LOCUS       NM_001105528            3420 bp    mRNA    linear   PRI 25-MAR-2025
DEFINITION  Homo sapiens coiled-coil domain containing 178 (CCDC178),
            transcript variant 1, mRNA.
ACCESSION   NM_001105528 XM_011525948
VERSION     NM_001105528.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3420)
  AUTHORS   Gu,Y., Chen,G. and Ning,X.
  TITLE     Homeobox Protein BarH-like 1 Promotes Gastric Cancer Progression by
            Activating Coiled-Coil Domain-Containing Protein 178
  JOURNAL   Dig Dis Sci 69 (4), 1182-1199 (2024)
   PUBMED   38358459
  REMARK    GeneRIF: Homeobox Protein BarH-like 1 Promotes Gastric Cancer
            Progression by Activating Coiled-Coil Domain-Containing Protein
            178.
REFERENCE   2  (bases 1 to 3420)
  AUTHORS   Sigg,M.A., Menchen,T., Lee,C., Johnson,J., Jungnickel,M.K.,
            Choksi,S.P., Garcia,G. 3rd, Busengdal,H., Dougherty,G.W.,
            Pennekamp,P., Werner,C., Rentzsch,F., Florman,H.M., Krogan,N.,
            Wallingford,J.B., Omran,H. and Reiter,J.F.
  TITLE     Evolutionary Proteomics Uncovers Ancient Associations of Cilia with
            Signaling Pathways
  JOURNAL   Dev Cell 43 (6), 744-762 (2017)
   PUBMED   29257953
REFERENCE   3  (bases 1 to 3420)
  AUTHORS   Hu,X., Zhao,Y., Wei,L., Zhu,B., Song,D., Wang,J., Yu,L. and Wu,J.
  TITLE     CCDC178 promotes hepatocellular carcinoma metastasis through
            modulation of anoikis
  JOURNAL   Oncogene 36 (28), 4047-4059 (2017)
   PUBMED   28319061
  REMARK    GeneRIF: CCDC178 as a novel candidate oncogene involved in anoikis
            resistance and hepatocellular carcinoma (HCC) metastasis, and raise
            the possibility that CCDC178 may be a new therapeutic target for
            HCC.
REFERENCE   4  (bases 1 to 3420)
  AUTHORS   Yu,B., Zheng,Y., Alexander,D., Manolio,T.A., Alonso,A.,
            Nettleton,J.A. and Boerwinkle,E.
  TITLE     Genome-wide association study of a heart failure related
            metabolomic profile among African Americans in the Atherosclerosis
            Risk in Communities (ARIC) study
  JOURNAL   Genet Epidemiol 37 (8), 840-845 (2013)
   PUBMED   23934736
REFERENCE   5  (bases 1 to 3420)
  AUTHORS   Tao,S., Wang,Z., Feng,J., Hsu,F.C., Jin,G., Kim,S.T., Zhang,Z.,
            Gronberg,H., Zheng,L.S., Isaacs,W.B., Xu,J. and Sun,J.
  TITLE     A genome-wide search for loci interacting with known prostate
            cancer risk-associated genetic variants
  JOURNAL   Carcinogenesis 33 (3), 598-603 (2012)
   PUBMED   22219177
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK126038.1, BC091517.1, AC104956.6, BC130535.1, AC025888.8 and
            AK000027.1.
            
            On Apr 14, 2021 this sequence version replaced NM_001105528.3.
