LOCUS       NM_017950               4288 bp    mRNA    linear   PRI 08-OCT-2024
DEFINITION  Homo sapiens coiled-coil domain 40 molecular ruler complex subunit
            (CCDC40), transcript variant 1, mRNA.
ACCESSION   NM_017950 XM_371082 XM_930250 XM_934521 XM_942690 XM_946231
VERSION     NM_017950.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4288)
  AUTHORS   Wilken,A., Hoben,I.M., Wolter,A., Loges,N.T., Olbrich,H., Aprea,I.,
            Dworniczak,B., Raidt,J. and Omran,H.
  TITLE     Primary Ciliary Dyskinesia Associated Disease-Causing Variants in
            CCDC39 and CCDC40 Cause Axonemal Absence of Inner Dynein Arm Heavy
            Chains DNAH1, DNAH6, and DNAH7
  JOURNAL   Cells 13 (14), 1200 (2024)
   PUBMED   39056782
  REMARK    GeneRIF: Primary Ciliary Dyskinesia Associated Disease-Causing
            Variants in CCDC39 and CCDC40 Cause Axonemal Absence of Inner
            Dynein Arm Heavy Chains DNAH1, DNAH6, and DNAH7.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4288)
  AUTHORS   Liu,L., Zhou,K., Song,Y. and Liu,X.
  TITLE     CCDC40 mutation as a cause of infertility in a Chinese family with
            primary ciliary dyskinesia
  JOURNAL   Medicine (Baltimore) 100 (51), e28275 (2021)
   PUBMED   34941110
  REMARK    GeneRIF: CCDC40 mutation as a cause of infertility in a Chinese
            family with primary ciliary dyskinesia.
REFERENCE   3  (bases 1 to 4288)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 4288)
  AUTHORS   Fassad,M.R., Shoman,W.I., Morsy,H., Patel,M.P., Radwan,N.,
            Jenkins,L., Cullup,T., Fouda,E., Mitchison,H.M. and Fasseeh,N.
  TITLE     Clinical and genetic spectrum in 33 Egyptian families with
            suspected primary ciliary dyskinesia
  JOURNAL   Clin Genet 97 (3), 509-515 (2020)
   PUBMED   31650533
  REMARK    GeneRIF: Clinical and genetic spectrum in 33 Egyptian families with
            suspected primary ciliary dyskinesia.
REFERENCE   5  (bases 1 to 4288)
  AUTHORS   Antony,D., Becker-Heck,A., Zariwala,M.A., Schmidts,M.,
            Onoufriadis,A., Forouhan,M., Wilson,R., Taylor-Cox,T., Dewar,A.,
            Jackson,C., Goggin,P., Loges,N.T., Olbrich,H., Jaspers,M.,
            Jorissen,M., Leigh,M.W., Wolf,W.E., Daniels,M.L., Noone,P.G.,
            Ferkol,T.W., Sagel,S.D., Rosenfeld,M., Rutman,A., Dixit,A.,
            O'Callaghan,C., Lucas,J.S., Hogg,C., Scambler,P.J., Emes,R.D.,
            Chung,E.M., Shoemark,A., Knowles,M.R., Omran,H. and Mitchison,H.M.
  CONSRTM   Uk10k
  TITLE     Mutations in CCDC39 and CCDC40 are the major cause of primary
            ciliary dyskinesia with axonemal disorganization and absent inner
            dynein arms
  JOURNAL   Hum Mutat 34 (3), 462-472 (2013)
   PUBMED   23255504
  REMARK    GeneRIF: This study shows that CCDC39 and CCDC40 mutations are the
            major cause of Primary ciliary dyskinesia in patients with the
            previously termed 'radial spoke defect'.
REFERENCE   6  (bases 1 to 4288)
  AUTHORS   Blanchon,S., Legendre,M., Copin,B., Duquesnoy,P., Montantin,G.,
            Kott,E., Dastot,F., Jeanson,L., Cachanado,M., Rousseau,A.,
            Papon,J.F., Beydon,N., Brouard,J., Crestani,B., Deschildre,A.,
            Desir,J., Dollfus,H., Leheup,B., Tamalet,A., Thumerelle,C.,
            Vojtek,A.M., Escalier,D., Coste,A., de Blic,J., Clement,A.,
            Escudier,E. and Amselem,S.
