LOCUS       NM_031455               2747 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens coiled-coil domain containing 3 (CCDC3), transcript
            variant 1, mRNA.
ACCESSION   NM_031455 XR_016758 XR_018739
VERSION     NM_031455.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2747)
  AUTHORS   Omari,S., Lee,H., Wang,J., Zeng,S.X. and Lu,H.
  TITLE     Extracellular and intracellular functions of coiled-coil domain
            containing 3
  JOURNAL   J Mol Cell Biol 15 (6) (2023)
   PUBMED   37263799
  REMARK    GeneRIF: Extracellular and intracellular functions of coiled-coil
            domain containing 3.
REFERENCE   2  (bases 1 to 2747)
  AUTHORS   Mao,J., Lu,Q., Li,P., Shi,S., Li,J., Li,Y., Chen,S. and Xie,X.
  TITLE     CCDC3 Gene Regulates the Proliferation of Breast Cancer Cells
  JOURNAL   Bull Exp Biol Med 174 (5), 653-658 (2023)
   PUBMED   37052857
  REMARK    GeneRIF: CCDC3 Gene Regulates the Proliferation of Breast Cancer
            Cells.
REFERENCE   3  (bases 1 to 2747)
  AUTHORS   Li,C., Lee,H., Jung,J.H., Zhang,Y., Wang,J., Liu,C.,
            Sheffmaker,R.L., Segall,A.M., Zeng,S.X. and Lu,H.
  TITLE     Coiled-coil domain containing 3 suppresses breast cancer growth by
            protecting p53 from proteasome-mediated degradation
  JOURNAL   Oncogene 42 (2), 154-164 (2023)
   PUBMED   36396725
  REMARK    GeneRIF: Coiled-coil domain containing 3 suppresses breast cancer
            growth by protecting p53 from proteasome-mediated degradation.
REFERENCE   4  (bases 1 to 2747)
  AUTHORS   Liao,W., Liu,H., Zhang,Y., Jung,J.H., Chen,J., Su,X., Kim,Y.C.,
            Flores,E.R., Wang,S.M., Czarny-Ratajczak,M., Li,W., Zeng,S.X. and
            Lu,H.
  TITLE     Ccdc3: A New P63 Target Involved in Regulation Of Liver Lipid
            Metabolism
  JOURNAL   Sci Rep 7 (1), 9020 (2017)
   PUBMED   28827783
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2747)
  AUTHORS   Azad,A.K., Chakrabarti,S., Xu,Z., Davidge,S.T. and Fu,Y.
  TITLE     Coiled-coil domain containing 3 (CCDC3) represses tumor necrosis
            factor-alpha/nuclear factor kappaB-induced endothelial inflammation
  JOURNAL   Cell Signal 26 (12), 2793-2800 (2014)
   PUBMED   25193116
  REMARK    GeneRIF: CCDC3 represses TNF-alpha/NF-kappaB-induced
            pro-inflammatory response in endothelial cells.
REFERENCE   6  (bases 1 to 2747)
  AUTHORS   Lango Allen,H., Estrada,K., Lettre,G., Berndt,S.I., Weedon,M.N.,
            Rivadeneira,F., Willer,C.J., Jackson,A.U., Vedantam,S.,
            Raychaudhuri,S., Ferreira,T., Wood,A.R., Weyant,R.J., Segre,A.V.,
            Speliotes,E.K., Wheeler,E., Soranzo,N., Park,J.H., Yang,J.,
            Gudbjartsson,D., Heard-Costa,N.L., Randall,J.C., Qi,L., Vernon
            Smith,A., Magi,R., Pastinen,T., Liang,L., Heid,I.M., Luan,J.,
            Thorleifsson,G., Winkler,T.W., Goddard,M.E., Sin Lo,K., Palmer,C.,
            Workalemahu,T., Aulchenko,Y.S., Johansson,A., Zillikens,M.C.,
            Feitosa,M.F., Esko,T., Johnson,T., Ketkar,S., Kraft,P., Mangino,M.,
            Prokopenko,I., Absher,D., Albrecht,E., Ernst,F., Glazer,N.L.,
            Hayward,C., Hottenga,J.J., Jacobs,K.B., Knowles,J.W., Kutalik,Z.,
            Monda,K.L., Polasek,O., Preuss,M., Rayner,N.W., Robertson,N.R.,
            Steinthorsdottir,V., Tyrer,J.P., Voight,B.F., Wiklund,F., Xu,J.,
            Zhao,J.H., Nyholt,D.R., Pellikka,N., Perola,M., Perry,J.R.,
