LOCUS       NM_020893               7060 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens coiled-coil domain containing 180 (CCDC180),
            transcript variant 1, mRNA.
ACCESSION   NM_020893
VERSION     NM_020893.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7060)
  AUTHORS   Aoyama,T., Takasawa,A., Takasawa,K., Ono,Y., Emori,M., Murata,M.,
            Hayasaka,T., Fujitani,N., Osanai,M., Yamashita,T., Hasegawa,T. and
            Sawada,N.
  TITLE     Identification of Coiled-Coil Domain-Containing Protein 180 and
            Leucine-Rich Repeat-Containing Protein 4 as Potential
            Immunohistochemical Markers for Liposarcoma Based on Proteomic
            Analysis Using Formalin-Fixed, Paraffin-Embedded Tissue
  JOURNAL   Am J Pathol 189 (5), 1015-1028 (2019)
   PUBMED   30790560
  REMARK    GeneRIF: High CCDC180 expression is associated with Liposarcoma .
REFERENCE   2  (bases 1 to 7060)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   3  (bases 1 to 7060)
  AUTHORS   Fei,Y., Webb,R., Cobb,B.L., Direskeneli,H., Saruhan-Direskeneli,G.
            and Sawalha,A.H.
  TITLE     Identification of novel genetic susceptibility loci for Behcet's
            disease using a genome-wide association study
  JOURNAL   Arthritis Res Ther 11 (3), R66 (2009)
   PUBMED   19442274
REFERENCE   4  (bases 1 to 7060)
  AUTHORS   Vieira,A.R., McHenry,T.G., Daack-Hirsch,S., Murray,J.C. and
            Marazita,M.L.
  TITLE     Candidate gene/loci studies in cleft lip/palate and dental
            anomalies finds novel susceptibility genes for clefts
  JOURNAL   Genet Med 10 (9), 668-674 (2008)
   PUBMED   18978678
REFERENCE   5  (bases 1 to 7060)
  AUTHORS   Yu,L.R., Zhu,Z., Chan,K.C., Issaq,H.J., Dimitrov,D.S. and
            Veenstra,T.D.
  TITLE     Improved titanium dioxide enrichment of phosphopeptides from HeLa
            cells and high confident phosphopeptide identification by
            cross-validation of MS/MS and MS/MS/MS spectra
  JOURNAL   J Proteome Res 6 (11), 4150-4162 (2007)
   PUBMED   17924679
REFERENCE   6  (bases 1 to 7060)
  AUTHORS   Bechtel,S., Rosenfelder,H., Duda,A., Schmidt,C.P., Ernst,U.,
            Wellenreuther,R., Mehrle,A., Schuster,C., Bahr,A., Blocker,H.,
            Heubner,D., Hoerlein,A., Michel,G., Wedler,H., Kohrer,K.,
            Ottenwalder,B., Poustka,A., Wiemann,S. and Schupp,I.
  TITLE     The full-ORF clone resource of the German cDNA Consortium
  JOURNAL   BMC Genomics 8, 399 (2007)
   PUBMED   17974005
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 7060)
  AUTHORS   Humphray,S.J., Oliver,K., Hunt,A.R., Plumb,R.W., Loveland,J.E.,
            Howe,K.L., Andrews,T.D., Searle,S., Hunt,S.E., Scott,C.E.,
            Jones,M.C., Ainscough,R., Almeida,J.P., Ambrose,K.D., Ashwell,R.I.,
            Babbage,A.K., Babbage,S., Bagguley,C.L., Bailey,J., Banerjee,R.,
            Barker,D.J., Barlow,K.F., Bates,K., Beasley,H., Beasley,O.,
            Bird,C.P., Bray-Allen,S., Brown,A.J., Brown,J.Y., Burford,D.,
            Burrill,W., Burton,J., Carder,C., Carter,N.P., Chapman,J.C.,
            Chen,Y., Clarke,G., Clark,S.Y., Clee,C.M., Clegg,S., Collier,R.E.,
            Corby,N., Crosier,M., Cummings,A.T., Davies,J., Dhami,P., Dunn,M.,
            Dutta,I., Dyer,L.W., Earthrowl,M.E., Faulkner,L., Fleming,C.J.,
            Frankish,A., Frankland,J.A., French,L., Fricker,D.G., Garner,P.,
            Garnett,J., Ghori,J., Gilbert,J.G., Glison,C., Grafham,D.V.,
            Gribble,S., Griffiths,C., Griffiths-Jones,S., Grocock,R., Guy,J.,
            Hall,R.E., Hammond,S., Harley,J.L., Harrison,E.S., Hart,E.A.,
