LOCUS       NM_025059               5306 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens coiled-coil domain containing 170 (CCDC170), mRNA.
ACCESSION   NM_025059
VERSION     NM_025059.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5306)
  AUTHORS   Zhang,J., Cai,Q., Chen,W., Huang,M., Guan,R. and Jin,T.
  TITLE     Relationship between rs7586085, GALNT3 and CCDC170 gene
            polymorphisms and the risk of osteoporosis among the Chinese Han
            population
  JOURNAL   Sci Rep 12 (1), 6089 (2022)
   PUBMED   35414641
  REMARK    GeneRIF: Relationship between rs7586085, GALNT3 and CCDC170 gene
            polymorphisms and the risk of osteoporosis among the Chinese Han
            population.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5306)
  AUTHORS   Liu,X., Li,Y.G., Tan,F., Liu,J., Yi,R. and Zhao,X.
  TITLE     Three functional polymorphisms in CCDC170 were associated with
            osteoporosis phenotype
  JOURNAL   Biol Open 10 (4) (2021)
   PUBMED   33785515
  REMARK    GeneRIF: Three functional polymorphisms in CCDC170 were associated
            with osteoporosis phenotype.
REFERENCE   3  (bases 1 to 5306)
  AUTHORS   Wang,Q., Zhao,Y., Zheng,H., Wang,Q., Wang,W., Liu,B., Han,H.,
            Zhang,L. and Chen,K.
  TITLE     CCDC170 affects breast cancer apoptosis through IRE1 pathway
  JOURNAL   Aging (Albany NY) 13 (1), 1332-1356 (2020)
   PUBMED   33291081
  REMARK    GeneRIF: CCDC170 affects breast cancer apoptosis through IRE1
            pathway.
REFERENCE   4  (bases 1 to 5306)
  AUTHORS   Li,L., Lin,L., Veeraraghavan,J., Hu,Y., Wang,X., Lee,S., Tan,Y.,
            Schiff,R. and Wang,X.S.
  TITLE     Therapeutic role of recurrent ESR1-CCDC170 gene fusions in breast
            cancer endocrine resistance
  JOURNAL   Breast Cancer Res 22 (1), 84 (2020)
   PUBMED   32771039
  REMARK    GeneRIF: Therapeutic role of recurrent ESR1-CCDC170 gene fusions in
            breast cancer endocrine resistance.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5306)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 5306)
  AUTHORS   Ichikawa,S., Koller,D.L., Padgett,L.R., Lai,D., Hui,S.L.,
            Peacock,M., Foroud,T. and Econs,M.J.
  TITLE     Replication of previous genome-wide association studies of bone
            mineral density in premenopausal American women
  JOURNAL   J Bone Miner Res 25 (8), 1821-1829 (2010)
   PUBMED   20200978
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (bases 1 to 5306)
  AUTHORS   Rivadeneira,F., Styrkarsdottir,U., Estrada,K., Halldorsson,B.V.,
            Hsu,Y.H., Richards,J.B., Zillikens,M.C., Kavvoura,F.K., Amin,N.,
            Aulchenko,Y.S., Cupples,L.A., Deloukas,P., Demissie,S.,
            Grundberg,E., Hofman,A., Kong,A., Karasik,D., van Meurs,J.B.,
            Oostra,B., Pastinen,T., Pols,H.A., Sigurdsson,G., Soranzo,N.,
            Thorleifsson,G., Thorsteinsdottir,U., Williams,F.M., Wilson,S.G.,
            Zhou,Y., Ralston,S.H., van Duijn,C.M., Spector,T., Kiel,D.P.,
            Stefansson,K., Ioannidis,J.P. and Uitterlinden,A.G.
  CONSRTM   Genetic Factors for Osteoporosis (GEFOS) Consortium
  TITLE     Twenty bone-mineral-density loci identified by large-scale
            meta-analysis of genome-wide association studies
  JOURNAL   Nat Genet 41 (11), 1199-1206 (2009)
   PUBMED   19801982
REFERENCE   8  (bases 1 to 5306)
  AUTHORS   Styrkarsdottir,U., Halldorsson,B.V., Gretarsdottir,S.,
            Gudbjartsson,D.F., Walters,G.B., Ingvarsson,T., Jonsdottir,T.,
            Saemundsdottir,J., Snorradottir,S., Center,J.R., Nguyen,T.V.,
            Alexandersen,P., Gulcher,J.R., Eisman,J.A., Christiansen,C.,
            Sigurdsson,G., Kong,A., Thorsteinsdottir,U. and Stefansson,K.
