LOCUS       NM_025055               2750 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens coiled-coil domain containing 33 (CCDC33), transcript
            variant 1, mRNA.
ACCESSION   NM_025055
VERSION     NM_025055.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2750)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2750)
  AUTHORS   Daakour,S., Hajingabo,L.J., Kerselidou,D., Devresse,A.,
            Kettmann,R., Simonis,N., Dequiedt,F. and Twizere,J.C.
  TITLE     Systematic interactome mapping of acute lymphoblastic leukemia
            cancer gene products reveals EXT-1 tumor suppressor as a Notch1 and
            FBWX7 common interactor
  JOURNAL   BMC Cancer 16, 335 (2016)
   PUBMED   27229929
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2750)
  AUTHORS   Sahni,N., Yi,S., Taipale,M., Fuxman Bass,J.I.,
            Coulombe-Huntington,J., Yang,F., Peng,J., Weile,J., Karras,G.I.,
            Wang,Y., Kovacs,I.A., Kamburov,A., Krykbaeva,I., Lam,M.H.,
            Tucker,G., Khurana,V., Sharma,A., Liu,Y.Y., Yachie,N., Zhong,Q.,
            Shen,Y., Palagi,A., San-Miguel,A., Fan,C., Balcha,D., Dricot,A.,
            Jordan,D.M., Walsh,J.M., Shah,A.A., Yang,X., Stoyanova,A.K.,
            Leighton,A., Calderwood,M.A., Jacob,Y., Cusick,M.E.,
            Salehi-Ashtiani,K., Whitesell,L.J., Sunyaev,S., Berger,B.,
            Barabasi,A.L., Charloteaux,B., Hill,D.E., Hao,T., Roth,F.P.,
            Xia,Y., Walhout,A.J.M., Lindquist,S. and Vidal,M.
  TITLE     Widespread macromolecular interaction perturbations in human
            genetic disorders
  JOURNAL   Cell 161 (3), 647-660 (2015)
   PUBMED   25910212
REFERENCE   4  (bases 1 to 2750)
  AUTHORS   Kaczmarek,K., Niedzialkowska,E., Studencka,M., Schulz,Y. and
            Grzmil,P.
  TITLE     Ccdc33, a predominantly testis-expressed gene, encodes a putative
            peroxisomal protein
  JOURNAL   Cytogenet Genome Res 126 (3), 243-252 (2009)
   PUBMED   20068295
  REMARK    GeneRIF: Data show that CCDC33-dsRED fusion protein co-localized
            with a known peroxisomal protein, namely PXT1, and showed punctuate
            intracellular distribution.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DB049940.1, AC023300.19, AK057417.1, BC031684.1 and AI223423.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_025055.4.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK057417.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2148093, SAMEA2148874
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000398814.8/ ENSP00000381795.3
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-318               DB049940.1         38-355
            319-319             AC023300.19        87213-87213         c
            320-490             AK057417.1         246-416
            491-493             AC023300.19        79795-79797         c
            494-1375            AK057417.1         417-1298
            1376-1833           BC031684.1         623-1080
            1834-2749           AK057417.1         1757-2672
            2750-2750           AI223423.1         12-12               c
FEATURES             Location/Qualifiers
     source          1..2750
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q24.1"
     gene            1..2750
                     /gene="CCDC33"
                     /gene_synonym="CC2D3; CT61; HP11097"
                     /note="coiled-coil domain containing 33"
                     /db_xref="GeneID:80125"
                     /db_xref="HGNC:HGNC:26552"
                     /db_xref="MIM:618525"
     exon            1..415
                     /gene="CCDC33"
                     /gene_synonym="CC2D3; CT61; HP11097"
                     /inference="alignment:Splign:2.1.0"
     CDS             395..2662
                     /gene="CCDC33"
                     /gene_synonym="CC2D3; CT61; HP11097"
                     /note="isoform 1 is encoded by transcript variant 1;
                     cancer/testis antigen 61; coiled-coil domain-containing
                     protein 33; hypothetical protein HP11097"
                     /codon_start=1
                     /product="coiled-coil domain-containing protein 33 isoform
                     1"