            Surakka,I., Tammesoo,M.L., Altmaier,E.L., Amin,N., Aspelund,T.,
            Bhangale,T., Boucher,G., Chasman,D.I., Chen,C., Coin,L.,
            Cooper,M.N., Dixon,A.L., Gibson,Q., Grundberg,E., Hao,K., Juhani
            Junttila,M., Kaplan,L.M., Kettunen,J., Konig,I.R., Kwan,T.,
            Lawrence,R.W., Levinson,D.F., Lorentzon,M., McKnight,B.,
            Morris,A.P., Muller,M., Suh Ngwa,J., Purcell,S., Rafelt,S.,
            Salem,R.M., Salvi,E., Sanna,S., Shi,J., Sovio,U., Thompson,J.R.,
            Turchin,M.C., Vandenput,L., Verlaan,D.J., Vitart,V., White,C.C.,
            Ziegler,A., Almgren,P., Balmforth,A.J., Campbell,H., Citterio,L.,
            De Grandi,A., Dominiczak,A., Duan,J., Elliott,P., Elosua,R.,
            Eriksson,J.G., Freimer,N.B., Geus,E.J., Glorioso,N., Haiqing,S.,
            Hartikainen,A.L., Havulinna,A.S., Hicks,A.A., Hui,J., Igl,W.,
            Illig,T., Jula,A., Kajantie,E., Kilpelainen,T.O., Koiranen,M.,
            Kolcic,I., Koskinen,S., Kovacs,P., Laitinen,J., Liu,J., Lokki,M.L.,
            Marusic,A., Maschio,A., Meitinger,T., Mulas,A., Pare,G.,
            Parker,A.N., Peden,J.F., Petersmann,A., Pichler,I.,
            Pietilainen,K.H., Pouta,A., Ridderstrale,M., Rotter,J.I.,
            Sambrook,J.G., Sanders,A.R., Schmidt,C.O., Sinisalo,J., Smit,J.H.,
            Stringham,H.M., Bragi Walters,G., Widen,E., Wild,S.H.,
            Willemsen,G., Zagato,L., Zgaga,L., Zitting,P., Alavere,H.,
            Farrall,M., McArdle,W.L., Nelis,M., Peters,M.J., Ripatti,S., van
            Meurs,J.B., Aben,K.K., Ardlie,K.G., Beckmann,J.S., Beilby,J.P.,
            Bergman,R.N., Bergmann,S., Collins,F.S., Cusi,D., den Heijer,M.,
            Eiriksdottir,G., Gejman,P.V., Hall,A.S., Hamsten,A., Huikuri,H.V.,
            Iribarren,C., Kahonen,M., Kaprio,J., Kathiresan,S., Kiemeney,L.,
            Kocher,T., Launer,L.J., Lehtimaki,T., Melander,O., Mosley,T.H. Jr.,
            Musk,A.W., Nieminen,M.S., O'Donnell,C.J., Ohlsson,C., Oostra,B.,
            Palmer,L.J., Raitakari,O., Ridker,P.M., Rioux,J.D., Rissanen,A.,
            Rivolta,C., Schunkert,H., Shuldiner,A.R., Siscovick,D.S.,
            Stumvoll,M., Tonjes,A., Tuomilehto,J., van Ommen,G.J., Viikari,J.,
            Heath,A.C., Martin,N.G., Montgomery,G.W., Province,M.A., Kayser,M.,
            Arnold,A.M., Atwood,L.D., Boerwinkle,E., Chanock,S.J., Deloukas,P.,
            Gieger,C., Gronberg,H., Hall,P., Hattersley,A.T., Hengstenberg,C.,
            Hoffman,W., Lathrop,G.M., Salomaa,V., Schreiber,S., Uda,M.,
            Waterworth,D., Wright,A.F., Assimes,T.L., Barroso,I., Hofman,A.,
            Mohlke,K.L., Boomsma,D.I., Caulfield,M.J., Cupples,L.A.,
            Erdmann,J., Fox,C.S., Gudnason,V., Gyllensten,U., Harris,T.B.,
            Hayes,R.B., Jarvelin,M.R., Mooser,V., Munroe,P.B., Ouwehand,W.H.,
            Penninx,B.W., Pramstaller,P.P., Quertermous,T., Rudan,I.,
            Samani,N.J., Spector,T.D., Volzke,H., Watkins,H., Wilson,J.F.,
            Groop,L.C., Haritunians,T., Hu,F.B., Kaplan,R.C., Metspalu,A.,
            North,K.E., Schlessinger,D., Wareham,N.J., Hunter,D.J.,
            O'Connell,J.R., Strachan,D.P., Wichmann,H.E., Borecki,I.B., van
            Duijn,C.M., Schadt,E.E., Thorsteinsdottir,U., Peltonen,L.,
            Uitterlinden,A.G., Visscher,P.M., Chatterjee,N., Loos,R.J.,
            Boehnke,M., McCarthy,M.I., Ingelsson,E., Lindgren,C.M.,
            Abecasis,G.R., Stefansson,K., Frayling,T.M. and Hirschhorn,J.N.