  TITLE     New sequence variants associated with bone mineral density
  JOURNAL   Nat Genet 41 (1), 15-17 (2009)
   PUBMED   19079262
REFERENCE   9  (bases 1 to 5306)
  AUTHORS   Styrkarsdottir,U., Halldorsson,B.V., Gretarsdottir,S.,
            Gudbjartsson,D.F., Walters,G.B., Ingvarsson,T., Jonsdottir,T.,
            Saemundsdottir,J., Center,J.R., Nguyen,T.V., Bagger,Y.,
            Gulcher,J.R., Eisman,J.A., Christiansen,C., Sigurdsson,G., Kong,A.,
            Thorsteinsdottir,U. and Stefansson,K.
  TITLE     Multiple genetic loci for bone mineral density and fractures
  JOURNAL   N Engl J Med 358 (22), 2355-2365 (2008)
   PUBMED   18445777
REFERENCE   10 (bases 1 to 5306)
  AUTHORS   Mungall,A.J., Palmer,S.A., Sims,S.K., Edwards,C.A., Ashurst,J.L.,
            Wilming,L., Jones,M.C., Horton,R., Hunt,S.E., Scott,C.E.,
            Gilbert,J.G., Clamp,M.E., Bethel,G., Milne,S., Ainscough,R.,
            Almeida,J.P., Ambrose,K.D., Andrews,T.D., Ashwell,R.I.,
            Babbage,A.K., Bagguley,C.L., Bailey,J., Banerjee,R., Barker,D.J.,
            Barlow,K.F., Bates,K., Beare,D.M., Beasley,H., Beasley,O.,
            Bird,C.P., Blakey,S., Bray-Allen,S., Brook,J., Brown,A.J.,
            Brown,J.Y., Burford,D.C., Burrill,W., Burton,J., Carder,C.,
            Carter,N.P., Chapman,J.C., Clark,S.Y., Clark,G., Clee,C.M.,
            Clegg,S., Cobley,V., Collier,R.E., Collins,J.E., Colman,L.K.,
            Corby,N.R., Coville,G.J., Culley,K.M., Dhami,P., Davies,J.,
            Dunn,M., Earthrowl,M.E., Ellington,A.E., Evans,K.A., Faulkner,L.,
            Francis,M.D., Frankish,A., Frankland,J., French,L., Garner,P.,
            Garnett,J., Ghori,M.J., Gilby,L.M., Gillson,C.J., Glithero,R.J.,
            Grafham,D.V., Grant,M., Gribble,S., Griffiths,C., Griffiths,M.,
            Hall,R., Halls,K.S., Hammond,S., Harley,J.L., Hart,E.A.,
            Heath,P.D., Heathcott,R., Holmes,S.J., Howden,P.J., Howe,K.L.,
            Howell,G.R., Huckle,E., Humphray,S.J., Humphries,M.D., Hunt,A.R.,
            Johnson,C.M., Joy,A.A., Kay,M., Keenan,S.J., Kimberley,A.M.,
            King,A., Laird,G.K., Langford,C., Lawlor,S., Leongamornlert,D.A.,
            Leversha,M., Lloyd,C.R., Lloyd,D.M., Loveland,J.E., Lovell,J.,
            Martin,S., Mashreghi-Mohammadi,M., Maslen,G.L., Matthews,L.,
            McCann,O.T., McLaren,S.J., McLay,K., McMurray,A., Moore,M.J.,
            Mullikin,J.C., Niblett,D., Nickerson,T., Novik,K.L., Oliver,K.,
            Overton-Larty,E.K., Parker,A., Patel,R., Pearce,A.V., Peck,A.I.,
            Phillimore,B., Phillips,S., Plumb,R.W., Porter,K.M., Ramsey,Y.,
            Ranby,S.A., Rice,C.M., Ross,M.T., Searle,S.M., Sehra,H.K.,
            Sheridan,E., Skuce,C.D., Smith,S., Smith,M., Spraggon,L.,
            Squares,S.L., Steward,C.A., Sycamore,N., Tamlyn-Hall,G., Tester,J.,
            Theaker,A.J., Thomas,D.W., Thorpe,A., Tracey,A., Tromans,A.,
            Tubby,B., Wall,M., Wallis,J.M., West,A.P., White,S.S.,
            Whitehead,S.L., Whittaker,H., Wild,A., Willey,D.J., Wilmer,T.E.,
            Wood,J.M., Wray,P.W., Wyatt,J.C., Young,L., Younger,R.M.,
            Bentley,D.R., Coulson,A., Durbin,R., Hubbard,T., Sulston,J.E.,
            Dunham,I., Rogers,J. and Beck,S.