            Heath,P.D., Henderson,C.D., Hopkins,B.L., Howard,P.J., Howden,P.J.,
            Huckle,E., Johnson,C., Johnson,D., Joy,A.A., Kay,M., Keenan,S.,
            Kershaw,J.K., Kimberley,A.M., King,A., Knights,A., Laird,G.K.,
            Langford,C., Lawlor,S., Leongamornlert,D.A., Leversha,M., Lloyd,C.,
            Lloyd,D.M., Lovell,J., Martin,S., Mashreghi-Mohammadi,M.,
            Matthews,L., McLaren,S., McLay,K.E., McMurray,A., Milne,S.,
            Nickerson,T., Nisbett,J., Nordsiek,G., Pearce,A.V., Peck,A.I.,
            Porter,K.M., Pandian,R., Pelan,S., Phillimore,B., Povey,S.,
            Ramsey,Y., Rand,V., Scharfe,M., Sehra,H.K., Shownkeen,R.,
            Sims,S.K., Skuce,C.D., Smith,M., Steward,C.A., Swarbreck,D.,
            Sycamore,N., Tester,J., Thorpe,A., Tracey,A., Tromans,A.,
            Thomas,D.W., Wall,M., Wallis,J.M., West,A.P., Whitehead,S.L.,
            Willey,D.L., Williams,S.A., Wilming,L., Wray,P.W., Young,L.,
            Ashurst,J.L., Coulson,A., Blocker,H., Durbin,R., Sulston,J.E.,
            Hubbard,T., Jackson,M.J., Bentley,D.R., Beck,S., Rogers,J. and
            Dunham,I.
  TITLE     DNA sequence and analysis of human chromosome 9
  JOURNAL   Nature 429 (6990), 369-374 (2004)
   PUBMED   15164053
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL512590.2.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Apr 21, 2020 this sequence version replaced NM_020893.5.
            
            Summary: The protein encoded by this gene contains a coiled-coil
            domain. Alternative splicing results in multiple transcript
            variants encoding different isoforms. A single nucleotide
            polymorphism (SNP) in this gene has been associated with increased
            susceptibility to Behcet's Disease (PMID: 19442274). [provided by
            RefSeq, Dec 2016].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: CR749320.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2144120
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            MANE Ensembl match               :: ENST00000529487.3/
                                                ENSP00000434727.2
            RefSeq Select criteria           :: based on conservation,
                                                expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-148               AL512590.2         28918-29065
            149-298             AL512590.2         29242-29391
            299-489             AL512590.2         30673-30863
            490-578             AL512590.2         33372-33460
            579-688             AL512590.2         34495-34604
            689-817             AL512590.2         35652-35780
            818-928             AL512590.2         35877-35987
            929-1024            AL512590.2         36110-36205
            1025-1188           AL512590.2         38324-38487
            1189-1308           AL512590.2         39722-39841
            1309-1388           AL512590.2         41385-41464
            1389-1477           AL512590.2         44092-44180
            1478-1600           AL512590.2         45040-45162
            1601-1774           AL512590.2         46278-46451
            1775-1890           AL512590.2         47813-47928
            1891-2017           AL512590.2         49279-49405
            2018-2057           AL512590.2         51413-51452
            2058-2503           AL512590.2         51581-52026
            2504-2727           AL512590.2         64599-64822
            2728-2903           AL512590.2         68573-68748
