LOCUS       NM_152492               2125 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens coiled-coil domain containing 27 (CCDC27), mRNA.
ACCESSION   NM_152492
VERSION     NM_152492.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2125)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 2125)
  AUTHORS   Evans,D.M., Zhu,G., Dy,V., Heath,A.C., Madden,P.A., Kemp,J.P.,
            McMahon,G., St Pourcain,B., Timpson,N.J., Golding,J., Lawlor,D.A.,
            Steer,C., Montgomery,G.W., Martin,N.G., Smith,G.D. and
            Whitfield,J.B.
  TITLE     Genome-wide association study identifies loci affecting blood
            copper, selenium and zinc
  JOURNAL   Hum Mol Genet 22 (19), 3998-4006 (2013)
   PUBMED   23720494
REFERENCE   3  (bases 1 to 2125)
  AUTHORS   Comuzzie,A.G., Cole,S.A., Laston,S.L., Voruganti,V.S., Haack,K.,
            Gibbs,R.A. and Butte,N.F.
  TITLE     Novel genetic loci identified for the pathophysiology of childhood
            obesity in the Hispanic population
  JOURNAL   PLoS One 7 (12), e51954 (2012)
   PUBMED   23251661
REFERENCE   4  (bases 1 to 2125)
  AUTHORS   Fox,C.S., Liu,Y., White,C.C., Feitosa,M., Smith,A.V.,
            Heard-Costa,N., Lohman,K., Johnson,A.D., Foster,M.C.,
            Greenawalt,D.M., Griffin,P., Ding,J., Newman,A.B., Tylavsky,F.,
            Miljkovic,I., Kritchevsky,S.B., Launer,L., Garcia,M.,
            Eiriksdottir,G., Carr,J.J., Gudnason,V., Harris,T.B., Cupples,L.A.
            and Borecki,I.B.
  CONSRTM   GIANT Consortium; MAGIC Consortium; GLGC Consortium
  TITLE     Genome-wide association for abdominal subcutaneous and visceral
            adipose reveals a novel locus for visceral fat in women
  JOURNAL   PLoS Genet 8 (5), e1002695 (2012)
   PUBMED   22589738
REFERENCE   5  (bases 1 to 2125)
  AUTHORS   Zhang,H., Sol-Church,K., Rydbeck,H., Stabley,D., Spotila,L.D. and
            Devoto,M.
  TITLE     High resolution linkage and linkage disequilibrium analyses of
            chromosome 1p36 SNPs identify new positional candidate genes for
            low bone mineral density
  JOURNAL   Osteoporos Int 20 (2), 341-346 (2009)
   PUBMED   18597038
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC112112.1, DB048639.1, AL136528.11 and AK057387.1.
            
            On Nov 23, 2018 this sequence version replaced NM_152492.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            transcript and genomic sequence to make the sequence consistent
            with the reference genome assembly. The extent of this RefSeq
            transcript is supported by transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK057387.1, BC112108.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2148093
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000294600.7/ ENSP00000294600.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-187               BC112112.1         50-236
            188-579             DB048639.1         195-586
            580-831             BC112112.1         629-880
            832-832             AL136528.11        7862-7862           c
            833-1089            BC112112.1         882-1138
            1090-1171           AL136528.11        5939-6020           c
            1172-2125           AK057387.1         1224-2177
FEATURES             Location/Qualifiers
     source          1..2125
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p36.32"
     gene            1..2125
                     /gene="CCDC27"
                     /note="coiled-coil domain containing 27"
                     /db_xref="GeneID:148870"
                     /db_xref="HGNC:HGNC:26546"
     exon            1..350
                     /gene="CCDC27"
                     /inference="alignment:Splign:2.1.0"
     CDS             33..2003
                     /gene="CCDC27"
                     /codon_start=1
                     /product="coiled-coil domain-containing protein 27"
                     /protein_id="NP_689705.2"
                     /db_xref="CCDS:CCDS50.1"
                     /db_xref="GeneID:148870"
                     /db_xref="HGNC:HGNC:26546"
                     /translation="MFEAIFPSTPQARLKRDPREKPGLSSFRSTFRQQSSLGLCIPRL
                     MLPKEASPSQRHSSMSSSMARALVLLQSMASRDARCPEWKPHQKPRTLSKSVQTISRY
                     YRKTSEPKDAASLTGFMSKMELRRVFPTHPDCPQFSTRATSMSHCGSPTEADLSGEID
                     NSSETWRGTQDLFLARRGSDTNVDGYLLPFSKSICEFDYLRKRRKSQTLSPVTSSSVA
                     SQSCLRKRMPWYLSVIHEKDHCLSELEIQVQKKDEEILLLQEEREALKMQLKCLLKGK
                     GQETSMSPGRREQLSDASLKLGRLSLLKAFSRHEEELQHWWQMQEESAAPERGKEPDL
                     GGGEEDEGLEGEPDGVEDTGAWGGVSQMGSVHEEGSEEEEEEEGDRDEDSEERELPEE
