LOCUS       NM_001351596            1274 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens coiled-coil domain containing 197 (CCDC197),
            transcript variant 4, mRNA.
ACCESSION   NM_001351596
VERSION     NM_001351596.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1274)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 1274)
  AUTHORS   Namciu,S.J., Friedman,R.D., Marsden,M.D., Sarausad,L.M.,
            Jasoni,C.L. and Fournier,R.E.
  TITLE     Sequence organization and matrix attachment regions of the human
            serine protease inhibitor gene cluster at 14q32.1
  JOURNAL   Mamm Genome 15 (3), 162-178 (2004)
   PUBMED   15014966
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL079302.7.
            
            On May 17, 2019 this sequence version replaced NM_001351596.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189667.77306.1,
                                           SRR5189667.328548.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2148093
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000636493.2/ ENSP00000490086.1
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-271               AL079302.7         82638-82908
            272-508             AL079302.7         83336-83572
            509-591             AL079302.7         84920-85002
            592-770             AL079302.7         86482-86660
            771-902             AL079302.7         88560-88691
            903-1019            AL079302.7         90192-90308
            1020-1274           AL079302.7         93946-94200
FEATURES             Location/Qualifiers
     source          1..1274
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q32.12"
     gene            1..1274
                     /gene="CCDC197"
                     /gene_synonym="C14orf48; c14_5713; LINC00521"
                     /note="coiled-coil domain containing 197"
                     /db_xref="GeneID:256369"
                     /db_xref="HGNC:HGNC:19860"
     exon            1..271
                     /gene="CCDC197"
                     /gene_synonym="C14orf48; c14_5713; LINC00521"
                     /inference="alignment:Splign:2.1.0"
     exon            272..508
                     /gene="CCDC197"
                     /gene_synonym="C14orf48; c14_5713; LINC00521"
                     /inference="alignment:Splign:2.1.0"
     CDS             405..1223
                     /gene="CCDC197"
                     /gene_synonym="C14orf48; c14_5713; LINC00521"
                     /note="isoform 1 is encoded by transcript variant 4; long
                     intergenic non-protein coding RNA 521; coiled-coil
                     domain-containing protein 197"
                     /codon_start=1
                     /product="uncharacterized protein CCDC197 isoform 1"
                     /protein_id="NP_001338525.1"
                     /db_xref="CCDS:CCDS86426.1"
                     /db_xref="GeneID:256369"
                     /db_xref="HGNC:HGNC:19860"
                     /translation="MAAMDTGQRADPSNPGDKEGDLQGLWQELYQLQAKQKKLKREVE
                     KHKLFEDYLIKVLEKIPEGCTGWEEPEEVLVEATVKHYGKLFTASQDTQKRLEAFCQM
                     IQAVHRSLESLEEDHRALMLSLKIRLCQLQKKCYRKQEQWWQLKHSITYQKDIDFDTH
                     TSSSYNDQLLGYMQMTITNMARQCCPSAHGVPKSMDLFSKLDLIKEFMLDKMETVRLI
                     ALLTEPKVCWSWDSFGDQWLRRHPKPFRKCPRRRVSTPRTPFPSPHASECSGLY"
     exon            509..591
                     /gene="CCDC197"
                     /gene_synonym="C14orf48; c14_5713; LINC00521"
                     /inference="alignment:Splign:2.1.0"
     exon            592..770
                     /gene="CCDC197"
                     /gene_synonym="C14orf48; c14_5713; LINC00521"
                     /inference="alignment:Splign:2.1.0"
     exon            771..902
                     /gene="CCDC197"
                     /gene_synonym="C14orf48; c14_5713; LINC00521"
                     /inference="alignment:Splign:2.1.0"
     exon            903..1019
                     /gene="CCDC197"
                     /gene_synonym="C14orf48; c14_5713; LINC00521"
                     /inference="alignment:Splign:2.1.0"
     exon            1020..1274
                     /gene="CCDC197"
                     /gene_synonym="C14orf48; c14_5713; LINC00521"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agctaggccc cttcctcctc cagtgcctgt ctacctatgt ttgatgcttg gggctagaaa
       61 gactgacctt gtagcccctc accttctctc cccaatgcac tgggctggtt cagcagctga
      121 ccaatgaggg tcatgcttgc atactggcct tgggtgagtg gctcaggaac agtttgcaag
      181 accgtgttga agctacttgt aactagacca ttttcccagc ttgaccatga gcttcttcaa
      241 ggcatctctt ctcagtctcc actgtagctc tgtggggatg ctaaccctgg cttccaagga
      301 tctgaagagg aagctgcggc tgtgactgtc ccttttcggt ctgtcttcat cctgcctgac
      361 tcacgggtct cctgtcctcc tgcatagctt gcggtggtga ggtgatggca gccatggaca
      421 caggccagag agctgaccca agcaatcctg gtgacaagga aggggacctt caagggctgt
      481 ggcaggaact ctaccagctc caggctaagc agaagaagct caagagagaa gtcgagaagc
      541 acaagctttt tgaagactat ctgattaagg tccttgagaa aatccccgag ggctgcacgg
      601 gatgggagga gccggaggag gtgctggtgg aggccacggt gaagcactac gggaagctct
      661 tcacagccag ccaggacacg cagaagcgcc tcgaggcctt ctgccagatg atccaggctg
      721 tccaccggag cctggagtct ctggaggagg accacagggc tctcatgttg agcctcaaga
      781 tccggctgtg tcagctgcag aagaagtgct accgcaagca ggagcagtgg tggcagctga
      841 agcacagcat cacttaccag aaggacattg actttgacac acacaccagc agcagctata
      901 atgatcagct gctcggctac atgcaaatga ccatcaccaa catggcccgg cagtgctgcc
      961 cctctgccca cggcgtgccc aagagcatgg atctcttctc caagctcgat ctgattaagg
     1021 agttcatgtt ggacaaaatg gagactgtaa gactgatcgc actgctcacg gaacccaaag
     1081 tgtgctggtc atgggacagc ttcggggacc agtggctcag aagacacccc aaacccttca
     1141 ggaaatgtcc aaggaggcgg gtttccaccc ccaggacccc ctttcccagc ccccatgctt
     1201 cagagtgctc cggcctgtac tgaccagcct gcgccttgca ggccccatgg catcacgacc
     1261 tctccttacc tgcc
//
