LOCUS       NM_001378204            4752 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens coiled-coil domain containing 18 (CCDC18), transcript
            variant 3, mRNA.
ACCESSION   NM_001378204
VERSION     NM_001378204.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4752)
  AUTHORS   Gupta,G.D., Coyaud,E., Goncalves,J., Mojarad,B.A., Liu,Y., Wu,Q.,
            Gheiratmand,L., Comartin,D., Tkach,J.M., Cheung,S.W., Bashkurov,M.,
            Hasegan,M., Knight,J.D., Lin,Z.Y., Schueler,M., Hildebrandt,F.,
            Moffat,J., Gingras,A.C., Raught,B. and Pelletier,L.
  TITLE     A Dynamic Protein Interaction Landscape of the Human
            Centrosome-Cilium Interface
  JOURNAL   Cell 163 (6), 1484-1499 (2015)
   PUBMED   26638075
REFERENCE   2  (bases 1 to 4752)
  AUTHORS   Lee,S.Y., Obata,Y., Yoshida,M., Stockert,E., Williamson,B.,
            Jungbluth,A.A., Chen,Y.T., Old,L.J. and Scanlan,M.J.
  TITLE     Immunomic analysis of human sarcoma
  JOURNAL   Proc Natl Acad Sci U S A 100 (5), 2651-2656 (2003)
   PUBMED   12601173
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC126124.2 and AL139421.12.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR18074967.782102.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000690025.1/ ENSP00000510597.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-129               AC126124.2         19021-19149
            130-265             AC126124.2         21657-21792
            266-434             AC126124.2         22275-22443
            435-593             AC126124.2         24642-24800
            594-700             AC126124.2         30297-30403
            701-829             AC126124.2         31913-32041
            830-926             AC126124.2         40189-40285
            927-1048            AC126124.2         43807-43928
            1049-1340           AC126124.2         45404-45695
            1341-1465           AC126124.2         49099-49223
            1466-1626           AC126124.2         50398-50558
            1627-1850           AC126124.2         53040-53263
            1851-1961           AL139421.12        2068-2178
            1962-2093           AL139421.12        3170-3301
            2094-2228           AL139421.12        7041-7175
            2229-2306           AL139421.12        7291-7368
            2307-2423           AL139421.12        11765-11881
            2424-2591           AL139421.12        17858-18025
            2592-2734           AL139421.12        21680-21822
            2735-2898           AL139421.12        24742-24905
            2899-3112           AL139421.12        25115-25328
            3113-3212           AL139421.12        31537-31636
            3213-3329           AL139421.12        32270-32386
            3330-3473           AL139421.12        39903-40046
            3474-3677           AL139421.12        41767-41970
            3678-3815           AL139421.12        44180-44317
            3816-4016           AL139421.12        50133-50333
            4017-4484           AL139421.12        55779-56246
            4485-4752           AL139421.12        63895-64162
FEATURES             Location/Qualifiers
     source          1..4752
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p22.1"
     gene            1..4752
                     /gene="CCDC18"
                     /gene_synonym="NY-SAR-41"
                     /note="coiled-coil domain containing 18"
                     /db_xref="GeneID:343099"
                     /db_xref="HGNC:HGNC:30370"
     exon            1..129
                     /gene="CCDC18"
                     /gene_synonym="NY-SAR-41"
