LOCUS       NM_144681               1373 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens coiled-coil domain containing 42 (CCDC42), transcript
            variant 1, mRNA.
ACCESSION   NM_144681
VERSION     NM_144681.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1373)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 1373)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1373)
  AUTHORS   Tapia Contreras,C. and Hoyer-Fender,S.
  TITLE     CCDC42 Localizes to Manchette, HTCA and Tail and Interacts With
            ODF1 and ODF2 in the Formation of the Male Germ Cell Cytoskeleton
  JOURNAL   Front Cell Dev Biol 7, 151 (2019)
   PUBMED   31475146
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1373)
  AUTHORS   Pasek,R.C., Malarkey,E., Berbari,N.F., Sharma,N., Kesterson,R.A.,
            Tres,L.L., Kierszenbaum,A.L. and Yoder,B.K.
  TITLE     Coiled-coil domain containing 42 (Ccdc42) is necessary for proper
            sperm development and male fertility in the mouse
  JOURNAL   Dev Biol 412 (2), 208-218 (2016)
   PUBMED   26945718
REFERENCE   5  (bases 1 to 1373)
  AUTHORS   Rual,J.F., Hirozane-Kishikawa,T., Hao,T., Bertin,N., Li,S.,
            Dricot,A., Li,N., Rosenberg,J., Lamesch,P., Vidalain,P.O.,
            Clingingsmith,T.R., Hartley,J.L., Esposito,D., Cheo,D., Moore,T.,
            Simmons,B., Sequerra,R., Bosak,S., Doucette-Stamm,L., Le Peuch,C.,
            Vandenhaute,J., Cusick,M.E., Albala,J.S., Hill,D.E. and Vidal,M.
  TITLE     Human ORFeome version 1.1: a platform for reverse proteomics
  JOURNAL   Genome Res 14 (10B), 2128-2135 (2004)
   PUBMED   15489335
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK057296.1 and CV030241.1.
            
            On Nov 23, 2018 this sequence version replaced NM_144681.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK057296.1, SRR5189667.243899.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000293845.8/ ENSP00000293845.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-345               AK057296.1         1-345
            346-719             CV030241.1         119-492
            720-994             AK057296.1         720-994
            995-1000            CV030241.1         546-551
            1001-1373           AK057296.1         1001-1373
FEATURES             Location/Qualifiers
     source          1..1373
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17p13.1"
     gene            1..1373
                     /gene="CCDC42"
                     /gene_synonym="CCDC42A"
                     /note="coiled-coil domain containing 42"
                     /db_xref="GeneID:146849"
                     /db_xref="HGNC:HGNC:26528"
     exon            1..310
                     /gene="CCDC42"
                     /gene_synonym="CCDC42A"
                     /inference="alignment:Splign:2.1.0"
     CDS             228..1178
                     /gene="CCDC42"
                     /gene_synonym="CCDC42A"
                     /note="isoform 1 is encoded by transcript variant 1;
                     coiled-coil domain-containing protein 42A"
                     /codon_start=1
                     /product="coiled-coil domain-containing protein 42 isoform
                     1"
                     /protein_id="NP_653282.2"
                     /db_xref="CCDS:CCDS11145.1"
                     /db_xref="GeneID:146849"
