LOCUS       NM_030771               1452 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens coiled-coil domain containing 34 (CCDC34), transcript
            variant 1, mRNA.
ACCESSION   NM_030771
VERSION     NM_030771.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1452)
  AUTHORS   Cong,J., Wang,X., Amiri-Yekta,A., Wang,L., Kherraf,Z.E., Liu,C.,
            Cazin,C., Tang,S., Hosseini,S.H., Tian,S., Daneshipour,A., Wang,J.,
            Zhou,Y., Zeng,Y., Yang,S., He,X., Li,J., Cao,Y., Jin,L., Ray,P.F.
            and Zhang,F.
  TITLE     Homozygous mutations in CCDC34 cause male infertility with
            oligoasthenoteratozoospermia in humans and mice
  JOURNAL   J Med Genet 59 (7), 710-718 (2022)
   PUBMED   34348960
  REMARK    GeneRIF: Homozygous mutations in CCDC34 cause male infertility with
            oligoasthenoteratozoospermia in humans and mice.
REFERENCE   2  (bases 1 to 1452)
  AUTHORS   Zhou,M., Chen,X., Bai,H., Sun,Y., Zhang,Z., Li,S., Wang,X. and
            Zeng,M.
  TITLE     RABL2A-CCDC34 Axis Promotes Sorafenib Resistance in Hepatocellular
            Carcinoma
  JOURNAL   DNA Cell Biol 40 (11), 1418-1427 (2021)
   PUBMED   34767735
  REMARK    GeneRIF: RABL2A-CCDC34 Axis Promotes Sorafenib Resistance in
            Hepatocellular Carcinoma.
REFERENCE   3  (bases 1 to 1452)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   4  (bases 1 to 1452)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 1452)
  AUTHORS   Liu,L.B., Huang,J., Zhong,J.P., Ye,G.L., Xue,L., Zhou,M.H.,
            Huang,G. and Li,S.J.
  TITLE     High Expression of CCDC34 Is Associated with Poor Survival in
            Cervical Cancer Patients
  JOURNAL   Med Sci Monit 24, 8383-8390 (2018)
   PUBMED   30458457
  REMARK    GeneRIF: Immunochemical staining data showed that CCDC34 expression
            was dramatically higher in CC than in adjacent normal tissues (71.6
            vs. 20.9%; P<0.001). High expression of CCDC34 was strongly
            associated with histological grade (P=0.022), lymph node metastasis
            (P=0.044), and FIGO stage (P=0.002).
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1452)
  AUTHORS   Gong,Y., Qiu,W., Ning,X., Yang,X., Liu,L., Wang,Z., Lin,J., Li,X.
            and Guo,Y.
  TITLE     CCDC34 is up-regulated in bladder cancer and regulates bladder
            cancer cell proliferation, apoptosis and migration
  JOURNAL   Oncotarget 6 (28), 25856-25867 (2015)
   PUBMED   26312564
  REMARK    GeneRIF: CCDC34 is up-regulated in bladder cancer and regulates
            bladder cancer cell proliferation, apoptosis and migration.
REFERENCE   7  (bases 1 to 1452)
  AUTHORS   Kemp,J.P., Medina-Gomez,C., Estrada,K., St Pourcain,B., Heppe,D.H.,
            Warrington,N.M., Oei,L., Ring,S.M., Kruithof,C.J., Timpson,N.J.,
            Wolber,L.E., Reppe,S., Gautvik,K., Grundberg,E., Ge,B., van der
            Eerden,B., van de Peppel,J., Hibbs,M.A., Ackert-Bicknell,C.L.,
            Choi,K., Koller,D.L., Econs,M.J., Williams,F.M., Foroud,T.,
            Zillikens,M.C., Ohlsson,C., Hofman,A., Uitterlinden,A.G., Davey
            Smith,G., Jaddoe,V.W., Tobias,J.H., Rivadeneira,F. and Evans,D.M.
  TITLE     Phenotypic dissection of bone mineral density reveals skeletal site
            specificity and facilitates the identification of novel loci in the
            genetic regulation of bone mass attainment
  JOURNAL   PLoS Genet 10 (6), e1004423 (2014)
   PUBMED   24945404
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 1452)
  AUTHORS   Petroziello,J., Yamane,A., Westendorf,L., Thompson,M., McDonagh,C.,
            Cerveny,C., Law,C.L., Wahl,A. and Carter,P.