  TITLE     Delineation of CCDC39/CCDC40 mutation spectrum and associated
            phenotypes in primary ciliary dyskinesia
  JOURNAL   J Med Genet 49 (6), 410-416 (2012)
   PUBMED   22693285
  REMARK    GeneRIF: Aiming to delineate the CCDC39/CCDC40 mutation spectrum
            and associated phenotypes, a large cohort of patients with IDA
            defects were screened. Biallelic CCDC39 or CCDC40 mutations were
            identified in 30/34 unrelated families with IDA defects.
REFERENCE   7  (bases 1 to 4288)
  AUTHORS   Nakhleh,N., Francis,R., Giese,R.A., Tian,X., Li,Y., Zariwala,M.A.,
            Yagi,H., Khalifa,O., Kureshi,S., Chatterjee,B., Sabol,S.L.,
            Swisher,M., Connelly,P.S., Daniels,M.P., Srinivasan,A., Kuehl,K.,
            Kravitz,N., Burns,K., Sami,I., Omran,H., Barmada,M., Olivier,K.,
            Chawla,K.K., Leigh,M., Jonas,R., Knowles,M., Leatherbury,L. and
            Lo,C.W.
  TITLE     High prevalence of respiratory ciliary dysfunction in congenital
            heart disease patients with heterotaxy
  JOURNAL   Circulation 125 (18), 2232-2242 (2012)
   PUBMED   22499950
REFERENCE   8  (bases 1 to 4288)
  AUTHORS   Becker-Heck,A., Zohn,I.E., Okabe,N., Pollock,A., Lenhart,K.B.,
            Sullivan-Brown,J., McSheene,J., Loges,N.T., Olbrich,H.,
            Haeffner,K., Fliegauf,M., Horvath,J., Reinhardt,R., Nielsen,K.G.,
            Marthin,J.K., Baktai,G., Anderson,K.V., Geisler,R., Niswander,L.,
            Omran,H. and Burdine,R.D.
  TITLE     The coiled-coil domain containing protein CCDC40 is essential for
            motile cilia function and left-right axis formation
  JOURNAL   Nat Genet 43 (1), 79-84 (2011)
   PUBMED   21131974
  REMARK    GeneRIF: CCDC40 mutations in humans result in a variant of primary
            ciliary dyskinesia characterized by misplacement of the central
            pair of microtubules and defective assembly of inner dynein arms
            and dynein regulatory complexes.
REFERENCE   9  (bases 1 to 4288)
  AUTHORS   Wang,J., Lin,J., Chang,Y., Li,P. and Yang,Y.
  TITLE     MCM3AP, a novel HBV integration site in hepatocellular carcinoma
            and its implication in hepatocarcinogenesis
  JOURNAL   J Huazhong Univ Sci Technolog Med Sci 30 (4), 425-429 (2010)
   PUBMED   20714864
REFERENCE   10 (bases 1 to 4288)
  AUTHORS   Zariwala,M.A., Knowles,M.R. and Leigh,M.W.
  TITLE     Primary Ciliary Dyskinesia
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301301
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB230102.1, BC035251.1,
            DA842356.1, AB046860.1 and AW300891.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_017950.3.
