LOCUS       NM_018246               3627 bp    mRNA    linear   PRI 08-FEB-2025
DEFINITION  Homo sapiens coiled-coil domain containing 25 (CCDC25), transcript
            variant 1, mRNA.
ACCESSION   NM_018246 NM_001031708
VERSION     NM_018246.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3627)
  AUTHORS   Phimphila,A., Aung,T.M., Wongwattanakul,M., Maraming,P.,
            Tavichakorntrakool,R., Proungvitaya,T., Daduang,J. and
            Proungvitaya,S.
  TITLE     Serum CCDC25 Levels as a Potential Marker for Metabolic Syndrome
  JOURNAL   In Vivo 38 (2), 785-793 (2024)
   PUBMED   38418150
  REMARK    GeneRIF: Serum CCDC25 Levels as a Potential Marker for Metabolic
            Syndrome.
REFERENCE   2  (bases 1 to 3627)
  AUTHORS   Qian,Z., Zhao,H., Zhang,Y., Wang,Z., Zeng,F., Zhu,Y., Yang,Y.,
            Li,J., Ma,T. and Huang,C.
  TITLE     Coiled-coil domain containing 25 (CCDC25) regulates cell
            proliferation, migration, and invasion in clear cell renal cell
            carcinoma by targeting the ILK-NF-kappaB signaling pathway
  JOURNAL   FASEB J 38 (2), e23414 (2024)
   PUBMED   38236371
  REMARK    GeneRIF: Coiled-coil domain containing 25 (CCDC25) regulates cell
            proliferation, migration, and invasion in clear cell renal cell
            carcinoma by targeting the ILK-NF-kappaB signaling pathway.
REFERENCE   3  (bases 1 to 3627)
  AUTHORS   Tang,Q., Liang,B., Zhang,L., Li,X., Li,H., Jing,W., Jiang,Y.,
            Zhou,F., Zhang,J., Meng,Y., Yang,X., Yang,H., Huang,G. and Zhao,J.
  TITLE     Enhanced CHOLESTEROL biosynthesis promotes breast cancer metastasis
            via modulating CCDC25 expression and neutrophil extracellular traps
            formation
  JOURNAL   Sci Rep 12 (1), 17350 (2022)
   PUBMED   36253427
  REMARK    GeneRIF: Enhanced CHOLESTEROL biosynthesis promotes breast cancer
            metastasis via modulating CCDC25 expression and neutrophil
            extracellular traps formation.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3627)
  AUTHORS   Siriphak,S., Chanakankun,R., Proungvitaya,T., Roytrakul,S.,
            Tummanatsakun,D., Seubwai,W., Wongwattanakul,M. and Proungvitaya,S.
  TITLE     Kallikrein-11, in Association with Coiled-Coil Domain Containing
            25, as a Potential Prognostic Marker for Cholangiocarcinoma with
            Lymph Node Metastasis
  JOURNAL   Molecules 26 (11), 3105 (2021)
   PUBMED   34067437
  REMARK    GeneRIF: Kallikrein-11, in Association with Coiled-Coil Domain
            Containing 25, as a Potential Prognostic Marker for
            Cholangiocarcinoma with Lymph Node Metastasis.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3627)
  AUTHORS   Liu,R., Zhao,E., Wang,F. and Cui,H.
  TITLE     CCDC25: precise navigator for neutrophil extracellular traps on the
            prometastatic road
  JOURNAL   Signal Transduct Target Ther 5 (1), 162 (2020)
   PUBMED   32839429
  REMARK    GeneRIF: CCDC25: precise navigator for neutrophil extracellular
            traps on the prometastatic road.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3627)
  AUTHORS   Yang,L., Liu,Q., Zhang,X., Liu,X., Zhou,B., Chen,J., Huang,D.,
            Li,J., Li,H., Chen,F., Liu,J., Xing,Y., Chen,X., Su,S. and Song,E.
  TITLE     DNA of neutrophil extracellular traps promotes cancer metastasis
            via CCDC25
  JOURNAL   Nature 583 (7814), 133-138 (2020)
   PUBMED   32528174
  REMARK    GeneRIF: DNA of neutrophil extracellular traps promotes cancer
            metastasis via CCDC25.
REFERENCE   7  (bases 1 to 3627)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   8  (bases 1 to 3627)
  AUTHORS   Proungvitaya,S., Klinthong,W., Proungvitaya,T., Limpaiboon,T.,
            Jearanaikoon,P., Roytrakul,S., Wongkham,C., Nimboriboonporn,A. and
            Wongkham,S.
  TITLE     High expression of CCDC25 in cholangiocarcinoma tissue samples
  JOURNAL   Oncol Lett 14 (2), 2566-2572 (2017)
   PUBMED   28789463
REFERENCE   9  (bases 1 to 3627)
  AUTHORS   Ballif,B.A., Villen,J., Beausoleil,S.A., Schwartz,D. and Gygi,S.P.