  TITLE     Suppression subtractive hybridization and expression profiling
            identifies a unique set of genes overexpressed in non-small-cell
            lung cancer
  JOURNAL   Oncogene 23 (46), 7734-7745 (2004)
   PUBMED   15334068
REFERENCE   9  (bases 1 to 1452)
  AUTHORS   Kutsche,K., Glauner,E., Knauf,S., Pomarino,A., Schmidt,M.,
            Schroder,B., Nothwang,H., Schuler,H., Goecke,T., Kersten,A.,
            Althaus,C. and Gal,A.
  TITLE     Cloning and characterization of the breakpoint regions of a
            chromosome 11;18 translocation in a patient with hamartoma of the
            retinal pigment epithelium
  JOURNAL   Cytogenet Cell Genet 91 (1-4), 141-147 (2000)
   PUBMED   11173847
REFERENCE   10 (bases 1 to 1452)
  AUTHORS   Scanlan,M.J., Gordan,J.D., Williamson,B., Stockert,E., Bander,N.H.,
            Jongeneel,V., Gure,A.O., Jager,D., Jager,E., Knuth,A., Chen,Y.T.
            and Old,L.J.
  TITLE     Antigens recognized by autologous antibody in patients with
            renal-cell carcinoma
  JOURNAL   Int J Cancer 83 (4), 456-464 (1999)
   PUBMED   10508479
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC090597.9.
            
            On Nov 23, 2018 this sequence version replaced NM_030771.1.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.85613.1,
                                           SRR1803614.161479.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2161674
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000328697.11/ ENSP00000330240.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-380               AC090597.9         117150-117529       c
            381-519             AC090597.9         111717-111855       c
            520-627             AC090597.9         104646-104753       c
            628-786             AC090597.9         95706-95864         c
            787-928             AC090597.9         95010-95151         c
            929-1452            AC090597.9         92826-93349         c
FEATURES             Location/Qualifiers
     source          1..1452
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11p14.1"
     gene            1..1452
                     /gene="CCDC34"
                     /gene_synonym="L15; NY-REN-41; RAMA3; SPGF76"
                     /note="coiled-coil domain containing 34"
                     /db_xref="GeneID:91057"
                     /db_xref="HGNC:HGNC:25079"
                     /db_xref="MIM:612324"
     exon            1..380
                     /gene="CCDC34"
                     /gene_synonym="L15; NY-REN-41; RAMA3; SPGF76"
                     /inference="alignment:Splign:2.1.0"
     CDS             22..1143
                     /gene="CCDC34"
                     /gene_synonym="L15; NY-REN-41; RAMA3; SPGF76"
                     /note="isoform 1 is encoded by transcript variant 1;
                     coiled-coil domain-containing protein 34; NY-REN-41
                     antigen; renal carcinoma antigen NY-REN-41"
                     /codon_start=1
                     /product="coiled-coil domain-containing protein 34 isoform
                     1"
                     /protein_id="NP_110398.1"
                     /db_xref="CCDS:CCDS31448.1"
                     /db_xref="GeneID:91057"
                     /db_xref="HGNC:HGNC:25079"
                     /db_xref="MIM:612324"
                     /translation="MWAAGRWGPTFPSSYAGFSADCRPRSRPSSDSCSVPMTGARGQG
                     LEVVRSPSPPLPLSCSNSTRSLLSPLGHQSFQFDEDDGDGEDEEDVDDEEDVDEDAHD