            
            Transcript Variant: This variant (1) lacks an alternate in-frame
            exon in the 3' coding region, compared to variant 3, resulting in a
            shorter protein (isoform 1), compared to isoform 3.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            CDS exon combination :: BC130535.1 [ECO:0000331]
            RNAseq introns       :: single sample supports all introns
                                    SAMEA2158188 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            MANE Ensembl match        :: ENST00000383096.8/ ENSP00000372576.3
            RefSeq Select criteria    :: based on manual assertion,
                                         conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-69                AK126038.1         1-69
            70-1604             BC091517.1         42-1576
            1605-159191         AC104956.6         1-157587
            159192-159597       BC130535.1         1474-1879
            159598-337798       AC025888.8         1-178201
            337799-338940       BC130535.1         1881-3022
            338941-339206       AK000027.1         607-872
FEATURES             Location/Qualifiers
     source          1..3420
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="18"
                     /map="18q12.1"
     gene            1..3420
                     /gene="CCDC178"
                     /gene_synonym="C18orf34"
                     /note="coiled-coil domain containing 178"
                     /db_xref="GeneID:374864"
                     /db_xref="HGNC:HGNC:29588"
                     /db_xref="MIM:621139"
     exon            1..69
                     /gene="CCDC178"
                     /gene_synonym="C18orf34"
                     /inference="alignment:Splign:2.1.0"
     exon            70..189
                     /gene="CCDC178"
                     /gene_synonym="C18orf34"
                     /inference="alignment:Splign:2.1.0"
     exon            190..269
                     /gene="CCDC178"
                     /gene_synonym="C18orf34"
                     /inference="alignment:Splign:2.1.0"
     CDS             212..2815
                     /gene="CCDC178"
                     /gene_synonym="C18orf34"
                     /note="isoform 1 is encoded by transcript variant 1;
                     coiled-coil domain-containing protein 178"
                     /codon_start=1
                     /product="coiled-coil domain-containing protein 178
                     isoform 1"
                     /protein_id="NP_001098998.1"
                     /db_xref="CCDS:CCDS42424.1"
                     /db_xref="GeneID:374864"
                     /db_xref="HGNC:HGNC:29588"
                     /db_xref="MIM:621139"
                     /translation="MTENKTVSSSSTRDDQTNIGLTCQEVKALREKAWSRTNEGNAMS
                     QSLVLYGASKENSEGFHESKMTNTEGVNKGIYFSYPCRRHSCAVVNIPAPCVNKMISH
                     IQDVESKIQEHLKRFETSFEEWSRTSSTKDLKEDWSVTTPVKEVKPGEKRDEKCPELK
                     QEMETLLSEAIRLIKSLETDRADAEEALKQQRSRKNMINMKIDSWSVWKLQELPLAVQ
                     KEHEAYLSDVIELQWHLEDKANQLQHFEKQKTELEEANAKIQADIDYMNEHGPLLDSK
                     QNQELQDLKNHYKKKMEVMDLHRKVNEELEEALEACENARLKAQQIKEEIDKDIYQDE
                     KTIEAYKREIYQLNSLFDHYSSSVINVNTNIEEKEEEVTEAIRETKSSKNELHSLSKM
                     LEDLRRVYDQLTWKQKSHENQYLEAVNDFYAAKKTWDIELSDVAKDFSAISLACTKLT
                     EDNKKLEIDINKITVKTNESIRKKSKYESEIKYLTIMKLKNDKHLKNIYKEAYRIGTL
                     FHLTKHKTDEMEDKIAEVRRKFKGREEFLKKLTQGEVAAGMVLQKKLYSIYEVQALER
                     KELIKNRAICAMSLAELQEPLLQLEDEAERIRSLDKEHSVMLNNIIDQKDLIRRKVGK
                     VKKKLRKKGKKTLDALIETESKRSAIFKDLEATKSKTMIFYAKINELNEELKAKEEEK
                     KSFDQTLEILKNKFITMRFKREHAQTVFDHYMQEKKDCEERIFEEDQRFRVLLAVRQK
                     TLQDTQKIIADSLEENLRLAQEYQQLQITFLKEKDNYFNIYDKQLSLDTSIRDKKQLC
                     QLQRRMHTLWQEHFKLVVLFSQMRLANFQTDSQESIQKILAVQEESSNLMQHILGFFQ
                     TLTDGTCENDG"
     exon            270..329
                     /gene="CCDC178"
                     /gene_synonym="C18orf34"