                     /protein_id="NP_079331.3"
                     /db_xref="CCDS:CCDS42058.1"
                     /db_xref="GeneID:80125"
                     /db_xref="HGNC:HGNC:26552"
                     /db_xref="MIM:618525"
                     /translation="MGLKNKKNTEDPEEPLIASQSTEPEIGHLSPSKKETIMVTLHGA
                     TNLPACKDGSEPWPYVVVKSTSEEKNNQSSKAVTSVTSEPTRAPIWGDTVNVEIQAED
                     AGQEDVILKVVDNRKKQELLSYKIPIKYLRVFHPYHFELVKPTESGKADEATAKTQLY
                     ATVVRKSSFIPRYIGCNHMALEIFLRGVNEPLANNPNPIVVIARVVPNYKEFKVSQAN
                     RDLASVGLPITPLSFPIPSMMNFDVPRVSQNGCPQLSKPGGPPEQPLWNQSFLFQGRD
                     GATSFSEDTALVLEYYSSTSMKGSQPWTLNQPLGISVLPLKSRLYQKMLTGKGLDGLH
                     VERLPIMDTSLKTINDEAPTVALSFQLLSSERPENFLTPNNSKALPTLDPKILDKKLR
                     TIQESWSKDTVSSTMDLSTSTPREAEEEPLVPEMSHDTEMNNYRRAMQKMAEDILSLR
                     RQASILEGENRILRSRLAQQEEEEGQGKASEAQNTVSMKQKLLLSELDMKKLRDRVQH
                     LQNELIRKNDREKELLLLYQAQQPQAALLKQYQGKLQKMKALEETVRHQEKVIEKMER
                     VLEDRLQDRSKPPPLNRQQGKPYTGFPMLSASGLPLGSMGENLPVELYSVLLAENAKL
                     RTELDKNRHQQAPIILQQQALPDLLSGTSDKFNLLAKLEHAQSRILSLESQLEDSARR
                     WGREKQDLATRLQEQEKGFRHPSNSIIIEQPSALTHSMDLKQPSELEPLLPSSDSKLN
                     KPLSPQKETANSQQT"
     exon            416..579
                     /gene="CCDC33"
                     /gene_synonym="CC2D3; CT61; HP11097"
                     /inference="alignment:Splign:2.1.0"
     exon            580..713
                     /gene="CCDC33"
                     /gene_synonym="CC2D3; CT61; HP11097"
                     /inference="alignment:Splign:2.1.0"
     exon            714..823
                     /gene="CCDC33"
                     /gene_synonym="CC2D3; CT61; HP11097"
                     /inference="alignment:Splign:2.1.0"
     exon            824..940
                     /gene="CCDC33"
                     /gene_synonym="CC2D3; CT61; HP11097"
                     /inference="alignment:Splign:2.1.0"
     exon            941..1032
                     /gene="CCDC33"
                     /gene_synonym="CC2D3; CT61; HP11097"
                     /inference="alignment:Splign:2.1.0"
     exon            1033..1153
                     /gene="CCDC33"
                     /gene_synonym="CC2D3; CT61; HP11097"
                     /inference="alignment:Splign:2.1.0"
     exon            1154..1283
                     /gene="CCDC33"
                     /gene_synonym="CC2D3; CT61; HP11097"
                     /inference="alignment:Splign:2.1.0"
     exon            1284..1417
                     /gene="CCDC33"
                     /gene_synonym="CC2D3; CT61; HP11097"
                     /inference="alignment:Splign:2.1.0"
     exon            1418..1489
                     /gene="CCDC33"
                     /gene_synonym="CC2D3; CT61; HP11097"
                     /inference="alignment:Splign:2.1.0"
     exon            1490..1684
                     /gene="CCDC33"
                     /gene_synonym="CC2D3; CT61; HP11097"
                     /inference="alignment:Splign:2.1.0"
     exon            1685..1850
                     /gene="CCDC33"
                     /gene_synonym="CC2D3; CT61; HP11097"
                     /inference="alignment:Splign:2.1.0"
     exon            1851..1939
                     /gene="CCDC33"
                     /gene_synonym="CC2D3; CT61; HP11097"
                     /inference="alignment:Splign:2.1.0"
     exon            1940..2071
                     /gene="CCDC33"
                     /gene_synonym="CC2D3; CT61; HP11097"
                     /inference="alignment:Splign:2.1.0"
     exon            2072..2165
                     /gene="CCDC33"
                     /gene_synonym="CC2D3; CT61; HP11097"
                     /inference="alignment:Splign:2.1.0"
     exon            2166..2332
                     /gene="CCDC33"
                     /gene_synonym="CC2D3; CT61; HP11097"
                     /inference="alignment:Splign:2.1.0"
     exon            2333..2419
                     /gene="CCDC33"
                     /gene_synonym="CC2D3; CT61; HP11097"
                     /inference="alignment:Splign:2.1.0"
