LOCUS       NM_198515               1679 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens coiled-coil domain containing 172 (CCDC172), mRNA.
ACCESSION   NM_198515 XM_350804
VERSION     NM_198515.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1679)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 1679)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1679)
  AUTHORS   Yang,X., Coulombe-Huntington,J., Kang,S., Sheynkman,G.M., Hao,T.,
            Richardson,A., Sun,S., Yang,F., Shen,Y.A., Murray,R.R., Spirohn,K.,
            Begg,B.E., Duran-Frigola,M., MacWilliams,A., Pevzner,S.J.,
            Zhong,Q., Wanamaker,S.A., Tam,S., Ghamsari,L., Sahni,N., Yi,S.,
            Rodriguez,M.D., Balcha,D., Tan,G., Costanzo,M., Andrews,B.,
            Boone,C., Zhou,X.J., Salehi-Ashtiani,K., Charloteaux,B., Chen,A.A.,
            Calderwood,M.A., Aloy,P., Roth,F.P., Hill,D.E., Iakoucheva,L.M.,
            Xia,Y. and Vidal,M.
  TITLE     Widespread Expansion of Protein Interaction Capabilities by
            Alternative Splicing
  JOURNAL   Cell 164 (4), 805-817 (2016)
   PUBMED   26871637
REFERENCE   4  (bases 1 to 1679)
  AUTHORS   Yamaguchi,A., Kaneko,T., Inai,T. and Iida,H.
  TITLE     Molecular cloning and subcellular localization of Tektin2-binding
            protein 1 (Ccdc 172) in rat spermatozoa
  JOURNAL   J Histochem Cytochem 62 (4), 286-297 (2014)
   PUBMED   24394471
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC044830.1 and AJ457798.1.
            
            On Nov 23, 2018 this sequence version replaced NM_198515.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC044830.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2148093
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000333254.4/ ENSP00000329860.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-175               BC044830.1         21-195
            176-1679            AJ457798.1         178-1681
FEATURES             Location/Qualifiers
     source          1..1679
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q25.3"
     gene            1..1679
                     /gene="CCDC172"
                     /gene_synonym="C10orf96"
                     /note="coiled-coil domain containing 172"
                     /db_xref="GeneID:374355"
                     /db_xref="HGNC:HGNC:30524"
     exon            1..166
                     /gene="CCDC172"
                     /gene_synonym="C10orf96"
                     /inference="alignment:Splign:2.1.0"
     exon            167..310
                     /gene="CCDC172"
                     /gene_synonym="C10orf96"
                     /inference="alignment:Splign:2.1.0"
     CDS             232..1008
                     /gene="CCDC172"
                     /gene_synonym="C10orf96"
                     /note="UPF0628 protein C10orf96"
                     /codon_start=1
                     /product="coiled-coil domain-containing protein 172"
                     /protein_id="NP_940917.1"
                     /db_xref="CCDS:CCDS31291.1"
                     /db_xref="GeneID:374355"
                     /db_xref="HGNC:HGNC:30524"
                     /translation="MSLESLFQHIIFTEHQAEESRRLMREVRSEITRCREKIKKATEE
                     LNEEKIKLESKVQQFFEKSFFLQLLKAHENALEKQYSEITNHRNMLLQTFEAIKKQMI
                     EEEDKFIKEITDFNNDYEITKKRELLMKENVKIEISDLENQANMLKSEMKSMEHDSSQ
                     LNELQKQKSELIQELFTLQRKLKVFEDEENESICTTKYLEAEKIKISEKPQNDTECLR
                     LKKELELYKEDDMESVYEALQTEIEFLELTLAQKDLQESK"
     exon            311..396
                     /gene="CCDC172"
