LOCUS       NM_001395517            6683 bp    mRNA    linear   PRI 17-FEB-2024
DEFINITION  Homo sapiens coiled-coil domain containing 30 (CCDC30), transcript
            variant 10, mRNA.
ACCESSION   NM_001395517
VERSION     NM_001395517.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6683)
  AUTHORS   Zhang,J., Liu,L., Zhang,X., Jin,F., Chen,J., Ji,C., Gu,S., Xie,Y.
            and Mao,Y.
  TITLE     Cloning and characterization of a novel human prefoldin and SPEC
            domain protein gene (PFD6L) from the fetal brain
  JOURNAL   Biochem Genet 44 (1-2), 69-74 (2006)
   PUBMED   16710767
  REMARK    GeneRIF: A novel human prefoldin PFD6L from the fetal brain was
            cloned and characterized.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL445669.9, AL138788.6 and AC098484.2.
            
            ##Evidence-Data-START##
            RNAseq introns :: partial sample support SAMEA2142586, SAMEA2144120
                              [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000657597.2/ ENSP00000499662.2
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-613               AL445669.9         28424-29036
            614-719             AL445669.9         45599-45704
            720-873             AL445669.9         47801-47954
            874-945             AL445669.9         55296-55367
            946-1061            AL445669.9         62236-62351
            1062-1160           AL445669.9         63956-64054
            1161-1286           AL445669.9         101614-101739
            1287-1424           AL445669.9         104311-104448
            1425-1594           AL445669.9         110548-110717
            1595-1844           AL445669.9         121294-121543
            1845-2024           AL445669.9         131434-131613
            2025-2234           AL445669.9         142158-142367
            2235-2389           AL445669.9         146498-146652
            2390-2552           AL138788.6         2819-2981
            2553-2665           AL138788.6         24476-24588
            2666-2807           AL138788.6         50735-50876
            2808-2944           AL138788.6         55971-56107
            2945-3059           AL138788.6         58191-58305
            3060-3242           AL138788.6         59633-59815
            3243-3310           AL138788.6         66874-66941
            3311-3514           AL138788.6         67316-67519
            3515-6683           AC098484.2         2000-5168
FEATURES             Location/Qualifiers
     source          1..6683
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p34.2"
     gene            1..6683
                     /gene="CCDC30"
                     /gene_synonym="PFD6L; PFDN6L"
                     /note="coiled-coil domain containing 30"
                     /db_xref="GeneID:728621"
                     /db_xref="HGNC:HGNC:26103"
     exon            1..613
                     /gene="CCDC30"
                     /gene_synonym="PFD6L; PFDN6L"
                     /inference="alignment:Splign:2.1.0"
     exon            614..719
                     /gene="CCDC30"
                     /gene_synonym="PFD6L; PFDN6L"
                     /inference="alignment:Splign:2.1.0"
     CDS             705..3521
                     /gene="CCDC30"
                     /gene_synonym="PFD6L; PFDN6L"
                     /note="isoform 6 is encoded by transcript variant 10;
                     coiled-coil domain-containing protein 30; prefoldin
                     subunit 6-like protein"
                     /codon_start=1
                     /product="coiled-coil domain-containing protein 30 isoform