  TITLE     Phosphoproteomic analysis of the developing mouse brain
  JOURNAL   Mol Cell Proteomics 3 (11), 1093-1101 (2004)
   PUBMED   15345747
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA218015.1, BC065295.1 and AC013643.10.
            
            On Nov 23, 2018 this sequence version replaced NM_018246.2.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC065295.1, SRR1803615.69637.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000356537.9/ ENSP00000348933.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-46                DA218015.1         14-59
            47-809              BC065295.1         1-763
            810-2611            AC013643.10        122265-124066       c
            2612-3627           BC065295.1         2579-3594
FEATURES             Location/Qualifiers
     source          1..3627
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8p21.1"
     gene            1..3627
                     /gene="CCDC25"
                     /note="coiled-coil domain containing 25"
                     /db_xref="GeneID:55246"
                     /db_xref="HGNC:HGNC:25591"
                     /db_xref="MIM:619100"
     exon            1..128
                     /gene="CCDC25"
                     /inference="alignment:Splign:2.1.0"
     CDS             101..727
                     /gene="CCDC25"
                     /note="isoform 1 is encoded by transcript variant 1;
                     coiled-coil domain-containing protein 25"
                     /codon_start=1
                     /product="coiled-coil domain-containing protein 25 isoform
                     1"
                     /protein_id="NP_060716.2"
                     /db_xref="CCDS:CCDS6062.2"
                     /db_xref="GeneID:55246"
                     /db_xref="HGNC:HGNC:25591"
                     /db_xref="MIM:619100"
                     /translation="MVFYFTSSSVNSSAYTIYMGKDKYENEDLIKHGWPEDIWFHVDK
                     LSSAHVYLRLHKGENIEDIPKEVLMDCAHLVKANSIQGCKMNNVNVVYTPWSNLKKTA
                     DMDVGQIGFHRQKDVKIVTVEKKVNEILNRLEKTKVERFPDLAAEKECRDREERNEKK
                     AQIQEMKKREKEEMKKKREMDELRSYSSLMKVENMSSNQDGNDSDEFM"
     exon            129..176
                     /gene="CCDC25"
                     /inference="alignment:Splign:2.1.0"
     exon            177..216
                     /gene="CCDC25"
                     /inference="alignment:Splign:2.1.0"
     exon            217..268
                     /gene="CCDC25"
                     /inference="alignment:Splign:2.1.0"
     exon            269..344
                     /gene="CCDC25"
                     /inference="alignment:Splign:2.1.0"
     exon            345..448
                     /gene="CCDC25"
                     /inference="alignment:Splign:2.1.0"
     exon            449..651
                     /gene="CCDC25"
                     /inference="alignment:Splign:2.1.0"
     exon            652..697
                     /gene="CCDC25"
                     /inference="alignment:Splign:2.1.0"
     exon            698..3627
                     /gene="CCDC25"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1864..1869
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CCDC25"
                     /note="hexamer: AATAAA"
     polyA_site      1891
                     /gene="CCDC25"
                     /note="major polyA site"
     regulatory      3602..3607
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CCDC25"
                     /note="hexamer: AATAAA"
     polyA_site      3627
                     /gene="CCDC25"
                     /note="major polyA site"
ORIGIN      
        1 agttccgggg gccaggcggc cgccgcgagt ctggtatcct gagcttcgtg agttgagcgc
       61 tgctgctccg cggtggagtc accgcaccgc tcccgggatc atggtgttct acttcaccag
      121 cagcagcgtt aattcatctg cctacactat ttacatggga aaagataaat atgaaaatga
      181 agatctgatc aagcatggct ggcctgaaga tatctggttt catgtggaca aactctcttc
      241 ggctcatgta taccttcgat tacataaggg agagaatata gaagacatcc caaaggaagt
      301 gctgatggac tgtgcccacc ttgtgaaggc caatagcatt caaggctgca agatgaacaa
