAEEE
                     RHRKQARKVDHPLSEQVHQPLLEEQCSIDEPLFEDQCSFDQPQPEEQCIKTVNSFTIP
                     KKNKKKTSNQKAQEEYEQIQAKRAAKKQEFERRKQEREEAQRQYKKKKMEVFKILNKK
                     TKKGQPNLNVQMEYLLQKIQEKC"
     exon            166..475
                     /gene="CCDC59"
                     /gene_synonym="BR22; HSPC128; TAP26"
                     /inference="alignment:Splign:2.1.0"
     exon            476..575
                     /gene="CCDC59"
                     /gene_synonym="BR22; HSPC128; TAP26"
                     /inference="alignment:Splign:2.1.0"
     exon            576..1585
                     /gene="CCDC59"
                     /gene_synonym="BR22; HSPC128; TAP26"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1026..1031
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CCDC59"
                     /gene_synonym="BR22; HSPC128; TAP26"
                     /note="hexamer: AATAAA"
     regulatory      1041..1046
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CCDC59"
                     /gene_synonym="BR22; HSPC128; TAP26"
                     /note="hexamer: AATAAG"
     polyA_site      1049
                     /gene="CCDC59"
                     /gene_synonym="BR22; HSPC128; TAP26"
                     /note="major polyA site"
     polyA_site      1062
                     /gene="CCDC59"
                     /gene_synonym="BR22; HSPC128; TAP26"
     regulatory      1560..1565
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CCDC59"
                     /gene_synonym="BR22; HSPC128; TAP26"
                     /note="hexamer: AATAAA"
     polyA_site      1585
                     /gene="CCDC59"
                     /gene_synonym="BR22; HSPC128; TAP26"
ORIGIN      
        1 agtcggctgc aatggcgccg gtgaggcggt ccgcgaagtg gcggcctggt ggtattgagg
       61 cgcgtggtga aggggtttcc actgtcgggt acaggaataa gaatgtgaga cagaagacat
      121 ggcggcctaa ccacccgcaa gccttcgtgg ggagcgttcg cgagggacaa ggctttgctt
      181 ttcgaagaaa actgaaaata cagcaaagtt acaagaaatt gctacggaag gaaaagaagg
      241 ctcaaacgtc actggaatct caattcacag atcgataccc agataatctg aaacatctct
      301 atttagctga agaggaaaga cataggaagc aagcaagaaa agtcgaccat cctttgtcag
      361 aacaagttca ccagccgttg cttgaagaac agtgtagcat tgacgagcct ttatttgaag
      421 atcagtgtag ctttgaccag cctcagccag aagaacaatg tattaaaaca gtaaactcct
      481 ttacaattcc aaagaaaaat aaaaagaaaa catcaaatca aaaagcacaa gaagaatatg
      541 aacagataca agccaaacgt gctgctaaga aacaagaatt cgagaggaga aaacaggaga
      601 gagaagaagc ccaaaggcag tacaaaaaga agaaaatgga agtgtttaaa atactgaaca
      661 aaaagactaa aaagggccaa ccaaacttga atgtacaaat ggagtacctt cttcaaaaaa
      721 tacaagaaaa atgttaaaca ttttgttcct acaggttaaa atatctgctg cctattaggt
      781 tcttctgtga catgtgcctc ccagcagtga actaaatttg tcgacataaa ctggattgct
      841 aaactatgct aaatataaga tgttcacata tttttattat ggtaaaaaat tttctaaata
      901 tgttctacat gtttcttatt tatttgcctc tgaaggaagg ttggcctgaa gaactgaaag
      961 aacctcttat tttgcaagac aggcccaagc atgtaatact tttgtaccat atgagattta
     1021 tatgaaataa attttttaaa aataaggaat cagagctatc aatgaagcat ttcaatgaaa
     1081 tatttcaatt tagtaaacag ttacgttgtt ttaaaattta ttttaatgat gagggaggca
     1141 aagactcctc ttggactttt tatttatttt aagtacatgt tacagggtga tgggtgctga
     1201 aataaactgc cctcaccata taacaaagcg accttcacaa agcagtgaac tcaaagtctg
     1261 atatttataa acattccctt aaatggatgt acatggcttg ttagtctaag gtcttttaaa
     1321 taatgatgga aaccccacag tgtcacagca agaattaagc tttccagttc ctatggaccc
     1381 tatactttaa gaacattatc tctgtctccc ttgttggtac ccttgtgagc tgagataagc
     1441 cactgggata actgcttctc atgctttgca aattgcagaa gaatgagaaa ggcttgaaat
     1501 atatatatag tcattgtaag caaaaagggc tgaccaataa tacttgccaa atattgaata
     1561 ataaaatttt ataaatgata gcaaa
//