            
            Summary: This gene encodes a protein that is necessary for motile
            cilia function. It functions in correct left-right axis formation
            by regulating the assembly of the inner dynein arm and the dynein
            regulatory complexes, which control ciliary beat. Mutations in this
            gene cause ciliary dyskinesia type 15, a disorder due to defects in
            cilia motility. Alternative splicing results in multiple transcript
            variants. [provided by RefSeq, Aug 2011].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1). There are no
            publicly available full-length transcripts representing this
            variant, but it is supported by partial transcript alignments and
            by data in PMID:21131974.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA1968189,
                              SAMEA1968968 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000397545.9/ ENSP00000380679.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1                 DB230102.1         11-11
            2-227               BC035251.1         5-230
            228-573             DA842356.1         218-563
            574-1105            BC035251.1         577-1108
            1106-4279           AB046860.1         622-3795
            4280-4288           AW300891.1         18-26               c
FEATURES             Location/Qualifiers
     source          1..4288
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q25.3"
     gene            1..4288
                     /gene="CCDC40"
                     /gene_synonym="CFAP172; CILD15; FAP172"
                     /note="coiled-coil domain 40 molecular ruler complex
                     subunit"
                     /db_xref="GeneID:55036"
                     /db_xref="HGNC:HGNC:26090"
                     /db_xref="MIM:613799"
     exon            1..50
                     /gene="CCDC40"
                     /gene_synonym="CFAP172; CILD15; FAP172"
                     /inference="alignment:Splign:2.1.0"
     CDS             22..3450
                     /gene="CCDC40"
                     /gene_synonym="CFAP172; CILD15; FAP172"
                     /note="isoform 1 is encoded by transcript variant 1;
                     coiled-coil domain-containing protein 40; coiled-coil
                     domain containing 40"
                     /codon_start=1
                     /product="coiled-coil domain-containing protein 40 isoform
                     1"
                     /protein_id="NP_060420.2"
                     /db_xref="CCDS:CCDS42395.1"
                     /db_xref="GeneID:55036"
                     /db_xref="HGNC:HGNC:26090"
                     /db_xref="MIM:613799"
                     /translation="MAEPGGAAGRSHPEDGSASEGEKEGNNESHMVSPPEKDDGQKGE
                     EAVGSTEHPEEVTTQAEAAIEEGEVETEGEAAVEGEEEAVSYGDAESEEEYYYTETSS
                     PEGQISAADTTYPYFSPPQELPGEEAYDSVSGEAGLQGFQQEATGPPESRERRVTSPE
                     PSHGVLGPSEQMGQVTSGPAVGRLTGSTEEPQGQVLPMGVQHRFRLSHGSDIESSDLE
                     EFVSQEPVIPPGVPDAHPREGDLPVFQDQIQQPSTEEGAMAERVESEGSDEEAEDEGS
                     QLVVLDPDHPLMVRFQAALKNYLNRQIEKLKLDLQELVVATKQSRAQRQELGVNLYEV
                     QQHLVHLQKLLEKSHDRHAMASSERRQKEEELQAARALYTKTCAAANEERKKLAALQT
                     EMENLALHLFYMQNIDQDMRDDIRVMTQVVKKAETERIRAEIEKKKQDLYVDQLTTRA
                     QQLEEDIALFEAQYLAQAEDTRILRKAVSEACTEIDAISVEKRRIMQQWASSLVGMKH