                     /inference="alignment:Splign:2.1.0"
     exon            130..265
                     /gene="CCDC18"
                     /gene_synonym="NY-SAR-41"
                     /inference="alignment:Splign:2.1.0"
     CDS             132..4499
                     /gene="CCDC18"
                     /gene_synonym="NY-SAR-41"
                     /EC_number="4.6.1.2"
                     /note="isoform c is encoded by transcript variant 3;
                     coiled-coil domain-containing protein 18; sarcoma antigen
                     NY-SAR-41; sarcoma antigen NY-SAR-24"
                     /codon_start=1
                     /product="coiled-coil domain-containing protein 18 isoform
                     c"
                     /protein_id="NP_001365133.1"
                     /db_xref="CCDS:CCDS91004.1"
                     /db_xref="GeneID:343099"
                     /db_xref="HGNC:HGNC:30370"
                     /translation="MESSSSDYYNKDNEEESLLANVASLRHELKITEWSLQSLGEELS
                     SVSPSENSDYAPNPSRSEKLILDVQPSHPGLLNYSPYENVCKISGSSTDFQKKPRDKM
                     FSSSAPVDQEIKSLREKLNKLRQQNACLVTQNHSLMTKFESIHFELTQSRAKVSMLES
                     AQQQAASVPILEEQIINLEAEVSAQDKVLREAENKLEQSQKMVIEKEQSLQESKEECI
                     KLKVDLLEQTKQGKRAERQRNEALYNAEELSKAFQQYKKKVAEKLEKVQAEEEILERN
                     LTNCEKENKRLQERCGLYKSELEILKEKLRQLKEENNNGKEKLRIMAVKNSEVMAQLT
                     ESRQSILKLESELENKDEILRDKFSLMNENRELKVRVAAQNERLDLCQQEIESSRVEL
                     RSLEKIISQLPLKRELFGFKSYLSKYQMSSFSNKEDRCIGCCEANKLVISELRIKLAI
                     KEAEIQKLHANLTANQLSQSLITCNDSQESSKLSSLETEPVKLGGHQVAESVKDQNQH
                     TMNKQYEKERQRLVTGIEELRTKLIQIEAENSDLKVNMAHRTSQFQLIQEELLEKASN
                     SSKLESEMTKKCSQLLTLEKQLEEKIVAYSSIAAKNAELEQELMEKNEKIRSLETNIN
                     TEHEKICLAFEKAKKIHLEQHKEMEKQIERLEAQLEKKDQQFKEQEKTMSMLQQDIIC
                     KQHHLESLDRLLTESKGEMKKENMKKDEALKALQNQVSEETIKVRQLDSALEICKEEL
                     VLHLNQLEGNKEKFEKQLKKKSEEVYCLQKELKIKNHSLQETSEQNVILQHTLQQQQQ
                     MLQQETIRNGELEDTQTKLEKQVSKLEQELQKQRESSAEKLRKMEEKCESAAHEADLK
                     RQKVIELTGTARQVKIEMDQYKEELSKMEKEIMHLKRDGENKAMHLSQLDMILDQTKT
                     ELEKKTNAVKELEKLQHSTETELTEALQKREVLETELQNAHGELKSTLRQLQELRDVL
                     QKAQLSLEEKYTTIKDLTAELRECKMEIEDKKQELLEMDQALKERNWELKQRAAQVTH
                     LDMTIREHRGEMEQKIIKLEGTLEKSELELKECNKQIESLNDKLQNAKEQLREKEFIM
                     LQNEQEISQLKKEIERTQQRMKEMESVMKEQEQYIATQYKEAIDLGQELRLTREQVQN
                     SHTELAEARHQQVQAQREIERLSSELEDMKQLSKEKDAHGNHLAEELGASKVREAHLE
                     ARMQAEIKKLSAEVESLKEAYHMEMISHQENHAKWKISADSQKSSVQQLNEQLEKAKL
                     ELEEAQDTVSNLHQQVQDRNEVIEAANEALLTKESELTRLQAKISGHEKAEDIKFLPA
                     PFTSPTEIMPDVQDPKFAKCFHTSFSKCTKLRRSISASDLTFKIHGDEDLSEELLQDL
                     KKMQLEQPSTLEESHKNLTYTQPDSFKPLTYNLEADSSENNDFNTLSGMLRYINKEVR
                     LLKKSSMQTGAGLNQGENV"
     exon            266..434
                     /gene="CCDC18"
                     /gene_synonym="NY-SAR-41"
                     /inference="alignment:Splign:2.1.0"
     exon            435..593
                     /gene="CCDC18"
                     /gene_synonym="NY-SAR-41"
                     /inference="alignment:Splign:2.1.0"
     exon            594..700
                     /gene="CCDC18"
                     /gene_synonym="NY-SAR-41"
                     /inference="alignment:Splign:2.1.0"
     exon            701..829
                     /gene="CCDC18"
                     /gene_synonym="NY-SAR-41"
                     /inference="alignment:Splign:2.1.0"