            2904-3084           AL512590.2         70370-70550
            3085-3231           AL512590.2         71668-71814
            3232-3376           AL512590.2         75828-75972
            3377-3493           AL512590.2         76151-76267
            3494-3592           AL512590.2         78886-78984
            3593-3712           AL512590.2         81241-81360
            3713-3885           AL512590.2         82985-83157
            3886-4131           AL512590.2         83455-83700
            4132-4209           AL512590.2         85310-85387
            4210-4276           AL512590.2         86932-86998
            4277-4418           AL512590.2         87818-87959
            4419-4579           AL512590.2         91181-91341
            4580-4717           AL512590.2         91900-92037
            4718-4829           AL512590.2         92854-92965
            4830-4935           AL512590.2         95802-95907
            4936-5071           AL512590.2         96713-96848
            5072-7060           AL512590.2         98022-100010
FEATURES             Location/Qualifiers
     source          1..7060
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q22.33"
     gene            1..7060
                     /gene="CCDC180"
                     /gene_synonym="C9orf174; CFAP76; FAP76"
                     /note="coiled-coil domain containing 180"
                     /db_xref="GeneID:100499483"
                     /db_xref="HGNC:HGNC:29303"
     exon            1..148
                     /gene="CCDC180"
                     /gene_synonym="C9orf174; CFAP76; FAP76"
                     /inference="alignment:Splign:2.1.0"
     exon            149..298
                     /gene="CCDC180"
                     /gene_synonym="C9orf174; CFAP76; FAP76"
                     /inference="alignment:Splign:2.1.0"
     CDS             230..5203
                     /gene="CCDC180"
                     /gene_synonym="C9orf174; CFAP76; FAP76"
                     /note="isoform 1 is encoded by transcript variant 1;
                     Behcet's Disease Associated Gene 1; coiled-coil
                     domain-containing protein 180"
                     /codon_start=1
                     /product="coiled-coil domain-containing protein 180
                     isoform 1"
                     /protein_id="NP_065944.3"
                     /db_xref="CCDS:CCDS35077.3"
                     /db_xref="GeneID:100499483"
                     /db_xref="HGNC:HGNC:29303"
                     /translation="MSSVGKVTQVPNGKAYQQIFQAEVQLVHSLAATRKRAAERSVTL
                     KSGRIPMMKKVETPEGEVMSPRQQKWMHSLPNDWIMENPVLHREKERAKREKARESEN
                     TIAAREVRGLMDTIVPEKISTSTFQRQAEHKRKSYESALASFQEEIAQVGKEMEPLIV
                     DTGGLFLKKLTESDEEMNRLFLKVENDTNLEDYTIQALLELWDKVAGRLLLRKQEIKE
                     LDEALHSLEFSRTDKLKSVLKKYAEVIEKTSYLMRPEVYRLINEEAMVMNYALLGNRK
                     ALAQLFVNLMESTLQQELDSRHRWQGLVDTWKALKKEALLQSFSEFMASESIHTPPAV
                     TKELEVMLKTQNVLQQRRLKHLCTICDLLPPSYSKTQLTEWHSSLNSLNKELDTYHVD
                     CMMRIRLLYEKTWQECLMHVQNCKKQLLDWKAFTEEEAETLVNQFFFQMVGALQGKVE
                     EDLELLDKSFETLADQTEWQSSHLFKYFQEVVQLWEAHQSELLVQELELEKRMEQHRQ
                     KHSLESQVQEAHLDRLLDQLRQQSDKETLAFHLEKVKDYLKNMKSRYECFHTLLTKEV
                     MEYPAIMLKELNSYSSALSQYFFVREIFEQNLAGEVIFKFRQPEAHEKPSQKRVKKLR
                     KKQGSKEDMTRSEESISSGTSTARSVEEVEEENDQEMESFITEEVLGQQKKSPLHAKM
                     DESKEGSIQGLEEMQVEREGSLNPSLNEENVKGQGEKKEESEEEDEKEEEEEEEKLEE
                     EKEEKEAQEEQESLSVGEEEDKEEGLEEIYYEDMESFTISSGNTYFVFVPLEEEHCRK