  TITLE     The DNA sequence and analysis of human chromosome 6
  JOURNAL   Nature 425 (6960), 805-811 (2003)
   PUBMED   14574404
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL590543.8, DB232703.1, BC060803.1, AK225330.1 and AL359494.17.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_025059.3.
            
            Summary: The function of this gene and its encoded protein is not
            known. Several genome-wide association studies have implicated the
            region around this gene to be involved in breast cancer and bone
            mineral density, but no link to this specific gene has been found.
            [provided by RefSeq, May 2010].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC035003.2, AK225330.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968189, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000239374.8/ ENSP00000239374.6
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-23                AL590543.8         51783-51805
            24-578              DB232703.1         1-555
            579-1102            BC060803.1         505-1028
            1103-1478           AK225330.1         994-1369
            1479-2158           BC060803.1         1405-2084
            2159-5306           AL359494.17        93596-96743
FEATURES             Location/Qualifiers
     source          1..5306
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6q25.1"
     gene            1..5306
                     /gene="CCDC170"
                     /gene_synonym="bA282P11.1; C6orf97"
                     /note="coiled-coil domain containing 170"
                     /db_xref="GeneID:80129"
                     /db_xref="HGNC:HGNC:21177"
     exon            1..169
                     /gene="CCDC170"
                     /gene_synonym="bA282P11.1; C6orf97"
                     /inference="alignment:Splign:2.1.0"
     CDS             113..2260
                     /gene="CCDC170"
                     /gene_synonym="bA282P11.1; C6orf97"
                     /codon_start=1
                     /product="coiled-coil domain-containing protein 170"
                     /protein_id="NP_079335.2"
                     /db_xref="CCDS:CCDS43515.1"
                     /db_xref="GeneID:80129"
                     /db_xref="HGNC:HGNC:21177"
                     /translation="MSLDCTSHIALGAASPAPEETYDHLSEVPVTREQLNHYRNVAQN
                     ARSELAATLVKFECAQSELQDLRSKMLSKEVSCQELKAEMESYKENNARKSSLLTSLR
                     DRVQELEEESAALSTSKIRTEITAHAAIKENQELKKKVVELNEKLQKCSKENEENKKQ
                     VSKNCRKHEEFLTQLRDCLDPDERNDKASDEDLILKLRDLRKENEFVKGQIVILEETI
                     NVHEMEAKASRETIMRLASEVNREQKKAASCTEEKEKLNQDLLSAVEAKEALEREVKI
                     FQERLLAGQQVWDASKQEVSLLKKSSSELEKSLKASQDAVTTSQSQYFSFREKIAALL
                     RGRLSMTGSTEDTILEKIREMDSREESRDRMVSQLEAQISELVEQLGKESGFHQKALQ
                     RAQKAENMLETLQGQLTHLEAELVSGGVLRDNLNFEKQKYLKFLDQLSQKMKLDQMAA
                     ELGFDMRLDVVLARTEQLVRLESNAVIENKTIAHNLQRKLKTQKERLESKELHMSLLR