     exon            830..926
                     /gene="CCDC18"
                     /gene_synonym="NY-SAR-41"
                     /inference="alignment:Splign:2.1.0"
     exon            927..1048
                     /gene="CCDC18"
                     /gene_synonym="NY-SAR-41"
                     /inference="alignment:Splign:2.1.0"
     exon            1049..1340
                     /gene="CCDC18"
                     /gene_synonym="NY-SAR-41"
                     /inference="alignment:Splign:2.1.0"
     exon            1341..1465
                     /gene="CCDC18"
                     /gene_synonym="NY-SAR-41"
                     /inference="alignment:Splign:2.1.0"
     exon            1466..1626
                     /gene="CCDC18"
                     /gene_synonym="NY-SAR-41"
                     /inference="alignment:Splign:2.1.0"
     exon            1627..1850
                     /gene="CCDC18"
                     /gene_synonym="NY-SAR-41"
                     /inference="alignment:Splign:2.1.0"
     exon            1851..1961
                     /gene="CCDC18"
                     /gene_synonym="NY-SAR-41"
                     /inference="alignment:Splign:2.1.0"
     exon            1962..2093
                     /gene="CCDC18"
                     /gene_synonym="NY-SAR-41"
                     /inference="alignment:Splign:2.1.0"
     exon            2094..2228
                     /gene="CCDC18"
                     /gene_synonym="NY-SAR-41"
                     /inference="alignment:Splign:2.1.0"
     exon            2229..2306
                     /gene="CCDC18"
                     /gene_synonym="NY-SAR-41"
                     /inference="alignment:Splign:2.1.0"
     exon            2307..2423
                     /gene="CCDC18"
                     /gene_synonym="NY-SAR-41"
                     /inference="alignment:Splign:2.1.0"
     exon            2424..2591
                     /gene="CCDC18"
                     /gene_synonym="NY-SAR-41"
                     /inference="alignment:Splign:2.1.0"
     exon            2592..2734
                     /gene="CCDC18"
                     /gene_synonym="NY-SAR-41"
                     /inference="alignment:Splign:2.1.0"
     exon            2735..2898
                     /gene="CCDC18"
                     /gene_synonym="NY-SAR-41"
                     /inference="alignment:Splign:2.1.0"
     exon            2899..3112
                     /gene="CCDC18"
                     /gene_synonym="NY-SAR-41"
                     /inference="alignment:Splign:2.1.0"
     exon            3113..3212
                     /gene="CCDC18"
                     /gene_synonym="NY-SAR-41"
                     /inference="alignment:Splign:2.1.0"
     exon            3213..3329
                     /gene="CCDC18"
                     /gene_synonym="NY-SAR-41"
                     /inference="alignment:Splign:2.1.0"
     exon            3330..3473
                     /gene="CCDC18"
                     /gene_synonym="NY-SAR-41"
                     /inference="alignment:Splign:2.1.0"
     exon            3474..3677
                     /gene="CCDC18"
                     /gene_synonym="NY-SAR-41"
                     /inference="alignment:Splign:2.1.0"
     exon            3678..3815
                     /gene="CCDC18"
                     /gene_synonym="NY-SAR-41"
                     /inference="alignment:Splign:2.1.0"
     exon            3816..4016
                     /gene="CCDC18"
                     /gene_synonym="NY-SAR-41"
                     /inference="alignment:Splign:2.1.0"