                     SHSTFSAMFINDTSSAKFIEQVTIPSRLILEIKKQLRAGFFEHLEKWFDQCSLNTRVT
                     VATKINELDSELELHLHLHQPRAQQIEKDIHNVRAAELLLHQEQLDSHCAGVTETLKK
                     KRLMFCQFQEEQNVRSKNFRLKIYDMEHIFLNATRSQKLVTLSNTLHQELLSYVDVTQ
                     VSLRSFRQYLEESLGKLRYSNIEFIKHCRLFSEGGNFSPKEINSLCSRLEKEAARIEL
                     VESVIMLNMEKLENEYLDQANDVINKFESKFHNLSVDLIFIEKIQRLLTNLQVKIKCQ
                     VAKSNSQTNGLNFSLQQLQNKIKTCQESRGEKTTVTTEELLSFVQTWKEKLSQRIQYL
                     NCSLDRVSMTELVFTNTILKDQEEDSDILTSSEALEEEAKLDVVTPESFTQLSRVGKP
                     LIEDPAVDVIRKLLQLPNTKWPTHHCDKDPSQTGRGAWACGSRGSSEAGAGGAVCSPP
                     VLCSCPGPSSPKGFKRHRCQPENSGKKAVPSASATSAGSFTPHPKPNKMERKYRVLGD
                     KPPPAAEDFKGIILTLLWESSENLLTVAEEFYRKEKRPVTRPDCMCDTFDQCAENISK
                     KILEYQSQANKYHNSCLIELRIQIRRFEELLPQVCWLVMENFKEHHWKKFFTSVKEIR
                     GQFEEQQKRLEKRKDKNAQKLHLNLGHPVHFQEMESLHLSEEERQEELDSMIRMNKEK
                     LEECTRRNGQVFITNLATFTEKFLLQLDEVVTIDDVQVARMEPPKQKLSMLIRRKLAG
                     LSLKEESEKPLIERGSRKWPGIKPTEVTIQNKILLQPTSSISTTKTTLGHLAAVEARD
                     AVYLKYLASFEEELKRIQDDCTSQIKEAQRWKDSWKQSLHTIQGLYV"
     exon            299..489
                     /gene="CCDC180"
                     /gene_synonym="C9orf174; CFAP76; FAP76"
                     /inference="alignment:Splign:2.1.0"
     exon            490..578
                     /gene="CCDC180"
                     /gene_synonym="C9orf174; CFAP76; FAP76"
                     /inference="alignment:Splign:2.1.0"
     exon            579..688
                     /gene="CCDC180"
                     /gene_synonym="C9orf174; CFAP76; FAP76"
                     /inference="alignment:Splign:2.1.0"
     exon            689..817
                     /gene="CCDC180"
                     /gene_synonym="C9orf174; CFAP76; FAP76"
                     /inference="alignment:Splign:2.1.0"
     exon            818..928
                     /gene="CCDC180"
                     /gene_synonym="C9orf174; CFAP76; FAP76"
                     /inference="alignment:Splign:2.1.0"
     exon            929..1024
                     /gene="CCDC180"
                     /gene_synonym="C9orf174; CFAP76; FAP76"
                     /inference="alignment:Splign:2.1.0"
     exon            1025..1188
                     /gene="CCDC180"
                     /gene_synonym="C9orf174; CFAP76; FAP76"
                     /inference="alignment:Splign:2.1.0"
     exon            1189..1308
                     /gene="CCDC180"
                     /gene_synonym="C9orf174; CFAP76; FAP76"
                     /inference="alignment:Splign:2.1.0"
     exon            1309..1388
                     /gene="CCDC180"
                     /gene_synonym="C9orf174; CFAP76; FAP76"
                     /inference="alignment:Splign:2.1.0"
     exon            1389..1477
                     /gene="CCDC180"
                     /gene_synonym="C9orf174; CFAP76; FAP76"
                     /inference="alignment:Splign:2.1.0"
     exon            1478..1600
                     /gene="CCDC180"
                     /gene_synonym="C9orf174; CFAP76; FAP76"
                     /inference="alignment:Splign:2.1.0"
     exon            1601..1774
                     /gene="CCDC180"
                     /gene_synonym="C9orf174; CFAP76; FAP76"
                     /inference="alignment:Splign:2.1.0"
     exon            1775..1890
                     /gene="CCDC180"
                     /gene_synonym="C9orf174; CFAP76; FAP76"
