LOCUS       NM_018168               3088 bp    mRNA    linear   PRI 10-FEB-2025
DEFINITION  Homo sapiens coiled-coil domain containing 198 (CCDC198),
            transcript variant 2, mRNA.
ACCESSION   NM_018168
VERSION     NM_018168.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3088)
  AUTHORS   Petersen,J., Englmaier,L., Artemov,A.V., Poverennaya,I.,
            Mahmoud,R., Bouderlique,T., Tesarova,M., Deviatiiarov,R.,
            Szilvasy-Szabo,A., Akkuratov,E.E., Pajuelo Reguera,D., Zeberg,H.,
            Kaucka,M., Kastriti,M.E., Krivanek,J., Radaszkiewicz,T.,
            Gomoryova,K., Knauth,S., Potesil,D., Zdrahal,Z., Ganji,R.S.,
            Grabowski,A., Buhl,M.E., Zikmund,T., Kavkova,M., Axelson,H.,
            Lindgren,D., Kramann,R., Kuppe,C., Erdelyi,F., Mate,Z., Szabo,G.,
            Koehne,T., Harkany,T., Fried,K., Kaiser,J., Boor,P., Fekete,C.,
            Rozman,J., Kasparek,P., Prochazka,J., Sedlacek,R., Bryja,V.,
            Gusev,O. and Adameyko,I.
  TITLE     A previously uncharacterized Factor Associated with Metabolism and
            Energy (FAME/C14orf105/CCDC198/1700011H14Rik) is related to
            evolutionary adaptation, energy balance, and kidney physiology
  JOURNAL   Nat Commun 14 (1), 3092 (2023)
   PUBMED   37248239
  REMARK    Erratum:[Nat Commun. 2023 Jun 15;14(1):3565. doi:
            10.1038/s41467-023-39373-w.. PMID: 37322005]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3088)
  AUTHORS   Aksorn,N., Roytrakul,S., Kittisenachai,S., Leelawat,K.,
            Chanvorachote,P., Topanurak,S., Hamano,S. and Lek-Uthai,U.
  TITLE     Novel Potential Biomarkers for Opisthorchis viverrini Infection and
            Associated Cholangiocarcinoma
  JOURNAL   In Vivo 32 (4), 871-878 (2018)
   PUBMED   29936472
  REMARK    GeneRIF: According to our analysis, three proteins, namely
            aristaless-like homeobox1 isoform X1 (ALX1), major
            histocompatibility complex polypeptide-related sequence A (MICA),
            and uncharacterized protein C14orf105 isoform X12 were found to be
            potential markers for Opisthorchis viverrini (OV)- infection, as
            they were predominantly found in all OV-infected groups
REFERENCE   3  (bases 1 to 3088)
  AUTHORS   Nowicka-Bauer,K., Ozgo,M., Lepczynski,A., Kamieniczna,M.,
            Malcher,A., Skrzypczak,W. and Kurpisz,M.
  TITLE     Human sperm proteins identified by 2-dimensional electrophoresis
            and mass spectrometry and their relevance to a transcriptomic
            analysis
  JOURNAL   Reprod Biol 18 (2), 151-160 (2018)
   PUBMED   29526398
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BX470593.1, AK223127.1, AL355834.4 and AK001512.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 2, 2019 this sequence version replaced NM_018168.3.
