LOCUS       NM_001300969            1917 bp    mRNA    linear   PRI 12-JUL-2024
DEFINITION  Homo sapiens coiled-coil domain containing 181 (CCDC181),
            transcript variant 3, mRNA.
ACCESSION   NM_001300969 XM_005245381 XM_005245382
VERSION     NM_001300969.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1917)
  AUTHORS   Schwarz,T., Prieler,B., Schmid,J.A., Grzmil,P. and Neesen,J.
  TITLE     Ccdc181 is a microtubule-binding protein that interacts with Hook1
            in haploid male germ cells and localizes to the sperm tail and
            motile cilia
  JOURNAL   Eur J Cell Biol 96 (3), 276-288 (2017)
   PUBMED   28283191
REFERENCE   2  (bases 1 to 1917)
  AUTHORS   Ehret,G.B., O'Connor,A.A., Weder,A., Cooper,R.S. and Chakravarti,A.
  TITLE     Follow-up of a major linkage peak on chromosome 1 reveals
            suggestive QTLs associated with essential hypertension: GenNet
            study
  JOURNAL   Eur J Hum Genet 17 (12), 1650-1657 (2009)
   PUBMED   19536175
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   3  (bases 1 to 1917)
  AUTHORS   Harrington,J.J., Sherf,B., Rundlett,S., Jackson,P.D., Perry,R.,
            Cain,S., Leventhal,C., Thornton,M., Ramachandran,R.,
            Whittington,J., Lerner,L., Costanzo,D., McElligott,K., Boozer,S.,
            Mays,R., Smith,E., Veloso,N., Klika,A., Hess,J., Cothren,K., Lo,K.,
            Offenbacher,J., Danzig,J. and Ducar,M.
  TITLE     Creation of genome-wide protein expression libraries using random
            activation of gene expression
  JOURNAL   Nat Biotechnol 19 (5), 440-445 (2001)
   PUBMED   11329013
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC026073.2, AL049687.1, AK223354.1 and BG206257.1.
            
            On Aug 13, 2020 this sequence version replaced NM_001300969.1.
            
            Transcript Variant: This variant (3) differs in the 5' UTR and uses
            an alternate in-frame splice site, compared to variant 1. The
            encoded isoform (b) is longer than isoform a.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK223354.1, AK098712.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000367806.8/ ENSP00000356780.3
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-42                BC026073.2         1-42
            43-1139             AL049687.1         1-1097
            1140-1775           AK223354.1         1083-1718
            1776-1917           BG206257.1         360-501
FEATURES             Location/Qualifiers
     source          1..1917
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q24.2"
     gene            1..1917
                     /gene="CCDC181"
                     /gene_synonym="C1orf114"
                     /note="coiled-coil domain containing 181"
                     /db_xref="GeneID:57821"
                     /db_xref="HGNC:HGNC:28051"
                     /db_xref="MIM:620891"
     exon            1..187
                     /gene="CCDC181"
                     /gene_synonym="C1orf114"
                     /inference="alignment:Splign:2.1.0"
     exon            188..327
                     /gene="CCDC181"
                     /gene_synonym="C1orf114"
                     /inference="alignment:Splign:2.1.0"
     CDS             211..1740
                     /gene="CCDC181"
                     /gene_synonym="C1orf114"
                     /note="isoform b is encoded by transcript variant 3;
                     coiled-coil domain-containing protein 181"
                     /codon_start=1
                     /product="coiled-coil domain-containing protein 181
                     isoform b"
                     /protein_id="NP_001287898.1"
                     /db_xref="CCDS:CCDS72979.1"
                     /db_xref="GeneID:57821"
                     /db_xref="HGNC:HGNC:28051"
                     /db_xref="MIM:620891"
                     /translation="MNENKDTDSKKSEEYEDDFEKDLEWLINENEKSDASIIEMACEK
                     EENINQDLKENETVMEHTKRHSDPDKSLQDEVSPRRNDIISVPGIQPLDPISDSDSEN