                     /inference="alignment:Splign:2.1.0"
     exon            1891..2017
                     /gene="CCDC180"
                     /gene_synonym="C9orf174; CFAP76; FAP76"
                     /inference="alignment:Splign:2.1.0"
     exon            2018..2057
                     /gene="CCDC180"
                     /gene_synonym="C9orf174; CFAP76; FAP76"
                     /inference="alignment:Splign:2.1.0"
     exon            2058..2503
                     /gene="CCDC180"
                     /gene_synonym="C9orf174; CFAP76; FAP76"
                     /inference="alignment:Splign:2.1.0"
     exon            2504..2727
                     /gene="CCDC180"
                     /gene_synonym="C9orf174; CFAP76; FAP76"
                     /inference="alignment:Splign:2.1.0"
     exon            2728..2903
                     /gene="CCDC180"
                     /gene_synonym="C9orf174; CFAP76; FAP76"
                     /inference="alignment:Splign:2.1.0"
     exon            2904..3084
                     /gene="CCDC180"
                     /gene_synonym="C9orf174; CFAP76; FAP76"
                     /inference="alignment:Splign:2.1.0"
     exon            3085..3231
                     /gene="CCDC180"
                     /gene_synonym="C9orf174; CFAP76; FAP76"
                     /inference="alignment:Splign:2.1.0"
     exon            3232..3376
                     /gene="CCDC180"
                     /gene_synonym="C9orf174; CFAP76; FAP76"
                     /inference="alignment:Splign:2.1.0"
     exon            3377..3493
                     /gene="CCDC180"
                     /gene_synonym="C9orf174; CFAP76; FAP76"
                     /inference="alignment:Splign:2.1.0"
     exon            3494..3592
                     /gene="CCDC180"
                     /gene_synonym="C9orf174; CFAP76; FAP76"
                     /inference="alignment:Splign:2.1.0"
     exon            3593..3712
                     /gene="CCDC180"
                     /gene_synonym="C9orf174; CFAP76; FAP76"
                     /inference="alignment:Splign:2.1.0"
     exon            3713..3885
                     /gene="CCDC180"
                     /gene_synonym="C9orf174; CFAP76; FAP76"
                     /inference="alignment:Splign:2.1.0"
     exon            3886..4131
                     /gene="CCDC180"
                     /gene_synonym="C9orf174; CFAP76; FAP76"
                     /inference="alignment:Splign:2.1.0"
     exon            4132..4209
                     /gene="CCDC180"
                     /gene_synonym="C9orf174; CFAP76; FAP76"
                     /inference="alignment:Splign:2.1.0"
     exon            4210..4276
                     /gene="CCDC180"
                     /gene_synonym="C9orf174; CFAP76; FAP76"
                     /inference="alignment:Splign:2.1.0"
     exon            4277..4418
                     /gene="CCDC180"
                     /gene_synonym="C9orf174; CFAP76; FAP76"
                     /inference="alignment:Splign:2.1.0"
     exon            4419..4579
                     /gene="CCDC180"
                     /gene_synonym="C9orf174; CFAP76; FAP76"
                     /inference="alignment:Splign:2.1.0"
     exon            4580..4717
                     /gene="CCDC180"
                     /gene_synonym="C9orf174; CFAP76; FAP76"
                     /inference="alignment:Splign:2.1.0"
     exon            4718..4829
                     /gene="CCDC180"
                     /gene_synonym="C9orf174; CFAP76; FAP76"
                     /inference="alignment:Splign:2.1.0"
     exon            4830..4935