  TITLE     Hundreds of variants clustered in genomic loci and biological
            pathways affect human height
  JOURNAL   Nature 467 (7317), 832-838 (2010)
   PUBMED   20881960
REFERENCE   7  (bases 1 to 2747)
  AUTHORS   Johnson,A.D., Yanek,L.R., Chen,M.H., Faraday,N., Larson,M.G.,
            Tofler,G., Lin,S.J., Kraja,A.T., Province,M.A., Yang,Q.,
            Becker,D.M., O'Donnell,C.J. and Becker,L.C.
  TITLE     Genome-wide meta-analyses identifies seven loci associated with
            platelet aggregation in response to agonists
  JOURNAL   Nat Genet 42 (7), 608-613 (2010)
   PUBMED   20526338
REFERENCE   8  (bases 1 to 2747)
  AUTHORS   Kobayashi,S., Fukuhara,A., Taguchi,T., Matsuda,M., Tochino,Y.,
            Otsuki,M. and Shimomura,I.
  TITLE     Identification of a new secretory factor, CCDC3/Favine, in
            adipocytes and endothelial cells
  JOURNAL   Biochem Biophys Res Commun 392 (1), 29-35 (2010)
   PUBMED   20043878
REFERENCE   9  (bases 1 to 2747)
  AUTHORS   Simpson,J.C., Wellenreuther,R., Poustka,A., Pepperkok,R. and
            Wiemann,S.
  TITLE     Systematic subcellular localization of novel proteins identified by
            large-scale cDNA sequencing
  JOURNAL   EMBO Rep 1 (3), 287-292 (2000)
   PUBMED   11256614
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL355355.25 and AL353586.14.
            
            On Nov 23, 2018 this sequence version replaced NM_031455.3.
            
            Transcript Variant: This variant (1) represents the shorter
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC051334.1, AL136562.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2159368, SAMEA2159912
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000378825.5/ ENSP00000368102.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-517               AL355355.25        24725-25241         c
            518-692             AL355355.25        21866-22040         c
            693-2747            AL353586.14        43766-45820         c
FEATURES             Location/Qualifiers
     source          1..2747
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10p13"
     gene            1..2747
                     /gene="CCDC3"
                     /note="coiled-coil domain containing 3"
                     /db_xref="GeneID:83643"
                     /db_xref="HGNC:HGNC:23813"
                     /db_xref="MIM:620579"
     exon            1..517
                     /gene="CCDC3"
                     /inference="alignment:Splign:2.1.0"
     CDS             144..956
                     /gene="CCDC3"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; coiled-coil domain-containing protein 3;
                     favine; fat/vessel-derived secretory protein"
                     /codon_start=1
                     /product="coiled-coil domain-containing protein 3 isoform
                     1 precursor"
                     /protein_id="NP_113643.1"
                     /db_xref="CCDS:CCDS7093.1"
                     /db_xref="GeneID:83643"
                     /db_xref="HGNC:HGNC:23813"
                     /db_xref="MIM:620579"
                     /translation="MLRQLLLAALCLAGPPAPARACQLPSEWRPLSEGCRAELAETIV
                     YARVLALHPEAPGLYNHLPWQYHAGQGGLFYSAEVEMLCDQAWGSMLEVPAGSRLNLT
                     GLGYFSCHSHTVVQDYSYFFFLRMDENYNLLPHGVNFQDAIFPDTQENRRMFSSLFQF
                     SNCSQGQQLATFSSDWEIQEDSRLMCSSVQKALFEEEDHVKKLQQKVATLEKRNRQLR
                     ERVKKVKRSLRQARKKGRHLELANQKLSEKLAAGALPHINARGPVRPPYLRG"
     exon            518..692
                     /gene="CCDC3"
                     /inference="alignment:Splign:2.1.0"
     exon            693..2747
                     /gene="CCDC3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2718..2723
