LOCUS       NM_001351576            1107 bp    mRNA    linear   PRI 08-OCT-2024
DEFINITION  Homo sapiens coiled-coil domain containing 196 (CCDC196),
            transcript variant 5, mRNA.
ACCESSION   NM_001351576
VERSION     NM_001351576.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1107)
  AUTHORS   Jiang,C., Li,F., Yang,M., Duan,J., Lai,J., Sun,S. and Fan,S.
  TITLE     LINC00238 inhibits hepatic carcinoma progression by activating
            TMEM106C-mediated apoptosis pathway
  JOURNAL   Mol Med Rep 24 (5) (2021)
   PUBMED   34476506
  REMARK    GeneRIF: LINC00238 inhibits hepatic carcinoma progression by
            activating TMEM106Cmediated apoptosis pathway.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL355093.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA1968968,
                              SAMEA2148093 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            MANE Ensembl match        :: ENST00000636229.1/ ENSP00000489898.1
            RefSeq Select criteria    :: based on manual assertion,
                                         conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-182               AL355093.3         54622-54803         c
            183-335             AL355093.3         54365-54517         c
            336-432             AL355093.3         52918-53014         c
            433-483             AL355093.3         52137-52187         c
            484-561             AL355093.3         50355-50432         c
            562-645             AL355093.3         50070-50153         c
            646-705             AL355093.3         49489-49548         c
            706-847             AL355093.3         48980-49121         c
            848-906             AL355093.3         43007-43065         c
            907-1107            AL355093.3         42621-42821         c
FEATURES             Location/Qualifiers
     source          1..1107
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q23.3"
     gene            1..1107
                     /gene="CCDC196"
                     /gene_synonym="C14orf53; LINC00238; NCRNA00238"
                     /note="coiled-coil domain containing 196"
                     /db_xref="GeneID:440184"
                     /db_xref="HGNC:HGNC:20100"
     exon            1..182
                     /gene="CCDC196"
                     /gene_synonym="C14orf53; LINC00238; NCRNA00238"
                     /inference="alignment:Splign:2.1.0"
     CDS             133..1026
                     /gene="CCDC196"
                     /gene_synonym="C14orf53; LINC00238; NCRNA00238"
                     /note="long intergenic non-protein coding RNA 238"
                     /codon_start=1
                     /product="putative coiled-coil domain-containing protein
                     196"
                     /protein_id="NP_001338505.1"
                     /db_xref="CCDS:CCDS86402.1"
                     /db_xref="GeneID:440184"
                     /db_xref="HGNC:HGNC:20100"
                     /translation="MTSGANSSGSYLPSEIRSSKIDDNYLKELNEDLKLRKQELLEML
                     KPLEDKNNLLFQKLMSNLEEKQRSLQIMRQIMAGKGCEESSVMELLKEAEEMKQNLER
                     KNKMLRKEMEMLWNKTFEAEELSDQQKAPQTKNKADLQDGKAPKSPSSPRKTESELEK
                     SFAEKVKEIRKEKQQRKMEWVKYQEQNNILQNDFHGKVIELRIEALKNYQKANDLKLS
                     LYLQQNFEPMQAFLNLPGSQGTMGITTMDRVTTGRNEHHVRILGTKIYTEQQGTKGSQ
                     LDNTGGRLFFLRSLPDEALKN"
     exon            183..335
                     /gene="CCDC196"
                     /gene_synonym="C14orf53; LINC00238; NCRNA00238"
                     /inference="alignment:Splign:2.1.0"
     exon            336..432
                     /gene="CCDC196"
                     /gene_synonym="C14orf53; LINC00238; NCRNA00238"
                     /inference="alignment:Splign:2.1.0"
     exon            433..483
                     /gene="CCDC196"
                     /gene_synonym="C14orf53; LINC00238; NCRNA00238"
                     /inference="alignment:Splign:2.1.0"
     exon            484..561
                     /gene="CCDC196"
                     /gene_synonym="C14orf53; LINC00238; NCRNA00238"
                     /inference="alignment:Splign:2.1.0"
     exon            562..645
                     /gene="CCDC196"
                     /gene_synonym="C14orf53; LINC00238; NCRNA00238"
                     /inference="alignment:Splign:2.1.0"
     exon            646..705
                     /gene="CCDC196"
                     /gene_synonym="C14orf53; LINC00238; NCRNA00238"
                     /inference="alignment:Splign:2.1.0"
     exon            706..847
                     /gene="CCDC196"
                     /gene_synonym="C14orf53; LINC00238; NCRNA00238"
                     /inference="alignment:Splign:2.1.0"
     exon            848..906
                     /gene="CCDC196"
                     /gene_synonym="C14orf53; LINC00238; NCRNA00238"
                     /inference="alignment:Splign:2.1.0"
     exon            907..1107
                     /gene="CCDC196"
                     /gene_synonym="C14orf53; LINC00238; NCRNA00238"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1087..1092
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CCDC196"
                     /gene_synonym="C14orf53; LINC00238; NCRNA00238"
                     /note="hexamer: ATTAAA"
     polyA_site      1107
                     /gene="CCDC196"
                     /gene_synonym="C14orf53; LINC00238; NCRNA00238"
                     /note="major polyA site"
ORIGIN      
        1 gctgtagcta agatcagtcc actgcagcag gagtttcaag aacagcagca caaaaataat
       61 gacttaactg gatagaaaaa aaggcacata ttttcaggaa ggcctcttta ttcttagaag
      121 ttacccttca agatgacaag tggtgcaaac tcttcaggat cttacctgcc ctcagaaata
      181 agaagttcta aaatagatga caactacttg aaggaattga atgaggactt aaagctaagg
      241 aagcaggaac tgctagagat gctcaaacct ctagaagata aaaacaacct cttatttcaa
      301 aagttaatgt ctaacttgga ggaaaaacaa aggagtcttc agatcatgag acagatcatg
      361 gcagggaagg ggtgtgagga atcctcggtc atggagctcc ttaaggaagc agaggagatg
      421 aaacagaact tggaaaggaa aaacaagatg cttcggaagg aaatggagat gctatggaac
      481 aagacattcg aggcagaaga acttagtgat caacaaaaag caccacagac aaaaaacaag
      541 gcagacttgc aggatggaaa ggctcccaaa tccccctcat cacctaggaa gactgagagt
      601 gaactggaga aatcatttgc agagaaagtg aaggagataa ggaaggaaaa gcaacagagg
      661 aaaatggaat gggtcaagta tcaggaacaa aataacatcc ttcagaatga ttttcatggc
      721 aaagtgattg agctgagaat tgaagccttg aagaactacc agaaggccaa tgacctgaaa
      781 ttatcactgt atttgcagca gaattttgag ccaatgcaag catttttaaa tcttcctggg
      841 tcccaaggta ctatgggcat tacaactatg gacagagtga ctactggcag aaatgaacac
      901 catgtgagaa ttctgggaac aaagatctac acagaacaac aaggaactaa aggaagtcag
      961 cttgataata caggagggag actctttttt ctgaggtcat tgccagatga agcactgaag
     1021 aattagcagg ctttcgctcc atttgctttg gacagattta aagactaggc acagccattt
     1081 gtgttaatta aaatctctcg caccttt
//