                     /gene="CCDC180"
                     /gene_synonym="C9orf174; CFAP76; FAP76"
                     /inference="alignment:Splign:2.1.0"
     exon            4936..5071
                     /gene="CCDC180"
                     /gene_synonym="C9orf174; CFAP76; FAP76"
                     /inference="alignment:Splign:2.1.0"
     exon            5072..7060
                     /gene="CCDC180"
                     /gene_synonym="C9orf174; CFAP76; FAP76"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5221..5226
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CCDC180"
                     /gene_synonym="C9orf174; CFAP76; FAP76"
                     /note="hexamer: AATAAA"
     polyA_site      5243
                     /gene="CCDC180"
                     /gene_synonym="C9orf174; CFAP76; FAP76"
                     /note="major polyA site"
     regulatory      5539..5544
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CCDC180"
                     /gene_synonym="C9orf174; CFAP76; FAP76"
                     /note="hexamer: AATAAA"
     polyA_site      5560
                     /gene="CCDC180"
                     /gene_synonym="C9orf174; CFAP76; FAP76"
     regulatory      5581..5586
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CCDC180"
                     /gene_synonym="C9orf174; CFAP76; FAP76"
                     /note="hexamer: AACAAG"
     polyA_site      5604
                     /gene="CCDC180"
                     /gene_synonym="C9orf174; CFAP76; FAP76"
     regulatory      6522..6527
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CCDC180"
                     /gene_synonym="C9orf174; CFAP76; FAP76"
                     /note="hexamer: AATAAA"
     polyA_site      6546
                     /gene="CCDC180"
                     /gene_synonym="C9orf174; CFAP76; FAP76"
ORIGIN      
        1 gagcgccgtt aacttttccc cgaagagcat ggcagagtga agcacaagca ataatcctgt
       61 attattcgcg ttcccagagt cccttcggat ttgcgccatg cgcggcgggg agaaccggcc
      121 tcctgctcga gttcagagct catctgagga attggaattg agacaccaaa gcctagacgc
      181 gtttcctgga cgacggcttc ccggcagggg catccagcca gcggccaaga tgtcgtcagt
      241 ggggaaggtg acccaggttc cgaatgggaa agcctaccag cagatcttcc aggctgaggt
      301 gcagctggtc cactccctgg cggccaccag gaagcgggct gcagagcgtt ctgtgaccct
      361 gaagagtggc aggataccca tgatgaagaa ggtggagact cctgaagggg aggtgatgtc
      421 tccccgacag cagaagtgga tgcacagcct ccccaacgac tggatcatgg aaaaccctgt
      481 tctccacagg gaaaaggaaa gagccaagag ggaaaaagcc cgagagagtg agaacaccat
      541 cgctgcccga gaagtgcggg gtctcatgga tactatagtt cctgagaaga taagcaccag
      601 cacctttcaa aggcaagcag aacacaagag gaagagctac gagagcgctc tggccagctt
      661 tcaggaggag attgcgcagg tgggaaagga aatggaacct ctcatcgtgg acacaggggg
      721 actttttttg aagaagctga ctgagtctga tgaagaaatg aaccgtctct tcctaaaggt
      781 ggaaaatgac accaaccttg aggactacac catccaagcc ctgctggagc tgtgggataa
      841 ggtggccggg cggttactgc tccggaagca ggagattaag gagctggatg aggccctgca
      901 ctcgctggag ttctcccgaa ccgataaact aaaaagcgtg ttgaagaaat atgcagaagt
      961 catagagaaa acttcctacc tcatgcggcc cgaagtgtac aggctgataa atgaagaagc
     1021 catggtcatg aactatgccc tgctgggcaa ccggaaggct ctcgcccagc tgtttgtcaa
     1081 cctgatggag tccaccctgc agcaggagct ggacagccgc caccgctggc aaggcttggt
     1141 ggacacctgg aaggctctca agaaggaggc cctgctgcag agtttcagtg agttcatggc
     1201 cagtgagagt atccatactc ccccggctgt gacgaaggag ctagaggtca tgctgaagac
     1261 ccagaacgtc ctgcagcaaa ggcggctgaa gcatctctgc accatctgtg acctcctgcc
     1321 ccccagttac agcaaaactc agctgactga gtggcattct tccctcaact ccctgaacaa