                     6"
                     /protein_id="NP_001382446.1"
                     /db_xref="CCDS:CCDS90929.1"
                     /db_xref="GeneID:728621"
                     /db_xref="HGNC:HGNC:26103"
                     /translation="MLELQYHNEDLEKDKTSQNCLGRGMEQVAKKLGVAHEEIQRLTD
                     ELQVKEKEQCKLDSALKKAQLEIDKLKENLVKLKENDAADLQKAKEQNQRLDEEILAL
                     RNRVRSLDSEKKVLGEMVERLKGEVCESQENKQLGNHSPGKTVGGEQREQILKMSQEK
                     NEMFESEWSKEREREKQLASGLDTAEKALKVESEELQKSKSELICLYNEVHNLPGESE
                     SKDHFLIACDLLQRENSELETKVLKLSQEFAQLNHFTLGGKTAPSNLITSENTCKDPE
                     SNEPILETEIQSRKEETEELCPKLGERKQKEIPEESVKEGSFPREGQKEEGSQQNRDM
                     KDEEKEQQLTMKPEEIVRLREELSHINQSLLQSQSSGDSSDDSGAQHPSSGEKLKYNQ
                     QGEVQQLHQNLHRLQILCNSAENELRYERGQNLDLKQHNSLLQEENIKIKIELKHAQQ
                     KLLDSTKMCSSLTAEYKHCQQKIKELELEVLKHTQSIKSQNNLQEKLVQEKSKVADAE
                     EKILDLQRKLEHAHKVCLTDTCISEKQQLEEKIKEATQNEAKVKQQYQEEQQKRKLLY
                     QNVDELHRQVRTLQDKENLLEMTCSQQQSRIQQQEALLKQLENEKRKYDEHVKSNQEL
                     SEKLSKLQQEKEALREEYLRLLKLLNVHVRNYNEKHHQQKVKLQKVKYRLTNEVELRD
                     KRINQFEDEIGILQHKIEKEKAIQDQITAQNDTLLLEKRKLQEQVIEQEQLIHSNKWT
                     ISSIQSRVLYMDKENKQLQENSLRLTQQIGFLERIIRSIHIRRGENLKEFPVPKWWHR
                     GKLASLPPTKKQKEIYSTEVFTSNNAELQHEDESVPEATEKWKHSEQMETTISDILES
                     EVVNEILPLSNSSFSGKGLVESFASLQETEEIKSKEAMASSKSPEKSPENLVCSQNSE
                     AGYINVASLKETHGIQEQDQKSEL"
     exon            720..873
                     /gene="CCDC30"
                     /gene_synonym="PFD6L; PFDN6L"
                     /inference="alignment:Splign:2.1.0"
     exon            874..945
                     /gene="CCDC30"
                     /gene_synonym="PFD6L; PFDN6L"
                     /inference="alignment:Splign:2.1.0"
     exon            946..1061
                     /gene="CCDC30"
                     /gene_synonym="PFD6L; PFDN6L"
                     /inference="alignment:Splign:2.1.0"
     exon            1062..1160
                     /gene="CCDC30"
                     /gene_synonym="PFD6L; PFDN6L"
                     /inference="alignment:Splign:2.1.0"
     exon            1161..1286
                     /gene="CCDC30"
                     /gene_synonym="PFD6L; PFDN6L"
                     /inference="alignment:Splign:2.1.0"
     exon            1287..1424
                     /gene="CCDC30"
                     /gene_synonym="PFD6L; PFDN6L"
                     /inference="alignment:Splign:2.1.0"
     exon            1425..1594
                     /gene="CCDC30"
                     /gene_synonym="PFD6L; PFDN6L"
                     /inference="alignment:Splign:2.1.0"
     exon            1595..1844
                     /gene="CCDC30"
                     /gene_synonym="PFD6L; PFDN6L"
                     /inference="alignment:Splign:2.1.0"
     exon            1845..2024
                     /gene="CCDC30"
                     /gene_synonym="PFD6L; PFDN6L"
                     /inference="alignment:Splign:2.1.0"
     exon            2025..2234
                     /gene="CCDC30"
                     /gene_synonym="PFD6L; PFDN6L"
                     /inference="alignment:Splign:2.1.0"
     exon            2235..2389
                     /gene="CCDC30"
                     /gene_synonym="PFD6L; PFDN6L"
                     /inference="alignment:Splign:2.1.0"
     exon            2390..2552
                     /gene="CCDC30"
                     /gene_synonym="PFD6L; PFDN6L"
                     /inference="alignment:Splign:2.1.0"