                     SEAKVASLRGMELQGCASTQVESENNQEEQKQVRLPESRLTPWEVWFIGKEKEERDRL
                     QLKALEELNQQLEKRKEMEEREKRKIIAEEKHKEWVQKKNEQKRKEREQKINKEMEEK
                     AAKELEKEYLQEKAKEKYQEWLKKKNAEECERKKKEKEKEKQQQAEIQEKKEIAEKKF
                     QEWLENAKHKPRPAAKSYGYANGKLTGFYSGNSYPEPAFYNPIPWKPIHMPPPKEAKD
                     LSGRKSKRPVISQPHKSSSLVIHKARSNLCLGTLCRIQR"
     exon            381..519
                     /gene="CCDC34"
                     /gene_synonym="L15; NY-REN-41; RAMA3; SPGF76"
                     /inference="alignment:Splign:2.1.0"
     exon            520..627
                     /gene="CCDC34"
                     /gene_synonym="L15; NY-REN-41; RAMA3; SPGF76"
                     /inference="alignment:Splign:2.1.0"
     exon            628..786
                     /gene="CCDC34"
                     /gene_synonym="L15; NY-REN-41; RAMA3; SPGF76"
                     /inference="alignment:Splign:2.1.0"
     exon            787..928
                     /gene="CCDC34"
                     /gene_synonym="L15; NY-REN-41; RAMA3; SPGF76"
                     /inference="alignment:Splign:2.1.0"
     exon            929..1452
                     /gene="CCDC34"
                     /gene_synonym="L15; NY-REN-41; RAMA3; SPGF76"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1428..1433
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CCDC34"
                     /gene_synonym="L15; NY-REN-41; RAMA3; SPGF76"
                     /note="hexamer: AATAAA"
     polyA_site      1452
                     /gene="CCDC34"
                     /gene_synonym="L15; NY-REN-41; RAMA3; SPGF76"
                     /note="major polyA site"
ORIGIN      
        1 agtttgaact tggcgggcca gatgtgggcg gcggggcgct gggggcctac ttttccctct
       61 tcctacgccg gtttctctgc tgactgcaga cccaggtctc ggccctcctc ggactcctgc
      121 tcagtcccta tgacgggcgc acgtgggcag gggctggagg tggtgcgctc gccgtcgccg
      181 ccgctgccgc tgagctgcag caattccacc aggtcgctgt tgtctcccct tggccaccag
      241 agcttccagt ttgacgagga cgacggtgac ggggaggatg aggaagacgt ggatgatgag
      301 gaagacgtgg atgaagatgc ccatgattca gaggccaaag tggcgagcct gagaggaatg
      361 gagttacagg ggtgcgccag cactcaggtt gaatcagaaa ataaccaaga agaacagaaa
      421 caggtgcgct taccagaaag ccgcctgaca ccatgggagg tgtggtttat tggcaaagaa
      481 aaagaagaac gtgaccggct gcaactgaaa gctctagagg aattaaatca acaactagaa
      541 aaaagaaaag aaatggaaga acgtgaaaaa agaaagataa ttgctgaaga aaagcacaag
      601 gaatgggttc agaaaaagaa tgagcaaaaa agaaaagaaa gagaacaaaa aattaataaa
      661 gaaatggagg aaaaagcagc aaaggaactg gagaaagaat acttgcaaga aaaagcaaaa
      721 gaaaaatatc aagaatggtt aaagaaaaaa aatgctgaag aatgtgagag gaagaagaaa
      781 gaaaaggaaa aagaaaaaca acagcaagct gaaatacagg agaaaaagga aatagcagaa
      841 aaaaagtttc aagaatggtt ggaaaatgcg aaacataaac ctcgtccagc tgcaaagagc
      901 tatggttatg ccaatggaaa acttacaggt ttttacagtg gaaattccta tccagaacca
      961 gccttttata atccaattcc gtggaaacca attcatatgc cacctcccaa agaagctaag
     1021 gatctatcag gaaggaagag taaaagacct gtgataagtc agccacacaa gtcatcatct
     1081 ctggtaattc ataaagccag gagcaatctt tgccttggaa ctctgtgcag aatacaaaga
     1141 tagcgtatgt ggaaaataac atgcttttat ctggagctat ttaatttaaa aatcagaaat
     1201 tgttttttac tgctcagtca ataactcaac acttaatgtg attattgaca aatagcaatt
     1261 tttgcatttg tatatggagt ccttagagtt gaggaagata ttttctggat tttggttttt
     1321 ataaactttt taaggttgat cttggcatgt tgttttgcag aataagtggc tgaatatgta
     1381 agaattgtgt ttgtatttag cttgtattaa aagtacactg taataccaat aaaactaaca
     1441 atttttcttg ta
//