     1381 ggagctagac acctaccacg tggactgcat gatgcggatc cgcctgctgt atgagaagac
     1441 atggcaggag tgcctgatgc atgtgcagaa ttgtaagaag cagctgctgg actggaaagc
     1501 cttcactgag gaggaggcag agaccctggt gaaccagttc ttcttccaga tggtgggagc
     1561 actccagggc aaagtggagg aggacctgga gctcttggac aaatccttcg agactctggc
     1621 agatcagaca gagtggcaga gttcacacct cttcaagtat ttccaggagg tggtacaact
     1681 gtgggaggca caccagagcg agctgttggt gcaggagctg gagctggaga agaggatgga
     1741 gcagcaccgg cagaagcaca gcctggagag ccaggtgcag gaggcccacc tcgataggct
     1801 cttggaccaa ctgaggcagc aaagtgacaa agaaacactg gcgtttcacc tggaaaaggt
     1861 caaagattat ctgaagaaca tgaaatccag gtatgaatgt tttcacaccc tcctgacaaa
     1921 ggaagtgatg gagtacccag cgatcatgct gaaagaactc aactcctaca gctctgccct
     1981 cagccaatac ttctttgtgc gtgaaatctt tgaacagaac ttggctggag aagtcatttt
     2041 caaattcagg caaccagaag cacatgaaaa accctcccag aagagagtga aaaaactgag
     2101 gaagaagcaa gggtctaaag aggacatgac cagaagtgag gaaagcataa gtagtgggac
     2161 aagtactgcc aggtcagtag aagaggtgga agaagaaaac gatcaagaaa tggagtcctt
     2221 cataactgaa gaggtgctgg ggcagcagaa aaaatctcca ctgcatgcta agatggatga
     2281 gtccaaagaa ggctctattc agggactgga agaaatgcag gttgaaagag agggctcctt
     2341 aaacccatcc ctgaatgagg agaatgtgaa gggtcaagga gaaaagaagg aggagtcaga
     2401 ggaggaagat gagaaggagg aagaggagga ggaggagaag ctggaggaag agaaggagga
     2461 gaaggaggca caggaagagc aagagagttt atctgtgggt gaggaagaag acaaggaaga
     2521 gggtctagag gagatatact atgaggacat ggagtccttc acaatctcca gtggaaacac
     2581 ttattttgtc tttgtacccc tggaagaaga gcattgtagg aagtcccatt ccaccttctc
     2641 agccatgttc atcaacgaca cttccagtgc caagttcata gaacaagtga caattccatc
     2701 gagactaatt ttagaaatta agaaacaact tcgagctggc ttcttcgagc accttgagaa
     2761 gtggtttgac cagtgttccc tcaacacccg ggtcaccgtg gccaccaaaa tcaatgagct
     2821 ggattcagaa ctggagctgc atctgcacct gcaccagcca agagcccagc agattgaaaa
     2881 agacatccac aacgtcaggg cagccgagct tttgcttcat caagagcagt tggacagcca
     2941 ctgtgctggg gtgaccgaga cgctgaagaa gaagcggctg atgttctgcc agttccaaga
     3001 agagcaaaac gtgaggagca aaaacttccg ccttaagatc tatgacatgg agcacatctt
     3061 cttgaatgcc accaggagcc aaaagctggt cactctcagc aacacactgc accaggagtt
     3121 gcttagctat gttgatgtca cccaggtgtc cctgcgcagc ttccggcagt acttggagga
     3181 gagtctgggc aaactccgct actcaaatat tgagttcatc aaacactgca gattgttttc
     3241 agagggaggc aacttttctc ctaaagaaat caattcactg tgttcccgac tggagaagga
     3301 agctgcccgg atagagttgg ttgaaagtgt catcatgctc aacatggaga agttggagaa
     3361 tgagtacctg gaccaggcca atgatgtcat caacaagttt gaaagcaaat tccataacct
     3421 gtctgtggac cttattttca tagagaaaat ccagcggttg ctgacgaatc tgcaagtgaa
     3481 aatcaagtgc caggtggcaa aatccaattc gcaaacaaat ggattaaatt tctctctgca
     3541 acagcttcag aacaagataa aaacttgtca agagtccagg ggagagaaaa ccacagtgac
     3601 cacagaagaa ctcctcagct tcgtccaaac ttggaaggaa aaactgagcc agaggattca
     3661 gtaccttaac tgcagcctgg acagggtgtc catgactgaa ctggtcttta ccaacaccat
     3721 cctgaaggac caggaggaag acagtgacat cctgacatct tcagaagccc ttgaagagga
     3781 ggccaagctg gacgtggtca cccctgagtc cttcacccag ctgagccgcg tggggaagcc
     3841 cctgattgag gacccagctg tggatgtgat caggaagctc ctgcaacttc ccaacacaaa
     3901 atggccaacc caccattgtg acaaagatcc gtcccagaca ggtagaggcg catgggcctg
     3961 tgggtctcgg ggcagcagtg aggcaggggc tggtggtgct gtgtgctcac ctcctgtcct
     4021 ctgctcctgt cctgggccct cgtcacccaa aggcttcaag cgacatcggt gccagccaga
     4081 aaactctggg aagaaggctg tacccagtgc cagtgctacc tctgcaggca gcttcacacc
     4141 gcaccccaag cccaacaaaa tggagagaaa gtaccgggtg cttggggaca agcctccccc