                     SFQESKLESQKDLEEEEDEEVRRYIMEKIVQANKLLQNQEPVNDKRERKLKFKDQLVD
                     LEVPPLEDTTTFKNYFENERNMFGKLSQLCISNDFGQEDVLLSLTNGSCEENKDRTIL
                     VERDGKFELLNLQDIASQGFLPPINNANSTENDPQQLLPRSSNSSVSGTKKEDSTAKI
                     HAVTHSSTGEPLAYIAQPPLNRKTCPSSAVNSDRSKGNGKSNHRTQSAHISPVTSTYC
                     LSPRQKELQKQLEEKREKLKREEERRKIEEEKEKKRENDIVFKAWLQKKREQVLEMRR
                     IQRAKEIEDMNSRQENRDPQQAFRLWLKKKHEEQMKERQTEELRKQEECLFFLKGTEG
                     RERAFKQWLRRKRMEKMAEQQAVRERTRQLRLEAKRSKQLQHHLYMSEAKPFRFTDHY
                     N"
     exon            328..1278
                     /gene="CCDC181"
                     /gene_synonym="C1orf114"
                     /inference="alignment:Splign:2.1.0"
     exon            1279..1425
                     /gene="CCDC181"
                     /gene_synonym="C1orf114"
                     /inference="alignment:Splign:2.1.0"
     exon            1426..1580
                     /gene="CCDC181"
                     /gene_synonym="C1orf114"
                     /inference="alignment:Splign:2.1.0"
     exon            1581..1917
                     /gene="CCDC181"
                     /gene_synonym="C1orf114"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1890..1895
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CCDC181"
                     /gene_synonym="C1orf114"
                     /note="hexamer: AATAAA"
     polyA_site      1917
                     /gene="CCDC181"
                     /gene_synonym="C1orf114"
                     /note="major polyA site"
ORIGIN      
        1 gctctcgtag ttagagaggc ccggatggag gacgcagagg cacgctgttg ccatggcagt
       61 gtggtcctgg ctgccgcgga ggcaggtgcc ggggtctcct ttgcctcaat gtgaagagct
      121 tagaaagagg aggagaggag aactcccccg gccatctctg tgatcccagc cgccgcattt
      181 tacacagcat atttccttca caaacagaaa atgaatgaaa ataaagatac tgattcaaag
      241 aaaagtgaag aatacgaaga tgactttgaa aaggacctgg agtggttaat taatgaaaat
      301 gaaaaaagtg atgccagcat aatagagatg gcttgtgaga aggaagagaa tattaaccaa
      361 gacttaaaag agaatgagac agtaatggag cacaccaaac ggcattctga tcctgacaaa
      421 tctttgcagg atgaggtctc accaagaaga aatgacatca tttctgtacc aggtattcaa
      481 cctttggatc ccatatcaga ttcagatagt gaaaactctt tccaggaatc caaactagaa
      541 agccagaaag acttggagga ggaagaggat gaggaagtaa ggagatatat tatggagaaa
      601 attgtacaag ctaacaagct tctacagaat caagaaccgg tgaatgataa aagggagcga
      661 aaacttaagt tcaaggacca gttagttgat ttggaagttc ctccactaga agacactact
      721 acttttaaaa attattttga aaacgaaagg aatatgtttg ggaaactgtc acaattatgt
      781 atttccaatg attttggaca agaagatgtg ctcctgtcac ttactaatgg aagctgtgaa
      841 gaaaacaagg ataggacaat actggtagag agagatggaa aatttgaact tctgaattta
      901 caagacattg ccagtcaggg gtttttgcct cccattaata atgcaaatag tacagaaaat
      961 gaccctcagc agttgttacc cagatcttcc aactcctctg tcagtggcac caagaaagaa
     1021 gattctacag caaagattca tgctgtcact cactcatcaa caggagagcc gctggcttat
     1081 atcgctcagc caccactcaa ccgcaagact tgtccaagct ctgctgtcaa ctcagatcga
     1141 agtaaaggga atgggaaatc taatcacagg acacagtctg cacatatctc accagtgact
     1201 tcaacatact gtctttcccc tcgacagaaa gaactacaaa aacaactaga agaaaagaga
     1261 gaaaaactga aaagagagga agagcgacga aaaatagaag aagagaaaga aaaaaagaga
     1321 gagaatgaca tagtatttaa agcgtggttg caaaagaaaa gagagcaggt cttagaaatg
     1381 aggagaattc agcgagcaaa ggaaattgaa gacatgaaca gtagacagga aaacagagat
     1441 ccacaacaag cttttcgatt atggcttaaa aaaaagcacg aagagcagat gaaagaaaga
     1501 cagacagaag aactaagaaa gcaagaggaa tgtttattct tccttaaagg aacagaaggc
     1561 cgggaaaggg cctttaaaca atggttaaga aggaaacgga tggaaaaaat ggcagagcaa
     1621 caagctgtca gagagagaac tagacagctc cgactagaag ctaagcgttc taaacagtta
     1681 cagcaccacc tatatatgtc agaagccaaa ccttttcgtt ttactgatca ttataactga
     1741 aagtttctat taaatatttc agtgggcagc tgctatcaaa attttggata tgatttctta
     1801 gggtctgtgt actttggttg tattctaaat tatggaaatg gtatttatct tttattgaca
     1861 gtgaatttgt ttttttaata ctagaacaaa ataaattttt ttctcacagt gttgtaa
//