                     QKIAQLEEEKQARTALVVERDNAHLTIRNLQKKVERLQKELNTCRDLHTELKAKLADT
                     NELKIKTLEQTKAIEDLNKSRDQLEKMKEKAEKKLMSVKSELDTTEHEAKENKERARN
                     MIEVVTSEMKTLKKSLEEAEKREKQLADFREVVSQMLGLNVTSLALPDYEIIKCLERL
                     VHSHQHHFVTCACLKDVTTGQERHPQGHLQLLH"
     exon            170..298
                     /gene="CCDC170"
                     /gene_synonym="bA282P11.1; C6orf97"
                     /inference="alignment:Splign:2.1.0"
     exon            299..555
                     /gene="CCDC170"
                     /gene_synonym="bA282P11.1; C6orf97"
                     /inference="alignment:Splign:2.1.0"
     exon            556..700
                     /gene="CCDC170"
                     /gene_synonym="bA282P11.1; C6orf97"
                     /inference="alignment:Splign:2.1.0"
     exon            701..886
                     /gene="CCDC170"
                     /gene_synonym="bA282P11.1; C6orf97"
                     /inference="alignment:Splign:2.1.0"
     exon            887..1204
                     /gene="CCDC170"
                     /gene_synonym="bA282P11.1; C6orf97"
                     /inference="alignment:Splign:2.1.0"
     exon            1205..1405
                     /gene="CCDC170"
                     /gene_synonym="bA282P11.1; C6orf97"
                     /inference="alignment:Splign:2.1.0"
     exon            1406..1579
                     /gene="CCDC170"
                     /gene_synonym="bA282P11.1; C6orf97"
                     /inference="alignment:Splign:2.1.0"
     exon            1580..1822
                     /gene="CCDC170"
                     /gene_synonym="bA282P11.1; C6orf97"
                     /inference="alignment:Splign:2.1.0"
     exon            1823..2059
                     /gene="CCDC170"
                     /gene_synonym="bA282P11.1; C6orf97"
                     /inference="alignment:Splign:2.1.0"
     exon            2060..5306
                     /gene="CCDC170"
                     /gene_synonym="bA282P11.1; C6orf97"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5274..5279
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CCDC170"
                     /gene_synonym="bA282P11.1; C6orf97"
                     /note="hexamer: AATAAA"
     polyA_site      5306
                     /gene="CCDC170"
                     /gene_synonym="bA282P11.1; C6orf97"
                     /note="major polyA site"
ORIGIN      
        1 gcggtgttta cccgttgccc gaggagacac ccgcgccacc cgccggctcc cggcgccgcc
       61 gcttcctcag ggccggttcc gggtccgagc gcgcccccgg gctcgggtcg tcatgagcct
      121 ggactgcacc agccatatcg cgctgggtgc cgcttcgcca gcgcccgagg aaacttacga
      181 tcatctttcg gaagtcccgg tcacgcggga gcagttaaac cactatcgga atgtggctca
      241 aaatgctcga agtgaacttg cagcaacttt ggtcaaattt gaatgtgctc agtctgagct
      301 tcaagacctc cgatccaaga tgctttctaa agaagtctcc tgtcaagaac tgaaagctga
      361 aatggagagc tacaaggaaa acaatgccag aaaatcatct ctccttacct ctttgagaga
      421 cagagttcag gaactagaag aagaatcagc agcactttcc acttctaaaa tcagaacaga