            
            Transcript Variant: This variant (2) lacks an exon and uses an
            alternate splice site in the coding region, but maintains the
            reading frame, compared to variant 1. The encoded isoform (2) is
            shorter than isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK001512.1, AK223127.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN04284274 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000216445.8/ ENSP00000216445.3
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-6                 BX470593.1         19-24
            7-845               AK223127.1         1-839
            846-846             AL355834.4         200887-200887       c
            847-1213            AK223127.1         841-1207
            1214-2384           AK001512.1         1209-2379
            2385-3088           AL355834.4         198645-199348       c
FEATURES             Location/Qualifiers
     source          1..3088
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q22.3"
     gene            1..3088
                     /gene="CCDC198"
                     /gene_synonym="C14orf105; FAME"
                     /note="coiled-coil domain containing 198"
                     /db_xref="GeneID:55195"
                     /db_xref="HGNC:HGNC:20189"
     exon            1..365
                     /gene="CCDC198"
                     /gene_synonym="C14orf105; FAME"
                     /inference="alignment:Splign:2.1.0"
     CDS             143..1033
                     /gene="CCDC198"
                     /gene_synonym="C14orf105; FAME"
                     /note="isoform 2 is encoded by transcript variant 2;
                     uncharacterized protein C14orf105; Factor Associated with
                     Metabolism and Energy"
                     /codon_start=1
                     /product="factor associated with metabolism and energy
                     isoform 2"
                     /protein_id="NP_060638.2"
                     /db_xref="CCDS:CCDS9730.1"
                     /db_xref="GeneID:55195"
                     /db_xref="HGNC:HGNC:20189"
                     /translation="MGLSHSKTHLRVIKVAPLQNKEVETPSAGRVDFAFNQNLEEKTS
                     YSLARLQDQNKALEGQLPPLQENWYGRYSTASRDMYFDIPLEHRETSIIKRHPPQRLQ
                     KLEPIDLPRVITSGRLLSQREARTMHKAKQVLEKKMQTPMYTSENRQYLHKMQVLEMI
                     RKRQEAQMELKKSLHGEARINKQSPRDHKAKKTLQSTPRNDDHDLLTMLPDEILNRGP
                     GNSKNTEFLKHQAVNNYCPWKIGKMETWLHEQEAQGQLLWDSSSSDSDEQGKDEKKPR
                     ALVRTRTERIPLFDEFFDQE"
     exon            366..448
                     /gene="CCDC198"
                     /gene_synonym="C14orf105; FAME"
                     /inference="alignment:Splign:2.1.0"
     exon            449..535
                     /gene="CCDC198"
                     /gene_synonym="C14orf105; FAME"
                     /inference="alignment:Splign:2.1.0"
     exon            536..637
                     /gene="CCDC198"
                     /gene_synonym="C14orf105; FAME"
                     /inference="alignment:Splign:2.1.0"
     exon            638..797
                     /gene="CCDC198"
                     /gene_synonym="C14orf105; FAME"
                     /inference="alignment:Splign:2.1.0"
     exon            798..3088
                     /gene="CCDC198"
                     /gene_synonym="C14orf105; FAME"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1214..1219
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CCDC198"
                     /gene_synonym="C14orf105; FAME"
                     /note="hexamer: ACTAAA"
     polyA_site      1247
                     /gene="CCDC198"
                     /gene_synonym="C14orf105; FAME"
                     /note="major polyA site"
     regulatory      2039..2044
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CCDC198"
                     /gene_synonym="C14orf105; FAME"
                     /note="hexamer: ATTAAA"
     polyA_site      2061
                     /gene="CCDC198"
                     /gene_synonym="C14orf105; FAME"
                     /note="major polyA site"
     regulatory      3064..3069
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CCDC198"
