LOCUS       NM_144609               2114 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens coiled-coil domain containing 43 (CCDC43), transcript
            variant 1, mRNA.
ACCESSION   NM_144609
VERSION     NM_144609.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2114)
  AUTHORS   Yang,Q., Wang,Y., Li,M., Wang,Z., Zhang,J., Dai,W., Pei,M.,
            Hong,L., Xiao,Y., Hu,H., Li,J., Lin,J., Wu,X., Chen,Y., Huang,M.,
            Li,A., Liu,S., Tang,W., Xiang,L. and Wang,J.
  TITLE     HMGA1 promotes gastric cancer growth and metastasis by
            transactivating SUZ12 and CCDC43 expression
  JOURNAL   Aging (Albany NY) 13 (12), 16043-16061 (2021)
   PUBMED   34167089
  REMARK    GeneRIF: HMGA1 promotes gastric cancer growth and metastasis by
            transactivating SUZ12 and CCDC43 expression.
REFERENCE   2  (bases 1 to 2114)
  AUTHORS   Wang,J., Wu,X., Dai,W., Li,J., Xiang,L., Tang,W., Lin,J., Zhang,W.,
            Liu,G., Yang,Q., Lin,Z., Sun,Y., Zhang,Y., Chen,Y., Li,G., Li,A.,
            Liu,S., Li,Y. and Wang,J.
  TITLE     The CCDC43-ADRM1 axis regulated by YY1, promotes proliferation and
            metastasis of gastric cancer
  JOURNAL   Cancer Lett 482, 90-101 (2020)
   PUBMED   32278016
  REMARK    GeneRIF: The CCDC43-ADRM1 axis regulated by YY1, promotes
            proliferation and metastasis of gastric cancer.
REFERENCE   3  (bases 1 to 2114)
  AUTHORS   Wang,J., Liu,G., Liu,M., Xiang,L., Xiao,Y., Zhu,H., Wu,X., Peng,Y.,
            Zhang,W., Jiang,P., Li,A., Nan,Q., Chen,Y., Chen,C., Cheng,T.,
            Liu,S. and Wang,J.
  TITLE     The FOXK1-CCDC43 Axis Promotes the Invasion and Metastasis of
            Colorectal Cancer Cells
  JOURNAL   Cell Physiol Biochem 51 (6), 2547-2563 (2018)
   PUBMED   30562730
  REMARK    GeneRIF: This work identified that CCDC43 promoted
            epithelial-mesenchymal transition and was a direct transcriptional
            target of FOXK1 in colorectal cancer cells.
REFERENCE   4  (bases 1 to 2114)
  AUTHORS   Lee,O.H., Kim,H., He,Q., Baek,H.J., Yang,D., Chen,L.Y., Liang,J.,
            Chae,H.K., Safari,A., Liu,D. and Songyang,Z.
  TITLE     Genome-wide YFP fluorescence complementation screen identifies new
            regulators for telomere signaling in human cells
  JOURNAL   Mol Cell Proteomics 10 (2), M110.001628 (2011)
   PUBMED   21044950
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BG706097.1 and BC023298.1.
            
            On Nov 22, 2018 this sequence version replaced NM_144609.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.674952.1,
                                           SRR1803617.204567.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000315286.13/ ENSP00000323782.7
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-18                BG706097.1         31-48
            19-2114             BC023298.1         1-2096
FEATURES             Location/Qualifiers
     source          1..2114
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q21.31"
     gene            1..2114
                     /gene="CCDC43"
                     /note="coiled-coil domain containing 43"
                     /db_xref="GeneID:124808"
                     /db_xref="HGNC:HGNC:26472"
     exon            1..227
                     /gene="CCDC43"
                     /inference="alignment:Splign:2.1.0"
     CDS             24..698
                     /gene="CCDC43"
                     /note="isoform 1 is encoded by transcript variant 1;
                     coiled-coil domain-containing protein 43"
                     /codon_start=1
                     /product="coiled-coil domain-containing protein 43 isoform
                     1"
                     /protein_id="NP_653210.2"
                     /db_xref="CCDS:CCDS45704.1"
                     /db_xref="GeneID:124808"