                     /inference="alignment:Splign:2.1.0"
     exon            330..419
                     /gene="CCDC178"
                     /gene_synonym="C18orf34"
                     /inference="alignment:Splign:2.1.0"
     exon            420..559
                     /gene="CCDC178"
                     /gene_synonym="C18orf34"
                     /inference="alignment:Splign:2.1.0"
     exon            560..582
                     /gene="CCDC178"
                     /gene_synonym="C18orf34"
                     /inference="alignment:Splign:2.1.0"
     exon            583..668
                     /gene="CCDC178"
                     /gene_synonym="C18orf34"
                     /inference="alignment:Splign:2.1.0"
     exon            669..869
                     /gene="CCDC178"
                     /gene_synonym="C18orf34"
                     /inference="alignment:Splign:2.1.0"
     exon            870..1090
                     /gene="CCDC178"
                     /gene_synonym="C18orf34"
                     /inference="alignment:Splign:2.1.0"
     exon            1091..1233
                     /gene="CCDC178"
                     /gene_synonym="C18orf34"
                     /inference="alignment:Splign:2.1.0"
     exon            1234..1387
                     /gene="CCDC178"
                     /gene_synonym="C18orf34"
                     /inference="alignment:Splign:2.1.0"
     exon            1388..1483
                     /gene="CCDC178"
                     /gene_synonym="C18orf34"
                     /inference="alignment:Splign:2.1.0"
     exon            1484..1620
                     /gene="CCDC178"
                     /gene_synonym="C18orf34"
                     /inference="alignment:Splign:2.1.0"
     exon            1621..1804
                     /gene="CCDC178"
                     /gene_synonym="C18orf34"
                     /inference="alignment:Splign:2.1.0"
     exon            1805..1867
                     /gene="CCDC178"
                     /gene_synonym="C18orf34"
                     /inference="alignment:Splign:2.1.0"
     exon            1868..2029
                     /gene="CCDC178"
                     /gene_synonym="C18orf34"
                     /inference="alignment:Splign:2.1.0"
     exon            2030..2143
                     /gene="CCDC178"
                     /gene_synonym="C18orf34"
                     /inference="alignment:Splign:2.1.0"
     exon            2144..2289
                     /gene="CCDC178"
                     /gene_synonym="C18orf34"
                     /inference="alignment:Splign:2.1.0"
     exon            2290..2449
                     /gene="CCDC178"
                     /gene_synonym="C18orf34"
                     /inference="alignment:Splign:2.1.0"
     exon            2450..2599
                     /gene="CCDC178"
                     /gene_synonym="C18orf34"
                     /inference="alignment:Splign:2.1.0"
     exon            2600..2734
                     /gene="CCDC178"
                     /gene_synonym="C18orf34"
                     /inference="alignment:Splign:2.1.0"
     exon            2735..3420
                     /gene="CCDC178"
                     /gene_synonym="C18orf34"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3176..3181
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CCDC178"
                     /gene_synonym="C18orf34"
                     /note="hexamer: AATAAA"
     polyA_site      3204
                     /gene="CCDC178"
                     /gene_synonym="C18orf34"
                     /note="major polyA site"
     regulatory      3397..3402
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CCDC178"
                     /gene_synonym="C18orf34"
                     /note="hexamer: AATAAA"
     polyA_site      3420
                     /gene="CCDC178"
                     /gene_synonym="C18orf34"
                     /note="major polyA site"
ORIGIN      
        1 gaccgcagca gagccggagg ggtgggcagg cgcgggtccg ggagacgcgc ggggaaacgc
       61 gcggagccgt gtctgctcaa tcaagtcaaa tactgaacaa cttcctggcg gagaggctga