                     /gene_synonym="C14orf105; FAME"
                     /note="hexamer: ATTAAA"
     polyA_site      3088
                     /gene="CCDC198"
                     /gene_synonym="C14orf105; FAME"
                     /note="major polyA site"
ORIGIN      
        1 agagctagaa ggatgccatg aaggaaatga ctgctttgta aagcgagggt aaacttctga
       61 aatgctttga ttaaaataag ctatattaaa gaccccaaaa ccacttccct cgcagctttc
      121 ctctgaatgt ctttcacatg aaatgggcct gagtcactct aagactcacc ttagggtgat
      181 caaagtagca cctttgcaaa acaaagaggt agagactccc tcggctggcc gtgtggactt
      241 tgcattcaat cagaatttgg aagaaaagac ttcatattca ctggcaagac tgcaggacca
      301 gaataaagcc ttggaagggc agctgccacc tttacaagaa aactggtatg gaagatattc
      361 tacagcatcc agagacatgt attttgacat cccactggaa cacagagaaa caagtattat
      421 taaaaggcat ccaccccaaa gacttcaaaa gcttgaaccc attgacttgc cacgagtaat
      481 tacttcagga agactcctga gccagcgaga agccaggaca atgcacaaag caaagcaggt
      541 actagaaaag aaaatgcaaa ctccaatgta tacttctgag aacagacaat atttgcataa
      601 gatgcaagtg ctggaaatga tccgtaaaag acaagaggcc caaatggagt taaagaaaag
      661 tcttcatgga gaggcaagaa ttaataagca aagtccaagg gaccataaag ccaagaaaac
      721 ccttcaaagc accccaagga atgatgacca tgaccttcta accatgttgc ctgatgaaat
      781 cttgaacaga ggtcccggaa attcaaagaa tacagaattt ttgaaacatc aagcagtgaa
      841 taactactgt ccctggaaaa ttggcaaaat ggaaacatgg cttcatgaac aagaggccca
      901 gggacagctt ctctgggaca gttccagctc tgactcagat gagcagggga aagatgagaa
      961 gaagccacga gcactggtga ggaccaggac agagagaatc ccacttttcg atgagttttt
     1021 tgatcaagaa taagaatact attcattaac ctagaaactg agtgctttga aagcttgttt
     1081 tactctcaaa atcttccaaa ctgatatatg aattactttg aggacagcaa atcactttgg
     1141 taaaaagaaa tgatatcttt agagtcttat gattaacaag tccgtcacat gtgctgttaa
     1201 ctattgctgc ataactaaat gcctcaaaac acaggggcta accaagagcc attttattgt
     1261 ctcactttcc tgtgggttgc tgagttcagc taggtggttc ttctgctgtt cccttttgaa
     1321 atctttcatg tcattgaaat tggactacat ttggactact aagactggag tcatccagag
     1381 gccccattag gacactgaca cagggggacc ttgcccccta tccatgtagc ctcagagcat
     1441 ctgcatatga tctcttcagc aggacactgc agagatttct ctcatatgag cccagggctc
     1501 ccaaaagcaa ttgtctcaag aggaggaaac agaagttgcc agtcttctta aaagctagtc
     1561 atagaactga ctttgcatca cttccaccat gttctgttgg ttaaagtcat agaccagctt
     1621 ggagttaatg cagaagagga ctacacaagg gcatgagtgc caaagtgtgg tcctttgggg
     1681 ttcatctttg acatttgcca cctcaccatg tttttaaaaa gaaaattaga ttacataaaa
     1741 caaatagatg ggctggatgt ggtggctcac acctgtaatc ccagcacttt gggaggccga
     1801 ggtgggcaga tcacttgagg tcaggagttc aagaccagcc tggccaacat ggtgagacac
     1861 cgtctctact aaaatacaaa aattagccag acatggtggc attcgtctgt aatcccagct
     1921 acttgatgcg aaggctgagg caaaagaatt gcttgaaccc aggagataga ggttgcaatg
     1981 agccaagatc actccactgc actccagcct gggcgacaga atgagactct gtctcaaaat
     2041 taaaaaacaa aaaaccaaaa acaaatagat gaaaaagtag actggagaca aataaaagtg
     2101 agtttctaaa ggaaattcac agtaatgctg cattaaacac taagctcact taggtcactt
     2161 tctagtgagc taaccgtaac agagagccta caggatacac gtgagataat gtcacgtgta
     2221 gaagatcgtt gtgaattaaa gttcaaaatt aagacttctt agattatgat gtagatttta
     2281 gagctcctta aaacataaag cgaatcttat aaatgttcaa ttctaaagtt attccacttg
     2341 gaaaaattag cttttgggac aatttttaag aacttttgtg taaaatgcag ctccatgttt
     2401 agcataatct aaaaataatt tcaagcaatc cagaatcttc caagaattta ttaaagcttt
     2461 aaaacaaagc aaaacaaaaa gacccttttg tgccttatat gggaagactc caaaaacaga
     2521 aaaaaataga ggaaaacacc acttcaattt gacattcaat gcattcacat cagaaactaa
     2581 gaagataaca agcctgagat gtcaggtgat aaaaattcat gtttcttcca aggacagaag
     2641 gctattagat tgtcccaggc catatctatt cccagttctt tgtgagtagt cttcttactt
     2701 tttctgtggt aggtaagaag catatttcca ccaaaagaaa gcatgcattg tttgactagc
     2761 cagctttcta gaaaaaatga gatccttgag aggataaaca aatccaacct attcatggtg
     2821 tcctcactta ttgtggtcaa tttggaaggc ttaaaacaca aaaaatggga tggataactt
     2881 tgaacactaa aattagtgga gccaaaggca cgtcttcacc attctgttat gtgacttaaa
     2941 attcaatttc acgaaaccca cttccacaag cttaatgaac tgtgagctac atgagggcat
     3001 aaaccatgtc ttctttgtat ggtatttctg cttcctagca ggacagctgg caaagagttt
     3061 atcattaaat gtttgctgaa ttaatgaa
//