      481 aatcacagct cacgctgcaa tcaaggagaa ccaggaatta aagaagaaag ttgtagagtt
      541 aaatgaaaaa ttacaaaagt gttcaaaaga aaatgaggag aataagaaac aagtttcaaa
      601 gaattgcagg aaacatgagg aatttctgac tcaactgcgt gactgcttgg atccagatga
      661 gaggaatgac aaggcatcag atgaagattt aattttaaag cttagagacc tgcgcaaaga
      721 aaatgaattc gtgaaaggac aaattgttat tcttgaagag actataaatg tccatgagat
      781 ggaagcaaaa gctagcagag aaacgatcat gaggctggct tcagaagtca acagagagca
      841 gaaaaaagct gcctcctgta ctgaagagaa agagaagctg aaccaggacc tgctcagtgc
      901 tgtagaagca aaagaagctc ttgaaaggga agttaagatc ttccaagaaa ggctgcttgc
      961 tggccagcag gtctgggatg cctcaaagca ggaagtgagc ctcctgaaga aaagctcttc
     1021 tgagttggag aagagtttga aggccagtca ggatgcagtc acaacctcac aaagccagta
     1081 cttctcattt agggagaaaa tcgcagccct ccttaggggc agattgagca tgactgggtc
     1141 cactgaggac accattttgg agaagattcg agaaatggac agccgggaag aaagcaggga
     1201 ccggatggtc tcccagcttg aagcccaaat atctgagctt gttgaacagt tgggaaagga
     1261 gtctgggttt caccagaaag ctctccagag ggcccagaaa gcagagaata tgttggagac
     1321 tcttcagggt cagctgacac acctggaggc agagctggtt tctggaggtg ttttgcgaga
     1381 caacttgaat tttgagaaac aaaaatatct taaatttctg gatcagcttt ctcagaaaat
     1441 gaagttggac cagatggctg ccgaacttgg ctttgacatg cggctggacg tggttttagc
     1501 tcgaacagag cagctggttc gtcttgagag caatgcagtc attgagaaca agaccattgc
     1561 ccacaatttg cagagaaagc taaagacaca gaaagagaga ctggagagca aagaattaca
     1621 catgagcctc ctccggcaga aaatagccca gctggaggag gagaagcagg cacgcacggc
     1681 cttggtggtt gagagggaca acgcgcatct taccatcagg aacttgcaga agaaggtgga
     1741 gaggctgcag aaagagctga acacgtgtcg agacttgcac accgagctca aagccaaact
     1801 ggccgacacc aatgaactga agattaaaac tttggaacag actaaagcca ttgaagatct
     1861 aaacaaatcc agagaccaac tggagaagat gaaggagaaa gctgagaaaa agctcatgtc
     1921 tgtcaagtca gaactggata ccacagaaca tgaggctaag gagaataaag aaagggccag
     1981 aaacatgata gaagtggtaa ccagtgaaat gaagacacta aaaaaatctc tggaagaagc
     2041 agaaaagaga gaaaagcagc tggcagactt cagggaggtg gtgtcgcaga tgctaggctt
     2101 gaacgtgacc agccttgctc ttcctgatta tgaaatcatc aagtgtcttg aaagattggt
     2161 ccattcacat cagcatcact ttgttacctg tgcctgcctc aaagatgtga ctactgggca
     2221 agagaggcac ccacaaggcc atttacagct tcttcattga acactgtatc tcttgagaga
     2281 ggtggccata agacatggca cacaattccc aatttcacaa attcctcatg tctttgagat
     2341 ttgatcagtt tgtgaatatt ttatgctttg atgatatagt gagaatgcat cacttgcaaa
     2401 aacgatctca aaagtgtcag ccttagataa acgttcagca ttaaaaacgc ctattatttc
     2461 atttactagc attttaggat ccagaagaat tccaccagat tgcatgagtt agattgggaa
     2521 atgggagtgg gagataatat tgggaggtat ctattttaag tcaggggctt tactagccga
     2581 tttagttctc acaataacca tgtggagaag ctgtgacatt tttaatttac aacctttctg
     2641 gggctcagac ataaagttac ctatccaagg ttgcagttgg gtagtggtgg gaccaggatg
     2701 gacaactcat tggccctgcc tcaaaagcca tacctcttct cctgctatgc agaatctgtt
     2761 tctcctgaat ctctgtgatg ctggtgggaa ttgtttgcat agaggaagga caataaccct
     2821 gccatcgtga gttaatgtcc gggctggtca cagtggttca tgcctgtaat cccagcactt