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CCDC3"
                     /note="hexamer: AATAAA"
     polyA_site      2747
                     /gene="CCDC3"
                     /note="major polyA site"
ORIGIN      
        1 atgccgagcc ccgtggcgga gacagcggtg cgctcagctc ccgggagcgg cccgagcagc
       61 cgagcgccca gggctgccct tcccgggccg gcgggctccc cgggctcccc gccgccgccc
      121 cgtgcgcccc gggagggccc ggcatgctgc gccagctgct gctcgccgcg ctctgcctgg
      181 cgggtccccc agcgcccgcg cgcgcctgcc agctgccctc cgagtggagg cccctgagcg
      241 agggctgccg cgccgagctg gccgagacca tcgtgtacgc cagggtgctg gcgctgcacc
      301 ccgaggcgcc cggcctctac aaccacctgc cctggcagta ccacgccggc caggggggcc
      361 tcttctactc ggccgaggtc gagatgctgt gcgaccaggc gtggggcagc atgctggagg
      421 tgcccgccgg ctccaggctc aacctcaccg gcctgggcta cttctcgtgc cactcccaca
      481 ccgtggtcca ggactactcc tatttcttct tcctcaggat ggatgaaaat tataacctct
      541 tgcctcacgg agtcaatttc caagatgcca tcttcccaga cactcaagag aacagaagga
      601 tgttttctag ccttttccag ttttcaaact gttcgcaagg gcagcagctg gcgactttct
      661 ccagtgactg ggaaatccag gaagacagta ggctcatgtg ctcctcggtg cagaaggcct
      721 tgtttgagga ggaggaccac gtcaagaaac tgcagcagaa agtggccacc ctggagaagc
      781 gcaaccggca gctccgggag cgagtgaaga aggtcaagag gtccttgcgg caggcgcgta
      841 agaagggccg ccacctggag ctggcgaacc agaaactcag tgagaagctg gcggcgggcg
      901 cgctgccgca catcaatgcc cgggggcccg tgcgcccccc ctacctgcgg gggtaacggg
      961 cctgggggct gccaggtgtg cagggccaat cctgacggta attgagaatg agtgaggttt
     1021 cgtacatgca gctatttcaa gggttgtaag agtttttgtt tttaatcacg catttggtag
     1081 agtctaaatg gataaaatgc aaggcttgct ttccccttgg gtgctggcct caatgtcaga
     1141 ccccacgcgc tgccccttcc tggcctgacc ccagacgcag tgcctggcag tccagaggca
     1201 gtgggatccc tgagtgctga atgctcgcct gcagagcagc ccagaaagag ccctgactgg
     1261 ggagagaaca ttttagaatc tctagtgtaa aagacatcaa cgtgcttagc ctttatttca
     1321 gaaaaaaatc agggtggttc ccagctcccc agtccaggac aaccattagt cctgatgagt
     1381 gagctgacgc tggtgctgga acctgctggc acctcactgg ccacatcttt ggaaggggat
     1441 ggtggccttg catccaagat gcctgaaaat cagcacgtgc agggcctccc tatccagcca
     1501 gcattttcct tccagctgag gcaggtgaag acttcataag ctcatcacag gggagggaat
     1561 taggagcagg gcagcaggta attaaacaag ataaattata cctgatttcc aacaccagct
     1621 acaaagagtt gaagatgata cctatgggtc gcgttaacac agggggcaac tgccttgatc
     1681 ggcctgccat gggtcatcag actgcttcct aaattgagag aaactgagca atctctcagc
     1741 cactgctata gtctaacttc ttgtttgctg agtaattgtt tctaatgtct ctgaactcaa
     1801 agtgaggtgc tccaagacgc tgtgaacttc tgcaaagaca cctccttacc tactgggatc
     1861 acgtgacctg acctcactcc cagccaggct cccaaagggc tcattccagc cattccaatc
     1921 tcttcttctt tatgcaaaca cttttccccc acaacaagcc ttgtttgttc cgataggaat
     1981 acgtgtacgt cagtgcactt gtccttacgt cagttcctta caccaccaaa gcacttcacc
     2041 tttctggaaa taaaactttt aagacactac tataagtaaa aatgagagta ttcactagac
     2101 ttattgctca ggcacatttg agtgggtccc agctgtgtga ttaagaagtc aactgggtgg
     2161 ccttttctgg gttatcttct gatcatggcc tttcaaccca acaagggccc ttccctgctc
     2221 ttccaccagt aaaggctcct ggcctctcat caggatctgc cccccagaga ccccccccag
     2281 acactgcagg gcctggtgat gctgtcctct gtaccggaaa tggcaggcac tgtcagattt
     2341 ccactcttct gcctttagga aggctgggtg cttcttgctc tgacagccag tctggggaga
     2401 tgactcttac gttgcttgag tcttggtggc aggctgctgt ccacggggga gaagtctctg
     2461 ctctggactg gacagaagag agacttttac cctggggcac tcacacggcc aagcttctgc
     2521 caccacttca ttagctgtat tctccatagt atggtgaaat agcaggtgcg tcttctagtt
     2581 tattcctcct ggggacattt cctcaaagca gttttgcgcc cccgcaaggg aatggtcagc
     2641 ctaagggtaa tgtacagccc gtgcttggag aaccatggaa gctacacccc tacaggtgca
     2701 tactgttctg cttttccaat aaatacgagc ggcgatttca accacaa
//