     exon            2553..2665
                     /gene="CCDC30"
                     /gene_synonym="PFD6L; PFDN6L"
                     /inference="alignment:Splign:2.1.0"
     exon            2666..2807
                     /gene="CCDC30"
                     /gene_synonym="PFD6L; PFDN6L"
                     /inference="alignment:Splign:2.1.0"
     exon            2808..2944
                     /gene="CCDC30"
                     /gene_synonym="PFD6L; PFDN6L"
                     /inference="alignment:Splign:2.1.0"
     exon            2945..3059
                     /gene="CCDC30"
                     /gene_synonym="PFD6L; PFDN6L"
                     /inference="alignment:Splign:2.1.0"
     exon            3060..3242
                     /gene="CCDC30"
                     /gene_synonym="PFD6L; PFDN6L"
                     /inference="alignment:Splign:2.1.0"
     exon            3243..3310
                     /gene="CCDC30"
                     /gene_synonym="PFD6L; PFDN6L"
                     /inference="alignment:Splign:2.1.0"
     exon            3311..6683
                     /gene="CCDC30"
                     /gene_synonym="PFD6L; PFDN6L"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3661..3666
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CCDC30"
                     /gene_synonym="PFD6L; PFDN6L"
                     /note="hexamer: ATTAAA"
     polyA_site      3683
                     /gene="CCDC30"
                     /gene_synonym="PFD6L; PFDN6L"
                     /note="major polyA site"
     regulatory      6160..6165
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CCDC30"
                     /gene_synonym="PFD6L; PFDN6L"
                     /note="hexamer: AATAAA"
     polyA_site      6178
                     /gene="CCDC30"
                     /gene_synonym="PFD6L; PFDN6L"
     regulatory      6327..6332
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CCDC30"
                     /gene_synonym="PFD6L; PFDN6L"
                     /note="hexamer: AATAAA"
     polyA_site      6356
                     /gene="CCDC30"
                     /gene_synonym="PFD6L; PFDN6L"
     regulatory      6659..6664
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CCDC30"
                     /gene_synonym="PFD6L; PFDN6L"
                     /note="hexamer: ATTAAA"
     polyA_site      6683
                     /gene="CCDC30"
                     /gene_synonym="PFD6L; PFDN6L"
ORIGIN      
        1 gctatgacgc ccaggtctcc gtaggcacct gcagctagca gctgagcgcg taggggccga
       61 gcgaccccgg gacgctcgcg gcaccctccg caggaaaatt tccgacttgg ttcttgaggt
      121 tcctgcctca gccccaagga ggaaagcacc cattctcccc tcttttccgc attacgggcc
      181 ttttctgctt ctccccagta tggtccgaaa ctacaggagg ggaacccctc ctggcccggc
      241 ctttctattc cctggctgga gtgattccgc ctgaaggaga attcgcccgt tttccccgga
      301 cccagctgcc acaagcattt agtattaggc tgccgcttat tattagagcg ggcttagaac
      361 atcctcagcg aggtaggtcg gcgttccttt tctcacttaa aggtgaggtg tcgagacgcg
      421 cccctggaca gacaacgccc gaaggtccag gccactacga agtccacgga ggggcagctt
      481 tcccctacgt gtaggcccgc gaacaaagaa ctaccgtttt ctgatttttt ttggccgatg
      541 ttcgtcatgc agaaccttga atcccgatga agatttggag gccttttgta tcctcaacat
      601 cagaggtcat gaagttggag tgctggagtg cagtagcatg atctccgttc actgcagcct
      661 caacctcctg ggctcaagta atcctcctgt cttgtcctcc caaaatgctg gaattacagt
      721 atcataatga agacctggaa aaagacaaaa catcacaaaa ctgcctagga agaggaatgg
      781 aacaagtagc aaagaagtta ggggtggctc atgaagagat tcaaaggctc actgatgaac
      841 tacaagtgaa ggagaaggaa caatgtaaat tagattctgc acttaagaag gctcaactag