                     /gene_synonym="C10orf96"
                     /inference="alignment:Splign:2.1.0"
     exon            397..513
                     /gene="CCDC172"
                     /gene_synonym="C10orf96"
                     /inference="alignment:Splign:2.1.0"
     exon            514..679
                     /gene="CCDC172"
                     /gene_synonym="C10orf96"
                     /inference="alignment:Splign:2.1.0"
     exon            680..781
                     /gene="CCDC172"
                     /gene_synonym="C10orf96"
                     /inference="alignment:Splign:2.1.0"
     exon            782..884
                     /gene="CCDC172"
                     /gene_synonym="C10orf96"
                     /inference="alignment:Splign:2.1.0"
     exon            885..972
                     /gene="CCDC172"
                     /gene_synonym="C10orf96"
                     /inference="alignment:Splign:2.1.0"
     exon            973..1679
                     /gene="CCDC172"
                     /gene_synonym="C10orf96"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1654..1659
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CCDC172"
                     /gene_synonym="C10orf96"
                     /note="hexamer: ATTAAA"
     polyA_site      1679
                     /gene="CCDC172"
                     /gene_synonym="C10orf96"
                     /note="major polyA site"
ORIGIN      
        1 actggctcca gccttaggga aggttttggc cgtgggtttt gttggcacgt accattttgc
       61 tgaaagacag agcaccttga ggacgttatc cctaaaatga gagaggactg ggattgaaag
      121 gctgactaca gaaatggctg ctgcccagac gccctcaaaa gccaaggatc ctcagagttg
      181 gttataaaat atttaagggc gagaaaagga tcgcaggagc caggccctga gatgagcttg
      241 gagtccctgt ttcagcacat catcttcacc gagcatcagg cggaggagag tcgccgtttg
      301 atgcgagaag taaggtcgga aataaccaga tgtcgtgaaa aaattaagaa agcaacggag
      361 gagctgaatg aagagaaaat caagctggaa tctaaggttc aacagttttt tgaaaaatcc
      421 ttcttcttac agcttttgaa agctcatgaa aatgctttag aaaaacagta cagtgaaatt
      481 acaaaccata ggaatatgct tcttcaaacc tttgaggcta taaagaaaca aatgatagag
      541 gaggaagaca aatttattaa ggaaattaca gactttaata atgattatga aataacaaag
      601 aaaagagagc ttttgatgaa agaaaatgtc aagattgaaa tatctgactt agaaaaccaa
      661 gcaaacatgt tgaaaagtga aatgaagtca atggaacatg atagtagcca gttaaatgaa
      721 cttcaaaaac aaaagagtga attgatacaa gaattattta ctctccaaag aaaacttaaa
      781 gtttttgaag atgaagagaa tgaatccatt tgtactacca aatatctaga ggcagaaaaa
      841 ataaaaatca gtgaaaagcc tcaaaatgat acagaatgct taagacttaa aaaagaatta
      901 gaactttata aggaagatga catggaaagt gtttatgaag ctctccaaac agaaatagaa
      961 tttttggagt tgacattggc acagaaagat cttcaggaaa gcaaataact tacagagaat
     1021 tgatcagcca tctgagattt gatcagaata tctgagaatc aaatctttgt gatagatata
     1081 tgaatggtac ccgttacaac ggatccttgt gggaaatatg gggtttaaaa tattcaaatt
     1141 gttattatct agaaatgatg tgttagccct ttaagataat ttttgtcttg ttactcaaac
     1201 tttaagagtt cttctgtggt ttgattttgt ttctaaaaga aggaaaagga gaagaagtag
     1261 ataccgtgtt cccaggcttc ttatatgccc ctgaacctca agctgtccta ttctttctaa
     1321 tctatataat atggtttgga tctgtgtcca tgcccaaatc tcatgttgaa ttgtgatccc
     1381 cactgttgga ggtgggtcct gataggaggt gattgggtca tgggggtggg tttctcatga
     1441 atagcttagc accattcttc ttggtactgt ccttgagttc tcctgagagc tagttgttta
     1501 ctagtgtata gcacttctcc actttgctcc tgctgccacc gtatgagatg tctcactccc
     1561 cctttgcctt cagtcatgat tggaaacttc ctgaggcctc cctagaagca gaagtcacta
     1621 tgcttcctgt acagcctgca gaaccgtggg acaattaaac ttgtgttctt tgtaaatta
//