                     RDEAHRAVLEALRGCQHQAKSTDGEIEAYKKSIMKEEEKNEKLASILNRTETEATLLQ
                     KLTTQCLTKQVALQSQFNTYRLTLQDTEDALSQDQLEQMILTEELQAIRQAIQGELEL
                     RRKTDAAIREKLQEHMTSNKTTKYFNQLILRLQKEKTNMMTHLSKINGDIAQTTLDIT
                     HTSSRLDAHQKTLVELDQDVKKVNELITNSQSEISRRTILIERKQGLINFLNKQLERM
                     VSELGGEEVGPLELEIKRLSKLIDEHDGKAVQAQVTWLRLQQEMVKVTQEQEEQLASL
                     DASKKELHIMEQKKLRVESKIEQEKKEQKEIEHHMKDLDNDLKKLNMLMNKNRCSSEE
                     LEQNNRVTENEFVRSLKASERETIKMQDKLNQLSEEKATLLNQLVEAEHQIMLWEKKI
                     QLAKEMRSSVDSEIGQTEIRAMKGEIHRMKVRLGQLLKQQEKMIRAMELAVARRETVT
                     TQAEGQRKMDRKALTRTDFHHKQLELRRKIRDVRKATDECTKTVLELEETQRNVSSSL
                     LEKQEKLSVIQADFDTLEADLTRLGALKRQNLSEIVALQTRLKHLQAVKEGRYVFLFR
                     SKQSLVLERQRLDKRLALIATILDRVRDEYPQFQEALHKVSQMIANKLESPGPS"
     exon            51..114
                     /gene="CCDC40"
                     /gene_synonym="CFAP172; CILD15; FAP172"
                     /inference="alignment:Splign:2.1.0"
     exon            115..573
                     /gene="CCDC40"
                     /gene_synonym="CFAP172; CILD15; FAP172"
                     /inference="alignment:Splign:2.1.0"
     exon            574..697
                     /gene="CCDC40"
                     /gene_synonym="CFAP172; CILD15; FAP172"
                     /inference="alignment:Splign:2.1.0"
     exon            698..876
                     /gene="CCDC40"
                     /gene_synonym="CFAP172; CILD15; FAP172"
                     /inference="alignment:Splign:2.1.0"
     exon            877..960
                     /gene="CCDC40"
                     /gene_synonym="CFAP172; CILD15; FAP172"
                     /inference="alignment:Splign:2.1.0"
     exon            961..1180
                     /gene="CCDC40"
                     /gene_synonym="CFAP172; CILD15; FAP172"
                     /inference="alignment:Splign:2.1.0"
     exon            1181..1338
                     /gene="CCDC40"
                     /gene_synonym="CFAP172; CILD15; FAP172"
                     /inference="alignment:Splign:2.1.0"
     exon            1339..1461
                     /gene="CCDC40"
                     /gene_synonym="CFAP172; CILD15; FAP172"
                     /inference="alignment:Splign:2.1.0"
     exon            1462..1583
                     /gene="CCDC40"
                     /gene_synonym="CFAP172; CILD15; FAP172"
                     /inference="alignment:Splign:2.1.0"
     exon            1584..1827
                     /gene="CCDC40"
                     /gene_synonym="CFAP172; CILD15; FAP172"
                     /inference="alignment:Splign:2.1.0"
     exon            1828..2010
                     /gene="CCDC40"
                     /gene_synonym="CFAP172; CILD15; FAP172"
                     /inference="alignment:Splign:2.1.0"
     exon            2011..2256
                     /gene="CCDC40"
                     /gene_synonym="CFAP172; CILD15; FAP172"
                     /inference="alignment:Splign:2.1.0"
     exon            2257..2470
                     /gene="CCDC40"
                     /gene_synonym="CFAP172; CILD15; FAP172"
                     /inference="alignment:Splign:2.1.0"
     exon            2471..2640
                     /gene="CCDC40"
                     /gene_synonym="CFAP172; CILD15; FAP172"
                     /inference="alignment:Splign:2.1.0"
     exon            2641..2732