     4201 tgctgccgag gattttaagg ggatcatctt gaccctcctc tgggagagca gtgagaacct
     4261 gctgacagtc gcagaggagt tctaccgtaa agaaaaacgc ccagtcacca ggcctgactg
     4321 catgtgtgac acctttgacc agtgcgccga gaacattagc aaaaagatcc tggagtatca
     4381 gagccaggca aataagtacc acaactcctg cctcatagaa ttacggatcc agatcaggag
     4441 atttgaggag ctgctgcccc aagtgtgttg gctggtgatg gagaatttca aggaacacca
     4501 ctggaaaaag tttttcacct ctgtgaagga gatccgagga cagttcgagg aacagcagaa
     4561 gcggctggag aaaagaaagg acaaaaatgc ccagaagctc catctaaatc ttggacaccc
     4621 cgtacatttc caagaaatgg agtctctaca cttaagtgaa gaggaaaggc aggaagagct
     4681 ggacagcatg attaggatga acaaggagaa gctggaggaa tgtaccagaa ggaatggcca
     4741 ggttttcata accaacttgg ccaccttcac cgagaagttc ctactgcagt tggatgaggt
     4801 ggtcaccatt gacgatgtcc aggttgcaag gatggagccc cccaaacaga aattatcaat
     4861 gctcatacga aggaaactcg ctgggctctc cctgaaggaa gagagtgaga aacccctgat
     4921 tgaacgtgga agcaggaagt ggccagggat caaacccacc gaagtcacca tccaaaacaa
     4981 gattcttctc cagccaacat catcgatttc caccaccaaa accaccctgg gccacctggc
     5041 ggccgtggaa gcccgagatg ctgtgtacct gaaatattta gcatcatttg aggaggagct
     5101 aaagaggatc caggatgact gtacatctca gataaaggag gctcagcgct ggaaggacag
     5161 ctggaagcag tccctgcaca ctatccaagg cctgtatgtg tgaccctccg ccccaccatg
     5221 aataaacact ttcttataca gactccttcc ctgtccatct acctgcctac ctactttccg
     5281 tccatccctc cctcccttca tccctccacc cctgctctgt gccgggcact gtagctttac
     5341 cagcgaacag gacacagcat ggtccctgcc cacgtggagc cctcttccca tgaggaaggc
     5401 aagcatgaaa ggggaattcc acgtggttag cagggagggt gagtaccagg aatcagtcac
     5461 ttcaaatagg caccagagct tcaaaggaca tcacctccaa acagcatgct gggcagggca
     5521 cgtcatcttg aaaaatgaaa taaaggtcat gggaaaatga tattttaatt taacagaata
     5581 aacaagtatg ggttataatt gcaactctgc actggttcct agacccaaca aataactaat
     5641 ccaatgttga ttggtatttg tgccacaatt tgtctgagca aattgcaata ttttggaaaa
     5701 aaaaaaatct tccaggctcc tttagtcctg tgttgcccag atcattctct tggagtcctc
     5761 cagcctgcca gtctcttgtt cgtcaactct cttcttcaat tacatggcgt gagcgtacag
     5821 ccttcatttg tcggtagctg tgtgtgtcat ctggacaggt ttcctcagcc atagacctag
     5881 gaggccccag ctcccaaatt tccagcccct gaaagctgtg tgaccctcca agtgcagttc
     5941 cctcacctgg ggacactcac tctgctctcc tggtttgctc cacccagtga ggccctgctt
     6001 ggttagcttg gttagcttgg tggcctttgt gcactgaagc caggagagtg aggagtcccc
     6061 ttccatcaag gcaaaagcaa tctcctgttc ttttctgtgc tccccccacc cccaccccaa
     6121 tgtgctacct ttcattgctt attattccga aaggaatata tgcgcattgt agaaaaaaga
     6181 atttatgaaa ccagcaaaag gataacttta aaatcctgag ccgggcgcgg tggctcacgc
     6241 ctgtaatcct agcactttgg gaggccaagg cgagcagatc atctgagctc aggagttcgg
     6301 ggccagctga ggcaacatga cgaaacccca tatctactaa aaatacaaaa agttagccag
     6361 gcatggtggc acacacctgt aatcccagct actggggagg ctgaggcatg agaatcgctt
     6421 taacctggga ggtggaggtt gcagtgagcc aagatcatgc cacttcactc tggcctgagc
     6481 aacagaatga gactctgtct caaataaacg aataaataaa taataaaatc ctggaatcta
     6541 gagacagtca ctgtccatag catctttcca tgtatgtgag ttatttttat aaaatggaat
     6601 cataacatgc attaggttcc ataaactgct tggtaaatgt taactggata aaccctatgc
     6661 catatccttc agtattcatt tacatcattg gttttcatac ttttctgact ctgacccact
     6721 gtataaacat gttctaaaca cacggtcctt gcacacatac acaacttgag accaacaggt
     6781 cacaggacag cacttaacct tactagaaag gctgctttct aatattttct ccctgctttt
     6841 taaatcctag cccagtccac taactcagtt catggcccac aaaggggctt tgattgcagt
     6901 gtgggacact gtcatttaaa cagctgcaga gtgttcccac tgcctgggga accagatcgc
     6961 ctctgtcgga caagggcgag gatgtcccat gcagggctcc tagaaagaag gcagagatga
     7021 catcctccca cattagctct ttgtacacat ctgtaatcat
//