     exon            4017..4484
                     /gene="CCDC18"
                     /gene_synonym="NY-SAR-41"
                     /inference="alignment:Splign:2.1.0"
     exon            4485..4752
                     /gene="CCDC18"
                     /gene_synonym="NY-SAR-41"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4604..4609
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CCDC18"
                     /gene_synonym="NY-SAR-41"
                     /note="hexamer: AATAAA"
     regulatory      4631..4636
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CCDC18"
                     /gene_synonym="NY-SAR-41"
                     /note="hexamer: AAGAAA"
     polyA_site      4632
                     /gene="CCDC18"
                     /gene_synonym="NY-SAR-41"
                     /note="major polyA site"
     polyA_site      4653
                     /gene="CCDC18"
                     /gene_synonym="NY-SAR-41"
     regulatory      4729..4734
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CCDC18"
                     /gene_synonym="NY-SAR-41"
                     /note="hexamer: TATAAA"
     polyA_site      4752
                     /gene="CCDC18"
                     /gene_synonym="NY-SAR-41"
ORIGIN      
        1 ggttcgaatt ctgtgctgcc ggggttcgct ggttctccga gttgtgtccg aggcttccac
       61 gcgcaggggc ccgggaaagg gtcagaggct tcctaacgca gactcgagtg cgaagcgcgc
      121 agtcgccgga aatggaatct agttcatcag actactataa taaagacaat gaagaggaaa
      181 gtttgcttgc aaatgttgct tccttaagac atgaactgaa gataacagaa tggagtttgc
      241 agagtttagg ggaagagtta tccagtgtta gtccaagtga aaattctgat tatgccccta
      301 atccttcaag gtctgaaaag ctaattttgg atgttcagcc tagccaccct ggacttttga
      361 attattcacc ttatgaaaac gtctgtaaaa tatctggtag cagcactgat tttcaaaaaa
      421 agccaagaga taagatgttt tcatcttctg cccctgtgga tcaggagatt aaaagccttc
      481 gagagaaact aaataaactt aggcaacaga atgcttgttt ggtcacacag aatcattcct
      541 taatgactaa atttgaatct attcactttg aattaacaca gtcaagagca aaagtttcta
      601 tgcttgagtc tgctcaacag caggcagcca gtgtcccaat cttagaagaa cagattataa
      661 atttggaagc agaggtttca gctcaagata aagttttgag agaggcagaa aataagctgg
      721 aacagagcca gaaaatggta attgaaaagg aacagagttt gcaggagtcc aaagaggaat
      781 gtataaaatt aaaggtggac ttacttgaac aaaccaaaca aggaaaaaga gctgaacgac
      841 aaaggaatga agcactatat aatgccgaag agctgagtaa agctttccaa caatataaaa
      901 aaaaagtggc tgaaaaactg gaaaaggttc aagctgaaga agaaatatta gagagaaatc
      961 taactaactg tgaaaaagaa aataaaaggc tacaagaaag gtgtggtcta tataaaagtg
     1021 aacttgaaat tctgaaagag aaattaaggc agttaaaaga agaaaataac aacggaaaag
     1081 aaaaattaag gatcatggca gtgaaaaatt cagaagtcat ggcacaacta actgaatcta
     1141 gacaaagtat tttgaagcta gagagtgagt tagagaacaa agacgaaata cttagagaca
     1201 aattttcttt aatgaatgaa aaccgagaat taaaggtccg tgttgcagca cagaatgagc
     1261 gactagattt atgtcaacaa gaaattgaaa gttcaagggt agaactaaga agtttggaaa
     1321 agattatatc ccagttgcca ttaaaaagag aattatttgg ctttaaatca tatctttcta
     1381 aataccagat gagtagcttc tcaaacaagg aagaccgttg cattggctgc tgtgaggcaa
     1441 ataaattggt gatttcggaa ttgagaatta agcttgcaat aaaagaggca gaaattcaaa
     1501 agcttcatgc aaacctgact gcaaatcagt tatctcagag tcttattact tgtaatgaca
     1561 gccaagaaag tagcaaatta agtagtttag aaacagaacc tgtaaagcta ggtggtcatc
     1621 aagtagcaga aagcgtaaaa gatcaaaatc aacatactat gaacaagcaa tatgaaaaag
     1681 agaggcaaag acttgttact ggaatagaag aactacgtac taagctgata caaatagaag
     1741 ctgaaaattc tgatttgaag gttaacatgg ctcacagaac tagtcagttt cagctgattc
     1801 aagaggagct gctagagaaa gcttcaaact ccagcaaact ggaaagtgaa atgacaaaga