                     /db_xref="HGNC:HGNC:26472"
                     /translation="MAAPSEVAAIAPGEGDGGGGGFGSWLDGRLEALGVDRAVYGAYI
                     LGILQEEEEEEKLDALQGILSAFLEEDSLLNICKEIVERWSETQNVVTKVKKEDEVQA
                     IATLIEKQAQIVVKPRMVSEEEKQRKAALLAQYADVTDEEDEADEKDDSGATTMNIGS
                     DKLLFRNTNVEDVLNARKLERDSLRDESQRKKEQDKLQRERDKLAKQERKEKEKKRTQ
                     RGERKR"
     exon            228..315
                     /gene="CCDC43"
                     /inference="alignment:Splign:2.1.0"
     exon            316..451
                     /gene="CCDC43"
                     /inference="alignment:Splign:2.1.0"
     exon            452..510
                     /gene="CCDC43"
                     /inference="alignment:Splign:2.1.0"
     exon            511..2114
                     /gene="CCDC43"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2094..2099
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CCDC43"
                     /note="hexamer: AATAAA"
     polyA_site      2114
                     /gene="CCDC43"
                     /note="major polyA site"
ORIGIN      
        1 gcttgcagga ccctgacccc aagatggcgg cgcccagcga agtggccgcg atagcccctg
       61 gcgaaggcga tggcggaggc ggcggctttg gctcctggct ggacggacgg ttggaggcac
      121 tgggagtgga ccgagccgtt tatggagcct acatcttggg tatcctgcag gaggaggagg
      181 aagaagagaa gctggacgct ctgcagggga tcctctctgc tttcctggaa gaagattccc
      241 tccttaatat ctgcaaggag attgtggaac gatggtcaga aactcagaat gttgtcacca
      301 aagtgaaaaa agaagatgaa gtacaggcca ttgccaccct aattgagaag caggcacaaa
      361 tcgtagtaaa gccaaggatg gtgtcagaag aggagaagca gagaaaagct gccctcctgg
      421 cccagtatgc tgatgtgaca gatgaagagg atgaagcaga tgagaaggat gattcaggtg
      481 ctaccacaat gaacattggt tctgacaaac ttctgttccg aaacaccaat gtggaagatg
      541 tccttaatgc ccgaaaactg gagcgagact cacttcggga tgaatcccaa aggaagaagg
      601 aacaggacaa gctgcagagg gagagagaca aactagccaa gcaggagcgc aaggaaaagg
      661 aaaaaaaaag gacacagaga ggggagcgaa agcgataacc ttggcctact ctattctttc
      721 cccccatgaa cttatcaaag ggagaactgg ttgtgtattt aagagaaatg agagtgcatt
      781 gcaaagtagt ttcccaaggc atttccccta ttgtttacat ggtcaaaagg aaaatcaaaa
      841 tcacttctaa ttacaaaatg tgctgttttg gtggggtggg caatcagatt attatagttg
      901 atgactgtac caaagatctg gaatgggggc cacctttata ttttaatact caagtcctgt
      961 gctccttttg gccactttaa aaagtcttcc ctcaccttgg ataaatagga ttcagaaagc
     1021 taacagtttt cattctgaag gagcagaaac ataatcaatc cctccctgag ataaaatgtg
     1081 ggcatgcaca ttgctttgga gtcagtattc agctgtaagt gtagtattgt tttatggctg
     1141 aaatagaaag ctaatgaaga ggcctacctg gatccagatt ttatgttaac atggcagcaa
     1201 aactaggaaa atgggaagaa attacttgcg gggtgttcta gatctgattt tttttttttt
     1261 tttgaaagtt tcagcctgtg ggaggaaaag aggtatcttt taaaatagag atagttacat
     1321 attttcctca tctaggctgt gtcactattg ggtgcaagga tatcattgtt ggctagattc
     1381 attttgtata atcatgtatc ctcttgtgtg ctggtagaga ttttaatcct gatttttcca
     1441 taaaacatga gtattaagaa ataattcctg gtttggagaa actggagaaa tcaccctttt
     1501 aaggaagaaa cactggaaat ttctgctaac accaagatat ttaagagtgt acatagtagg
     1561 tgctcaacaa atttattgaa tgaatgagtg aatggaaaaa ctgggagagt caaaagtgag
     1621 cagaagctct ccatttctac ttctgtcaca aaccacatta aattgtaaat aaggcccttc
     1681 tccacttgac ttcaggcagc agattgtcta gaagcctaag gacagcaatt tctctgacaa
     1741 gacaaagtag atattttata ccaggggttg gcaaactact gcccacgggc cgaatttggc
     1801 ccagtctgtt tttgtatggt gcaaactaaa aatgattttt acatttttaa agagttataa
     1861 aagaaaaaaa tatgtggtct gtgaaatcta aaatatttac tacctggcct gttggaggaa
     1921 aggtttgcca atctctgttt tataccatta actatgagat taacaaaaac ttttaccttt
     1981 gtgcagaagg ttaaaaaaaa aaaaacatgg ttaaggaaaa ggagacatgt tacctcttca
     2041 tacactccta taactgtggc attgcaaaaa ataaaaataa ccacctttaa aaaaataaat
     2101 cttatttaaa ttgc
//