     2881 tgggagtcca aggcaggcat atcatttgag gtcaggagtt taagaccagc ctggctaaca
     2941 tagtgagacc ctgtttctac taaaaataca aaaataagcc aggtgtggtg gtgcatgact
     3001 gtaatcccaa ctactcagca ggagaagcac ttgaacccag gagacggagg cggcagtgag
     3061 ccaagattgt gccactgcac tccagcctgg gcgacagagt gaaactacat ctcagaaaaa
     3121 aaaaaaaaaa aaaaaaaaaa aagttaatgt ccaaaaatga cagatttaca agtgtaagct
     3181 atatgatttc ttcaaaaagc aaaagcaata tacctaattc atttggatca aacttacata
     3241 ggtctcaggt cctgtaagaa acttgcctgt tctaactgtt gctaccagat tatatctggt
     3301 ggtaattgtt aatgtttcag cagggctggt ctcagtcctt taaaatggaa agctttattt
     3361 ggagcccaac cctataagat gaagaaatcc tatatagtct tattcaccaa tatatccaat
     3421 acacccacag caatggtacc tttttaagat caggatttta ttatgaattc ctgtcacttt
     3481 ctgttttcca tttaaatttc tattttacaa atttttcagg gaatcatatt cttaacttca
     3541 ctgagaaaaa tgtgttactc ttttggacaa tttatcttat ttctatcata taagatgtat
     3601 ttttttattg tccttaaaag aagctctagc atgaaattaa aggaaaggga aagaaataga
     3661 tctggtgcac ccgaacatta ggagaaaatg aaaaatatac aaccaaccgt tcgtgagtca
     3721 tcaaaaagtc aaagtcagcc tggccaacat ggcaaaactc cgtctctgca aaaaatacaa
     3781 aaatgagccc ggtatgttgg catatgcctg taatcccagc tactcgagag gctgagacac
     3841 gaaaattgct tgaacctggg aggcggaggt tgcaatgagc cgagatcgcg ctactgcact
     3901 ccagcctggg caacagagag agaccttgtc tcaaaaaaca acaacaacaa aaagtcaaag
     3961 tcataataag caaattattg gcttctttct tctagactaa aagaaattaa agagatgaaa
     4021 caatcaattg caagggtcaa aactagattg gatcttggtt tgaatgaaaa aaagcataaa
     4081 atattcttgc aataattgta aaaatttgaa tgtggactaa gtcctagatt atattaaaat
     4141 atttttaatt ttttaagctt gacaaatgca ctgattgtta tactttaaat aactaaaaat
     4201 ctgagaatcc acagtgctac agacaataag tgataaaatg ggaaaaaata gtgaagatct
     4261 tcttttagga aaactaccaa taaatgtaga atggatgatt ccaaaaaaaa aaaaaaaaag
     4321 aagaaagaga gaaagaaaga aacagaaaaa cctaaaagaa agcgaatgaa tttgacacct
     4381 gttggttgga tgacagacca cacagaggga gagtgaccag gctttgcttg tggagcgggc
     4441 atccctgcct agctatctcc ttcatgtgca aggacagtat aagtagtatt ttgcatgtga
     4501 gtaaacacac ctgcgcagcc ctggctgagg tcactaggct ggccagaggc aggacaggca
     4561 gtcttgaatt tcctctaggg gaggcctgca gttttcccca ccaacccctt ttcacatgct
     4621 ccaaagatgt agtagtgtct gctgttttgg atcgaaaatc accttgagtg gaggaagtga
     4681 cttcactggg tctctggagg ctctcggagc ttgagtggct ctgccccacc ctgaatcatg
     4741 cacccataaa tgcagttatg ggtggatgtg ggtgtatgag agtggagatt gtttttgtac
     4801 attctctttg ttttcatttt ccaaatataa tctttaataa acttgattta gtttcttggg
     4861 aaatttattt tctacgctat tcaaagatat tttaaataat attttaaaaa catgaaattt
     4921 ttttttcatt tttgatttga tatcattaat tttatatcag gattcatgta agagactaaa
     4981 aatgatccat agtggttagt actgtaattt ctgtttatta catgaaatta cattccattt
     5041 atccaaatat atgtttatat aatatttcca ctgtgtgact ctagtgatct ttaacataca
     5101 cagaatgatc tacagtgatc tttaacatac tcagaaatat gaaaaatgtt tgaatatgat
     5161 ctttagggac ttctaatgaa aagggtatat gaaatgggaa caataaattc tgtacatgta
     5221 tacagtccat atacacatta agtgtttgtc atttggacaa attgaaaact tttaataaag
     5281 ccattttctt ctttgttaaa atgcca
//
