LOCUS       NM_001080792            1509 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens coiled-coil domain containing 32 (CCDC32), transcript
            variant 3, mRNA.
ACCESSION   NM_001080792
VERSION     NM_001080792.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1509)
  AUTHORS   Wainberg,M., Kamber,R.A., Balsubramani,A., Meyers,R.M.,
            Sinnott-Armstrong,N., Hornburg,D., Jiang,L., Chan,J., Jian,R.,
            Gu,M., Shcherbina,A., Dubreuil,M.M., Spees,K., Meuleman,W.,
            Snyder,M.P., Bassik,M.C. and Kundaje,A.
  TITLE     A genome-wide atlas of co-essential modules assigns function to
            uncharacterized genes
  JOURNAL   Nat Genet 53 (5), 638-649 (2021)
   PUBMED   33859415
REFERENCE   2  (bases 1 to 1509)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   3  (bases 1 to 1509)
  AUTHORS   Harel,T., Griffin,J.N., Arbogast,T., Monroe,T.O., Palombo,F.,
            Martinelli,M., Seri,M., Pippucci,T., Elpeleg,O. and Katsanis,N.
  TITLE     Loss of function mutations in CCDC32 cause a congenital syndrome
            characterized by craniofacial, cardiac and neurodevelopmental
            anomalies
  JOURNAL   Hum Mol Genet 29 (9), 1489-1497 (2020)
   PUBMED   32307552
  REMARK    GeneRIF: Loss of function mutations in CCDC32 cause a congenital
            syndrome characterized by craniofacial, cardiac and
            neurodevelopmental anomalies.
REFERENCE   4  (bases 1 to 1509)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 1509)
  AUTHORS   Lee,O.H., Kim,H., He,Q., Baek,H.J., Yang,D., Chen,L.Y., Liang,J.,
            Chae,H.K., Safari,A., Liu,D. and Songyang,Z.
  TITLE     Genome-wide YFP fluorescence complementation screen identifies new
            regulators for telomere signaling in human cells
  JOURNAL   Mol Cell Proteomics 10 (2), M110.001628 (2011)
   PUBMED   21044950
REFERENCE   6  (bases 1 to 1509)
  AUTHORS   Adams,M.D., Dubnick,M., Kerlavage,A.R., Moreno,R., Kelley,J.M.,
            Utterback,T.R., Nagle,J.W., Fields,C. and Venter,J.C.
  TITLE     Sequence identification of 2,375 human brain genes
  JOURNAL   Nature 355 (6361), 632-634 (1992)
   PUBMED   1538749
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC091045.3.
            
            On May 6, 2020 this sequence version replaced NM_001080792.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038197.86041.1,
                                           SRR1163658.217119.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1968189,
                                           SAMEA1968540 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000416810.7/ ENSP00000397515.2
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-67                AC091045.3         144181-144247       c
            68-323              AC091045.3         141977-142232       c
            324-480             AC091045.3         136421-136577       c
            481-1509            AC091045.3         132304-133332       c
FEATURES             Location/Qualifiers
     source          1..1509
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q15.1"
     gene            1..1509
                     /gene="CCDC32"
                     /gene_synonym="C15orf57; CFNDS"
                     /note="coiled-coil domain containing 32"
                     /db_xref="GeneID:90416"
                     /db_xref="HGNC:HGNC:28295"
                     /db_xref="MIM:618941"
     exon            1..67
                     /gene="CCDC32"
                     /gene_synonym="C15orf57; CFNDS"
                     /inference="alignment:Splign:2.1.0"
     exon            68..323
                     /gene="CCDC32"