                     /db_xref="HGNC:HGNC:26528"
                     /translation="MSLGIMEEEDLAEYFRLQYGERLLQMLQKLPNVEGASESPSIWL
                     LEKKKETEIMHQTMVQKKKMFQRRMETLNLRWEELGVKEAQLKAHIQKSEQFIQENDQ
                     KRIRAMKKANKERELKCQHMQELTKRKQEMVALRLEHQRLSAKLKDYYIFNKYLEKVV
                     ENSEFEEIHEVIARYKTLVSMRHDLMQSAQEGQEKIERAKARLARYMEEKDDEILQQN
                     NELARLQMRFDRARSNVIFWESRWAHIQNTAAKKTLLLGTIKMATLNLFQIVSKHLKE
                     VTEVALEDTHKQLDMIQQFIQDRSDIWAEVKKKEQQRVRI"
     exon            311..416
                     /gene="CCDC42"
                     /gene_synonym="CCDC42A"
                     /inference="alignment:Splign:2.1.0"
     exon            417..521
                     /gene="CCDC42"
                     /gene_synonym="CCDC42A"
                     /inference="alignment:Splign:2.1.0"
     exon            522..719
                     /gene="CCDC42"
                     /gene_synonym="CCDC42A"
                     /inference="alignment:Splign:2.1.0"
     exon            720..941
                     /gene="CCDC42"
                     /gene_synonym="CCDC42A"
                     /inference="alignment:Splign:2.1.0"
     exon            942..1100
                     /gene="CCDC42"
                     /gene_synonym="CCDC42A"
                     /inference="alignment:Splign:2.1.0"
     exon            1101..1373
                     /gene="CCDC42"
                     /gene_synonym="CCDC42A"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      1373
                     /gene="CCDC42"
                     /gene_synonym="CCDC42A"
                     /note="major polyA site"
ORIGIN      
        1 gttgctaggt aaccacatct cccataactg ccccagcaca tcgtcctgag ccgcccaacc
       61 tgtctccagc caccttctgt ggagtctcaa actccatcat ctgtgggacc ctgtaggccg
      121 aagggagaaa caagagtgca gccaccaccc ctgagccacc tgtggctctg ctacccacaa
      181 tttcactgtg aagagtcagc tgcctgggcc gtgaggtcac tgccaccatg agtctgggca
      241 tcatggaaga ggaagacctg gccgagtact tccggctgca gtatggggag cggctgctgc
      301 agatgctcca gaaactcccc aatgttgagg gggcgtcgga gtccccatcc atctggctac
      361 tggagaagaa aaaggagaca gaaatcatgc atcaaactat ggtgcagaag aagaagatgt
      421 ttcagcgcag aatggaaacc ctgaacctgc gctgggagga actgggcgtt aaggaagccc
      481 aactgaaggc tcacatccag aagtctgagc agttcatcca ggagaacgac cagaaacgga
      541 tccgcgccat gaagaaagcc aacaaggagc gagaactcaa gtgccagcac atgcaggagc
      601 tgaccaagcg caagcaggag atggtggcgc tgcggctgga gcaccagcgg ctgagcgcca
      661 agctgaagga ctactacatc ttcaacaagt acctagagaa ggtggtggag aactccgagt
      721 tcgaggagat ccatgaggtg attgcacgct acaagacgct ggtgagcatg cgccacgacc
      781 tcatgcagtc tgcgcaggaa ggccaggaga agattgagcg cgccaaggcc cggctggcgc
      841 gctacatgga ggaaaaggat gatgagatcc tgcagcaaaa caatgagctg gcaaggctgc
      901 agatgcgctt tgaccgtgcc cgcagcaatg tcatcttctg ggaatctcgc tgggcgcaca
      961 tccagaacac cgcagccaag aagaccctcc tgcttggcac cattaagatg gccacgctga
     1021 acctcttcca gatcgtgagc aagcacctga aggaggtgac tgaggtggca ctggaggaca
     1081 cccacaagca gctggacatg atccagcaat ttatccaaga ccggtcggac atctgggcag
     1141 aggtgaaaaa gaaggaacaa cagcgagtcc ggatttaagg aggcagcctt gttccagaat
     1201 gtcctgagac agagatcgtg aaagaagaag tcgtgagcct gcggtccagt cagtccagct
     1261 cgggaccgat gcctgctgtg ccttcctgct gagggacacc tgcttatttt cccccgtggg
     1321 cctcactcta tccctgaaaa cagtgaatgt tatatgaagt ttgttctcaa gtt
//