     1861 aatgttctca acttttaact cttgagaaac agctggaaga aaagatagtt gcttattcct
     1921 ctattgctgc aaaaaatgca gaactagaac aggagcttat ggaaaagaat gaaaagataa
     1981 ggagtctaga aaccaatatt aatacagagc atgagaaaat ttgtttagcc tttgaaaaag
     2041 caaagaaaat tcacttggaa cagcataaag aaatggaaaa gcagattgaa agacttgaag
     2101 ctcaactaga gaaaaaggac caacaattta aagaacaaga aaagactatg tccatgttgc
     2161 aacaagatat aatatgcaaa caacatcatc ttgaatcact agatagactc ttgacggaaa
     2221 gcaaagggga aatgaaaaag gaaaatatga agaaagatga agctttaaaa gcattacaga
     2281 accaagtatc tgaagaaaca atcaaggtta ggcaactaga ttcagcattg gaaatttgta
     2341 aggaagaact tgtcttgcat ttgaatcaat tggaaggaaa taaggaaaag tttgaaaaac
     2401 agttaaagaa gaaatctgaa gaggtatatt gtttacagaa agagctaaag ataaaaaatc
     2461 acagtcttca agagacttct gagcaaaacg ttattctaca gcatactctt cagcaacagc
     2521 agcaaatgtt acaacaagag acaattagaa atggagagct agaagatact caaactaaac
     2581 ttgaaaaaca ggtgtcaaaa ctggaacaag aacttcaaaa acaaagggaa agttcagctg
     2641 aaaagttgag aaaaatggag gagaaatgtg aatcagctgc acatgaagca gatttgaaaa
     2701 ggcaaaaagt gattgagctt actggcactg ccaggcaagt aaagattgag atggatcagt
     2761 acaaagaaga gctgtctaaa atggaaaagg aaataatgca cctaaaacga gatggagaaa
     2821 ataaagcaat gcacctctct caattagata tgatcttaga tcagacaaag acagagctag
     2881 aaaagaaaac aaatgctgta aaggagttag aaaagttaca gcacagtact gaaactgaac
     2941 taacagaagc cttgcaaaaa cgggaagtac ttgagactga actacaaaat gctcatggag
     3001 aattaaaaag tactttaaga caactccagg aattgagaga tgtactacag aaggctcaat
     3061 tatcattaga ggaaaaatac actactataa aggatctcac agctgaactt agagaatgca
     3121 agatggagat tgaagacaaa aagcaggagc tccttgaaat ggatcaggca cttaaagaga
     3181 gaaattggga actaaagcaa agagcagctc aggttacaca tttggatatg actattcgtg
     3241 agcacagagg agaaatggaa caaaaaataa ttaaattaga aggtactctg gagaaatcag
     3301 aattggaact taaagaatgt aacaaacaga tagaaagtct gaatgacaaa ttacaaaatg
     3361 ctaaagaaca gcttcgagaa aaagagttta taatgctaca aaatgaacag gagataagtc
     3421 aactgaaaaa agaaattgaa agaacacaac aaaggatgaa agaaatggag agtgttatga
     3481 aagagcaaga acagtacatt gccactcagt acaaggaggc catagatttg gggcaagaat
     3541 tgaggctgac ccgggagcag gtgcagaact ctcatacaga attggcagag gctcgtcatc
     3601 agcaagtcca agcacagaga gaaatagaaa ggctctctag tgaactggag gatatgaagc
     3661 aactctctaa agagaaagat gctcatggaa accatttagc tgaagaactg ggggcttcta
     3721 aagtacgtga agctcattta gaagcaagaa tgcaagcaga aatcaagaaa ttgtcagcag
     3781 aagtagaatc tctcaaagaa gcttatcata tggagatgat ttcacatcaa gagaaccatg
     3841 caaagtggaa gatttctgct gactctcaaa agtcttctgt tcagcaacta aacgaacagt
     3901 tagagaaggc aaaattggaa ttagaagaag ctcaggatac tgtaagcaat ttgcatcaac
     3961 aagtccaaga taggaatgaa gtaattgaag ctgcaaatga agcattactt actaaagaat
     4021 cagaattaac cagattacag gccaaaattt ctggacatga aaaggcagaa gacatcaagt
     4081 ttctgccagc cccatttaca tctccaacag aaattatgcc tgatgttcaa gatccaaaat
     4141 ttgctaaatg ttttcacaca tctttttcca agtgtacaaa attacgtcgc tctattagtg
     4201 ccagtgatct tactttcaaa attcatggtg atgaagatct ttctgaagaa ttactacagg
     4261 acttaaagaa aatgcaatta gaacagcctt caacattaga agaaagccat aagaatctga
     4321 cttacaccca gccagactca tttaaacctc tcacatataa cctagaagct gatagttctg
     4381 agaataatga ctttaacacg cttagtggga tgctaagata cataaacaaa gaagtaagac
     4441 tattaaaaaa gtcttctatg caaacaggtg ctggtttaaa tcagggagaa aatgtgtaat
     4501 tcaaagaaga tactgatgtg ttgaaaaaat ggaatttttg gtactgtgct gtttacttat
     4561 tatatgtagc tcatacttca tagaagctgt tattttgctt ttgaataaat tttatatttc
     4621 aatattttaa aagaaagccc ttctaaaact taattatatt tttaaagaaa atttattatt
     4681 ttatttattg ttttttggct taaacttgct gctttctttt gctttttata taaaaatcat
     4741 tgttaaaatg ca
//