                     /gene="CCDC40"
                     /gene_synonym="CFAP172; CILD15; FAP172"
                     /inference="alignment:Splign:2.1.0"
     exon            2733..2853
                     /gene="CCDC40"
                     /gene_synonym="CFAP172; CILD15; FAP172"
                     /inference="alignment:Splign:2.1.0"
     exon            2854..3042
                     /gene="CCDC40"
                     /gene_synonym="CFAP172; CILD15; FAP172"
                     /inference="alignment:Splign:2.1.0"
     exon            3043..3201
                     /gene="CCDC40"
                     /gene_synonym="CFAP172; CILD15; FAP172"
                     /inference="alignment:Splign:2.1.0"
     exon            3202..4288
                     /gene="CCDC40"
                     /gene_synonym="CFAP172; CILD15; FAP172"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3628..3633
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CCDC40"
                     /gene_synonym="CFAP172; CILD15; FAP172"
                     /note="hexamer: AATAAA"
     polyA_site      3648
                     /gene="CCDC40"
                     /gene_synonym="CFAP172; CILD15; FAP172"
     regulatory      4259..4264
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CCDC40"
                     /gene_synonym="CFAP172; CILD15; FAP172"
                     /note="hexamer: AATAAA"
     polyA_site      4288
                     /gene="CCDC40"
                     /gene_synonym="CFAP172; CILD15; FAP172"
                     /note="major polyA site"
ORIGIN      
        1 agcgtcgcct agcaacggga aatggcggaa ccgggcggcg cggcgggccg gtcccatccg
       61 gaagatggat cggcttctga gggagagaag gaagggaata atgaaagcca catggtgtca
      121 ccaccagaga aggatgatgg ccagaaaggt gaagaagctg tcggtagcac agagcatcct
      181 gaggaagtca caacccaagc ggaagctgca attgaagagg gggaggtgga gacagaaggg
      241 gaagcagcag tggaagggga agaggaggct gtgtcctatg gagatgctga aagcgaagag
      301 gaatattact atacagaaac ttcatccccg gaagggcaaa tcagtgctgc agatacgact
      361 tacccgtatt tcagtcctcc tcaggaactg cctggagagg aggcatacga tagtgttagc
      421 ggggaggctg gtctccaagg cttccagcaa gaggccaccg gtccaccaga atccagagaa
      481 aggagggtca cctccccaga gccatcccac ggagtcttag gcccgtcgga gcaaatgggc
      541 caggtcacct ctgggccagc agtgggcaga ttgacaggat ccacagagga gccccagggg
      601 caggtgctcc caatgggcgt ccagcaccgc ttccggctga gccacgggag cgacatcgag
      661 tcctcagacc tggaggagtt cgtctcgcag gagccagtga tccccccagg ggtgcccgat
      721 gcccacccca gggaaggaga cctgccagtg ttccaggacc agatccagca gcccagcacc
      781 gaggaggggg ccatggcaga gagagtggag tccgagggga gtgacgagga agcagaagac
      841 gaagggtccc agctggtggt tttggaccca gaccaccccc tgatggtaag attccaggct
      901 gccctgaaga actacctgaa ccgacagatc gaaaagttga agctggacct ccaagagctg
      961 gttgtggcta ccaagcagag ccgagcccag cggcaggagc tgggggtgaa tctctatgag
     1021 gtgcagcagc acctggtaca cctgcagaag ctgctggaga agagtcacga ccgccacgca
     1081 atggcctcga gcgagcgcag gcagaaggag gaggagctgc aggccgcccg cgctctctac
     1141 accaagacct gcgcagccgc caacgaggag cgcaaaaagt tggcggctct gcagactgag
     1201 atggagaact tggccctgca tctcttctac atgcagaaca tcgaccagga catgcgtgac
     1261 gacatccgcg tgatgacaca agtggtaaag aaggccgaga cggagaggat ccgggcagaa
     1321 atcgagaaga aaaagcagga cctgtatgtg gaccagctca ccactcgagc ccagcaactg
     1381 gaagaagaca ttgccctgtt tgaggctcag tacttggccc aagctgagga cacccggatt
     1441 ttaaggaaag cagtgagtga ggcctgcacc gagatcgacg ccatcagcgt ggagaagagg
     1501 cgcatcatgc agcaatgggc cagcagcctg gtgggcatga agcaccgcga cgaggcgcac