                     EEIPRRRASSLAESFEEELLAQLEEYEQVILDFQFNLEATRTRYSLATGVIASLQQQV
                     DFQETQLRKINTENETLQKELRERRQQLQAMTDKFSNLREDKKHQEMMGLIEKDNQLL
                     RQQVSELERKLTKRDCVISELDTKVSQLQEQVELDQNHLQRWKQLQEDLQSKKEMIQQ
                     AEQHTRVALESSQSRLERLRNKIIQATFSISGTKSLANEISDNDILEALQRIISERSD
                     YYNQLKQKGVKVPPLQQSEAFLTSKSKKGTSK"
     exon            351..474
                     /gene="CCDC27"
                     /inference="alignment:Splign:2.1.0"
     exon            475..585
                     /gene="CCDC27"
                     /inference="alignment:Splign:2.1.0"
     exon            586..743
                     /gene="CCDC27"
                     /inference="alignment:Splign:2.1.0"
     exon            744..893
                     /gene="CCDC27"
                     /inference="alignment:Splign:2.1.0"
     exon            894..986
                     /gene="CCDC27"
                     /inference="alignment:Splign:2.1.0"
     exon            987..1353
                     /gene="CCDC27"
                     /inference="alignment:Splign:2.1.0"
     exon            1354..1484
                     /gene="CCDC27"
                     /inference="alignment:Splign:2.1.0"
     exon            1485..1562
                     /gene="CCDC27"
                     /inference="alignment:Splign:2.1.0"
     exon            1563..1775
                     /gene="CCDC27"
                     /inference="alignment:Splign:2.1.0"
     exon            1776..1880
                     /gene="CCDC27"
                     /inference="alignment:Splign:2.1.0"
     exon            1881..2125
                     /gene="CCDC27"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2101..2106
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CCDC27"
                     /note="hexamer: ATTAAA"
     polyA_site      2125
                     /gene="CCDC27"
                     /note="major polyA site"
ORIGIN      
        1 gatctcctcc cactgcacca gccagcaggt tcatgttcga ggccatcttc ccctccacac
       61 cccaagccag gctgaagaga gatccacggg aaaagccggg cctgtcctca ttcaggtcca
      121 cattcaggca acaaagctca cttggtcttt gcatcccacg cctcatgtta cctaaggagg
      181 ccagcccatc tcagaggcac agttcgatgt ccagctcgat ggccagggcc ctggtgctcc
      241 tccagagcat ggccagccgg gacgcccggt gcccagaatg gaaaccgcac caaaagccac
      301 gcacgctcag caagtcggtc cagaccatca gccgctacta caggaagacg agtgaaccca
      361 aggatgccgc cagcctcacc ggcttcatgt ccaaaatgga acttcgaagg gtcttcccca
      421 cgcatcctga ctgcccccag ttcagcacca gggccacatc catgtcccac tgtggttcac
      481 ccactgaggc cgatttgtcc ggagagattg acaacagctc ggagacctgg agaggcaccc
      541 aggacctgtt cttggccagg cggggctcag acacgaacgt ggacgggtac ctccttccct
      601 tcagtaagag catctgcgag ttcgattact tgcggaagag gagaaaatcc cagactttga
      661 gtccggtcac cagcagctca gtcgcatctc agagctgcct gagaaagagg atgccctggt
      721 acctctcagt catccacgag aaggatcact gcctgtctga gctggagata caggttcaga
      781 agaaagacga ggagatcctg ctgctccagg aggagaggga ggccctgaag atgcagctga
      841 aatgccttct gaaaggcaaa ggccaagaga catccatgtc cccaggcagg agggagcagc
      901 tctcagacgc ttcgctgaag ctgggcaggc tgagcctcct gaaggccttc tccagacatg
      961 aggaggagct gcagcactgg tggcagatgc aggaggagtc tgcggcaccg gagaggggca
     1021 aggagcccga cctgggaggt ggcgaggagg acgagggcct ggaaggggag cccgatgggg
     1081 tggaggacac gggtgcctgg ggaggtgtga gccagatggg atccgtgcat gaggagggaa
     1141 gcgaggagga ggaagaggag gaaggggaca gggatgagga ctcagaggaa agggagctgc
     1201 cggaggaaga ggagatcccc aggagaaggg cctcctccct ggccgagtcg tttgaggagg
     1261 agctgctggc ccagctggag gagtacgagc aggtcatcct ggacttccag ttcaacctgg
     1321 aggccaccag gaccagatac tcccttgcaa caggagtgat tgcgtcttta caacaacaag
     1381 tggatttcca agaaacccag ctgcgaaaga tcaatacgga aaatgagacg ctgcagaagg
     1441 agctccgaga gcggaggcag cagctacaag ccatgaccga caagttctcc aacctccgag
     1501 aagataagaa acaccaagag atgatggggc tcattgaaaa ggacaaccag ctcctccgac
     1561 agcaagtgtc ggaactggag agaaagctca ccaagcggga ctgtgtcatc tcagagttgg
     1621 acaccaaggt cagccagctg caggagcagg tggaactgga ccagaaccac ctgcagaggt
     1681 ggaagcagct gcaggaggat ttgcagagca agaaggagat gattcagcag gcagagcagc
     1741 acacccgcgt ggccctggag agctcccagt ccaggctcga gaggttaagg aataagatca
     1801 tccaggccac ctttagcatc tccgggacca agtccttggc caacgagatc tctgacaatg
     1861 acatcctgga agccctgcag agaattatct cagagagaag cgactactat aatcagctga
     1921 agcagaaagg cgtcaaagtg ccccccctgc aacagtcaga ggccttcctg accagcaaat
     1981 ccaagaaggg gacctccaag taggcccagc caggccccca aatacggtca gcccagcaga
     2041 ggccggggcc cagctccaga accacccgcc cccaccatgc gtcctgctct cagactcaga
     2101 attaaacccc ggtgttggca ctgtc
//