     exon            2420..2533
                     /gene="CCDC33"
                     /gene_synonym="CC2D3; CT61; HP11097"
                     /inference="alignment:Splign:2.1.0"
     exon            2534..2750
                     /gene="CCDC33"
                     /gene_synonym="CC2D3; CT61; HP11097"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2729..2734
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CCDC33"
                     /gene_synonym="CC2D3; CT61; HP11097"
                     /note="hexamer: ATTAAA"
     polyA_site      2750
                     /gene="CCDC33"
                     /gene_synonym="CC2D3; CT61; HP11097"
                     /note="major polyA site"
ORIGIN      
        1 attgttttcc aggcctgggc agagacaggg cccccctgcc ccatctctcc accgtcctag
       61 gtgtgccaag agtcaattgc ctcattgctg accctgtcca gctggccatg gccctcaacc
      121 cccaaggccc ttccacccac agaccatctc gctgctgaga gatccaggac ctgctcccac
      181 ctggccaccc tccccctccc cccacatcca ggccccaggg ctggtgtgtg gcacccctga
      241 gaccacattg acctccatac tgtctactac ccataaggac tccaagacgc ccaggccagc
      301 tgtctgggca ggactgattc ctgatcaccc actgatacca agtactcatc cccaagattg
      361 ttaaacaagg ccagacactc ctggcctcaa gaggatggga ctgaaaaaca aaaagaacac
      421 tgaagaccca gaggagcccc tgatcgcctc ccagagcacg gaacctgaga tcggtcacct
      481 gtctccctct aagaaggaga ccatcatggt caccctccat ggggctacca acctgcctgc
      541 ctgcaaggat ggctccgagc cgtggcccta tgtggtggtg aaaagcacat ctgaggaaaa
      601 gaacaatcag agctccaagg cagtcacatc tgtgacctca gagcccacca gagcccctat
      661 ctggggggac acggtgaatg tggagatcca agctgaggat gcagggcaag aagatgtgat
      721 cctcaaggtg gtggacaaca gaaagaaaca ggagttgttg tcctacaaaa tccccatcaa
      781 gtacctgcgt gtcttccacc cctaccactt tgagctggtg aagcccactg agtctgggaa
      841 agccgatgaa gccactgcca agacccagtt gtacgcaaca gtcgttcgga agagcagctt
      901 cataccccgc tacatcggct gcaaccacat ggctctggag atctttctcc ggggagtcaa
      961 cgagcccctg gccaacaacc ccaaccccat agtggtgatt gcccgggtcg ttcccaacta
     1021 caaggaattt aaggtcagcc aggctaacag ggacctggcc tctgtggggc tgcccatcac
     1081 cccactgtcc ttccctatcc cgtccatgat gaactttgac gtgcctcgcg tcagccagaa
     1141 cggatgccct cagctgtcca agcctggggg acccccagag cagcccctgt ggaatcagtc
     1201 cttcctcttc caaggccgag atggagctac cagcttctca gaagacacag ccctggtgct
     1261 ggagtactac tcctcaactt caatgaaagg cagccagccg tggaccctca accagcccct
     1321 gggcatctct gtgttgccgc taaagagccg tttgtaccag aagatgctga cagggaaagg
     1381 cttggacggg cttcacgtgg agcggctccc catcatggac accagcctga aaactatcaa
     1441 tgatgaggcc cccacagtgg ctctctcctt ccagctgctt tcctctgaga gaccagaaaa
     1501 cttcttgaca ccaaacaaca gcaaggctct tcctaccttg gaccccaaga tcctggataa
     1561 gaagctgaga accatccaag agtcctggtc caaggacaca gtgagctcca caatggactt
     1621 gagcacgtcc actccacgag aagcagagga ggaacctctg gtgcctgaga tgtcccatga
     1681 cacagagatg aacaactacc ggcgggccat gcagaagatg gcagaggaca tcctgtctct
     1741 gcggagacag gccagcatcc tggaaggaga gaaccgcata ctgaggagcc gcctggccca
     1801 gcaggaggag gaagaggggc agggcaaagc cagtgaggcc cagaacacgg tgtccatgaa
     1861 gcagaaactg ctgctgagtg agctggatat gaagaaactg agggacaggg tgcagcattt
     1921 gcagaatgag ctgattcgaa agaatgatcg agagaaggag ctgctccttc tgtatcaggc
     1981 ccagcagcca caggccgctc tgctgaagca gtaccagggc aagctgcaga agatgaaggc
     2041 gctggaggag actgtgcggc accaagagaa ggtgatcgag aagatggagc gggtgctgga
     2101 ggacaggctg caggacagga gcaagccccc tcctctgaac aggcagcagg gaaagcccta
     2161 cacgggcttc cctatgctct cagcctctgg ccttcccttg ggttctatgg gagagaacct
     2221 gccggttgaa ctttactcgg tgctgctggc agaaaacgcg aagctgcgga cggagctgga
     2281 taagaaccgc caccagcagg cccccatcat tctgcagcaa caggccctgc cggatctcct
     2341 ctctggtact tcagacaagt tcaacctcct ggccaagctg gaacacgctc agagccggat
     2401 cctgtccctg gaaagccagt tagaggactc agctcgacgc tggggacgag agaagcagga
     2461 tctggccaca cggctgcagg agcaagaaaa aggtttcagg cacccctcga actccatcat
     2521 catagaacag cctagtgccc tcacccactc catggacctc aagcagccct cagagctgga
     2581 gcccctgctg cccagctcag actctaagct caacaagccc ttgagccccc agaaggagac
     2641 cgctaactct cagcagacct gagccccaga gcaggcctcc ttccctgtgt gctggggagt
     2701 ctcatcaccg ccccctaaaa atgacgttat taaatgttgt agctctgtga
//