      361 cgttaatgtg gtatatacgc cgtggtctaa cctgaagaaa acagctgaca tggatgtggg
      421 gcagataggc tttcacaggc agaaggatgt aaaaattgtg acagtggaga agaaagtaaa
      481 tgagatcctg aaccgattag aaaagaccaa agtcgagcgg ttcccagacc tagcagcaga
      541 gaaagaatgc agagatcgtg aagagaggaa tgagaaaaaa gcccaaattc aggaaatgaa
      601 aaagagagaa aaagaagaaa tgaagaagaa gagggaaatg gatgaactta ggagctattc
      661 atcactaatg aaagttgaaa atatgtcttc aaatcaggat ggcaatgatt cagatgaatt
      721 catgtaaaag gagaaaagga gaaaaggacc tttgaaagat gtgaatgtag agacaattgc
      781 agaccttttg gtttcatctg tgttctgaaa tataaaatac aaccaaaatt ctaccttcat
      841 cctacccaga aattattgat tttcaagttt taaaaaaatt gtaccttttt tgctgacaga
      901 aaaggatcag atatgtataa aatagttgaa cttgacagca tataacttaa agtgaaaatg
      961 tttttgccag aacatgtctt ggtaccttgt gaaagcaggc tgcccttgtt cttgagatag
     1021 actttaaaat gaaccagctc tgaaaagtac ttctgctgct ctggtctatc cctgaaaaca
     1081 gatgtcttga aacacttttc atattcttaa aataatcttc acttctgtta agaagaacat
     1141 gttggtgggt aattatgcga atgtttccct gtccctgatt tctcgattag gcgtatgggt
     1201 tttgaaaaag agatttttca gaagattgtc agcttcagta ttcatgttcc atcgtgtcat
     1261 ctgggtctgt tagtgtagtg accctcagtg cagtctgtcc cagcgtttac gtccttgctt
     1321 cctctgagca gaggcctcca tcttagtatc aacatattta aagaaattga tggtgttcat
     1381 caagctgggg cctgtggcag ttgttgcctg agcaccaagt aacccaagcc acctatgtga
     1441 caacttctgg gcccaggagt aatttctcag cattgagggt aaaataggat ggagtgctct
     1501 gttgatcatt tgggagatgt aggttacctg atttgtgcct taggatgcag cgtgaagcag
     1561 aagtccatat tgcaattatg attttagaag gaactaagca ttttactcac acccacagca
     1621 gcaagaatga cctcctgcag cagatattcc acctgtaata gcactttgga actgtgggca
     1681 aaaccaaaag gctagtgttt ccatttattc catgttggtg tatggggttg aactggaaaa
     1741 ttccctgagg caaaactcac tggccaaatt ttgagagggt atagaaaatg actttagaga
     1801 tgagtggttt tgtgtatgtg tctgatgata ttcagtctga tgttccgcaa ttttaaaagt
     1861 tataataaaa taccattttt ttaatctgga aggacattga tatatgaatt cttagaattt
     1921 gctattaaaa agggtagccc ccattccaca agctggtttt gagggtgatc ttgctctaaa
     1981 aaacctcatt catcataggc tcagtctgac aggttctgta cggggctatc atctttctcc
     2041 tcctctgcta aatgcctctt tcttccagct gctcactggg tcaaagggat gtcctttctc
     2101 agatgtattc ttgatacatc tcagatgtat tcgtagctgt gctccttcca tacttccaag
     2161 gagtccggct tctacagaat tcctctgtac ctcacactgc aacacatgta gatagcgctt
     2221 ttgaaaaata catatatttt tactatagta tgagaggtcc tggggctcaa actttaaaca
     2281 tttcctaact cagcttacac tggtttaaaa tgtccaggtc tctgctgaat tctcttgttg
     2341 aattcatagc tctgtgttga ttcctatgcc cctaaccctg cagcctcttt gttttatttt
     2401 tttccccatc tctgttggtc ccagggaaag caaggaaatt ttcttttgag gacttatagg
     2461 ttgattgccc acaggtcaaa ctgttggcat tgaactcctc tcatttcttg ccattggatt
     2521 gtttcctaaa cgttggatag gagaattcga aattgttgct atttttatga gctgtgccct
     2581 tgatcaaatc tgtgctgtgg gtctgagtca ctttgccaat gtcgtcttca gtttcaacac
     2641 tctgatcagc atgcaggcga ggggcatgtt taatttactt cactaactgc tatattctat
     2701 agctttagac ttcatatttc ttatccacct ttgtctaggc tcacgatctt tgggcaaggg
     2761 agctttgtca ccgtggttgg gctagaacaa atattgagaa gtttaccaac acagatgttg
     2821 agaagtttat tgaaaggcac tgacattagc agaataagtg atggacatta gttgaacccc
     2881 ttcagtgtct atgtgtttta ttgtattgtc tttaactcgt tcttgaagca cagatttcag
     2941 cgagcctttc agctattcag tgccagcggt tttccccact caggaaagat ggtgtgagcc
     3001 atacacacag caggattaga cggggagagt ttcagctgca gcttctagtt taagaccaaa
     3061 gcccttcctc ccgctgctgc atctgtctga gaggggaagc tcttgttttc caagctggaa
     3121 ccgtttatga ggaaaactga gcagggtggc aaaatggaaa aggaacaatt ttctagtttt
     3181 tcctacgcgt gatattgacg cgtgcttttt ctttgatttg aggtacagca tgtaaataac
     3241 aaatttccat attcaaaatg atcatattag agtgactgag tgaccttttg attttgaagc
     3301 agactaaaat ctgaccagac cacaatgaaa agtataaaat tagaaactta aattccaagc
     3361 taaatttcag ctttgaccca cctaactcca gtgaataggt ggcagctcag aaacaaggac
     3421 agcactgctg ctgccagagc aagctcacat ccagctggca cttcgtgaga gctccttcct
     3481 gccgggcacg tgtgagttca gcgtgggcaa gagactttta tgcacattct gtcattcaaa
     3541 agggaaatga tgccaacccc agatgcagca tgtcctgaat gaatgatctg taaaatacaa
     3601 taataaaagc ttatagtttg agtagaa
//