                     /gene_synonym="C15orf57; CFNDS"
                     /inference="alignment:Splign:2.1.0"
     CDS             80..637
                     /gene="CCDC32"
                     /gene_synonym="C15orf57; CFNDS"
                     /note="isoform 2 is encoded by transcript variant 3;
                     uncharacterized protein C15orf57; coiled-coil
                     domain-containing protein 32"
                     /codon_start=1
                     /product="coiled-coil domain-containing protein 32 isoform
                     2"
                     /protein_id="NP_001074261.1"
                     /db_xref="CCDS:CCDS10060.1"
                     /db_xref="GeneID:90416"
                     /db_xref="HGNC:HGNC:28295"
                     /db_xref="MIM:618941"
                     /translation="MKMFESADSTATRSGQDLWAEICSCLPNPEQEDGANNAFSDSFV
                     DSCPEGEGQREVADFAVQPAVKPWAPLQDSEVYLASLEKKLRRIKGLNQEVTSKDMLR
                     TLAQAKKECWDRFLQEKLASEFFVDGLDSDESTLEHFKRWLQPDKVAVSTEEVQYLIP
                     PESQVEKPVAEDEPAAGDKPAAAEQ"
     exon            324..480
                     /gene="CCDC32"
                     /gene_synonym="C15orf57; CFNDS"
                     /inference="alignment:Splign:2.1.0"
     exon            481..1509
                     /gene="CCDC32"
                     /gene_synonym="C15orf57; CFNDS"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1488..1493
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CCDC32"
                     /gene_synonym="C15orf57; CFNDS"
                     /note="hexamer: TATAAA"
     polyA_site      1509
                     /gene="CCDC32"
                     /gene_synonym="C15orf57; CFNDS"
                     /note="major polyA site"
ORIGIN      
        1 ccctcccgat ttcctccggg ctacaggcga cagagctgag ccaagcgttt actgggcagc
       61 tgttacgctc agattccaaa tgaaaatgtt tgagagcgct gactctacag ccacaagatc
      121 tggccaggat ctctgggctg aaatttgttc ctgtctgcca aatcctgaac aagaagatgg
      181 tgccaacaat gcattctcag actcctttgt ggattcttgc cctgaaggtg aaggccagag
      241 ggaggtggct gactttgctg tccagccagc tgtaaagcct tgggctccct tgcaggattc
      301 agaagtgtat ttagcatctc tagagaagaa gctaagaaga atcaaaggtt taaatcagga
      361 agtgacttcc aaggacatgc ttcgaactct ggcccaagcc aagaaggaat gctgggatcg
      421 gttcctccag gagaagttag cttcagagtt ctttgtggat ggacttgatt ctgatgagag
      481 caccttggaa catttcaaga ggtggctcca gccagataaa gtagccgtca gcacagagga
      541 ggtccagtat ctgattcctc cagagtcaca ggttgagaag ccagtggccg aggacgagcc
      601 agcagccggg gacaagccag cagcagcaga acagtaaatt acacacacac acacacacac
      661 acacacacac acacacacac acacacacac acacacacac acgccgagca gctgtctcgg
      721 gtccagagcg agcagcgtgg agctcagtga cagcagcagg gagaaatcca ctgaaggaaa
      781 aaacccaaat ttccactcca caaagaaaac agctgcaagc ccccagggac ttacctgggg
      841 ctggcatgtg tgactgtctc ggatgaagtg actgacccag tgcacactgg atcaaaatgc
      901 tgctttcctc tgtgtctcac agcttggctg agctctgtct ctgcaggtta gaagtctgct
      961 aaagatcaaa tgtgaaagta cttggagaaa ctgaggcctc ttatgtgtaa tgtgtaagtt
     1021 aagtgagcca tatattttct tgcctcttcc ggacattcat gcttgtgtcc caagcattcc
     1081 cttggtgaat tgtcacgtga gtggggccag taagagtgaa gtctgctcct tgaatccaag
     1141 ccccatctgg ggcttctcta acaaatctgt agtaagtata cggactccag ggagagaggc
     1201 tgggcttctt tctctcattt gttccttgtg gaacaaatgg gcaaaagaag tgtgaaaatg
     1261 tgggtgttta tgtctgtgta tatgtatttt ttacttcatg catggcttct cctccaactt
     1321 cctcctgcac ttaaaaaggg ccaggttcca aattagactt gtaaatatgg tgttagtgtt
     1381 tgacactact cctggatagt tccaaacatc ttccttgtgg caggtttcct ggctgagccc
     1441 gagcttccct ccctgtttat tgtgttcatg atcagtatgt gtttccatat aaaacttttc
     1501 tcaacggaa
//