     1561 agggcggtgc tggaggcgct cagaggatgc cagcatcaag ccaaatccac cgacggcgag
     1621 attgaggcct ataagaaatc catcatgaag gaggaagaaa agaacgagaa gctggcgagc
     1681 atcctgaacc ggacagagac ggaagccaca ctgctgcaga agctcaccac ccagtgcctg
     1741 accaagcagg tggccctgca gagccagttc aatacctaca ggctcaccct gcaggacaca
     1801 gaggatgccc tcagccagga ccagctggaa caaatgatac tcacggagga gttgcaggcc
     1861 atccgccaag ccatccaggg cgagctggag ctcaggagga agacggatgc tgccatccgg
     1921 gagaagctgc aggagcacat gacctccaac aagaccacca aatacttcaa ccagctcatc
     1981 ctgaggctgc agaaggagaa gaccaacatg atgacacatc tttccaaaat caacggtgac
     2041 attgcccaga ccaccctgga catcacacac accagcagca ggctggacgc acaccagaag
     2101 accctggtgg agctggacca ggacgtgaag aaagtcaacg agctcatcac caacagccag
     2161 agcgagatct cccggcgcac gatcctgatc gagaggaagc aagggctcat caacttcctc
     2221 aacaagcagc tggagcggat ggtctccgag ctgggggggg aagaagtggg gcccctggag
     2281 cttgaaatca aaaggctgag caagctgatc gacgagcacg atggcaaggc ggtccaggcc
     2341 caggtgacct ggctgcgcct gcagcaggag atggtcaagg tgacacagga gcaggaggag
     2401 cagctggcct ccctggacgc atccaagaag gagctccaca tcatggagca gaagaaacta
     2461 cgagtagaaa gcaagattga gcaggagaag aaggagcaga aggagatcga gcaccacatg
     2521 aaggacctgg acaacgacct gaagaagctc aacatgttga tgaataaaaa ccggtgcagc
     2581 tcggaggagc tggagcagaa caaccgggtg acagagaatg agttcgtgcg ctcgctgaag
     2641 gcctctgaga gggagaccat caagatgcag gacaagctga accagctcag cgaggagaag
     2701 gcgaccctcc tgaatcaact ggtggaagca gaacaccaga ttatgctttg ggagaaaaaa
     2761 atccaactgg caaaagagat gcgttcctca gtggattccg agatcggcca gacggagatc
     2821 cgggccatga agggcgagat ccacaggatg aaggtcaggc tcgggcagct gctgaagcag
     2881 caggagaaga tgatccgtgc catggagttg gcggttgccc gcagagagac cgtcaccacc
     2941 caggccgagg ggcagcgcaa gatggacagg aaggcgctca cccgcaccga cttccaccac
     3001 aagcagcttg agctgcgccg gaaaatcagg gacgttcgca aggccaccga tgagtgcacc
     3061 aaaaccgtcc tggaactgga agaaacacaa agaaatgtga gcagctccct cctagagaag
     3121 caggaaaagc tgtcggtgat tcaggcagac ttcgacacac tcgaggccga cctcacccgg
     3181 cttggggccc tcaaacgaca gaacctttca gagatcgtgg ccctgcagac acgccttaag
     3241 cacctgcagg ctgtgaagga ggggcgctac gtgttcctgt tccgctccaa gcagtcccta
     3301 gtgctggagc gccagcgcct ggacaagcga ctggctctca tcgccaccat cctggaccgc
     3361 gtgcgggacg agtaccccca gttccaggag gccctgcaca aggtcagcca gatgatcgcc
     3421 aacaagctcg agtcaccagg gccctcctag ggagcagcct ggactccgcc ttgcaaggcc
     3481 tccaggaaga gatccggaat tgtgtttgtc atgagggact tggaatcttt tgtgttccta
     3541 aaaaccacat gtaccctcag aagggcatcg tttaagagaa ataagccagc cccacccata
     3601 ggaatctttt tagccactca gcaatttaat aaaccaggta aaatcctagc gtttcccatg
     3661 gcatcccatc gcaaagacag agcctgtgac tgcagaccca cacacccaca ctcccacact
     3721 gggcttactc gtccaggtaa cactttggtt tgcagcactc ccaaatctgc acgtgcctct
     3781 cacaacacaa cgctgccaca ggtccacaag ctggtgggct gagcagaggt gggaaagtta
     3841 aggcagctcc agccagcctg gcccgggagg ctggtccccc cagcacttcc ctctactagg
     3901 tgcatctgaa aacccacaaa ccaccttctt taccagtttt cccatcccca ccccttagaa
     3961 ctctcaggtc ccttttcctg cccccatgtc cccatttgag ttaaattcag atccacagct
     4021 tgcaggagaa agtcagtggc cccagacaca cgtaacaggg tgagcactga aataagagca
     4081 cgctggggcg tccacaccaa gggactacgc cccagtctgc ccacctatct tttctccatc
     4141 attaacccag cgctctttct ccctggactt ccaagtacca atgaccttgg ggcttctttg
     4201 cagtttaaag ggaaaatgct ctacaaaata atttcacttt caaacatttc agcagaagaa
     4261 taaaatcttt tttctgaata tctagtaa
//