      121 gaattttata cttgcttgct cgaaagcacc ccaaataaga tgatccacgc caacacctcc
      181 cctttacagg ttttaaaata ttcttataac tatgactgaa aacaagacag tttcctcttc
      241 ttccactaga gatgatcaaa ccaatatagg tttaacatgt caggaagtaa aggctctcag
      301 agagaaggca tggtcaagga caaatgaagg caatgccatg tctcaaagtt tggttctata
      361 tggagcctct aaggagaaca gtgaaggttt tcatgaaagt aaaatgacaa atactgaagg
      421 ggtgaataaa ggcatttact ttagctaccc atgtcgacgt cacagctgtg ccgtagtaaa
      481 tattccagca ccttgtgtca acaaaatgat ttcacacatc caagatgtgg agtccaaaat
      541 acaggagcat ttgaaaaggt ttgaaacttc ttttgaagaa tggagcagaa cttcttccac
      601 aaaagacctg aaagaagatt ggagtgtaac tacaccagtg aaagaggtca aaccaggaga
      661 aaagagagat gaaaagtgtc cagagttaaa gcaggaaatg gaaacattgc tctcagaggc
      721 cattcgtctc attaaaagtc tagaaactga ccgggcagac gctgaagaag ctttaaaaca
      781 acagagatca agaaagaata tgattaacat gaaaattgac tcttggtcag tctggaaact
      841 tcaagaactc ccattggctg tgcagaaaga acatgaggcc tatttgagtg atgttataga
      901 attacaatgg catcttgaag ataaagctaa tcaactacaa cattttgaaa aacaaaagac
      961 agagttagaa gaagcaaatg caaagattca agcagacata gactacatga atgaacatgg
     1021 ccctctactg gactctaagc agaatcagga acttcaagat ctgaagaacc attataaaaa
     1081 aaaaatggag gtaatggacc tacacagaaa agttaatgaa gaacttgaag aagctttaga
     1141 agcctgtgaa aatgccagat tgaaggctca gcaaattaaa gaagagattg ataaggatat
     1201 ttaccaggat gaaaaaacca tagaggccta caagagagag atatatcaac ttaacagtct
     1261 atttgatcat tactcttcat cagtgataaa tgttaatact aatattgagg agaaggaaga
     1321 ggaagtgact gaagcaataa gggaaacaaa gtcatcaaaa aatgaattac attctctatc
     1381 aaaaatgctg gaagatttga gaagagttta tgaccaacta acctggaagc aaaaaagtca
     1441 tgaaaatcag tatctggaag cagttaatga tttttatgct gcaaaaaaaa catgggatat
     1501 tgagctttct gatgttgcaa aagatttttc agctatttct ttggcatgta caaaactgac
     1561 ggaagacaat aaaaaacttg agattgatat taacaaaata acagtaaaaa ccaatgaaag
     1621 catacggaaa aaatcaaaat acgaatctga aataaaatat ttgacaataa tgaagttaaa
     1681 gaatgataaa catctcaaga acatctataa ggaggcttat cgcattggta ctcttttcca
     1741 cctaaccaaa cacaagacag atgaaatgga agataaaata gcagaagtga gaagaaagtt
     1801 caagggtaga gaagaattcc tgaaaaaact cactcaaggt gaagtggctg ctggaatggt
     1861 gcttcagaaa aaactatatt ccatttacga agtccaggca cttgagcgga aagagcttat
     1921 aaaaaataga gcaatatgtg ccatgtcact ggcagaacta caggaacctc tgcttcaact
     1981 agaagatgaa gctgaaagaa tcagaagtct cgacaaagaa cattctgtta tgcttaataa
     2041 tataattgat cagaaagatc ttattagaag aaaggtggga aaagtaaaga aaaaattacg
     2101 aaaaaagggg aagaaaaccc ttgatgcatt aatagaaact gagagtaaac gctcagcaat
     2161 ttttaaagac ctagaagcaa ctaaaagtaa gacaatgatt ttttatgcaa aaataaatga
     2221 attgaatgag gaattaaaag caaaagaaga agaaaagaaa agttttgatc agacacttga
     2281 aatattaaag aacaaattta taactatgag atttaaaagg gaacatgcac aaactgtgtt
     2341 tgatcattat atgcaagaga aaaaagactg tgaagagaga atctttgagg aagatcagag
     2401 atttagagtg ctccttgctg taagacaaaa aactcttcaa gatacccaaa aaataatagc
     2461 tgattcactt gaagaaaatc tgcgtttagc tcaagagtat caacagctac agattacatt
     2521 cttaaaagaa aaggacaatt atttcaatat atatgataaa cagctatcac ttgatacttc
     2581 aattagagat aagaaacagc tctgtcagct gcagagaagg atgcacacac tgtggcagga
     2641 gcacttcaaa ctggtggtcc tcttcagcca gatgaggctg gccaacttcc agacagactc
     2701 tcaggagagt attcagaaaa tattagctgt gcaggaggaa tcttcaaatt taatgcaaca
     2761 catcttaggt ttcttccaga ctttgacaga tggcacatgc gaaaacgatg gttaagcaaa
     2821 caaccaatgt atcttggatg ctgaaataaa agacaagaaa agtcacacag ttcagataac
     2881 agtgtaattg gacattcacc tgtttgccat ttcacacttc catgaacgaa aaactcactc
     2941 acctcccagc atgctttgcc actcttttac tcacagcaaa tccataacaa tgaaacaggt
     3001 gactttcatg ctgctgtcag gaacgatcta atttcagctc tgggtgactg attgcaattg
     3061 gctttgcctc atctgataat taatctatgt caccattaat tggaagagag aataattact
     3121 ggcggtgttg acagtgactg ttcgcttccc cagatttccc tatcgtcttg gcccaaataa
     3181 aggctttgcc attcagtact taaagtttgt gtaaactgta acaatatcta tgcccatgtg
     3241 acactttgag acactctgtc taatgtactt ttgtttttgt gtttaccagt cttttttagc
     3301 tcactgagag ctgtctctct caatcactcc tcaatgttct atcttaattt tgtggaagtt
     3361 taaagttttc aatgagctgg agatgaatga ttaatgaata aatttaaatg cttcattttg
//