      901 aaattgacaa attgaaggaa aatttggtaa agctgaaaga aaatgatgca gctgacctac
      961 agaaagcaaa ggaacaaaat cagagactgg atgaggaaat tctggcttta agaaataggg
     1021 ttcgatcact tgactcagaa aaaaaggtgc ttggtgaaat ggttgaaaga cttaaaggag
     1081 aggtgtgtga atctcaagag aataagcaac ttggaaacca ctcccctgga aaaactgtgg
     1141 gtggtgaaca gagagaacag atcctgaaaa tgagccaaga aaaaaatgaa atgtttgaaa
     1201 gtgagtggtc aaaagagaga gagagagaga agcagttggc atctggtctt gacactgcag
     1261 agaaggcctt gaaagttgaa agtgaggaat tgcaaaaatc aaagtcagag cttatatgcc
     1321 tttataatga agttcacaat cttccagggg aatcagaaag caaagaccat tttttaatag
     1381 catgtgacct gttacaaaga gagaattctg aattagaaac aaaggtcttg aagctttcac
     1441 aagaatttgc acaattaaat cattttactc tagggggaaa aactgcacct tctaatttaa
     1501 ttacaagtga aaatacctgt aaagatcctg aatctaatga accaattttg gaaacagaaa
     1561 ttcaaagccg aaaggaagag acagaggaac tctgtcccaa attaggagaa agaaagcaga
     1621 aggaaattcc agaggagtca gtaaaggagg gcagttttcc aagagagggg cagaaggagg
     1681 agggctcaca acagaatcga gatatgaaag atgaagaaaa agaacagcag ttaaccatga
     1741 agcctgagga aattgtgagg cttagagaag agctgagcca tataaatcag agccttcttc
     1801 agtctcagag ctctggggat agttcagatg acagtggtgc ccagcatcca tcatctggag
     1861 aaaaactaaa atacaaccag caaggggaag tacaacaact tcaccagaat ttgcaccggc
     1921 tccagattct atgcaactca gctgaaaatg agcttcgata tgaacgaggg cagaacttgg
     1981 acttaaagca acataatagc ttacttcagg aagaaaacat taagataaag attgaactaa
     2041 agcatgccca acagaagtta ttagacagca caaagatgtg ctcttcactc acggcagagt
     2101 acaagcactg tcagcagaaa atcaaggaac tggagttgga agtacttaaa cacactcaga
     2161 gcattaaatc acagaacaac ctacaggaaa agctggttca ggagaaatct aaagttgctg
     2221 atgcagagga aaagattttg gacctgcagc ggaaattaga acatgctcat aaagtctgtc
     2281 tcacagacac ttgtatttca gagaagcagc agctagagga aaagataaaa gaagcaacac
     2341 aaaatgaagc taaagtaaag caacaatatc aagaagaaca acagaagagg aaacttctat
     2401 atcagaacgt agatgagtta cacaggcaag tgagaacctt acaagataaa gaaaatctac
     2461 tggaaatgac ctgttctcag caacaatcca gaattcagca acaagaggcc ctacttaaac
     2521 aactggaaaa tgaaaaaaga aaatatgatg agcatgtcaa aagcaaccag gaattgtcag
     2581 agaagctatc taagctacag caagagaagg aagctctacg tgaagaatat ttgcgattat
     2641 tgaagctgct taatgtccat gtgagaaact ataatgagaa acatcaccaa caaaaagtca
     2701 agcttcaaaa agtcaagtat cgtttaacta atgaagtaga actacgagat aagagaatta
     2761 accaatttga agatgaaatt ggaatcctgc aacataaaat agaaaaggag aaggcaatac
     2821 aggaccagat cactgcccaa aatgataccc tgcttctaga aaaaaggaaa cttcaggagc
     2881 aagtcataga gcaagaacag ttgatccaca gcaacaaatg gacgatatct tccatccaga
     2941 gcagggtact ttacatggat aaagaaaata agcaattaca ggaaaatagt cttcgtctca
     3001 cacagcagat tggcttctta gagcgaatta taaggagcat ccatattcgc agaggagaga
     3061 atcttaagga gtttcctgtt ccaaaatggt ggcatagagg caagctggct tctctccctc
     3121 caacaaagaa acagaaagaa atatacagca ctgaggtctt caccagcaac aatgcagaac
     3181 tccagcatga ggatgagtca gttcctgagg ccacagagaa gtggaaacac tctgagcaga
     3241 tggaaacaac aattagtgac atccttgaat ccgaagtagt gaatgaaata ttgcctttat
     3301 caaactccag tttttcagga aaaggtttgg tagagtcatt tgcaagtctt caagagactg
     3361 aagagatcaa gtcaaaagaa gcaatggcaa gttcaaagtc ccctgaaaag tctcctgaga
     3421 atcttgtgtg ttcacagaat tctgaggctg gatacataaa tgtggcttct ctgaaggaga
     3481 cacatggtat acaagaacaa gaccaaaagt cagaactata aaatcactgg tgcctaaagc
     3541 tatactgaac aaaagtggta atttaaagcc tggacaaaag gtggaccatg acattgagaa
     3601 gagttaccac agatcccaaa tggatatcac ccaagagtct tcaaaactgc tgataaattc
     3661 attaaagcag ttgtaaaaat ggatttctca agtttgtttg atatcctcag atgccttgta
     3721 ttgaccaaaa tattgacttt agttcaatga tttatttagg tttctcttca gcagagcaca
     3781 tgtagggtta attcaacatt ctttcccatt atcatgggta tcttttctga tttatttttt
     3841 aacagtaaaa acaatacagt cacattaaag caaattttgt ttttaaaaaa accctcctat
     3901 gctgggcgtg gtggctcacg cctataatcc cagcactttg ggaggctgag gtgggtggat
     3961 cacgaggtca ggagatcgag accatcctgg ctaacacggt gaaaccctgt ctctactaaa
     4021 aatacaaaaa aattaaccga gtgtggtggc gggtgcctgt agtcccagct actcagaagg
     4081 ctgaggcagg agaatggcgt gaacctgcga tagcaccact gcactccagc ctgggtgaca
     4141 gagtgagact ccgtctcaaa aaaagcaaaa aacaaaaaca aaaaccctcc tataatacca
     4201 taagcttttt tttttttttt tgagacggag tctcttactc tgtcacccag gctgaagtgc
     4261 agtggcatga tctccgctca ctgcaacctc tgcctcccag gttcaaccaa ttctcctgcc
     4321 tcagcctccc aagtagctgg gattataggt gcccgccacc atgcccagct aatttttgta
     4381 tttttagtag agacaaggtt tcaccatgtt ggccatgctg gtcttgaact cctgacctca
     4441 ggtgatccac ccacctcagc ctcccaaagt gctgggatta caccaatacc acagtcttaa
     4501 cacaactaat tttattttac agttattccc ttttggtcct aattcaagta catatattct
     4561 aagtggttat tataatattg tatattcatt ttcacagttt gatttttaat ttactgtata
     4621 taccatggaa acattttcaa tcgccatatg atattcaatc atgttgatgt tctataatta
     4681 tttttatggg aaaagtttta aatgtttaat gaagaagatt tagagcaata cattatttaa
     4741 aagtggatag gaggttgggc gtggtggctt acacctgtga tcccagcact ttgggaggcc
     4801 gaggtgggca gatcacctga ggtcaggagt tcgagaccag cttggccaac ttagggaaac
     4861 cccgtctcta acaaaaatac aaaaacaatt agccaggtgt ggtagtgcgc gcgcctgtag
     4921 tcccagctac tggggaggct gaggcaggag aatcacttga acccgagagg cagaggttgc
     4981 agtgagccga gactgcacca gtgcactcca gcctgggtga cagagcaaga ctccatctcg
     5041 aaaaaataaa taaaataaaa taaaataaaa gtggatagga aaataccaag agcttttcct
     5101 gggggagggg gtatgagaag agagttcaca taaaccccat tacacagaaa ctacccctaa
     5161 atatttccaa acaggagtac aaagtaggtg aacagtctcc agctcatctt tagtgtagtg
     5221 ggactgcttc ttcagaaaag atcagcaaca ttcacatcca tttcatctat cagggtggaa
     5281 cagtactgct cagtatctct gaggatgtgg atgttctata aattaaacgt tctcttgttt
     5341 ggcatttaag ctgtttttac tttttttttt tttttttttt ttttgagaca gggtctcact
     5401 ttgtaaccca ggctggagtg cagtggtttg attactgctc atgcagcctc aacctcccat
     5461 gcttaagtga tcctctctcc tcagcctctc ccaagtacag gcatgtgcta ccatgcctgg
     5521 ctcatttttg tactttttgt aaagacgagg tctcactctc actctattgt tcaagctggt
     5581 ctcaaatttc tgggctcaag tgatcctccc acctaagcct cctaggtgat aggattatag
     5641 gatgagcctc tatgccaggc ctggttttac tttgttacta tttaagatta tgctgtgttg
     5701 aaggtctttg tgcatgtagt tcttttcttc ttttgaatta ctccagaaaa caaattcgca
     5761 agattggact gagtcaaagg atataaatgt taatattgct ctaggacatc acttcctttg
     5821 ctttaaaaaa gggttctgcc tgaccaggtg cggtggctca cgcctataat cccagcattt
     5881 tgggaggccg aggcaggtgg atcacttgag gccaggagtt caagaccagc caggccaaca
     5941 tggcaaagcc ctgtctctac taaaaataca aaaattagcc gggtatggtg gtgcacacct
     6001 gtagtccctg ctatgcggga ggctgaggct cgagaatcac ctgaacccaa gaggtagaag
     6061 tttcagtgag ctgagaccac tccactgtac tccagcctgg gcaaaaagtg agactctgtc
     6121 tcaaaaaata ataataataa atacataaat aataaaataa ataaaaagtg tgtcaacata
     6181 ctgttttcat agtcaagtta ctcaacctcc ttgagcctca atttcttgat tcctaaaatg
     6241 ggaacaataa tagttctcta tcccataggg ttgtgaggac caaatgaaat gaagcatgta
     6301 aagtatttag cacgtagtaa ctgcttaata aatgctatca tcatttattt tcactagagg
     6361 tttatcaatg tactattttt ttcacaacct catcaacatt ggatattatc aattttaaag
     6421 atttattcta aaacagttgg tataaaatta tactgaagcg tgactgctgc tgttcctttt
     6481 ccccctcctc ccctttcttc tttttcagtt ggaggagacc aagaggagag gatcagtaac
     6541 cagaaataaa aatgaccctt tacattgaga cacactgtat ttttatatgt aatccttgct
     6601 ttctcagaca acagagctag aaagatgatc ataggaacta ggaaataata actattttat
     6661 taaatgcatg ctgttatatt gaa
//
